Double-frequency ultrasonic multi-dimensional focused cerebrovascular thrombolytic system

Abstract

The invention discloses a double-frequency ultrasonic multi-dimensional focused noninvasive cerebrovascular thrombolytic system, which is characterized in that: a craniocerebral vertical positioning ring is worn for image detection and acquisition of positioning image data; the position and treatment position of a focus can be determined by using a medical image three-dimensional reconstruction technique; a multi-dimensional low-power low-frequency ultrasonic transducer is placed on the same cut face of a focus of cerebral embolism to form a stable ultrasonic cavitation effect is formed in the thrombus or the focus of the cerebral embolism; a medium-frequency and / or high-frequency focused ultrasound transducer is used to radiate the thrombus by a focused ultrasonic focal point from a position on the same cut face of body surface which is most close to the focus, the focused ultrasonic waves are focused with high power, high sound intensity and high accuracy and are intermittently emitted in a pulse modulation ultrasonic wave mode in a short time to form an instant unstable ultrasonic cavitation effect in the thrombus to induce blasting in the thrombus, so that the thrombus is disintegrated and dissolved quickly; and while the thrombus is quickly and effectively dissolved, the inner wall of the blood vessel and surrounding normal brain tissues are not damaged, so in-vitro noninvasive thrombolytic effect is achieved.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to a dual-frequency ultrasonic multi-dimensional focusing non-invasive cerebrovascular thrombolysis technology and its application. Background technique [0002] Cerebrovascular disease is a common and frequently-occurring disease that seriously endangers human life and health. It has the characteristics of high morbidity, high disability rate, high mortality rate and high recurrence rate. Cerebral infarction accounts for 70-80% of cerebrovascular diseases. Most cerebral infarctions are caused by acute thrombosis or thrombus transfer to other parts, resulting in local cerebrovascular occlusion. The treatment of cerebral infarction is currently believed to be based on thrombolysis in the acute stage. (The best treatment time window is 1-3 hours, and should not exceed 6 hours in principle.) Restoring cerebral blood flow is the most effective treatment, but in practice, due to limitat...

AI Technical Summary

Problems solved by technology

[0011] The extracorporeal ultrasonic thrombolysis therapy technology introduced in the current public literature uses a non-focused ultrasonic treatment head, which directly places the ultrasonic treatment head on the cranium for treatment. The shortcoming is that no positioning technology is used. In this state, The sound intensity of treatment should not be higher than 1.5W / cm2, otherwise it may cause brain tissue damage, and the thrombolytic effect produced by this sound intensity is obviously limited. Since the treatment is not selective, normal brain tissue and thrombus formation sites Exposure to the same ultrasonic power radiation may generate high heat to the surrounding normal brain tissue, scalp and skull, and cause necrosis of the surrounding normal brain tissue, scalp and skull cells

[0012] At present, a single ultrasonic treatment head is usually used clinically, and the ultrasonic beam is passed through the head to reach the intracranial thrombus in a hand-held manner. The problem with this treatment method is: if the ultrasonic dose of a single ultrasonic treatment head reaches the required treatment When the intensity is 2-3W / cm2, due to the high ultrasonic intensity, local high fever will be generated in the skull, and the scalp and skull cells will be necrotic. In order to avoid the above side effects, the extracranial ultrasound dose can only be reduced during treatment, thus , limiting the effect of ultrasonic thrombolysis

The currently widely used ultrasound equipment with a frequency of 800KHz for physiotherapy is obviously not the most ideal ultrasonic thrombolysis equipment for dissolving thrombus.

[0016] Although low-frequency ultrasound has the above-mentioned advantages, in specific applications, because its wavelength is too large (take 25KHz ultrasound as an example, the wavelength is 6cm), and according to acoustic theory, the focal spot area cannot be smaller than the wavelength by applying modern acoustic focusing technology. (That is, the focal spot of 25KHz focused ultrasound cannot be less than 6cm), therefore, the purpose of focused ultrasound therapy cannot be achieved; while high-frequency ultrasound can use focusing technology to achieve the purpose of focusing to several millimeters, but due to its significant heating effect, and May damage surrounding tissue

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