8 results about "Acute thrombosis" patented technology

The application belongs to the technical field of pharmaceutical preparations, and specifically provides a kind of indobufen freeze-dried oral disintegrating tablet and a preparation method thereof.The freeze-dried oral disintegrating tablet contains indobufen and xanthan gum, and the freeze-dried oral disintegrating tablet can be obtained by freeze-drying technology after the above components are prepared into a suspension.The freeze-dried oral disintegrating tablet provided by the application has the technical characteristics of good properties, complete demolding, high drug loading, good content uniformity, rapid disintegration and rapid dissolution, and can meet the needs of rapid anti-platelet therapy in acute thrombosis events.

The invention relates to the technical field of medical instruments, in particular to an internal and external fiber coated intravascular stent as well as a preparation method and application thereof. An inner fiber covering film and an outer fiber covering film with certain functions are respectively prepared by utilizing a coaxial electrostatic spinning technology, and the fiber covering film with a core-shell structure is prepared. The inner-layer fiber covering film takes a degradable polymer as a shell layer preparation raw material, so that the shell layer can be degraded within a certain time, thrombus and inflammation resistance is realized, and endothelialization is promoted; the anti-thrombus substance loaded on the shell layer is used for resisting acute thrombus, and can be used as a protective layer to ensure the activity of the substance for promoting vascular endothelial growth in the core layer, and the load can realize a slow release function, so that the loss of expected functions due to quick release of the load is avoided. The outer fiber membrane takes a degradable polymer as a shell layer preparation raw material, so that the shell layer can be degraded within a certain time, and tissue integration and infection resistance are promoted; antibacterial substances are loaded on the core layer and are slowly released under the wrapping of the shell layer.

The invention belongs to the technical field of pharmaceutical preparations, and particularly provides an indobufen oral soluble film and a preparation method thereof. The oral soluble film contains indobufen, a film-forming material and a plasticizer, and after the components are prepared into a suspension, the oral soluble film can be obtained through coating and drying. The oral soluble film provided by the invention has the technical characteristics of complete appearance, good mechanical properties, high drug loading capacity, rapid disintegration, rapid dissolution, no bitter taste and good mouthfeel, and can meet the requirements of rapid antiplatelet treatment in acute thrombosis events.

This invention provides a multifunctional electrospun material and its application, as well as an artificial blood vessel and its preparation method. The electrospun material includes an electrospun material substrate and deferoxamine. This electrospun material possesses anti-inflammatory, antioxidant, antibacterial, and anticoagulant functions. When applied to the preparation of artificial blood vessels, it can improve the regenerative capacity of blood vessels, especially by protecting vascular cells through inhibiting inflammation and hyperglycemia-induced oxidative stress in diabetic and elderly patients, thereby promoting angiogenesis. The loaded deferoxamine can achieve long-term, slow release according to the environment of the transplantation site. The released deferoxamine can prevent acute thrombosis by inhibiting platelet adhesion and activation, and can also protect the microenvironment of the transplantation site by resisting oxidative stress and inflammation levels, promoting cell infiltration and regeneration, and protecting regenerated cells.

The invention provides a multifunctional electrospinning material and application thereof, an artificial blood vessel and a preparation method of the artificial blood vessel. The electrospinning material comprises an electrospinning material base material and deferoxamine. The electrospinning material has anti-inflammatory, anti-oxidation, antibacterial and anti-coagulation functions; when applied to preparation of artificial blood vessels, the compound can improve the regeneration capacity of the blood vessels, and particularly protect vascular cells by inhibiting inflammation and hyperglycemia induced oxidative stress in diabetes and elderly patients, so that the regeneration of the blood vessels is promoted. The loaded deferoxamine can be slowly released for a long time according to the environment of a transplantation site, and the released deferoxamine can avoid the formation of acute thrombus by inhibiting the adhesion and activation of platelets; meanwhile, the microenvironment of a transplantation part can be changed by resisting oxidative stress and inflammation level, infiltration and regeneration of cells are promoted, and the regenerated cells are protected.

An immunosensor device is disclosed for rapid detection of circulating biomarkers associated with thrombosis, including C-reactive protein (CRP), calprotectin, soluble platelet selectin (sP-selectin), and D-dimer. The immunosensors were fabricated using fiber-laser engraving of carbon nanotubes and CO2-laser cutting of microfluidic channels and features, along with the electrochemical deposition of gold nanoparticles to conjugate with biomarker-specific aptamers and antibody. Using unsupervised clustering based on 4-biomarker concentrations, thrombotic events were predicted in 49 of 53 patients. The 4-biomarker combination yielded an area under the receiver operating characteristic curve (AUC) of 0.95, demonstrating high sensitivity and specificity for acute thrombosis prediction compared to the AUC values for individual biomarker: CRP (0.773), calprotectin (0.711), sP-selectin (0.683), and D-dimer (0.739). The immunosensor device with unsupervised clustering provides accurate and efficient methods for predicting thrombosis, guiding personalized medicine.

Provided herein are methods of enhancing mechanical thrombectomy during endovascular therapy for acute thrombosis using 3,3′-diindolylmethane.

The invention belongs to the technical field of pharmaceutical preparations, and particularly provides an indobufen freeze-dried orally disintegrating tablet and a preparation method thereof. The freeze-dried orally disintegrating tablet contains indobufen and xanthan gum, and after the components are prepared into a suspension, the freeze-dried orally disintegrating tablet can be obtained through a freeze-drying technology. The freeze-dried orally disintegrating tablet provided by the invention has the technical characteristics of good character, complete demolding, high drug loading capacity, good content uniformity, rapid disintegration and rapid dissolution, and can meet the requirements of rapid antiplatelet therapy in acute thrombosis events.