The invention discloses a Qingkailing suppository, relates to a Chinese medicine compound preparation, the raw materials of which mainly come from plants and animals, in particular to a novel formulation of Qingkailing preparation. The Qingkailing suppository provided by the invention for supplying rectum with medicine adopts the following components of cholic acid, hyodeoxycholic acid, baicalin, buffalo horn, the hydrolysate of mother-of-pearl, gardenia, banlangen, the water purified extract of honeysuckle as Qingkailing combination. The suppository which is 1-3g weight is made from the raw materials and supplementary materials with the following weight proportions of 8-13 proportions of Qingkailing combination, 5-50 proportions of suppository base, 0.1-5 proportions of surfactant, 0.05-3 proportions of sorbefacient, and 0-3 proportions of additional agent. The Qingkailing suppository of the invention not only can compensate the defects that the oral taking preparation is slow to take effect and injection preparation has great toxicity, but also can prolong the duration of the medicine, provides a wider selection range for clinics and sufferers, has simple production technology, is suitable for industrialized batch production, and is suitable to be taken by infants.