The invention discloses a slow-release 
microsphere preparation containing a recombined human haemopoietin. The slow-release 
microsphere preparation is prepared by the S / O / W compound 
emulsion solvent volatilization method. The preparation method comprises that: firstly, by the freeze-
drying method, a micro particle containing the 
human serum albumin and the recombined human haemopoietin is prepared; secondly, by using a biodegradable high molecular material of 
lactic acid-
glycollic acid block 
copolymer as a 
carrier material, the micro particle containing the 
human serum albumin and the recombined human haemopoietin is encapsulated; and thirdly, the 
lactic acid-
glycollic acid block 
copolymer slow-release 
microsphere preparation containing the recombined human haemopoietin is prepared. The microsphere of the invention has the advantages of 
smooth surface, uniform appearance, regular size and no adhesion, the average particle size is between 70 and 105mu m; moreover, the microsphere is high in 
drug-carrying quantity and encapsulating rate, and the 
in vitro slow release period is more than 30 days. The obtained slow-release microsphere preparation is good in 
biocompatibility and can be used for non-
intravenous drug administration such as hypodermic 
drug administration and intramuscular 
drug administration, and when used as a drug preparation for treating 
renal anemia, the slow-release microsphere preparation can improve the 
hematocrit of a patient.