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488results about How to "No adhesion" patented technology

Detachable T-shaped microchannel device and method for preparing monodisperse polymer microspheres by same

The invention discloses a detachable T-shaped microchannel device and a method for preparing monodisperse polymer microspheres by the same. The method comprises the following steps of: performing heat treatment on a needle tube serving as a disperse phase flowing channel, and processing a duct with the same outer diameter as the needle tube on a pipeline serving as a continuous phase flowing channel to make the disperse phase needle tube and the continuous phase tube form a T-shaped channel; under the stable operating condition, making dispersed fluid form uniform micro liquid drops at a T-shaped tube orifice through the shearing force of continuous phase fluid to the disperse phase fluid; and under the action of a shaker, diffusing an organic solvent out of the liquid drops, and curing the liquid drops to form the polymer microspheres with uniform particle size. The T-shaped microchannel device is simple in equipment and can be detached, and pipelines are easy to dredge after being blocked; and the prepared polymer microspheres have uniform particle size, the particle size distribution coefficient of less than 15 percent, the minimum particle size distribution coefficient of 3 percent, and smooth surfaces without adhesion.
Owner:ZHEJIANG UNIV

Nanometer medicament microspheres

The invention discloses nanometer medicament microspheres. The microspheres comprise a medicament, nanoparticles, a polymer and medicinal auxiliary materials. The invention further provides a preparation method of the nanometer medicament microspheres. The method comprises the following steps of: preparing a medicament and medicinal auxiliary materials into a nanometer medicament; adding the nanometer medicament into a polymer-containing organic solvent mixed solution for emulsifying; adding a nanometer medicament-in-oil mixed suspension into a water mixed suspension containing nanoparticles or containing nanoparticles and a surfactant for emulsifying to obtain an oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil compound emulsion; and curing the obtained compound emulsion, and centrifugally collecting microspheres, wherein the obtained microspheres comprise the medicament, nanoparticles, the polymer and the medicinal auxiliary materials. An appropriate polymer material and an appropriate microsphere preparation method are selected, the prepared microspheres have high envelop rate, and a layer of self-assembled nanoparticles on the surfaces of the microspheres has the effects of improving cell adhesion and reducing inflammation and microencapsulation caused by local excessive acid and hydrophobic materials. The method disclosed by the invention can be applied to preparation of other medicament slow release or controlled release microspheres.
Owner:JINSHAN HOSPITAL FUDAN UNIV

Preparation method of medical quick imbibition foam material

The invention relates to a method for preparing a medical quick liquid-absorbing foam material. The method comprises the steps of well mixing polyvinyl alcohol aqueous solution, aldehyde and a pore-forming agent, adding acid to the mixture, continuing to stir the mixture, pouring the mixed solution into a die, curing and molding the mixed solution, washing and drying the obtained product and obtaining a target object. The material has abundant mutually communicated opening structures through a method of using mechanical foaming together with the pore-forming agent. The prepared material is good in biological compatibility and excellent in hydrophilcity, has the liquid-absorbing capability much higher than common cotton yarn and paper, has the capability of quickly absorbing a large amount of distilled water, physiological saline and urine, turns into soft tenacious elastic sponge after absorbing liquid, is resistant to heat and ultraviolet radiation, and can be disinfected in a plurality of ways. The prepared material is a rigid foam material in a dry state, is a spongy material in a wet state, has the apparent density of between 0.04 and 0.09 g/cm and the liquid-absorbing ratio of between 1,800 and 2,800 percent, and can be applied to medical operations.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI

Liraglutide sustained-release microsphere preparation and preparation method thereof

The invention relates to a liraglutide sustained-release micro sphere preparation and a preparation method thereof. The liraglutide sustained-release microsphere preparation comprises 5mg to 100mg of liraglutide, 0.5mg to 10mg of a protective agent and 50mg to 1000mg of a polylactic acid-glycolic acid copolymer, wherein the protective agent is one or a mixture of a plurality of sucrose, mycose, gelatin, mannitol, glycine, lysine and human serum albumin; the molecular weight of the polylactic acid-glycolic acid copolymer is 5000-20000 Daltons, and the ratio of polylactic acid to glycolic acid in the polylactic acid-glycolic acid copolymer is 1:3 to 3:1. According to the liraglutide sustained-release microsphere preparation disclosed by the invention, regular microspheres and medicines uniformly distributed in the microspheres can be obtained by just emulsifying and volatizing an organic solvent; processing procedures are simple; operation is simple; good repeatability is realized in preparation; the prepared liraglutide sustained-release microsphere preparations in batches have no remarkable difference; the obtained microspheres are uniform in grain size, narrow in distribution, controllable in grain size, round and orderly in surfaces and low in burst release rate.
Owner:浙江美华鼎昌医药科技有限公司 +1

Two-dimension fountain device

ActiveCN102814255ASolve the entanglementSolve the problem of winding on the rotary transmission mechanismEngine sealsMovable spraying apparatusWater flowEngineering
The invention relates to a two-dimension fountain device, which comprises a lower dimension mechanism and an upper dimension mechanism. The lower dimension mechanism and the upper dimension mechanism respectively comprise a motor, a speed reducer, an output shaft, a three-way connector and an overflow support ring. The upper dimension mechanism also comprises a shower nozzle with an elbow pipe. In the lower dimension mechanism, an outlet at the lower end of the shell of the speed reducer is connected with a water-proof tube; the bottom part of the water-proof tube is provided with a cable input connector; the outer wall of the lower end of the output shaft in the water-proof tube is connected with a nut; the inner wall of the lower end of the output shaft in the water-proof tube is connected with a conducting ring seat; and the bottom part of the conducting ring seat is connected with an axial conducting ring inserted into the conducting ring seat. The first ports of the two three-way connectors and the outlet of the shell of the corresponding speed reducer as well as the corresponding input shaft are respectively and hermetically connected through two rubber seal rings, a skeleton seal ring, a seal stop bowl and a stainless steel snap ring. The third ports of the two three-way connectors and the corresponding overflow support ring are hermetically connected through a polytetrafluoroethylene ring. The two-dimension fountain device is good in sealing property under high-pressure water flow, can be used for enabling the shower nozzle to continuously and freely rotate for 360 degrees and can be widely applied to various fountain facilities.
Owner:北京中科恒业中自技术有限公司

Gauze spreading machine

A gauze spreading machine comprises a body of the spreading machine which is arranged on a paving bed in a sliding way, and a cloth spreading mechanism arranged on the body of the spreading machine; the gauze spreading machine is characterized in that the body of the gauze spreading machine is also provided with a gauze special spreading mechanism which comprises a bracket, a cloth supporting mechanism arranged at one side of the bracket, a cloth removing device which is used for ripping away the cloth and is positioned above the cloth supporting mechanism on the bracket, a tension device that is used for tensioning the cloth and is arranged above the cloth removing device on the bracket, a light panel that is used for laying the cloth and arranged on the bracket, a turning roll wheel that is used for turning the cloth and is arranged under the light panel, and a cloth laying mechanism arranged below the turning roll wheel. When in work, winding cloth or piece goods can be placed on the cloth supporting mechanism, one end of the cloth passes in the middle of the a cloth removing roll wheel and then passes through the tension device upwards; then, the cloth is flatly laid by the light panel, passes through the cloth turning roll wheel, and is sequentially penetrated into the cloth laying mechanism; therefore, gauze spreading task can be carried out when the machine is actuated.
Owner:SPEEDFLY ZHEJIANG AUTOMATION TECH

Polyester film with adhesion resisting function and preparation method of polyester film

The invention discloses a polyester film with an adhesion resisting function. The polyester film is of a structure comprising a layer A, a layer B and a layer C, wherein the layer A and the layer C are surface layers; the layer B is a core layer; the layer A comprises the components of 65-80 percent of polyester slice for a general film and 20-30 percent of general adhesion resisting agent; the layer B comprises the components of 80-85 percent of master batch polyester slice for a functional film, 3-5 percent of general adhesion resisting master batch and 12-15 percent of high-performance adhesion resisting agent; and the layer C comprises the components of 50-65 percent of polyester slice for the general film and 35-50 percent of general adhesion resisting agent. The high heat resistance and excellent adhesion resistance are achieved by the steps of slicing, mixing, melting co-extrusion, longitudinal drawing, transverse drawing, drawing and trimming, coiling, splitting and forming a finished product. The products prepared by the preparation method disclosed by the invention is environment-friendly and can be directly recycled, so that the pollution to the environment is reduced; and the polyester film can be widely applied to packaging of cakes, seasonings, fast foods and candies and packaging of medical products.
Owner:JIANGSU SHUANGXING COLOR PLASTIC NEW MATERIALS

Sustained-release micro-spheres preparation containing recombined erythropoietin and preparation method and use thereof

The invention discloses a slow-release microsphere preparation containing a recombined human haemopoietin. The slow-release microsphere preparation is prepared by the S/O/W compound emulsion solvent volatilization method. The preparation method comprises that: firstly, by the freeze-drying method, a micro particle containing the human serum albumin and the recombined human haemopoietin is prepared; secondly, by using a biodegradable high molecular material of lactic acid-glycollic acid block copolymer as a carrier material, the micro particle containing the human serum albumin and the recombined human haemopoietin is encapsulated; and thirdly, the lactic acid-glycollic acid block copolymer slow-release microsphere preparation containing the recombined human haemopoietin is prepared. The microsphere of the invention has the advantages of smooth surface, uniform appearance, regular size and no adhesion, the average particle size is between 70 and 105mu m; moreover, the microsphere is high in drug-carrying quantity and encapsulating rate, and the in vitro slow release period is more than 30 days. The obtained slow-release microsphere preparation is good in biocompatibility and can be used for non-intravenous drug administration such as hypodermic drug administration and intramuscular drug administration, and when used as a drug preparation for treating renal anemia, the slow-release microsphere preparation can improve the hematocrit of a patient.
Owner:HEBEI NORMAL UNIV

Method for preparing microspheres by using oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil

The invention discloses a method for preparing microspheres by using oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil. The method comprises the following steps of: preparing a medicament and medicinal auxiliary materials into a nanometer medicament; adding the nanometer medicament into a polymer-containing organic solvent mixed solution for emulsifying; adding a nanometer medicament-in-oil mixed suspension into a water mixed suspension containing nanoparticles or containing nanoparticles and a surfactant for emulsifying to obtain an oil-in-nanoparticle mixed suspension-nanometer medicament-in-oil compound emulsion; and curing the obtained compound emulsion, and centrifugally collecting microspheres, wherein the obtained microspheres comprise the medicament, nanoparticles, the polymer and the medicinal auxiliary materials. An appropriate polymer material and an appropriate microsphere preparation method are selected, the prepared microspheres have high envelop rate, and a layer of self-assembled nanoparticles on the surfaces of the microspheres has the effects of improving cell adhesion and reducing inflammation and microencapsulation caused by local excessive acid and hydrophobic materials. The method disclosed by the invention can be applied to preparation of other medicament slow release or controlled release microspheres.
Owner:JINSHAN HOSPITAL FUDAN UNIV

Preparation method of aromatic polyamide core-shell paraffin phase change microcapsule

The invention relates to a preparation method of an aromatic polyamide core-shell paraffin phase change microcapsule, belonging to the field of preparation of the paraffin phase change microcapsule, and aiming to provide a preparation method of the paraffin phase change microcapsule of which the product has good heat resistance, chemical stability and compactness. In the method, trimesoyl chloride is adopted as an oil phase monomer, organic amine--ethylene diamine or piperazine is adopted as a water phase monomer, and the wall material of the prepared paraffin phase change microcapsule is cross-linking aromatic polyamide. The product microcapsule prepared by the technology of the invention does not contain autopolymer of a cyst wall material, the microcapsules do not adhere to each other, and a monodisperse state can be formed in a substrate easily. The coating ratio of the microcapsule is as high as 87.7%. The microcapsule prepared by the technology of the invention has no slow release, and the 5% thermo gravimetric temperature is 220 DEG C. The aromatic polyamide core-shell paraffin phase change microcapsule prepared by the technology of the invention can be applied to the fields of thermal-storage thermo-regulated fiber, solar energy and nuclear energy utilization, enhanced heat transfer, electronics, spaceflight and composite materials.
Owner:DALIAN POLYTECHNIC UNIVERSITY

Method for processing purified konjac flour

InactiveCN102640909ANo gelatinizationNo adhesionFood preparationOxygenPolyphenol oxidase
A method for processing purified konjac flour comprises twelve steps of material selection, swelling, extraction, material placing in a low temperature oxygen-free room, grinding, dehydration, dehumidification drying, dry grinding, winnowing, sieving, checkout and homogeneous warehousing. The method for processing the purified konjac flour has the advantages that the swelling and the extraction can enable impurities in the konjac flour to be soluble in impregnation liquid and accordingly separated out, the activity of polyphenol oxidase can be restrained and brown stain can be prevented through processing in the low temperature oxygen-free room. Starch and the impurities attached to glucomannan particles can be further peeled off through the grinding, and then the impurities are removed through the dehydration. Heating can be avoided and brown stain, gelatinization and adhesion can be prevented through the dehumidification drying. By means of the grinding in the low temperature environment, the ragility of konjac particles can be improved, the impurities can be easily separated, and small particles can be obtained. Various levels of purified konjac flour meeting the national requirements is obtained after the sieving. Therefore, produced purified konjac flour does not contain sulfur, is free of brown stain, gelatinization and adhesion and is pure white, and the product quality is improved.
Owner:重庆天娇农业开发有限公司

Water-soluble polyvinyl alcohol chopped fiber as well as preparation method and application thereof

The invention discloses a water-soluble polyvinyl alcohol chopped fiber of which the water dissolving temperature is 65-75 DEG C. The water-soluble polyvinyl alcohol chopped fiber is prepared by performing spinning and spinning after-treatment on polyvinyl alcohol and water serving as raw materials, wherein the polymerization degree of the polyvinyl alcohol is 1,400+ / -200, the alcoholysis degree is 98.3-99.9 percent, and the mass percentage concentration is 21.0-23.0 percent. The water-soluble polyvinyl alcohol chopped fiber has low water dissolving temperature, and has particularly prominent application effects in the fields of soluble embroidery base cloth, water-soluble paper and the like in the industries of spinning and non-woven fabrics; the water-soluble polyvinyl alcohol chopped fiber is free from salt, so that fiber adhesion is prevented during drying after desalination in the production process; and meanwhile, the strength of the water-soluble polyvinyl alcohol chopped fiber is more than or equal to 3.2 cN / dtex, and the crispation number is more than or equal to 4 / 25 millimeters. The preparation method contributes to industrial mass production, the dissolving temperature of the prepared water-soluble polyvinyl alcohol chopped fiber is 65-75 DEG C, and grading, packaging and transportation are easy.
Owner:CHINA PETROCHEMICAL CORP +1
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