Azithromycin for suspension and its preparing method
A technology of azithromycin and dry suspension, which is applied in the field of dry suspension of azithromycin for medicine and its preparation, which can solve the problems of difficult to effectively cover up the bitter taste of the drug and poor dissolution of the drug, and achieve wide application, tight packaging and stable good sex effect
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[0037] Example 1:
[0038] Element
[0039] Preparation:
[0040] (1) prepare 10% Eudragit E100 (butyl methacrylate: dimethylaminoethyl methacrylate: methyl methacrylate 25:50:25 copolymer) solution;
[0041] (2) Azithromycin, sucrose, mannitol, and sodium phosphate are mixed through an 80-mesh sieve and placed in the top spray of the fluidized bed. The air inlet temperature is 40°C and the pressure is 0.25 MPa;
[0042] (3) spray Eudragit E100 (butyl methacrylate: dimethylaminoethyl methacrylate: methyl methacrylate 25:50:25 copolymer) solution;
[0043] (4) top spray drying, the inlet temperature is 50 ℃, and the drying time is 70 minutes;
[0044] (5) granulation: take the remaining sucrose and mannitol and mix the alcohol solution for granulation, dry and granulate, screen the obtained granules, and select a 30-mesh sieve;
[0045] (6) Mixing: The coating raw materials, sucrose and mannitol granules are manually mixed according to the equal increment method, ...
Example Embodiment
[0046] Example 2:
[0047] Element
[0048] Preparation:
[0049] (1) prepare 10% IV No. acrylic resin solution;
[0050] (2) Azithromycin, sucrose, mannitol, and sodium phosphate are mixed with an 80-mesh sieve and placed in a fluidized bed top spray, the inlet air temperature is 40°C, and the pressure is 0.5 MPa;
[0051] (3) spray No. IV acrylic resin solution;
[0052] (4) Top spray drying, the inlet air temperature is 50°C, and the drying time is 100 minutes;
[0053] (5) granulation: take the remaining sucrose and mannitol and mix the alcoholic solution for granulation, dry and granulate, screen the obtained granules, and select a 50-mesh sieve;
[0054] (6) Mixing: Mix the coating raw materials, sucrose and mannitol granules according to the equal increment method, and then mix with the remaining raw and auxiliary materials in the same way and dry.
Example Embodiment
[0055] Example 3:
[0056] time min
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