94 results about "Erythromycin" patented technology

The invention discloses hip cream as well as a preparation method and application thereof, and belongs to the technical field of infant care products. The hip cream comprises a phase A, a phase B and a phase C, wherein the phase A comprises caprylic capric triglyceride, olive oil, camellia-seed oil, cera alba, sunflower seed oil and white ozocerite; a phase B: trihydroxy stearin; a phase C: VE acetate, folium artemisiae argyi essential oil, Roman chamomile, tea tree oil and double purple oil; and phase D: simmondsia chinensis seed oil. According to the invention, by optimizing the components and dosage in the hip cream, the prepared hip cream has good anti-inflammatory, soothing, moisturizing and skin repairing effects, the problems of red buttocks of newborns and skin ulceration, water loss, chapping, desquamation and the like caused by the red buttocks of the newborns are reduced, and meanwhile, the use of medicaments such as erythromycin ointment and the like is reduced. Meanwhile, the surface of the paper diaper can be coated with the hip cream to obtain the paper diaper containing the hip cream coating, the repairing and other effects of the hip cream are utilized, meanwhile, the paper diaper containing the hip cream has better soft feeling and smooth feeling, and damage caused by friction of the paper diaper is reduced.

The invention discloses staphylococcus vorus X9 with an antibiotic degradation function and application of the staphylococcus vorus X9 in antibiotic degradation, and belongs to the technical field of microorganisms. The staphylococcus vorus X9 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.32162. The strain has an excellent degradation effect on erythromycin and oxytetracycline, so that the strain has application value and prospect in the field of antibiotic degradation. Therefore, the compound can be prepared into a microbial agent which is used for purifying an environment polluted by antibiotics.

The invention discloses a chromogenic culture medium for detecting gram-negative bacteria in bovine mastitis and a test plate thereof, the culture medium comprises a nutritional ingredient mixture, a composite inhibitor, a composite chromogenic enzyme substrate and cold water gel, the compound chromogenic enzyme substrate is red tetrazole, 5-bromo-6-chloro-3-indole-beta-D-galactoside, and 5-bromo-4-chloro-3-indole-beta-D-glucopyranoside, and the compound chromogenic enzyme substrate is a compound chromogenic enzyme substrate, and the compound chromogenic enzyme substrate is 5-bromo-6-chloro-3-indole-beta-D-glucopyranoside. The chromogenic culture medium and the test board prepared from the chromogenic culture medium can effectively inhibit the growth of non-gram negative bacteria, have the characteristics of strong specificity, high sensitivity, short detection period, easy observation and low detection cost, and have huge development potential and wide application prospects in microbiological detection.

The invention discloses a hydrogel microneedle patch and a preparation method and application thereof.The hydrogel microneedle patch is characterized in that a gel main body is obtained by mixing PEG600 and PEG1000 according to the mass ratio of 3: 4, erythromycin, vaccarin and 7-demethylated corticin are loaded, a temperature response type gel microneedle is prepared, DG is in a solid needle shape at the room temperature, and the temperature response type gel microneedle patch is a hydrogel microneedle patch. Under the action of external force, the medicine can penetrate through a biological membrane secreted by bacteria and then is quickly melted into liquid by virtue of body temperature, and loaded medicine is released; in the invention, the wound healing is promoted through the synergistic effect between the hydrogel and the medicine. The hydrogel microneedle patch prepared by the invention can remarkably promote rapid healing of a staphylococcus aureus infected wound surface and can remarkably promote rapid healing of a back wound surface of a diabetic rat.

The invention relates to novel rufomycin analogs targeting C1pC1 protease. The compounds of the invention have antibacterial activity, for example, with anti-tuberculosis properties, and are useful for the treatment of, for example, tuberculosis.

The invention discloses a Weissella virida 38-3 strain and an application thereof. Relates to the technical field of microorganisms. The invention provides a strain and application thereof. The strain is safe in separation source, high in growth speed and excellent in fermentation performance; the strain has the advantages of good biological safety, no hemolytic activity and no generation of bioamine, is sensitive to antibiotics such as ampicillin, erythromycin, kanamycin, streptomycin, tetracycline, vancomycin, chloramphenicol, gentamicin, clindamycin, ciprofloxacin, cefixime and the like, has good probiotic performance, has good gastric juice and intestinal juice tolerance and strong cell surface adhesion, and can be used for preparing antibiotics. Good pathogenic bacterium inhibiting and cholesterol lowering capabilities are realized. The strain disclosed by the invention can be used as a probiotic to prepare a food leavening agent, multifunctional medicines, functional foods or health-care foods, and has wide market prospects and application values.

The invention relates to the technical field of medical drugs, in particular to a traditional Chinese medicine for pressure sore rehabilitation treatment and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 2 parts of honeysuckle flowers, 2 parts of fructus forsythiae, 2 parts of purslane, 1 part of radix isatidis, 1 part of polygonum cuspidatum, 1 part of indigo naturalis, 2 parts of rehmannia glutinosa libosch, 2 parts of prepared rehmannia roots and 1 part of donkey-hide gelatin. The traditional Chinese medicine composition further comprises the following auxiliary materials in parts by weight: 2 parts of tung oil, 1 part of alcohol and 1 part of erythromycin. According to the traditional Chinese medicine for pressure sore rehabilitation treatment and the preparation method and application thereof, inflammation can be effectively reduced, inflammation is one of important factors of pressure sore development, the medicine for clearing away heat and toxic materials can help relieve inflammatory response and improve blood circulation, and sufficient nutrition and oxygen can be provided by promoting local blood circulation; the medicine for clearing away heat and toxic materials has the antibacterial effect, infection can be prevented or controlled, the healing quality is improved, and the healing period is shortened.

The present invention discloses a method for simultaneously reducing the biological inhibition of antibiotics and thiocyanate in erythromycin wastewater, and relates to the technical field of industrial wastewater treatment. The specific treatment method includes: by regulating the water quality characteristics of the wastewater, adding a selective reaction reagent, and regulating the reaction temperature, time, and stirring rate, the simultaneous microbial toxicity reduction of antibiotics and thiocyanate in the erythromycin wastewater is achieved. The method of the present invention has a stable reaction process, easy-to-regulate process conditions, a short time consumption, a strong selectivity in the removal process, and no need to regulate or remove other substances in the wastewater; it effectively solves the problem that erythromycin wastewater has a strong inhibitory effect on anaerobic biological processes due to the presence of high concentrations of erythromycin residual titers and thiocyanate ions, making it difficult to enter the anaerobic biological treatment process for efficient organic matter removal, and has good industrial application prospects.

The invention discloses a method for synchronously reducing biological inhibition of antibiotics and thiocyanate radicals in erythromycin wastewater, and relates to the technical field of industrial wastewater treatment. The specific treatment method comprises the following steps: regulating and controlling the water quality characteristics of the wastewater, adding a selective reaction reagent, and regulating and controlling the reaction temperature, time and stirring rate to realize synchronous microbial toxicity reduction of antibiotics and thiocyanate radicals in the erythromycin wastewater. According to the method, the reaction process is stable, the process conditions are easy to regulate and control, the consumed time is short, the selectivity of the removal process is high, and other substances in the wastewater do not need to be regulated and controlled or removed; the problems that high-concentration erythromycin residual titer and thiocyanate ions exist in the erythromycin wastewater, so that the inhibition performance on the anaerobic biological process is high, and the erythromycin wastewater is difficult to enter an anaerobic biological treatment process for efficient organic matter removal are effectively solved, and the erythromycin wastewater has a very good industrial application prospect.

The invention discloses an efficient detoxification and nutrient recovery method for aerobic composting of fungus-enhanced erythromycin fermentation fungus residues, and belongs to the field of solid waste disposal and resource reutilization. The method comprises the following steps: mixing erythromycin fermentation mushroom dregs subjected to high-temperature sterilization treatment with corn straw powder, inoculating trichoderma asperellum, and carrying out aerobic composting fermentation. According to the method, aerobic co-compost of erythromycin fermentation mushroom dregs and crop straws is strengthened by inoculating an antibiotic degrading microbial agent taking trichoderma asperellum as a core, and an organic fertilizer which is high in nutrient content and is non-toxic and harmless is produced, so that an efficient, economical and environment-friendly solution is provided for solving the problem of resource utilization of the erythromycin fermentation mushroom dregs.

The invention discloses a method for preparing azithromycin by using a microchannel reactor. The method uses erythromycin as a starting material and prepares azithromycin through oximation, rearrangement, reduction and methylation reactions. During the oximation reaction, the contact time of the feed liquid in the microchannel reactor is very short, which greatly reduces the safety risk of the oximation reaction. The reduction reaction is carried out in the microchannel reactor, and neither explosive sodium (potassium) borohydride nor a high-pressure reactor is used, which reduces the safety risk. A tray layer of palladium carbon is laid on the reaction bed to achieve the hydrogenation target, while greatly improving the utilization efficiency of palladium carbon. In the rearrangement reaction, a milder leaving group, sodium 2-naphthalenesulfonate, is used to replace the existing leaving group. Water is used as a solvent and the reaction is carried out at room temperature. The method is green, safe, and has a high yield, and is suitable for industrial production.

The invention provides a method for improving spore production of natamycin producing bacteria, belongs to the technical field of streptomyces culture, and mainly provides an FtsZ gene, and the nucleotide sequence of the FtsZ gene is shown as SEQ ID NO.1; the FtsZ gene is applied to promotion of spore production of streptomyces gilvosporeus; the invention provides a genetically engineered bacterium for improving the sporulation quantity of streptomyces gilvosporeus. The genetically engineered bacterium is obtained by introducing an FtsZ gene and an erythromycin strong promoter ermEp into the streptomyces gilvosporeus through a carrier, a strain of streptomyces gilvosporeus F607-F is provided, the streptomyces gilvosporeus F607-F is preserved on October 28, 2024, and the preservation number of the streptomyces gilvosporeus F607-F is CCTCC M 20242352; the invention also provides a solid culture medium for promoting spore production of streptomyces gilvosporeus. The genetically engineered bacterium F607-F provided by the invention has the spore production advantage and can produce natamycin at high yield.

The invention discloses an erythromycin chiral silica gel filler and a preparation method thereof. The preparation method comprises the following steps: firstly, preparing epoxy propoxylated silica gel from gamma-epoxypropyltrimethoxysilane (gamma-GPS), then reacting with erythromycin, and carrying out end group end-capping treatment by using trimethylchlorosilane to seal residual hydroxyl on the surface of the silica gel, so as to obtain the erythromycin chiral silica gel filler. According to the invention, gamma-epoxypropoxypropyltrimethoxysilane is adopted as a spacer arm to bond erythromycin to macroporous silica gel, a novel chiral filler is prepared, and effective separation of specific enantiomers in a complex sample can be realized.

The invention provides a method for analyzing related substances of erythromycin cyclic ester tablets, and relates to the field of drug detection. According to the method for analyzing the related substances of the erythromycin cyclic ester tablets, high performance liquid chromatography is adopted for detection, and chromatographic conditions are as follows: octadecylsilane chemically bonded silica is used as a filler; an ammonium sulfate buffer solution is used as a mobile phase A, acetonitrile is used as a mobile phase B, and isopropanol is used as a mobile phase C. The method for analyzing the related substances of the erythromycin cyclic ester tablets has good specificity, quantitation limit, detection limit, linearity, accuracy, precision (repeatability and intermediate precision), filter membrane adsorbability, solution stability and durability, can better meet the requirements of the method for analyzing the related substances of the erythromycin cyclic ester tablets, is better in quality control, and is beneficial to improvement of medicine safety.

The invention discloses an innovative berberine and erythromycin combined medicine composition. The composition has a remarkable effect on resisting MRSA (Methicillin Resistant Staphylococcus Aureus) infection. The MIC value of the berberine is 62.5 mu g / mL, the MIC value of the erythromycin is 2000 mu g / mL, and the MIC value of the berberine / berberine is 500 / 31.25 mu g / ml when the berberine and the erythromycin are jointly used. The administration time of the two drugs has important influence on the effect of drug combination: when erythromycin is administered within 0 hour and berberine is administered at different time, the antibacterial effect is quite stable; and if the berberine is administered firstly, the administration time of the erythromycin is delayed, and the antibacterial effect is weakened. Through combined administration, the time of MRSA entering the logarithmic phase can be obviously delayed. When gradient concentration drug combination is adopted, a strong intervention effect on the MRSA biofilm is shown, and particularly, the combination effect of 1 / 2 MIC concentration is most remarkable. The invention provides a new drug combination strategy for clinical anti-MRSA infection, and has important application value.

The invention provides Kineococcus G2 and application of the Kineococcus G2 in preparation of a pigment with antioxidant activity, the Kineococcus new strain G2 is CCTCC No. M20242602, the strain is spherical, the size is 1.0 * 1.5 mu m, the optimal growth temperature is 30-37 DEG C, the pH value is 7.0-9.0, and the salt concentration is 1.0%-2.0%. The strain G2 is not sensitive to bacitracin, ciprofloxacin and norfloxacin, and is sensitive to novobiocin, polymyxin, gentamicin, piperacillin, ofloxacin, erythromycin, streptomycin, kanamycin, rifampicin, ampicillin, vancomycin, carbenicillin, chloramphenicol, tetracycline, penicillin, cefoperazone, oxacillin, amoxicillin and neomycin. Pigment generated by fermentation of the G2 strain has good antioxidant activity, and when the concentration is 10 micrograms / mL, the scavenging activity on DPPH is 25.00%, the scavenging activity on hydroxyl radicals is 80.58%, and the iron ion reducing capacity is 1.57, which are all higher than those of contrast beta-carotenoid. The application of the new Kineococcus strain G2 can lay a foundation for the research of antioxidant drugs such as medical treatment and health care product development.

The invention discloses an erythromycin enteric-coated preparation and a preparation method thereof, and relates to the technical field of medicines. The erythromycin enteric-coated preparation comprises a plain pill and a water-soluble coating material, and the plain pill is prepared from the following raw materials in parts by weight: 125 parts of erythromycin, 35 parts of lactose monohydrate, 5 parts of povidone K90, 5 parts of monopotassium phosphate and 34-47.6 parts of purified water. According to the preparation method, K90 is taken as a raw material, after K90 is added, the erythromycin pellets have good forming degree during extrusion forming, the situation that the viscosity is too high does not exist, the obtained pellets are uniform in particle size and appropriate in size, and when the product is prepared, the sieving step can be omitted, the preparation steps can be reduced, and the production cost can be reduced.

The invention provides a staphylococcus aureus drug resistance prediction method based on whole genome association analysis and machine learning, and belongs to the technical field of bioinformatics and artificial intelligence crossing. Five common antibiotics such as erythromycin, ciprofloxacin, penicillin, fusidic acid and methicillin are selected as modeling objects. Performing comparison and SNP site detection on a strain genome by using a reference genome, and constructing a variation matrix; then, a pyseer tool is adopted for GWAS analysis, and genetic loci significantly related to the drug resistance of each antibiotic are screened as modeling features; and for each antibiotic, respectively constructing an independent machine learning model, inputting the SNP features screened by the GWAS, and outputting a drug resistance / sensitivity classification label. Through cross validation and independent test set evaluation, the model has excellent accuracy and F1 score on multiple antibiotics. According to the method, drug resistance prediction can be achieved based on genome data without traditional drug sensitivity experiments, and the method has the remarkable time advantage, popularization value and scientific research significance.

This invention discloses a compound ointment for protecting the nasal mucosa and repairing skin damage, and its preparation method, belonging to the field of pharmaceutical technology. The compound ointment is formulated with Sophora japonica fruit extract, erythromycin ointment, vitamin B6, levofloxacin hydrochloride tablets, loratadine tablets, fluticasone propionate nasal spray, sesame oil, and honey in specific weight proportions. The components work synergistically, providing protection for the nasal mucosa, treatment of rhinitis, reduction of cold air and external pollutant intrusion, and prevention of colds. It can also treat hemorrhoids, scars, eczema, and other skin damage, achieving "one medicine for multiple uses." This compound ointment has a stable dosage form, is convenient to use, has high utilization rate, high safety, and no obvious side effects, making it suitable for various populations and possessing good industrialization prospects.

The invention relates to a novel method for synthesizing clarithromycin, which specifically comprises the following steps: simultaneously protecting 9-position carbonyl, 11-position hydroxyl and 12-position hydroxyl of erythromycin by using o-aminophenylboronic acid and derivatives thereof, protecting 2 '-position hydroxyl and 4'-position hydroxyl of erythromycin by using trimethylsilyl, methylating, and hydrolyzing to obtain clarithromycin. The method has the effects of short process route, cheap and easily available raw materials, high yield and low cost.

The invention discloses D-type mannosylerythritol lipid as well as a preparation method and application thereof. According to the invention, the green and bio-friendly D-type mannosylerythritol lipid is used as a biological bacteriostatic agent and is independently used or combined with other bacteriostatic agents (cefaclor, gentamicin or erythromycin and the like); effective inhibition and even killing of various pathogenic microorganisms (methicillin-resistant staphylococcus aureus, bacillus subtilis or bacillus cereus and the like) are realized. The novel bacteriostatic strategy of the D-type mannosylerythritol lipid provided by the invention not only can effectively realize efficient bacteriostasis, reduce the dosage of an antibacterial agent and reduce the graded bacteriostatic concentration index to 0.09, but also shows good biocompatibility, has a therapeutic index as high as 44.81, and has a wide application prospect.

The application provides a multi-layer dry heat sterilization device for erythromycin eye ointment production, and belongs to the technical field of dry heat sterilization cabinets. The device comprises a dry heat sterilization cabinet, a shelf is arranged in the dry heat sterilization cabinet, a tray base is arranged on the shelf, a plurality of first avoiding grooves are symmetrically arranged on the outer walls of the two sides of the tray base, first guide plates are symmetrically and fixedly connected to the inner walls of the two sides of the tray base close to the top, connecting columns are fixedly connected to the outer walls of the two sides of the tray base close to the first avoiding grooves, first handles are fixedly connected to the ends of the connecting columns away from the tray base, an auxiliary assembly is arranged on the tray base, and the auxiliary assembly is used for improving the temperature rising speed of the aluminum pipe. The auxiliary assembly can shorten the temperature rising time of the aluminum pipe of the eye ointment and reduce the operation energy consumption of the dry heat sterilization cabinet when the dry heat sterilization cabinet works.

The application discloses a dog-derived Enterococcus faecalis ZJUIDS-D016 with anti-aging effect and application, the dog-derived Enterococcus faecalis ZJUIDS-D016 is classified and named as (Enterococcus faecalis) Enterococcus faecalis ), and the preservation number is CGMCC 27038.The strain of the application is isolated from the intestinal tract of a healthy dog, has acid resistance, bile salt resistance and broad-spectrum antibacterial activity, and is sensitive to chloramphenicol, erythromycin and penicillin.The strain of the application has strong host adaptability, can colonize in the intestinal tract of a dog and secrete organic acids and bacteriocins, significantly inhibits the proliferation of common pathogenic bacteria such as dog pathogenic escherichia coli, effectively improves the intestinal health of pets and delays aging, and is suitable for preparing pet probiotic products.

The invention relates to the technical field of bacteriostatic agents, in particular to picolinamide tri-quaternary ammonium salts bridged by methane triformamide as well as a preparation method and application of the picolinamide tri-quaternary ammonium salts. The structural formula of the picolinamide tri-quaternary ammonium salt bridged by methanetriformamide is shown as a formula I: # imgabs0. The picolinamide tri-quaternary ammonium salt bridged by methanetriformamide provided by the invention has a good antibacterial effect on staphylococcus aureus in gram-positive bacteria, and when the concentration is 6.25 mu g / mL, the staphylococcus aureus in gram-positive bacteria can be effectively inhibited; the antibacterial rate of staphylococcus aureus exceeds the antibacterial effect of antibiotic erythromycin with the concentration of 50 mu g / mL, and the compound has the characteristics of small dosage and excellent performance. The structure of the picolinamide triquaternary ammonium salt bridged by methanamide provided by the invention contains the characteristics of three types of bacteriostatic agents including amide, pyridine and quaternary ammonium salt, and the synergistic effect of the three types of bacteriostatic agents can be achieved without compounding when the picolinamide triquaternary ammonium salt bridged by methanamide is used.

The invention provides an erythromycin enteric-coated tablet and a preparation method thereof, and relates to the technical field of erythromycin medicine preparation. The erythromycin enteric-coated tablet is prepared from erythromycin, corn starch, modified corn starch, carboxymethyl starch sodium, sodium dodecyl sulfate, magnesium stearate, cane sugar, ethanol, polyacrylic resin II, polyacrylic resin III and edible triethyl citrate. The defects in the prior art are overcome, the stability of the erythromycin enteric-coated tablet in gastric acid and the disintegration efficiency of the erythromycin enteric-coated tablet in intestinal juice are effectively improved, and the quality and the curative effect of the medicine are comprehensively improved.

This invention relates to the field of industrial process automation control and waste liquid resource utilization technology, specifically to a concentration regulation system for preparing liquid fertilizer from erythromycin waste liquid based on process control. The system includes: a data acquisition terminal acquiring fluid dynamics time-series data, concentration characterization time-series data, and actuator status data; an ideal reference reconstruction module reconstructing ideal concentration data based on the fluid dynamics time-series data and actuator status data; an interference simulation module injecting interference into the ideal concentration data based on preset fouling characteristics, rheological interference characteristics, and fluid dynamics time-series data to generate simulated concentration data; a coupling decision module generating actual concentration estimation data based on the concentration characterization time-series data, and accordingly generating regulation commands including closed-loop regulation, freeze regulation, cleaning, and temperature compensation commands; and a regulation execution module responding to the regulation commands and controlling the corresponding mechanisms. This invention ensures that the actions do not excessively rely on pollution observation values.

The utility model discloses a kind of erythromycin zinc acetate ointment production stirring devices, including support frame, stirring mechanism, dustproof mechanism and heating mechanism, the stirring mechanism includes stirring barrel, first stirring device, second stirring device and connecting assembly, the stirring barrel is set on support frame upper end face, the inlet pipe is provided on the upper end surface of the stirring barrel, the first stirring device includes first motor, main shaft and first stirring blade, the first motor passes through stirring barrel and is connected with main shaft, the first stirring blade is fixedly connected with main shaft, the second stirring device includes shaft, second stirring blade, large gear and pinion, the shaft is rotatably connected with connecting assembly, the large gear and the pinion are arranged in the inside of stirring barrel, one end of the shaft is fixedly connected with pinion, the large gear is fixedly connected with the upper of the inner wall of stirring barrel, the large gear and pinion are engaged, this stirring mechanism significantly improves mixing efficiency and mixing homogeneity.

The invention relates to application of an activating agent in promotion of uranium element discharge. Specifically, the activating agent is prepared from rifampicin, erythromycin, progesterone, aldosterone, bilirubin, cholate vinblastine, doxomicin, adriamycin, paclitaxel, bosentan, ambrisentan, digoxin, verapamil, tonavir, amprenavir, indinavir, hypericum perforatum juice, curcumin, atorvastatin beclomethasone, budesonide, divaricasone carbamazepine and caffeine. And phenytoin. The use dosage of the activating agent is 10 to 60 mg / kg. According to the method, the accumulation amount of uranium in important organs such as bones and kidneys can be remarkably reduced, so that the potential toxic influence on the key organs is reduced.

Disclosed herein are new salts and polymorphs of cethromycin for the treatment of diseases due to infection by bacteria and certain protozoans, including, for example, malaria, Babesosis, Toxoplasmosis, diarrheal disease, respiratory disease, sexually transmitted bacterial infections, and some bioterror bacteria, including, for example, plague, tularemia and post-inhalation anthrax. Also disclosed herein are new salts and polymorphs of cethromycin for the treatment of inflammatory diseases, including, for example, pelvic inflammatory disease, and peptic ulcer disease.

The invention discloses a bacillus amyloliquefaciens genetically engineered bacterium with high antibiotic resistance as well as a construction method and application thereof, the construction of the engineered bacterium comprises the following steps: bacillus amyloliquefaciens is taken as a starting strain, an RNA (Ribonucleic Acid) molecular chaperonin hfq coding gene is knocked out, and the nucleotide sequence of the RNA molecular chaperonin hfq is shown as SEQ ID NO.1. The RNA molecular chaperonin hfq is obtained through cloning, the tolerance of engineering bacteria to erythromycin and ampicillin is increased by 2.44 times and 3.79 times by knocking out the gene or reducing the expression of the gene, and the enhancement of the antibiotic resistance of bacillus is crucial to the threat of drug-resistant bacteria, the improvement of environmental adaptability and the development of biotechnology application. By strengthening the resistance gene, drug-resistant pathogens can be efficiently inhibited, the antibacterial curative effect can be improved, the metabolic activity can be maintained in a complex antibiotic environment, and the pollution repair and industrial fermentation efficiency can be guaranteed.