456 results about "Erythromycin" patented technology

Several diterpene glycosides (e.g., rubusoside, rebaudioside, steviol monoside and stevioside) were discovered to enhance the solubility of a number of pharmaceutically and medicinally important compounds, including but not limited to, paclitaxel, camptothecin, curcumin, tanshinone HA, capsaicin, cyclosporine, erythromycin, nystatin, itraconazole, and celecoxib. The use of the diterpene glycoside rubusoside increased solubility in all tested compounds. The diterpene glycosides are a naturally occurring class of water solubility-enhancing compounds that are non-toxic and that will be useful as new complexing agents or excipients in the pharmaceutical, agricultural (e.g., solubilizing pesticides), cosmetic and food industries. Aqueous solutions by using rubusoside to increase the solubility of otherwise insoluble drugs will have several new routes of administration. In addition, aqueous solutions of therapeutic compounds with rubusoside were shown to retain the known pharmacological activity of the compounds.

A series of novel steroid derivatives are described. The steroid derivatives are antibacterial agents. The steroid derivatives also act to sensitize bacteria to other antibiotics including erythromycin and novobiocin.

A series of novel steroid derivatives are described. The steroid derivatives are antibacterial agents. The steroid derivatives also act to sensitize bacteria to other antibiotics including erythromycin and novobiocin.

The invention discloses a method for preparing azithromycin. The method comprises the following steps of: in acid aqueous solution and under an action of potassium borohydride, performing the reduction reaction of erythromycinA6, 9-imine ether represented by a formula II, then performing methylation reaction, and putting the reaction products in a mixed solvent of water and halogenated hydrocarbons for hydrolysis reaction so as to obtain the azithromycin represented by a formula I. In the method, the reducer is properly consumed, the yield is high, and the cost of the preparation of the azithromycin is obviously reduced. The invention also relates to a method for preparing the erythromycinA6, 9-imine ether and erythromycinA9-oxime.

The invention relates to a method for producing an organic fertilizer by using erythromycin waste residue and tetracycline urea double salt mother liquor. The method is characterized by comprising the following steps: evenly mixing erythromycin waste residue hydrolysate obtained by heating and hydrolyzing under an acid condition with dialysate of the tetracycline urea double salt mother liquor separated by an organic membrane in a manner of nanofiltration separation at a volume ratio of (2-3):1; then adding 5-10% of ammonium humate and 10-15% of bentonite based on total volume; evenly stirring, detecting that the total nutrient (N+P2O5+K2O) is greater than or equal to 2.0%, the organic matter is greater than or equal to 20% and the dry matter is greater than or equal to 35%; spraying and pelletilizing when the PH is 5.5-8.5, drying until the moisture is smaller than or equal to 20%, and sieving, so as to obtain the product, namely the organic fertilizer. By adopting the method, the organic fertilizer is prepared from the hydrolyzed erythromycin waste residue hydrolysate obtained by hydrolytic degradation and the dialysate of the tetracycline urea double salt mother liquor separated by the organic membrane by nanofiltration separation in a mixing manner, so that the problem of environmental pollution of antibiotic residues is ended; reutilization of resources is taken in; new economic benefits are brought about for enterprises; furthermore, the method is sufficient in raw materials, and low in manufacturing cost.

The invention provides an erythromycin enteric-coated capsule and the preparation method. The invention is characterized in that: the component ratio of the enteric-coated liquid of the enteric-pellets capsules contained in the enteric-coated capsules counted by weight percentage is that: polyacrylic resin: II: 1, diethyl phthalate: 0.07 to 0.1, Tween-80:0.08 to 0.12, castor oil: 0.08 to 0.12, ethanol whose concentration is bigger than or equal to 95%: 12 to 14; all are counted as weight percentage. The invention conquers defects in the prior art, elevates the product quality, keeps the releasing degree of the product stable and guarantees the quality as well as healing effect of the product during the period of validity, and also the preparation is simple and convenient, the work efficiency is high and the quality of the products is quite well.

The invention relates to method for purifying erythromycin A from fermented liquid by adopting a resin adsorption method, which includes the following steps: (1) adsorption, (2) washing of impurities, (3) desorption, (4) salifying of eluent and the like. The method overcomes the defects of lower elution rate of 1BV erythromycin, more impurity contents in products and the like in the existing resin adsorption and separation technology. In addition, the invention also provides a resin regeneration method which includes the following main steps: mixed solution consisting of 0.1 mol / L-1.0 mol / L NaOH aqueous solution and a water soluble or partially water soluble organic solvent is adopted for washing resin to be regenerated, so as to solve the problem of poor resin regeneration effect in the prior art.

The invention relates to a culturing medium and fermentation method for producing erythrocin through fermentation of streptomyces erythreus. A primary seed medium, a secondary seed medium and a fermentation medium for producing erythrocin through fermentation of streptomyces erythreus all contains sucrose and a corn steep liquor. According to the invention, the corn steep liquor, urea, sucrose, and other intermediate-acting carbon sources and nitrogen sources are adopted to substitute original slow-acting carbon sources and nitrogen sources; moreover, the corn steep liquor, urea, and sucrose are soluble in water, so that the viscosity of the fermentation liquor is lowered, the dissolved oxygen is increased, the utilization speed is increased, especially during the later period of fermentation, the solid residue at the end of the fermentation is reduced, the bacteria dregs and the BOD content and the COD contend in the waste water are all greatly reduced, energy-reserving and consumption-lowering are both realized, and the good effects of treatment from the source and clean production are achieved.

The invention provides an erythromycin enteric-coated pellet which is suitable to be prepared by a boiling coating granulator, wherein the enteric-coated coating liquid comprises polyacrylic resin II, diethyl phthalate, tween-80, and an ethanol solution. In addition, the invention also provides a process and an intermediate material for preparing the erythromycin enteric-coated pellet, such as enteric-coated coating liquid and the like.