55 results about "Enteric coated tablets" patented technology

The invention belongs to the technical field of proton pump inhibition medicine preparations, and relates to a rabeprazole sodium enteric-coated tablet and a preparation method thereof. The technical problems that an existing rabeprazole sodium enteric-coated tablet is insufficient in stability, lagged in dissolution and the like are solved. The enteric-coated tablet consists of a tablet core and an enteric-coated coating layer wrapped outside the tablet core, wherein the tablet core comprises auxiliary materials such as rabeprazole sodium, a filling agent, an adhesive, a stable dissolution promoter and the like; the enteric coating layer comprises an enteric coating material, a plasticizer, an anti-sticking agent and a solvent. Through the synergistic effect of the compound stabilizer and process control, the stability and dissolution performance of the enteric-coated tablet are synergistically improved, meanwhile, the production process is simplified, and the preparation method is suitable for industrial application.

The invention provides a bromocriptine mesylate enteric-coated tablet and a preparation method thereof. Specifically, the bromocriptine mesylate enteric-coated tablet comprises a tablet core and an enteric coating layer wrapping the tablet core. The enteric-coated tablet disclosed by the invention is simple in process, good in stability and small in gastrointestinal side effect, the bioavailability of the enteric-coated tablet is more than two times that of a common tablet sold in the market, the dosage is expected to be reduced, the side effect is further reduced, and the enteric-coated tablet has excellent clinical value.

1. The name of the design product: packaging box (omeprazole enteric-coated tablets). 2. The use of the design product: used for the outer packaging of products. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: the unfolded state reference drawing.

This utility model relates to the technical field of coating devices, specifically a coating device for the enteric coating layer of bisacodyl enteric-coated tablets. It includes a cabinet with a roller inside. A rotating ring is connected to the left side wall of the cabinet, and the left end of the rotating ring is rotatably connected to the inner left side wall of the cabinet via a bearing. In operation, bisacodyl tablets are placed into the roller, the door is closed, and a motor drives the drive wheel, transmission belt, driven wheel, rotating ring, and roller to rotate. Support rollers provide support and improve the stability of the roller's rotation. A peristaltic pump draws and delivers the coating solution to the nozzle of a spray gun. The spray gun is connected to a compressed air pipeline, and the compressed air is used to evenly spray the coating solution onto the surface of the bisacodyl tablets for coating. The rotation of the roller causes the tablets to continuously rotate, ensuring the uniformity of the coating solution spray, thereby effectively coating the surface of the bisacodyl tablets with an enteric coating layer.

The invention discloses an artemisia selengensis leaf extract self-microemulsifying drug delivery system and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The system is composed of artemisia selengensis leaf extract and a self-microemulsion drug delivery system composed of an oil phase, a surfactant and a cosurfactant, and the mass ratio of the oil phase to the surfactant to the cosurfactant is (10-20): (60-80): (10-30). According to the invention, the liquid system is solidified into powder through an adsorption carrier, and the powder is further prepared into enteric-coated tablets. The drug delivery system can significantly improve the solubility, stability and intestinal absorption efficiency of caffeoylquinic acid compounds (CQAs) in the artemisia selengensis leaves, effectively inhibits degradation of the caffeoylquinic acid compounds in gastric juice, shows excellent xanthine oxidase inhibitory activity, can be used for preparing functional foods or drugs for reducing uric acid, and realizes high-valued utilization of artemisia selengensis leaf resources.

The invention discloses a galanthamine hydrobromide enteric-coated tablet and a preparation method thereof. The tablet is composed of a tablet core, an isolation layer and an enteric layer, the tablet core contains 5.0%-16.0% of galanthamine hydrobromide, and auxiliary materials such as mannitol, a mixture of magnesium stearate and sodium stearyl fumarate in a specific proportion, colloidal silicon dioxide and the like are matched; the isolating layer adopts an opadry II type film coating, and the enteric-coated layer adopts an opadry Acryl-EZE II type enteric-coated coating. The dissolution rate of the tablet in an acidic medium with the pH value of 1.2 for 2 hours is less than 5%, the release rate of the tablet in a medium with the pH value of 5.5 or 6.8 for 45 minutes is more than or equal to 80%, the tablet is sealed and placed at 40 DEG C + / -2 DEG C / 75% + / -5% RH for 6 months, the stability is good, and the pharmacokinetic parameters are excellent. The preparation method comprises the steps of raw and auxiliary material pretreatment, graded premixing, total mixing and lubricating, tabletting, two-step coating and the like, and the process is stable and controllable. The enteric-coated tablet disclosed by the invention is strong in targeted release property, high in stability and good in bioavailability, and can guarantee the effectiveness and safety of medication.

The invention provides a method for separating and detecting components in butanedisulfonic acid ademetionine enteric-coated tablets, and belongs to the technical field of medicine quality analysis. According to the method, ammonium formate solution-water-acetonitrile and ammonium formate solution-acetonitrile-methyl tert-butyl ether are used as a mobile phase system, and the pH value of the ammonium formate solution is controlled to be 2.2-3.1, so that adenosine and adenine can be effectively separated; according to the method, the S-adenosyl-L-methionine glycine isomer 2, adenosine, adenine and S-adenosyl-L-homocysteine can be separated, the time consumption is short, the separation efficiency is high, the operation is simple, the separation cost is low, and the quality control of butanedisulfonic acid adenosyl methionine or related preparations can be improved. According to the method, the detection of the ademetionine and the related impurities is not influenced by auxiliary materials, the method is efficient and convenient, good in reproducibility, high in specificity, high in accuracy and high in sensitivity, and the quality control of the ademetionine sample can be realized.

The invention discloses an in-vitro dissolution method of a posaconazole enteric-coated tablet, which is characterized in that a Tween-80 (TWEEN-80) surfactant is added into a dissolution medium, so that the solubility of the posaconazole enteric-coated tablet in a phosphate buffer solution is remarkably improved, the phenomenon that a solution in a dissolution cup is not uniform is solved, the jump point phenomenon of a dissolution curve is eliminated, and the dissolution rate of the posaconazole enteric-coated tablet is improved. When a phosphate buffer solution added with a certain amount of surfactant is used as a dissolution medium, the accumulated dissolution amount at each time point is stable, the dissolution curve is smooth, the detection result is accurate and reliable, the repeatability and predictability of the dissolution test are remarkably improved, and a more reliable detection method is provided for the initial stage of drug research and development and quality control.

The invention discloses a progesterone enteric-coated tablet processing technology. The technology comprises the following steps: 1, preparing a tablet core; 2, coating an isolating layer; 3, coating an enteric-coated layer; and 4, coloring layer coating. According to the processing technology of the progesterone enteric-coated tablet, the overall technological steps, technological parameters in all the technological steps and the raw material formula are optimized, the steps are simple, operation is easy, the quality of all layers of coatings can be effectively controlled, the stability and consistency of the final product are ensured, the prepared progesterone enteric-coated tablet can stably release medicine in the intestinal tract, and the bioavailability of the product is improved. The absorption speed is high, and the medication comfort and compliance of a patient are improved, so that the requirements of clinical treatment are better met.

This application provides a pharmaceutical composition comprising: an active ingredient, a filler, a disintegrant, and optionally one or more of a binder, a flow aid, and a lubricant. It also provides an enteric-coated tablet comprising (1) a core containing the aforementioned pharmaceutical composition; (2) an optional insulating layer; and (3) an enteric coating layer. The active ingredient in the enteric-coated tablet is not released in the stomach but is released in the intestines, preventing the active ingredient in the composition from degrading in the acidic environment of the stomach.

The utility model provides an air heater for enteric-coated tablet coating production, which comprises an air supply mechanism, a heating mechanism and a temperature adjusting tank, and the air outlet end of the air supply mechanism is connected with the temperature adjusting tank through a first connecting pipe. The heating mechanism is connected with the gas outlet end of the gas supply mechanism through a second connecting pipe, the heating mechanism is connected with the temperature adjusting tank through a third connecting pipe, and a gas distribution mechanism is installed on the temperature adjusting tank. By arranging the electromagnetic heating assembly and the net type heating mechanism, air fed into the net type heating mechanism by the air supply mechanism can be rapidly heated to a required temperature through the electromagnetic heating assembly during use, so that hot air can be timely supplied to a drying system for use; and meanwhile, the electromagnetic heating mode is adopted, so that the energy utilization rate can be increased, energy consumption is reduced, and the electricity utilization cost needed by air heating is reduced.

This utility model belongs to the field of pharmaceutical machinery technology, specifically relating to a coating device for the sugar coating layer of bisacodyl enteric-coated tablets. It includes a base and a coating pan. A frame is fixedly mounted on the base, and control buttons are located outside the frame. A blower is located inside the frame, and an air duct is fixedly mounted on the frame, communicating with the blower. A tilting and adjustable safety component is provided between the base, frame, and coating pan. This utility model, through corresponding structural improvements, utilizes a worm gear and worm design to enable rapid angle tilting of the coating pan, facilitating feeding by the operator. The design of the arc-shaped through-hole, telescopic rod, and pin allows for positioning at the feeding and rotation positions, reducing the burden on the worm gear and extending the overall service life. Heating by a heating device ensures a uniform sugar coating thickness, preventing the coated tablets from becoming too wet and improving coating efficiency.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a diclofenac sodium enteric-coated tablet and a preparation method thereof. The diclofenac sodium enteric-coated tablet comprises a quick-release layer, a slow-release layer and an enteric-coated layer; the quick-release layer comprises the following components in parts by weight: 20-40 parts of diclofenac sodium, 5-15 parts of a disintegrating agent, 20-50 parts of a filling agent, 1-3 parts of a lubricant and 1-5 parts of a binder; the slow-release layer comprises the following components in parts by weight: 50-80 parts of diclofenac sodium, 5-15 parts of crosslinked chitosan, 1-3 parts of a lubricant and 1-5 parts of a binder; and the enteric-coated layer comprises the following components in parts by weight: 20-45 parts of an enteric material and 5-15 parts of N-acetylneuraminic acid derivative. The diclofenac sodium enteric-coated tablet has excellent in-vitro cumulative release degree, and has low hygroscopicity, high stability and high friability.

The utility model discloses a packaging processing device for enteric-coated tablet production, and relates to the technical field of medicine production. The device comprises a belt type conveying device, a plurality of supporting legs are installed at the bottom of the belt type conveying device, a plurality of supports are installed at the top of the belt type conveying device, a material storage box is installed at the tops of the supports, a discharging pipe is installed at the bottom of the material storage box, and a piece adding cylinder is fixedly connected to the bottom of the discharging pipe. Two tablet plates are arranged at the top of the belt type conveying device, and the positioning part is installed in the belt type conveying device. According to the utility model, the positioning part is arranged, specifically, the motor is started to drive the two-way threaded rod to rotate clockwise, so that the two movable frames and the positioning plates on the outer surface of the two-way threaded rod are close to each other, the motor is closed after the width of the tablet plate is adjusted to a proper position, and the right sides of the two positioning plates are V-shaped, so that the tablet plate can be guided to enter between the two positioning plates to be aligned with the tablet adding cylinder; and the mode can flexibly adapt to tablet plates with different widths, so that the applicability is improved.

The application provides a method for separating and detecting ingredients in a butanedisulfonic acid ademetionine enteric-coated tablet, and belongs to the technical field of drug quality analysis. The application uses ammonium formate solution-water-acetonitrile and ammonium formate solution-acetonitrile-methyl tert-butyl ether as a mobile phase system, and controls the pH value of the ammonium formate solution to be 2.2-3.1, so that adenosine and adenine can be effectively separated, and ademetionine, decarboxylated ademetionine, S-adenosyl-L-methionine glycine isomer 2, adenosine, adenine and S-adenosyl-L-homocysteine can be highly separated at one time, the method has the advantages of short time consumption, high separation efficiency, simple operation, low separation cost, and is favorable for improving the quality control of butanedisulfonic acid ademetionine or related preparations. In the application, the detection of ademetionine and related impurities is not affected by excipients, and has the advantages of high efficiency, convenience, good reproducibility, strong specificity, high accuracy and high sensitivity, and can realize the quality control of ademetionine samples.

This invention discloses a traditional Chinese medicine composition for treating ulcerative colitis, its preparation method, combined drugs, and applications. The traditional Chinese medicine composition for treating ulcerative colitis of this invention is made from the following raw materials in parts by weight: Astragalus membranaceus 13-26 parts, Lonicera japonica 10-20 parts, Sargentodoxa cuneata 10-20 parts, Prunus mume 8-16 parts, Agrimonia pilosa 8-16 parts, Allium macrostemon 6-12 parts, Platycodon grandiflorus 6-12 parts, Coptis chinensis 3-6 parts, and Panax notoginseng powder 1-3 parts. An animal model of ulcerative colitis was constructed using DSS induction, and the results showed that the traditional Chinese medicine composition of this invention has a certain therapeutic effect on ulcerative colitis. Clinical studies showed that the traditional Chinese medicine composition of this invention, used in combination with mesalazine enteric-coated tablets, can reduce the modified Mayo score and serum inflammatory markers in patients with active ulcerative colitis, improve colonic mucosal inflammation and gastrointestinal symptoms, and effectively treat active ulcerative colitis of the damp-heat type.

1.The name of the design product: packaging box (alengling aspirin enteric-coated tablets). 2.The use of the design product: used for the outer packaging of medicines. 3.The design points of the design product: the combination of shape, pattern and color. 4.The picture or photo that best shows the design points: front view. 5.The design contains colors.

The invention belongs to the technical field of medicines, and particularly relates to a tiopronin composition and a preparation method thereof. The composition is an enteric-coated tablet which is composed of a tablet core and an enteric coating layer, wherein the tablet core contains tiopronin, porous starch, chitosan, vitamin C and other pharmaceutically acceptable filler, adhesive, disintegrating agent and lubricant. The tablet prescription can reduce the impurity content of the preparation product and improve the stability; meanwhile, the dissolution rate of tiopronin is improved; the content is uniform, unpleasant odor is effectively covered, and improvement of patient compliance is facilitated; the preparation method of the composition is simple and suitable for industrial production.

The utility model discloses an efficient dusting machine for enteric-coated tablet production, which relates to the technical field of medicine production and comprises a vehicle body, universal wheels are fixedly mounted below the vehicle body, a handle is fixedly mounted on the side surface of the vehicle body, a baffle is fixedly mounted in the vehicle body, and a negative pressure suction head is detachably mounted at the top of the vehicle body. A guide pipe is fixedly installed at the bottom of the negative pressure suction head, a through hole is formed in the top of the vehicle body, the guide pipe penetrates through the vehicle body, a dust suction pipe is fixedly installed on the left side of the baffle, a pipe hoop is arranged between the dust suction pipe and the guide pipe and is in threaded connection with the dust suction pipe and the guide pipe, the dust suction pipe penetrates through the baffle, and the right side of the baffle is filled with alkali liquor. According to the powder cleaning vehicle, powder in a workshop can be cleaned, the influence of excessive powder in the workshop on the body health of production personnel is avoided, the powder cleaning vehicle is easy and convenient to disassemble and convenient to clean, and the dust removal efficiency is improved.

To provide a solid preparation that contains lactoferrin and cells of Lacticaseibacillus casei but does not show a decrease in in-vivo collapsibility.SOLUTION: A solid preparation comprising (A) lactoferrin, (B) cells of Lacticaseibacillus casei, and (C) an excipient, where the excipient (C) comprises (C1) at least one of cellulose or a derivative thereof and (C2) at least one sugar alcohol.SELECTED DRAWING: None

The utility model relates to an enteric-coated tablet counting and subpackaging device which aims at solving the technical problem that at present, counted medicine cannot be conveniently and rapidly collected in a centralized mode, the enteric-coated tablet counting and subpackaging device comprises a fixing plate, a material distributing shell and a material conveying device, a plurality of counting holes are evenly formed in the surface of the fixing plate, and the material distributing shell is attached to the top of the fixing plate; the blocking plate is arranged at the bottom of the fixing plate and is arranged under the material distributing shell; the strip-shaped hole is formed in one side wall of the fixing plate, a driving assembly is installed in the strip-shaped hole, and the driving assembly is used for driving the material distributing shell and the blocking plate to move; according to the tablet counting device, the driving assembly drives the distributing shell to move, so that tablets can be guided into the counting holes to be counted, the counted tablets can automatically fall into the collecting hopper, the tablets can be rapidly collected, the working efficiency is improved, the labor intensity of workers is reduced, and the working efficiency is improved. And the phenomenon that the tablets are scattered is avoided.

The invention belongs to the technical field of medicines, and particularly relates to a salazosulfapyridine composition and a preparation method thereof. The sulfasalazine enteric-coated tablet composition is prepared by the invention. The enteric-coated tablet comprises a tablet core and an enteric coating. The tablet core is prepared from salazosulfapyridine, polyarginine, Gelucire 39 / 01 and other pharmaceutically acceptable filling agents, binding agents, disintegrating agents and lubricating agents. The stability of the active ingredients is improved by adding the polyarginine and wrapping the Gelucire 39 / 01, the drug release is stable, the preparation process is simple, and the preparation method is suitable for industrial production.

The invention belongs to the technical field of chemical component detection, and particularly relates to a method for detecting N-nitrosoduloxetine residues in duloxetine hydrochloride enteric-coated tablets. The detection method comprises the following steps: S1, diluting duloxetine hydrochloride enteric-coated tablets with a diluting solvent to prepare a test solution; s2, diluting N-nitrosoduloxetine with a diluting solvent to prepare a reference solution; s3, determining the test solution and the reference solution by adopting a liquid chromatography triple quadrupole tandem mass spectrometer, and calculating the content of N-nitrosoduloxetine according to a detection map; the method for detecting the residual N-nitrosoduloxetine in the duloxetine hydrochloride enteric-coated tablet, provided by the invention, has relatively low detection limit and quantitation limit, also has relatively high accuracy, repeatability and intermediate precision, and can be used for rapidly detecting the content of the N-nitrosoduloxetine in the duloxetine hydrochloride enteric-coated tablet.

The invention discloses a rabeprazole sodium enteric-coated tablet and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The rabeprazole sodium enteric-coated tablet is sequentially provided with a medicine core layer, an enteric-coated layer and a gastric-soluble layer from inside to outside. The medicine core layer is obtained by mixing, granulating and tabletting the following raw material components: rabeprazole sodium, an adhesive, a filler, a stabilizer, a disintegrating agent, a lubricant and absolute ethyl alcohol; the enteric-coated layer is obtained by atomizing and spraying an enteric-coated coating solution and is prepared from the following raw material components: modified starch, a plasticizer, enteric-coated acrylic resin, talcum powder and an ethanol water solution; the gastric-soluble layer is obtained by atomizing and spraying a gastric-soluble coating solution, and is prepared from the following raw material components: chitosan, a plasticizer, an auxiliary flexibilizer and an acetic acid aqueous solution. According to the rabeprazole sodium enteric-coated tablet, the medicine core layer is protected through the enteric-coated layer and the gastric-coated layer, the overall stability of the rabeprazole sodium enteric-coated tablet is greatly improved, and the efficacy utilization rate of rabeprazole sodium is increased.

The application belongs to the technical field of chemical component detection, and particularly relates to a detection method of N-nitrosoldoxetin residual in doxepin hydrochloride enteric-coated tablets; the detection method comprises the following steps: S1, diluting doxepin hydrochloride enteric-coated tablets with a dilution solvent to prepare a test sample solution; S2, diluting N-nitrosoldoxetin with a dilution solvent to prepare a control sample solution; S3, determining the test sample solution and the control sample solution by using a liquid chromatography triple quadrupole tandem mass spectrometer, and calculating the content of N-nitrosoldoxetin according to a detection spectrum; the detection method of N-nitrosoldoxetin residual in doxepin hydrochloride enteric-coated tablets provided by the application has lower detection limit and quantitative limit, and has higher accuracy, repeatability and intermediate precision, and can quickly detect the content of N-nitrosoldoxetin in doxepin hydrochloride enteric-coated tablets.

The invention relates to an aspirin enteric-coated tablet and a preparation method thereof.The aspirin enteric-coated tablet comprises a tablet core and a coating wrapping the tablet core, the tablet core is composed of aspirin, powdery cellulose, corn starch and hydroxypropyl starch, and the coating is an enteric-coated layer and can effectively improve the flowability, compressibility and mixing uniformity of dry powder; meanwhile, the coating layer can resist gastric acid for a long time, so that the release of aspirin in the stomach is reduced.

The invention provides an enteric-coated tablet for treating neuritis and a preparation method of the enteric-coated tablet. The enteric-coated tablet is prepared from the following components in percentage by weight: 0.01%-1% of mecobalamin, 60%-80% of butanedisulfonic acid adenosyl methionine, 10%-30% of a diluent, 4%-9% of an adhesive, 1%-5% of a disintegrating agent, 0.1%-1% of a lubricant and 8%-16% of an enteric-coated material. The enteric-coated tablet disclosed by the invention is simple in production process, universal in production equipment and low in cost, mainly overcomes the defect of large in-vivo absorption difference, and has a remarkable curative effect on treating neuritis.

The invention relates to the field of pharmaceutical preparations, in particular to butanedisulfonic acid ademetionine enteric-coated tablets and a preparation method thereof. The invention provides a butanedisulfonic acid ademetionine enteric-coated tablet. The butanedisulfonic acid ademetionine enteric-coated tablet comprises a tablet core and an enteric coating layer, wherein the tablet core comprises butanedisulfonic acid adenosyl methionine, glyceryl behenate, a filling agent, a disintegrating agent and a lubricating agent; the enteric coating layer comprises a coating premix; the coating premix comprises hydroxypropyl methylcellulose acetate succinate and an anhydrous solvent. The ademetionine butanedisulfonate enteric-coated tablet obtained by matching the glyceryl behenate and the hydroxypropyl methylcellulose acetate succinate is lower in water content, degradation of S-S ademetionine and increase of related substances are not obvious under an accelerated test condition, the product stability is better, and the medication safety of a patient can be better ensured.

The application belongs to the technical field of medicine, and specifically provides an entero-soluble ibrexin tablet with high bioavailability and a preparation method thereof. The entero-soluble tablet comprises a tablet core and an enteric coating, wherein the tablet core comprises an ibrexin coating compound, microcrystalline cellulose and magnesium stearate, and the ibrexin coating compound comprises ibrexin or a pharmaceutically acceptable salt thereof, an acid regulator, povidone and cross-linked sodium carboxymethyl cellulose. The ibrexin entero-soluble tablet of the application can make the drug reach the end of the small intestine or the colon for release, thereby avoiding the metabolism of cytochrome P450 (CYP) 3A, and at the same time, the acid regulator can locally provide an acidic environment for the active ingredient, so that the ibrexin is rapidly dissolved and released, and the side effects such as vomiting in the gastrointestinal tract are reduced.

The invention relates to the field of pharmaceutical preparations, and particularly discloses a metformin hydrochloride tablet and a preparation method thereof. The method comprises the following steps: carrying out low-temperature crushing, graded screening and pre-drying treatment on a metformin hydrochloride raw material medicine to obtain a pretreated raw material; mixing the pretreated raw materials with auxiliary materials, and sequentially carrying out semi-dry granulation and fluidized bed granulation to obtain porous particles; drying the porous particles, mixing the dried porous particles with a lubricant, and tabletting to obtain a plain tablet; and coating the tablets by adopting a fluidized bed bottom spraying process. Wherein when the enteric-coated tablet is prepared, a coating solution containing acrylic resin, a plasticizer and a pore-foaming agent is adopted. According to the invention, the contradiction between particle strength and high porosity is synergistically solved through a composite granulation process, so that the tablet disintegrates rapidly and is dissolved out completely; the reliable protection of the enteric-coated tablet in the stomach and the rapid release of the enteric-coated tablet in the intestine are realized through a precise coating process, and the gastrointestinal tract stimulation risk is remarkably reduced.