34 results about "Enteric coated tablets" patented technology

The invention belongs to the technical field of proton pump inhibition medicine preparations, and relates to a rabeprazole sodium enteric-coated tablet and a preparation method thereof. The technical problems that an existing rabeprazole sodium enteric-coated tablet is insufficient in stability, lagged in dissolution and the like are solved. The enteric-coated tablet consists of a tablet core and an enteric-coated coating layer wrapped outside the tablet core, wherein the tablet core comprises auxiliary materials such as rabeprazole sodium, a filling agent, an adhesive, a stable dissolution promoter and the like; the enteric coating layer comprises an enteric coating material, a plasticizer, an anti-sticking agent and a solvent. Through the synergistic effect of the compound stabilizer and process control, the stability and dissolution performance of the enteric-coated tablet are synergistically improved, meanwhile, the production process is simplified, and the preparation method is suitable for industrial application.

The invention provides a bromocriptine mesylate enteric-coated tablet and a preparation method thereof. Specifically, the bromocriptine mesylate enteric-coated tablet comprises a tablet core and an enteric coating layer wrapping the tablet core. The enteric-coated tablet disclosed by the invention is simple in process, good in stability and small in gastrointestinal side effect, the bioavailability of the enteric-coated tablet is more than two times that of a common tablet sold in the market, the dosage is expected to be reduced, the side effect is further reduced, and the enteric-coated tablet has excellent clinical value.

This utility model relates to the technical field of coating devices, specifically a coating device for the enteric coating layer of bisacodyl enteric-coated tablets. It includes a cabinet with a roller inside. A rotating ring is connected to the left side wall of the cabinet, and the left end of the rotating ring is rotatably connected to the inner left side wall of the cabinet via a bearing. In operation, bisacodyl tablets are placed into the roller, the door is closed, and a motor drives the drive wheel, transmission belt, driven wheel, rotating ring, and roller to rotate. Support rollers provide support and improve the stability of the roller's rotation. A peristaltic pump draws and delivers the coating solution to the nozzle of a spray gun. The spray gun is connected to a compressed air pipeline, and the compressed air is used to evenly spray the coating solution onto the surface of the bisacodyl tablets for coating. The rotation of the roller causes the tablets to continuously rotate, ensuring the uniformity of the coating solution spray, thereby effectively coating the surface of the bisacodyl tablets with an enteric coating layer.

The invention discloses an artemisia selengensis leaf extract self-microemulsifying drug delivery system and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The system is composed of artemisia selengensis leaf extract and a self-microemulsion drug delivery system composed of an oil phase, a surfactant and a cosurfactant, and the mass ratio of the oil phase to the surfactant to the cosurfactant is (10-20): (60-80): (10-30). According to the invention, the liquid system is solidified into powder through an adsorption carrier, and the powder is further prepared into enteric-coated tablets. The drug delivery system can significantly improve the solubility, stability and intestinal absorption efficiency of caffeoylquinic acid compounds (CQAs) in the artemisia selengensis leaves, effectively inhibits degradation of the caffeoylquinic acid compounds in gastric juice, shows excellent xanthine oxidase inhibitory activity, can be used for preparing functional foods or drugs for reducing uric acid, and realizes high-valued utilization of artemisia selengensis leaf resources.

The invention discloses a galanthamine hydrobromide enteric-coated tablet and a preparation method thereof. The tablet is composed of a tablet core, an isolation layer and an enteric layer, the tablet core contains 5.0%-16.0% of galanthamine hydrobromide, and auxiliary materials such as mannitol, a mixture of magnesium stearate and sodium stearyl fumarate in a specific proportion, colloidal silicon dioxide and the like are matched; the isolating layer adopts an opadry II type film coating, and the enteric-coated layer adopts an opadry Acryl-EZE II type enteric-coated coating. The dissolution rate of the tablet in an acidic medium with the pH value of 1.2 for 2 hours is less than 5%, the release rate of the tablet in a medium with the pH value of 5.5 or 6.8 for 45 minutes is more than or equal to 80%, the tablet is sealed and placed at 40 DEG C + / -2 DEG C / 75% + / -5% RH for 6 months, the stability is good, and the pharmacokinetic parameters are excellent. The preparation method comprises the steps of raw and auxiliary material pretreatment, graded premixing, total mixing and lubricating, tabletting, two-step coating and the like, and the process is stable and controllable. The enteric-coated tablet disclosed by the invention is strong in targeted release property, high in stability and good in bioavailability, and can guarantee the effectiveness and safety of medication.

The invention discloses an in-vitro dissolution method of a posaconazole enteric-coated tablet, which is characterized in that a Tween-80 (TWEEN-80) surfactant is added into a dissolution medium, so that the solubility of the posaconazole enteric-coated tablet in a phosphate buffer solution is remarkably improved, the phenomenon that a solution in a dissolution cup is not uniform is solved, the jump point phenomenon of a dissolution curve is eliminated, and the dissolution rate of the posaconazole enteric-coated tablet is improved. When a phosphate buffer solution added with a certain amount of surfactant is used as a dissolution medium, the accumulated dissolution amount at each time point is stable, the dissolution curve is smooth, the detection result is accurate and reliable, the repeatability and predictability of the dissolution test are remarkably improved, and a more reliable detection method is provided for the initial stage of drug research and development and quality control.

The invention discloses a progesterone enteric-coated tablet processing technology. The technology comprises the following steps: 1, preparing a tablet core; 2, coating an isolating layer; 3, coating an enteric-coated layer; and 4, coloring layer coating. According to the processing technology of the progesterone enteric-coated tablet, the overall technological steps, technological parameters in all the technological steps and the raw material formula are optimized, the steps are simple, operation is easy, the quality of all layers of coatings can be effectively controlled, the stability and consistency of the final product are ensured, the prepared progesterone enteric-coated tablet can stably release medicine in the intestinal tract, and the bioavailability of the product is improved. The absorption speed is high, and the medication comfort and compliance of a patient are improved, so that the requirements of clinical treatment are better met.

This application provides a pharmaceutical composition comprising: an active ingredient, a filler, a disintegrant, and optionally one or more of a binder, a flow aid, and a lubricant. It also provides an enteric-coated tablet comprising (1) a core containing the aforementioned pharmaceutical composition; (2) an optional insulating layer; and (3) an enteric coating layer. The active ingredient in the enteric-coated tablet is not released in the stomach but is released in the intestines, preventing the active ingredient in the composition from degrading in the acidic environment of the stomach.

The utility model provides an air heater for enteric-coated tablet coating production, which comprises an air supply mechanism, a heating mechanism and a temperature adjusting tank, and the air outlet end of the air supply mechanism is connected with the temperature adjusting tank through a first connecting pipe. The heating mechanism is connected with the gas outlet end of the gas supply mechanism through a second connecting pipe, the heating mechanism is connected with the temperature adjusting tank through a third connecting pipe, and a gas distribution mechanism is installed on the temperature adjusting tank. By arranging the electromagnetic heating assembly and the net type heating mechanism, air fed into the net type heating mechanism by the air supply mechanism can be rapidly heated to a required temperature through the electromagnetic heating assembly during use, so that hot air can be timely supplied to a drying system for use; and meanwhile, the electromagnetic heating mode is adopted, so that the energy utilization rate can be increased, energy consumption is reduced, and the electricity utilization cost needed by air heating is reduced.

This utility model belongs to the field of pharmaceutical machinery technology, specifically relating to a coating device for the sugar coating layer of bisacodyl enteric-coated tablets. It includes a base and a coating pan. A frame is fixedly mounted on the base, and control buttons are located outside the frame. A blower is located inside the frame, and an air duct is fixedly mounted on the frame, communicating with the blower. A tilting and adjustable safety component is provided between the base, frame, and coating pan. This utility model, through corresponding structural improvements, utilizes a worm gear and worm design to enable rapid angle tilting of the coating pan, facilitating feeding by the operator. The design of the arc-shaped through-hole, telescopic rod, and pin allows for positioning at the feeding and rotation positions, reducing the burden on the worm gear and extending the overall service life. Heating by a heating device ensures a uniform sugar coating thickness, preventing the coated tablets from becoming too wet and improving coating efficiency.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a diclofenac sodium enteric-coated tablet and a preparation method thereof. The diclofenac sodium enteric-coated tablet comprises a quick-release layer, a slow-release layer and an enteric-coated layer; the quick-release layer comprises the following components in parts by weight: 20-40 parts of diclofenac sodium, 5-15 parts of a disintegrating agent, 20-50 parts of a filling agent, 1-3 parts of a lubricant and 1-5 parts of a binder; the slow-release layer comprises the following components in parts by weight: 50-80 parts of diclofenac sodium, 5-15 parts of crosslinked chitosan, 1-3 parts of a lubricant and 1-5 parts of a binder; and the enteric-coated layer comprises the following components in parts by weight: 20-45 parts of an enteric material and 5-15 parts of N-acetylneuraminic acid derivative. The diclofenac sodium enteric-coated tablet has excellent in-vitro cumulative release degree, and has low hygroscopicity, high stability and high friability.

The utility model discloses a packaging processing device for enteric-coated tablet production, and relates to the technical field of medicine production. The device comprises a belt type conveying device, a plurality of supporting legs are installed at the bottom of the belt type conveying device, a plurality of supports are installed at the top of the belt type conveying device, a material storage box is installed at the tops of the supports, a discharging pipe is installed at the bottom of the material storage box, and a piece adding cylinder is fixedly connected to the bottom of the discharging pipe. Two tablet plates are arranged at the top of the belt type conveying device, and the positioning part is installed in the belt type conveying device. According to the utility model, the positioning part is arranged, specifically, the motor is started to drive the two-way threaded rod to rotate clockwise, so that the two movable frames and the positioning plates on the outer surface of the two-way threaded rod are close to each other, the motor is closed after the width of the tablet plate is adjusted to a proper position, and the right sides of the two positioning plates are V-shaped, so that the tablet plate can be guided to enter between the two positioning plates to be aligned with the tablet adding cylinder; and the mode can flexibly adapt to tablet plates with different widths, so that the applicability is improved.

The application provides a method for separating and detecting ingredients in a butanedisulfonic acid ademetionine enteric-coated tablet, and belongs to the technical field of drug quality analysis. The application uses ammonium formate solution-water-acetonitrile and ammonium formate solution-acetonitrile-methyl tert-butyl ether as a mobile phase system, and controls the pH value of the ammonium formate solution to be 2.2-3.1, so that adenosine and adenine can be effectively separated, and ademetionine, decarboxylated ademetionine, S-adenosyl-L-methionine glycine isomer 2, adenosine, adenine and S-adenosyl-L-homocysteine can be highly separated at one time, the method has the advantages of short time consumption, high separation efficiency, simple operation, low separation cost, and is favorable for improving the quality control of butanedisulfonic acid ademetionine or related preparations. In the application, the detection of ademetionine and related impurities is not affected by excipients, and has the advantages of high efficiency, convenience, good reproducibility, strong specificity, high accuracy and high sensitivity, and can realize the quality control of ademetionine samples.

This invention discloses a traditional Chinese medicine composition for treating ulcerative colitis, its preparation method, combined drugs, and applications. The traditional Chinese medicine composition for treating ulcerative colitis of this invention is made from the following raw materials in parts by weight: Astragalus membranaceus 13-26 parts, Lonicera japonica 10-20 parts, Sargentodoxa cuneata 10-20 parts, Prunus mume 8-16 parts, Agrimonia pilosa 8-16 parts, Allium macrostemon 6-12 parts, Platycodon grandiflorus 6-12 parts, Coptis chinensis 3-6 parts, and Panax notoginseng powder 1-3 parts. An animal model of ulcerative colitis was constructed using DSS induction, and the results showed that the traditional Chinese medicine composition of this invention has a certain therapeutic effect on ulcerative colitis. Clinical studies showed that the traditional Chinese medicine composition of this invention, used in combination with mesalazine enteric-coated tablets, can reduce the modified Mayo score and serum inflammatory markers in patients with active ulcerative colitis, improve colonic mucosal inflammation and gastrointestinal symptoms, and effectively treat active ulcerative colitis of the damp-heat type.

1.The name of the design product: packaging box (alengling aspirin enteric-coated tablets). 2.The use of the design product: used for the outer packaging of medicines. 3.The design points of the design product: the combination of shape, pattern and color. 4.The picture or photo that best shows the design points: front view. 5.The design contains colors.

The invention belongs to the technical field of medicines, and particularly relates to a tiopronin composition and a preparation method thereof. The composition is an enteric-coated tablet which is composed of a tablet core and an enteric coating layer, wherein the tablet core contains tiopronin, porous starch, chitosan, vitamin C and other pharmaceutically acceptable filler, adhesive, disintegrating agent and lubricant. The tablet prescription can reduce the impurity content of the preparation product and improve the stability; meanwhile, the dissolution rate of tiopronin is improved; the content is uniform, unpleasant odor is effectively covered, and improvement of patient compliance is facilitated; the preparation method of the composition is simple and suitable for industrial production.

The utility model relates to an enteric-coated tablet counting and subpackaging device which aims at solving the technical problem that at present, counted medicine cannot be conveniently and rapidly collected in a centralized mode, the enteric-coated tablet counting and subpackaging device comprises a fixing plate, a material distributing shell and a material conveying device, a plurality of counting holes are evenly formed in the surface of the fixing plate, and the material distributing shell is attached to the top of the fixing plate; the blocking plate is arranged at the bottom of the fixing plate and is arranged under the material distributing shell; the strip-shaped hole is formed in one side wall of the fixing plate, a driving assembly is installed in the strip-shaped hole, and the driving assembly is used for driving the material distributing shell and the blocking plate to move; according to the tablet counting device, the driving assembly drives the distributing shell to move, so that tablets can be guided into the counting holes to be counted, the counted tablets can automatically fall into the collecting hopper, the tablets can be rapidly collected, the working efficiency is improved, the labor intensity of workers is reduced, and the working efficiency is improved. And the phenomenon that the tablets are scattered is avoided.

The invention provides an enteric-coated tablet for treating neuritis and a preparation method of the enteric-coated tablet. The enteric-coated tablet is prepared from the following components in percentage by weight: 0.01%-1% of mecobalamin, 60%-80% of butanedisulfonic acid adenosyl methionine, 10%-30% of a diluent, 4%-9% of an adhesive, 1%-5% of a disintegrating agent, 0.1%-1% of a lubricant and 8%-16% of an enteric-coated material. The enteric-coated tablet disclosed by the invention is simple in production process, universal in production equipment and low in cost, mainly overcomes the defect of large in-vivo absorption difference, and has a remarkable curative effect on treating neuritis.

The application belongs to the technical field of medicine, and specifically provides an entero-soluble ibrexin tablet with high bioavailability and a preparation method thereof. The entero-soluble tablet comprises a tablet core and an enteric coating, wherein the tablet core comprises an ibrexin coating compound, microcrystalline cellulose and magnesium stearate, and the ibrexin coating compound comprises ibrexin or a pharmaceutically acceptable salt thereof, an acid regulator, povidone and cross-linked sodium carboxymethyl cellulose. The ibrexin entero-soluble tablet of the application can make the drug reach the end of the small intestine or the colon for release, thereby avoiding the metabolism of cytochrome P450 (CYP) 3A, and at the same time, the acid regulator can locally provide an acidic environment for the active ingredient, so that the ibrexin is rapidly dissolved and released, and the side effects such as vomiting in the gastrointestinal tract are reduced.

The invention relates to the field of pharmaceutical preparations, and particularly discloses a metformin hydrochloride tablet and a preparation method thereof. The method comprises the following steps: carrying out low-temperature crushing, graded screening and pre-drying treatment on a metformin hydrochloride raw material medicine to obtain a pretreated raw material; mixing the pretreated raw materials with auxiliary materials, and sequentially carrying out semi-dry granulation and fluidized bed granulation to obtain porous particles; drying the porous particles, mixing the dried porous particles with a lubricant, and tabletting to obtain a plain tablet; and coating the tablets by adopting a fluidized bed bottom spraying process. Wherein when the enteric-coated tablet is prepared, a coating solution containing acrylic resin, a plasticizer and a pore-foaming agent is adopted. According to the invention, the contradiction between particle strength and high porosity is synergistically solved through a composite granulation process, so that the tablet disintegrates rapidly and is dissolved out completely; the reliable protection of the enteric-coated tablet in the stomach and the rapid release of the enteric-coated tablet in the intestine are realized through a precise coating process, and the gastrointestinal tract stimulation risk is remarkably reduced.

The application discloses a rabeprazole sodium enteric-coated tablet and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The rabeprazole sodium enteric-coated tablet is sequentially provided with a medicine core layer, an enteric-coated layer and a gastric-soluble layer from inside to outside. The medicine core layer is obtained by mixing and granulating the following raw material components and tabletting: rabeprazole sodium, a binder, a filling agent, a stabilizer, a disintegrating agent, a lubricant and anhydrous ethanol; the enteric-coated layer is obtained by atomization spraying of an enteric-coated solution and is prepared by dispensing the following raw material components: modified starch, a plasticizer, an enteric-coated acrylic acid resin, talcum powder and an ethanol aqueous solution; and the gastric-soluble layer is obtained by atomization spraying of a gastric-soluble coating solution and is prepared by dispensing the following raw material components: chitosan, a plasticizer, an auxiliary toughening agent and an acetic acid aqueous solution. In the application, the protection of the medicine core layer is realized by the enteric-coated layer and the gastric-soluble layer, the overall stability of the rabeprazole sodium enteric-coated tablet is greatly improved, and the drug efficacy utilization rate of rabeprazole sodium is improved.

The utility model relates to a component detection device for an enteric-coated tablet, and aims to solve the technical problems that pollution is easily caused in the process of transferring the ground enteric-coated tablet at present, and thiamphenicol in the enteric-coated tablet is easily decomposed when being transferred and ground due to the fact that the thiamphenicol is easily decomposed when being exposed to light, so that the component detection result of the enteric-coated tablet is influenced. Comprising a grinding pipe, an extraction pipe, a filter pipe and a storage pipe, the grinding pipe, the extraction pipe, the filter pipe and the storage pipe are sequentially connected from top to bottom, the top of the grinding pipe is connected with a cover plate through a bolt, a driving motor is installed on the cover plate, a grinding mechanism is arranged in the grinding pipe and connected with the driving end of the driving motor, and the driving end of the driving motor is connected with the extraction pipe. According to the utility model, the grinding, extracting and filtering of the enteric-coated tablet can be continuously completed in a sealed space, and the treated sample does not need to be transferred, so that the influence on the component detection result of the enteric-coated tablet caused by pollution and photolysis of thiamphenicol in the enteric-coated tablet in the transferring process is avoided.

The application discloses a traditional Chinese medicine micro-capsule enteric-coated tablet for promoting intestinal mucosa repair and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine pharmacy, and comprises a micro-capsule tablet core and an enteric-coated layer coated on the outer surface of the micro-capsule tablet core, wherein the micro-capsule tablet core comprises microcapsules with white-bark tree gum liquid as a wall material and Chinese herbal medicine extract as a core material, the Chinese herbal medicine extract comprises water-soluble inclusion compounds prepared by extracting aloe emodin, Danshen, processed ginger, Sanqi and spina date seed and then being wrapped by beta-cyclodextrin, and active polysaccharide retentate prepared by extracting Herba Baphicacanthis, fried coix seed, white peony root, licorice, Fructus Mume, Astragalus and dendrobium by complex enzymolysis and then being separated by ultrafiltration, and the white-bark tree gum liquid is prepared by swelling white-bark tree in cold water and then being treated by high-pressure homogenization; the micro-capsule is adsorbed on an intestinal ulcer surface to form a physical isolation barrier, and the ultrafiltration detoxification and cyclodextrin wrapping process improves the utilization degree and safety of active ingredients at a target site.

Embodiments herein provide a pharmaceutical formulation comprising an anti-inflammatory antipyretic agent with reduced side effects, addressing gastric problems. An enteric-coated tablet of the present invention comprises esomeprazole, aceclofenac, and paracetamol, along with maize starch, microcrystalline cellulose, povidone K30, colloidal anhydrous silica, and magnesium stearate.

The invention relates to the technical field of biological medicine, in particular to an ilaprazole enteric-coated tablet and a preparation method thereof. The ilaprazole enteric-coated tablet prepared by the invention comprises a tablet core, an isolating layer and an enteric-coated layer, and an alkaline stabilizer magnesium hydroxide is added into the tablet core to provide an alkaline environment to improve the stability and ensure the curative effect of the medicine. A hydrophilic gastric-soluble film coating premix is used as an isolating layer, ethanol is added as an isolating layer coating solvent, and coating parameters are controlled, so that the problem that disintegration and stability of the tablet core are affected due to the fact that water permeates into the tablet core in the isolating and coating process is greatly avoided. Sodium hydroxide is added into the isolating layer, so that even if trace water goes deep in the coating process, the sodium hydroxide can ensure the high pH value of water permeating into the tablet core, and the raw materials cannot be degraded. The problem that dissolution is unqualified after the enteric-coated tablet is resistant to acid is solved. Magnesium hydroxide is added into a tablet core, sodium hydroxide is added into an isolation coating solution, the compactness of an isolation coating film is controlled through coating parameters, and the problem that dissolution is unqualified after acid resistance is successfully solved.

This invention discloses an enteric-coated oxaprozin tablet and its preparation method. The tablet core comprises the following components in parts by weight: 200 parts oxaprozin, 10-30 parts disintegrant, 10-30 parts binder, and 0.5-4 parts lubricant. The disintegrant is low-substituted hydroxypropyl cellulose. In a simulated gastric acid dissolution medium (pH 1.2), the oxaprozin active pharmaceutical ingredient provided by this invention did not release at the end of the experiment, exhibiting no gastric irritation and good acid resistance. In a simulated intestinal dissolution medium (pH 6.8), Examples 1-4 showed slow initial release, with near-complete release after 30 minutes, avoiding intestinal irritation caused by rapid release. Therefore, the oxaprozin formulation provided by this invention can solve the problems of poor acid resistance and excessive intestinal irritation caused by rapid release in the first 10 minutes, which are present in existing oxaprozin enteric-coated microgranules.

The invention relates to the technical field of pharmaceutical preparations, in particular to a PAR-1 inhibitor enteric-coated preparation as well as a preparation method and application thereof. The PAR-1 inhibitor is prepared into enteric-coated tablets or enteric-coated capsules by adding auxiliary materials and enteric-coated materials into a cyclodextrin inclusion compound, the cyclodextrin inclusion compound comprises a PAR-1 (Protein Activated Receptor 1) inhibitor, sodium sulfobutyl beta-cyclodextrin and a pH (Potential of Hydrogen) regulator. The auxiliary material comprises one or more of a filling agent, an adhesive, a disintegrating agent and a lubricating agent. And the adhesive is hydroxypropyl methyl cellulose E4M. According to the invention, a cyclodextrin inclusion technology is adopted, a pH regulator is added to improve the inclusion rate, the inclusion rate is combined with a suspending material hydroxypropyl methyl cellulose E4M, the cyclodextrin inclusion compound is solubilized, and the hydroxypropyl methyl cellulose E4M is beneficial for maintaining the supersaturated state of the raw material, so that the solubility of the raw material at an absorption part is improved to the maximum extent, and the bioavailability of the raw material is improved. The absorption is promoted; the bioavailability is improved.

The utility model relates to a high-speed bottle unscrambler for producing enteric-coated tablets, which aims at solving the technical problem that the current bottle unscrambler cannot quickly and accurately move to a specified position and keep fixed at the specified position, and comprises a bottle unscrambling mechanism, a bottle feeding mechanism, a bottle discharging mechanism, a bottle discharging mechanism and a bottle discharging mechanism, and is characterized in that the bottle unscrambling mechanism comprises a driving disc arranged on the surface of a circular truncated cone; four notches are formed in the outer side of the driving disc, arc-shaped baffles are fixedly connected to circular truncated cones on the two sides of the driving disc, and the arc-shaped baffles movably abut against the outer side of the driving disc; the fixing mechanism comprises an arc-shaped groove formed in an inner cavity of the notch, an arc-shaped pressing plate is slidably connected into the arc-shaped groove, a limiting groove is formed in an inner cavity of the arc-shaped groove, a push plate is slidably connected to an inner cavity of the limiting groove, and the bottom of the push plate penetrates through the limiting groove and is arranged below the driving disc. The bottle moving mechanism has the advantages that after the bottle is quickly and accurately moved to a designated position, the filled bottle is fixed, and the bottle moving mechanism is convenient to use.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a diclofenac sodium enteric-coated tablet and a preparation method thereof. The diclofenac sodium enteric-coated tablet comprises a quick release layer, a slow release layer and an enteric coating layer, the quick release layer comprises the following components in parts by weight: 20-40 parts of diclofenac sodium, 5-15 parts of a disintegrating agent, 20-50 parts of a filling agent, 1-3 parts of a lubricating agent and 1-5 parts of an adhesive; the sustained release layer comprises the following components in parts by weight: 50-80 parts of diclofenac sodium, 5-15 parts of cross-linked chitosan, 1-3 parts of a lubricant and 1-5 parts of an adhesive; the enteric coating layer is prepared from the following components in parts by weight: 20 to 45 parts of enteric material and 5 to 15 parts of N-acetylneuraminic acid derivative. The diclofenac sodium enteric-coated tablet disclosed by the invention has excellent in-vitro accumulative release rate, relatively low hygroscopicity and relatively high stability and friability.

The application discloses a fresh panax notoginseng enteric-coated tablet and a preparation method thereof. The fresh panax notoginseng enteric-coated tablet comprises fresh panax notoginseng extract and excipients. The fresh panax notoginseng extract is extracted from the dug panax notoginseng root without drying treatment and comprises panax notoginseng saponins, panax notoginseng element and panax notoginseng polysaccharide. The excipients are excipients and coating film components. The preparation method comprises the following steps: fresh panax notoginseng extract extraction, fresh panax notoginseng extract tablet core preparation, fresh panax notoginseng extract tablet core coating, and fresh panax notoginseng extract extraction, which comprises fresh panax notoginseng cleaning, weighing, wet crushing, solid-liquid separation, alcohol precipitation, polysaccharide separation, vacuum drying, dry granulation, tablet pressing and coating. The fresh panax notoginseng raw material is directly extracted, so that the active components are not destroyed due to heating in the drying process of panax notoginseng medicinal materials and the risk of mold growth of the dried panax notoginseng medicinal materials is avoided. The wet crushing extraction method is adopted, so that the heat-sensitive components are not destroyed in the process of extracting the active components of panax notoginseng by heating, and the panax notoginseng extract, panax notoginseng saponins, panax notoginseng element and panax notoginseng polysaccharide have good biological activity. The enteric coating avoids the decomposition of the drug under the acidic condition of the stomach and improves the bioavailability of the active components in the body.