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58281results about How to "Improve product quality" patented technology

Product quality enhancement in mammalian cell culture processes for protein production

The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-galactose, preferably with feed medium containing D-galactose, preferably daily, to sustain a sialylation effective level of D-galactose in the culture for its duration, thus increasing sialylation of the produced proteins. The methods can also comprise at least two temperature shifts performed during the culturing period, in which the temperature is lower at the end of the culturing period than at the time of initial cell culture. The cell culture processes of the invention involving two or more temperature shifts sustain a high cell viability, and can allow for an extended protein production phase. The methods can also comprise the delayed addition of polyanionic compound at a time after innoculation. Supplementation of the cultures with D-galactose, preferably in a feed medium, to sustain galactose at sialylation effective levels in the cultures until the end of a culture run reverses a decline in sialylation that accompanies culture scale up, and is advantageous for large scale culturing processes.
Owner:BRISTOL MYERS SQUIBB CO

Special biological fish-fertilizer for aquaculture and preparation method thereof

The invention discloses a special biological fish fertilizer and a preparation method for the fertilizer used in aquiculture; wherein, the biological fish fertilizer mainly comprises raw materials as follows: microbiological preparation, inorganic fertilizers, fermentation organics, micro-mineral amino acid chelate, mineral composites, and water quality improver. The preparation method for the special biological fish fertilizer in aquiculture comprises steps as follows: microbiological preparation is produced; fermentation organics is then produced, and the micro-mineral amino acid chelate is produced, eventually the finished products are made. The special biological fish fertilizer has the advantages of limiting the growth and reproduction of the harmful algae, promoting the large-scale growth and reproduction of the suitable food for fish, effectively improving the water quality and purifying the water environment, strengthening the fish immunity, reducing the diseases, reducing cost due to the small use level, convenient use, mild odor, no pollution to the water, and environment protection. By combining the modern bioengineering technique, low-temperature drying technique, spray-drying technique, and super-fine crushing techniques, the preparation method has the advantages of stable quality for the fish fertilizers and lower overall cost.
Owner:WUHAN KEYANG BIOTECH

Manufacturing Method of Semiconductor Device

The present invention has been achieved reflecting such situation, and its object is to provide a manufacturing method of a semiconductor device capable of continuously performing the mounting process which applies a so-called DBG process and a flip chip bonding method, and can contribute to simplify the manufacturing process and to improve the reliability with no void in the product. The manufacturing method of a semiconductor device according to the present invention comprises:laminating a surface protective sheet to a circuit surface side of a wafer formed with grooves which divide each circuit wherein an adhesive film is adhered on the circuit surface of the wafer;reducing the thickness of the wafer and finally dividing the wafer into individual chips by grinding a back face of the wafer;picking up individual chips together with the adhesive film;die-bonding said individual chip to predetermined position of a chip mounting substrate via said adhesive film;fixing the chip to the chip mounting substrate by heating the die-bonded chip having the adhesive film; andapplying a static pressure larger than an ambient pressure by 0.05 MPa or more to a stacked body including the adhesive film one or more times, at any point between adhering the wafer to the adhesive film and fixing the chip to the chip mounting substrate.
Owner:LINTEC CORP

Atmospheric vacuum distillation method and apparatus with vacuum flash vaporizer

The invention relates to an atmospheric and vacuum distillation device with a vacuum flash tower and a method thereof. The atmospheric and vacuum distillation device with a vacuum flash tower is characterized in that the vacuum flash tower arranged in front of a vacuum furnace is connected with the vacuum furnace and a vacuum tower through a pump and a pipeline. Constant bottom oil (1) is introduced into the vacuum flash tower (2)at first, and the operation pressure at the top part of the vacuum flash tower is higher than the operation pressure at the top part of the vacuum tower (9) by10 to 200mmHg; Flash cap gas (3) is introduced into the upper part or the lower part of an outlet for a side product which is similar to Flash cap gas fraction; flash bottom oil (5) is introduced into the vacuum furnace (7) through a flash bottom oil pump (6); when the flash bottom oil is heated to 350 to 430 degrees, air-liquid mixing vacuum tower feed material is obtained through partial vaporization and is introduced into a flash evaporation segment (10) of the vacuum tower through a transfer line (8); and products with different fractions are drawn from the side of the vacuum tower and vacuum residue is drawn from the bottom of the vacuum tower. Through adding the vacuum flash tower to improve the working process of the atmospheric and vacuum distillation device, the invention achieves the advantages of increasing treatment capacity, increasing vacuum distillation yield, and reducing energy consumption.
Owner:TIANJIN UNIV +2

Method for producing basic copper chloride, cupric sulfate pentahydrate from copper-containing etching waste liquid

The invention relates to a method for producing copper chloride hydroxide and blue vitriod by using cupriferous etching wastewater; the method comprises the following steps: acidic copper chloride etching wastewater and alkaline copper chloride etching wastewater are neutralized and crystallized to get acidic copper chloride crystal under the condition of strictly controlling filling liquid and the Ph range of a reaction kettle, and then pumped and filtrated, and centrifugated; part of the obtained alkaline copper chloride crystal is dried to obtain finished products while the other is added with NaOH solution for alkali conversion to obtain copper oxide, and then is acidulated by sulphuric acid, crystallized, washed, centrifugated, and dried to obtain blue vitriod products. The method for producing blue vitriod by directly using sulphuric acid-oxyful etching wastewater includes the following steps: sulphuric acid-oxyful etching wastewater and composition brass wasterwater in a PCB manufacture are blended together and added with NaOH to form cupric hydroxide precipitation which filtrated, washed, and then acidulated by sulphuric acid to obtain copper sulphate solution; after the copper sulphate solution is cooled, crystallized, centrifugated and dried, and the blue vitriod is obtained.
Owner:HUIZHOU DONGJIANG ENVIRONMENTAL PROTECTION TECH

Soil fertility amendment and preparation method thereof

The invention provides a multifunctional soil nutrient conditioner formula with low cost, practicality and effectiveness and a preparation method thereof aiming at the technical problems. The production technology is simple, the production cost is low, and no harmful gas and sewage are generated during production. The product can effectively provide dozens of nutritive elements required for plant growth, is applied by being combined with a common fertilizer and an organic fertilizer, and can obviously improve the utilization rate of the fertilizer, so as to reduce the fertilizer input; and simultaneously the product can obviously stimulate action of beneficial floras of the soil, inhibit action of causal organisms, and increase the disease suppression of the soil and the resistance of plants, and then can effectively control generation of physiological diseases and soil-borne diseases, so as to reduce the pesticide input. The fertilizer input and the pesticide input can be reduced by more than 15 to 30 percent, and the yield can be increased by more than 15 to 30 percent, and simultaneously the product quality is obviously improved and cost conservation and synergism are obvious. Moreover, the soil improvement effect is obvious, and the sustainable utilization capacity can be obviously enhanced.
Owner:仲元(北京)绿色生物技术开发有限公司 +1

Metal powder preparation device and method therefor

The invention relates to a metal powder preparation device and method therefor. The device comprises an atomization furnace, a heater, a cooler, an atomization chamber, an atomizer, a pneumatic classifier, a middle bin, a sieving funnel, a screening machine, a deduster, a balance tank, a shell-and-tube heat exchanger, a vacuum obtaining device, a control system, an infusion tube, a conduit, a pipeline, a gas channel, a pneumatic butterfly valve, an electromagnetic valve and the like. The method comprises atmosphere preparation, metal smelting, infusion, centrifugal atomizing, pneumatic classification, mechanical screening, gas purification, cooling and the like, the metal is smelted and treated so as to be poured onto the atomizer for centrifugal atomization to form powder, the powder is classified by the pneumatic classifier, after classification, rough powder is screened by the mechanical screening so as to obtain the finished powder, fine powder is sent into the deduster by airflow for purification, the purified gas is driven by a high pressure centrifugal fan so as to be speeded up to be atomized and classified again after being subjected to heat exchange through the shell-and-tube heat exchanger. The device can be used for continuous production of spherical powder below -320 meshes, and the oxygen content is less than or equal to 80ppm.
Owner:BEIJING COMPO ADVANCED TECH
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