1423 results about "Side product" patented technology

The invention discloses a supported nickel catalyst for preparing 1, 3-propylene glycol through hydrogenation of 3-hydroxypropionaldehyde as well as a preparation method and application of the supported nickel catalyst, and relates to the technical field of catalysts. The modified long-chain multi-carbon inducer is used, and a special long-chain molecular structure and a branched chain group of the inducer can effectively and selectively adsorb and occupy a micropore impregnation site; the preparation method has the beneficial effects that more active component nickel species are obviously promoted to be dispersed in main reaction confinement spaces such as mesopores and macropores and interact with the carrier to form effective active sites, and active component steeping liquor is inhibited from entering micropore channels due to capillary action; the active site failure caused by agglomeration of nickel species in micropores in the subsequent drying and roasting process of the catalyst precursor is avoided, the efficient and directional reaction is ensured, the generation of by-products is greatly reduced, the pressure is relieved for the subsequent product rectification separation, and the final product purity is improved. The catalyst provided by the invention can still keep an excellent catalytic effect when the air speed of a 3-hydroxypropionaldehyde solution is increased to 6.5 h <-1 >.

The invention discloses an ether polymerization inhibitor special for a butadiene extraction system and a preparation method of the ether polymerization inhibitor. The ether polymerization inhibitor comprises the following raw materials: a polymerization inhibitor intermediate, a solvent and a dispersing agent, the production process comprises the following steps: preparing a polymerization inhibitor intermediate, preparing a solvent, compounding, feeding and mixing, filtering, removing impurities and detecting. According to the method, firstly, a polymerization inhibitor 701 and diethylene glycol normal pressure etherification process is adopted, and beta-hydroxyethyl methyl ether is introduced to seal a terminal group, so that the power consumption is reduced, the generation of byproducts is inhibited, the solubility of an intermediate acetonitrile is improved to be greater than or equal to 30g / L, and the anti-interference performance is greatly enhanced; the solvent doped with a small amount of silane modified nano diatomite is prepared, impurities can be adsorbed, metal ions can be chelated, the dispersing agent can be assisted to be evenly distributed, the problems that a pure water solvent is single in function and the dispersing agent is prone to agglomeration are solved, and the polymerization inhibition efficiency and the stability of an extraction system are guaranteed.

The invention belongs to the field of chemical engineering manufacturing industry, and relates to equipment and a method for producing cyclic ketone compounds by oxidizing cycloolefin by using waste gas produced by adipic acid. Raw material gas A containing nitrous oxide from an adipic acid production process production line can be subjected to oxygen removal, so that the oxygen content is less than 100ppm; the raw material gas A containing nitrous oxide from the adipic acid production line can also be purified into purer gas containing 50-99% of N2O, and the purer gas is used for reacting with the cycloolefin compound; the reaction equation is CnH2n-2 (cycloolefin) + N2O (nitrous oxide)-> CnH2n-2O (a product cyclic ketone compound) + a byproduct + N2 superscript (nitrogen), wherein n is a positive integer from 4 to 24. The device is stable in consumption quota, low in production cost and high in economic benefit compared with the prior art.

The invention provides chlorotrifluoroethylene continuously prepared based on a microchannel reactor and a preparation method of the chlorotrifluoroethylene, and the chlorotrifluoroethylene comprises the following raw materials in parts by weight: 1, 1, 2-trifluoro-1, 2, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3 The low-temperature refrigerant refrigerant is prepared from the following components in parts by weight: 90 to 100 parts of 1, 2-trichloroethane, 1 to 5 parts of a zinc fluoride induced palladium-copper bimetallic catalyst, 8 to 15 parts of a cyclohexyl dimethyl ether-formic acid composite hydrogen donor, 0.5 to 2 parts of trifluoroacetic anhydride, 0.1 to 0.5 part of a perfluoropolyether lubricant, a proper amount of a low-temperature mixed refrigerant and 15 to 20 percent by weight of diluted hydrochloric acid. According to the invention, the preparation efficiency and product purity of chlorotrifluoroethylene can be improved, and stable operation of the preparation system and reasonable treatment of byproducts can be guaranteed.

The invention discloses a synthesis method of allyl phosphonic acid diester. According to the method, phosphorous acid diester and an allyl chloride compound are used as raw materials and react in the presence of a specific transition metal catalyst and alkali under the conditions of normal pressure and 45-60 DEG C to obtain the allyl phosphonic acid diester. The method has the advantages of mild reaction conditions, simple operation, high product yield (90-99%), no by-product, no generation of halogenated alkane gas and easy industrial production, and is suitable for the fields of polymer flame retardants, electronic materials, pesticide and medicine intermediates and the like.

The invention discloses a method for improving the performance of clostridium aerovorans for synthesizing ethanol by utilizing gas fermentation. The method comprises the following steps: enabling the clostridium aerovorans to over-express ethanol synthesis pathway genes ald, adhE1 and adhE2; the expression of genes CLJU23220, CLJU25810 and CLJU25840 in the synthetic route of the 2, 3-butanediol is inhibited; and overexpressing acetic acid reuse genes aor1 and aor2. According to the clostridium yangdall engineering bacteria constructed by the method, the yield of ethanol synthesized by fermentation of synthesis gas is increased by 700% or above and reaches 1.70 g / L or above, and the synthesis amount of a by-product acetic acid is reduced by 18%.

The invention discloses low-odor thermoplastic vulcanized rubber for an automobile skin as well as a preparation method and application of the low-odor thermoplastic vulcanized rubber. The raw materials comprise 50 to 80 parts of ethylene-propylene-diene copolymer rubber, 20 to 50 parts of polypropylene, 5 to 15 parts of a compatilizer, 0.5 to 2.5 parts of a compound cross-linking agent, 0.5 to 2.0 parts of an odor adsorbent and 0.5 to 1.0 part of an antioxidant. The preparation method comprises the following steps: banburying and blending, dynamically vulcanizing by using a first double-screw extruder, adsorbing and deeply devolatilizing by using a second double-screw extruder, and carrying out vacuum baking at 100 DEG C. By utilizing the synergistic effect of the cross-linking agent and the assistant cross-linking agent, the degradation of polypropylene is inhibited while the cross-linking efficiency is ensured, and a low-boiling-point reaction by-product (tert-butyl alcohol) is thoroughly removed through a multi-stage devolatilization process, so that the problems that the traditional TPV material is strong in odor and easy to atomize are solved. The smell grade of the obtained material is less than or equal to 3.0 grade, and the atomization value is lt; and the coating is suitable for high-end automotive trim skins.

The invention belongs to the technical field of low-carbon dehydrogenation aids, and particularly relates to a heat balance aid as well as a preparation method and application thereof. The heat balance auxiliary agent comprises Al, Ca, Si, Cu and Mn elements existing in an oxide form; wherein the Al2O3, the CaO and the SiO2 jointly form a skeleton structure of the auxiliary agent, and the CuO and the MnO2 are used as active components and are attached to the skeleton structure; the molar ratio of metal elements in the heat balance auxiliary agent is as follows: Al: Ca: Si: Cu: Mn = (49-78.9): (15-25): (1-10): (5-15): (0.1-1). The heat balance additive prepared by the invention shows excellent anti-sintering capability, long service life and stable heat supply performance under harsh reaction conditions such as propane dehydrogenation, and can effectively improve the selectivity of target olefin and reduce the generation of byproducts such as methane.

The invention belongs to the technical field of organic synthesis, and particularly relates to an alkyl pentafluorosulfenyl compound and a preparation method and application thereof.The preparation method comprises the following steps that in the protective gas atmosphere, in a solvent, SF5Cl serves as a pentafluorosulfenyl source, an olefin compound serves as a reaction substrate and a free radical trapping agent, a thiol compound serves as a hydrogen source, and the alkyl pentafluorosulfenyl compound is obtained through a one-step reaction; under the action of an olefin additive, the alkyl pentafluorothio compound is constructed by a one-step method through a visible light-induced free radical process, and the olefin additive is used for inhibiting generation of a pentafluorothio chloride byproduct from a pentafluorothio source and an olefin compound. According to the method disclosed by the invention, a series of alkyl pentafluorosulfenyl compounds can be prepared by only needing olefin double bonds in substrates and selecting more substrates through the reaction, the reaction is simple, the reaction condition is mild, the reaction can be completed under visible light, the reaction time is short, the implementation is easy, and the method is suitable for industrial production. And a method support is provided for further screening the alkyl pentafluorosulfenyl compound with excellent biological activity.

The invention relates to the technical field of C9 heavy aromatics, in particular to a method and device for producing mesitylene from C9 heavy aromatics, and the method comprises the following steps: firstly, in the presence of a catalyst, mixing the C9 heavy aromatics with hydrogen, performing dealkylation isomerization reaction and dehydrogenation separation to obtain a liquid-phase product, and then performing two-stage separation on the liquid-phase product to obtain mesitylene. And mesitylene is produced to the maximum extent. The C9 heavy aromatics are subjected to selective dealkylation and trimethylbenzene isomerization reaction, and the obtained product does not contain propylbenzene, and the content of methyl-ethylbenzene is 1t; the method has the advantages that the yield of mesitylene is more than or equal to 0.2%, the interference of methyl ethyl benzene on the separation of the mesitylene is eliminated, the loss of the mesitylene is small, the one-way yield of the mesitylene is more than or equal to 12%, the reaction process is simple, the mesitylene and unsym-trimethylbenzene products are high in purity, the unsym-trimethylbenzene can be recycled to further increase the yield of the mesitylene, the process is flexible, byproducts are few, the product value is high, and the utilization value of C9 heavy aromatic hydrocarbon resources is obviously improved.

The invention provides a green and efficient production method of hexafluoropropylene oxide, and belongs to the technical field of synthesis of organic fluorine compounds. The method comprises the following steps: carrying out a continuous oxidation reaction on hexafluoropropylene, oxygen and a perfluoro solvent in an immersed supergravity reactor to generate HFPO and byproducts carbonyl fluoride and trifluoroacetyl fluoride, removing the solvent from the reacted liquid, feeding the liquid into an acyl fluoride rectifying tower, separating low-boiling-point acyl fluoride from the tower top, enriching HFPO, unreacted HFP and a small amount of acyl fluoride from the tower bottom, and carrying out a continuous oxidation reaction on the HFPO and the byproducts carbonyl fluoride and trifluoroacetyl fluoride. Converting acyl fluoride into anhydrous trifluoroacetic acid from a high-boiling-point substance at the bottom of the tower through a hydrolysis tower, carrying out alkali washing on the synthesis gas to obtain an HFPO crude product, and further carrying out drying and extractive distillation to obtain an HFPO product; acyl fluoride rectified by an acyl fluoride rectifying tower is directly used for producing PAVE, and long-chain perfluoroacyl fluoride accumulated in a solvent of oxidation reaction is hydrolyzed to synthesize a non-PFOA emulsifier. The method has the advantages of high HFPO selectivity, short reaction time and high safety; the method realizes resource comprehensive utilization of byproducts, and is environment-friendly and economical.

The invention discloses an environment-friendly early-strength alkali-free accelerator as well as a preparation method and application thereof, and belongs to the technical field of concrete admixtures. When the environment-friendly early-strength alkali-free accelerator is prepared, aluminum sulfate is not directly adopted to participate in the reaction, the accelerator is obtained by reacting concentrated sulfuric acid and fluosilicic acid with an aluminum oxide component in the industrial byproduct aluminum mud, and the solubility of aluminum ions is further improved by utilizing the principle that concentrated sulfuric acid releases a large amount of heat when encountering water and the principle that acid-base reaction releases heat; the resource utilization of the industrial byproduct aluminum mud is realized. According to the invention, the industrial by-product fluorosilicon slag is subjected to mechanical activation and chemical excitation and the synergistic effect of the grinding aid, so that the reaction activity of the fluorosilicon slag is greatly improved, the fluorosilicon slag is used for preparing the accelerator, the effects of accelerating and early strength are exerted, waste is turned into wealth, and the raw material cost of the accelerator is saved.

The invention belongs to the technical field of sodium hypochlorite production, and particularly relates to a method for producing sodium hypochlorite. A method for producing sodium hypochlorite comprises the following steps: adding a compound additive into a sodium hydroxide aqueous solution, and uniformly stirring to obtain a compound alkali-containing raw material solution; respectively introducing the composite alkali-containing raw material solution and chlorine into the micro-channel reactor through a metering pump, and controlling reaction conditions to generate a reaction solution containing sodium hypochlorite; introducing the reaction liquid into a ceramic membrane separation device, separating and removing unreacted solid impurities and by-product salts, and collecting permeate; unreacted sodium hydroxide is recycled and reused; and detecting the permeate liquid to be qualified to obtain a sodium hypochlorite finished product. According to the invention, four key links of compound additive addition, microchannel reaction, ceramic membrane separation and resin recovery are organically linked to form a systematic solution. Aiming at the core pain points of insufficient reaction, more byproducts, raw material waste, equipment corrosion and the like in the traditional process, the product purity is improved through the synergistic effect of all links.

The invention relates to the technical field of separation and purification, in particular to a method for recovering cis-15-tetracosenoic acid from an acer truncatum seed oil byproduct, which comprises the following steps: selecting the acer truncatum seed oil byproduct, crushing, sieving, washing, adding modified attapulgite and beta-cyclodextrin, stirring and adsorbing at constant temperature, and filtering; preparing the modified attapulgite; adding a KOH-EtOH solution containing lipase and polyethylene glycol into a pretreated product for refluxing, and adding a saturated saline solution for refluxing; standing and layering the reaction liquid, and extracting, acidifying, washing, drying and distilling an organic phase to obtain mixed fatty acid; and carrying out composite purification to obtain a pure cis-15-tetracosenoic acid product. According to the method, the purity and the extraction rate of the cis-15-tetracosenoic acid are remarkably improved, the oxidation, heat and storage stability of the product is enhanced, the color is improved, and the comprehensive application performance is better.

The invention provides a method for preparing (R)-4-chloro-3-hydroxybutyric acid ethyl ester ((R)-CHBE) through enzyme catalysis, which comprises the following steps: isopropanol is used as a hydrogen donor, a ketoreductase mutant is used for carrying out catalytic reduction reaction of COBE to prepare (R)-CHBE, and the ketoreductase mutant has amino acid mutation at the 83rd site on the basis of an amino acid sequence shown as SEQ ID NO.1. The invention also provides a preparation method of (R)-4-chloro-3-hydroxybutyric acid ethyl ester ((R)-CHBE). The thermal stability, namely heat resistance, of the ketoreductase mutant is improved, and by combining with the use of a rectifying tower, the method disclosed by the invention improves the utilization rate of isopropanol and can discharge a byproduct acetone in time, so that the substrate conversion rate and the product concentration are improved. The invention also provides an enzyme catalysis device used in the method.

The invention relates to the technical field of organic chemical synthesis, and discloses a continuous production process of a cationic etherifying agent, which comprises the following steps: taking trimethylamine hydrochloride and epoxy chloropropane as raw materials; the method comprises the following six steps: raw material pretreatment, premixing, continuous reaction, continuous separation, refining and product storage: mixing and dissolving trimethylamine hydrochloride and a solvent, preparing a catalyst solution, uniformly mixing the three materials through a static mixer, feeding into a multi-stage tubular reactor, and carrying out segmented temperature control continuous reaction, and performing flash evaporation solvent removal and rectification on the reaction product to obtain a crude product, and performing ion exchange impurity removal and reduced pressure distillation refining to finally obtain a high-purity product. The method solves the problems of low yield and more byproducts in the traditional process, and is suitable for industrial large-scale production.

The invention relates to a composite catalyst as well as a preparation method and application thereof, and mainly solves the problems of high temperature, more byproducts, catalyst residues, equipment corrosion, low catalytic efficiency of a novel catalyst and the like when a traditional strong acid catalyst system is used in the prior art. The research method comprises the following steps: preparing a sulfonic acid alkyl imidazole compound catalyst by a two-step method; 1 wt% of the catalyst is used for carrying out esterification reaction on polyhydric alcohol and fatty acid; after the reaction is finished, a product is separated from the catalyst, and the ionic liquid is recycled; and carrying out weak base washing, filtering and water washing refining on the product. The catalytic efficiency of the catalyst reaches up to 99.5% or above, the product hydroxyl value is smaller than 5 mgKOH / g, the acid value is smaller than 0.5 mgKOH / g, and the esterification efficiency is still kept to be 99.0% or above after the catalyst is recycled 6 times. The method has the advantages of simple process, mild reaction conditions and recyclable catalyst, well solves the problems of high temperature, catalyst residue, many byproducts and equipment corrosion in the traditional catalytic esterification system, and can be used in the preparation process of various ester products.

The application belongs to the technical field of methane coupling photocatalysts, and particularly discloses a preparation method and application of a catalyst modified by MgO and Au / TiO2(Br). The Au / MgO / TiO2(Br) catalyst prepared by the method is used for methane coupling catalysis, the catalytic reaction conditions are optimized, high catalytic efficiency is ensured, the selectivity of the target product C 2+ is up to 90% at a reaction temperature of 120 DEG C, and the yield is as high as 38.7 mmol / g / h. In addition, the process for preparing the Au / MgO / TiO2(Br) catalyst is simple, the preparation conditions of the catalyst are optimized, and no corrosive substance needs to be added in the catalyst reaction process, and no acid-base substance and toxic substance by-product are generated in the whole process, the harm of the reaction to the reaction operator is small, the environmental pollution is negligible.

The invention relates to a catalyst for preparing cyclododecanone through cyclododecanol dehydrogenation and a preparation method and application thereof. The catalyst component comprises copper, zinc, zirconium, sodium, calcium, aluminum and iron; the catalyst is prepared from the following components in percentage by mass in an oxide form: 40 to 65 weight percent of copper oxide, 10 to 21 weight percent of zinc oxide, 10 to 30 weight percent of zirconium oxide, 5 to 20 weight percent of sodium oxide, 1 to 5 weight percent of calcium oxide, 0.5 to 1.5 weight percent of aluminum oxide and 0.05 to 0.5 weight percent of iron oxide. In one embodiment, according to the preparation method of the catalyst provided by the invention, water vapor is added during roasting in a nitrogen environment, so that the release speed of carbon dioxide is controlled, and formation of carbon deposition in the roasting process is reduced. The catalyst can solve the problem of low selectivity caused by low dehydrogenation reaction conversion rate and many by-product cyclododecene, and has the characteristics of high strength, good hydrothermal resistance, long service life and the like.

The application discloses a rapid evaporation separation process of m-toluic acid, mainly including five steps of MX removal rapid evaporation, IPA removal rapid evaporation, MTA removal rapid evaporation, IPA refining and MTA refining. The process has the characteristics of short operation period, good separation effect and high MTA yield, and can recover IPA as a by-product, thereby avoiding generation of a large amount of residues.

The invention belongs to the technical field of organic synthesis, and particularly discloses a method for synthesizing carveol hydrate by using 2, 3-epoxy pinane, which comprises the following steps: by using 2, 3-epoxy pinane as a raw material, adding deionized water in a solvent in the presence of organic phosphoric acid as a catalyst and a micro-channel reactor as reaction equipment, carrying out ring-opening rearrangement reaction on the 2, 3-epoxy pinane to obtain carveol hydrate. Under the combined action of the catalyst and the microchannel reactor, high-yield and high-purity carveol hydrate is obtained; the method is mild in reaction condition, simple and convenient to operate, capable of effectively avoiding violent heat release of epoxy ring opening and generated by-products, high in reaction efficiency and good in industrial application prospect, the product yield can reach 98%, and the content can reach 99%.

The application provides a method for synthesizing triaminotriphenylmethane, which does not need to use a solvent, uses N,N'-dibenzylaniline and trialkoxymethane as synthetic raw materials, and makes N,N'-dibenzylaniline and trialkoxymethane undergo a Friedel-Crafts alkylation reaction, so as to avoid the generation of 2,4',4"-triaminotriphenylmethane isomers in a traditional synthesis method by using the steric effect of two benzyl protective groups, thereby obtaining 4,4',4"-tri(N,N'-dibenzylaminophenyl)methane with high selectivity. 4,4',4"-tri(N,N'-dibenzylaminophenyl)methane is further subjected to a debenzylation reaction under neutral conditions to form triaminotriphenylmethane. According to the chemical structural formula of the target product, the benzyl group as the protective group of the amino group is reduced under a neutral environment, and the benzyl group is removed, and the formed byproduct is only toluene, which not only ensures the high yield and high selectivity of the target product, but also is very beneficial to obtaining high-purity 4,4',4"-triaminotriphenylmethane, and conforms to the principle of green chemistry.

The application belongs to the technical field of oil exploitation, and particularly relates to a temporary plugging agent for fracturing acidification and a preparation method thereof. The preparation method is as follows: in a reactor, itaconic acid, p-styrene sulfonic acid, 2-allyloxy methyl-2-hydroxymethyl propane-1,3-diol, vinyl pyridine, pentaerythritol diacrylate, buffer salt and deionized water are sequentially added, stirring is conducted, the pH value is adjusted, and all raw materials are completely dissolved; an initiator is added from a high-position dropping tank, the reaction is automatically heated, the reaction is kept, a reducing agent is added, the reaction is terminated, the pH value is adjusted, and a temporary plugging agent solution is obtained; the temporary plugging agent solution is dried and granulated to obtain the product temporary plugging agent. The preparation method has the characteristics of simple synthesis process and no by-products; the temporary plugging agent has the advantages of large water absorption, large plugging strength, high breakthrough pressure, self-degradation and designable degradation time.

Systems and methods of producing 1-hexene are disclosed. The methods include oligomerizing ethylene to produce 1-hexene in a reactor unit, which involves flowing a first solvent system into the reactor unit, the first solvent system adapted to improve selectivity of 1-hexene in the oligomerizing of the ethylene. The methods can include flowing part of a second solvent system into the reactor unit under washing mode, the second solvent system adapted to dissolve by-products in the reactor unit being washed. The methods can include flowing part of a second solvent system into the catalyst preparation unit, the second solvent system adapted to dissolve catalysts in the catalyst preparation step. The systems can include a reactor, a wax / polymer removal unit, and at least two C6 distillation columns in series for producing 1-hexene.

The application relates to a synthesis method of an anti-freezing glycopeptide polypeptide and belongs to the technical field of polypeptide drug synthesis. The method comprises the following steps: 2-CL-Resin is used as a carrier resin, under the condition of adding an activating agent, the carrier resin and alanine are coupled to obtain Fmoc-Ala-2-CL-Resin; according to the amino acid sequence of the anti-freezing glycopeptide, other amino acids are sequentially coupled through a solid-phase synthesis method; after a protecting group is removed and the carrier resin is cleaved, the anti-freezing glycopeptide crude peptide is obtained; and after purification, salt conversion and freeze-drying, the anti-freezing glycopeptide polypeptide is obtained. The method has the advantages of short synthesis period, low cost, easy post-treatment, few by-products, high product yield, facilitation of large-scale production of the anti-freezing glycopeptide, and considerable economic applicative value and wide application prospect.

The invention discloses a preparation system and method of 2, 5-furandicarboxylic acid. The preparation system comprises a sectional reactor, a raw material storage tank, an oxidizing agent storage tank, a pH value adjusting tank and a solid-liquid separator, the sectional reactor comprises a shell, a reaction area and a reaction liquid collecting cavity; the reaction liquid collecting cavity is arranged between the reaction area and the shell; the reaction zone comprises alternately arranged catalyst bed layers and mixing chambers, the axial center of the sectional reactor is provided with a first mixing chamber, and the alternately arranged outermost layer is the catalyst bed layer; inlets are formed in the tops of all the mixing chambers; a reaction liquid outlet is formed in the bottom of the shell. The method has the advantages of high reaction efficiency, mild reaction conditions, few byproducts, simplicity in operation, low reaction cost and the like.

The present application relates to the technical field of alcohol aldehyde condensation reaction, and discloses an alcohol aldehyde condensation reaction method.The alcohol aldehyde condensation reaction method is carried out in an alcohol aldehyde condensation reaction device, the alcohol aldehyde condensation reaction device comprises a micro-channel alcohol aldehyde condensation reactor and an alcohol aldehyde condensation tube reactor which are connected in series; in the presence of an alkali catalyst, a reaction raw material n-butyl aldehyde is subjected to a first alcohol aldehyde condensation reaction in the micro-channel alcohol aldehyde condensation reactor to obtain a first alcohol aldehyde condensation reaction product; and the first alcohol aldehyde condensation reaction product is subjected to a second alcohol aldehyde condensation reaction in the alcohol aldehyde condensation tube reactor.The method uses a micro-channel alcohol aldehyde condensation reactor and an alcohol aldehyde condensation tube reactor to replace a full-mixing kettle reactor in the prior art to carry out alcohol aldehyde condensation reaction, so that the yield of a by-product heavy carbon alcohol can be significantly reduced, and the yield of a target product can be improved.

This invention discloses a cationic etherifying agent and its preparation method, belonging to the field of cationic etherifying agent production technology. The preparation method includes: continuously feeding trimethylamine and hydrochloric acid into a raw material pretreatment unit, pre-cooling to -10~20℃; entering a first tubular reactor, reacting at -10℃~20℃ and 0.15MPa for 10~60 minutes to generate trimethylammonium chloride; trimethylammonium chloride and epichlorohydrin entering a static mixer, simultaneously adding a catalyst and an organic amine; entering a second tubular reactor, reacting at 10~50℃ and 0.2MPa for 1~3 hours; during the reaction, monitoring the chloride ion concentration and epichlorohydrin residue in real time, dynamically adjusting the reaction parameters; filtering the reaction product through a nanofiltration membrane to obtain a high-purity cationic etherifying agent. This invention employs a continuous tubular reaction process combined with automatic control and nanofiltration membrane separation, resulting in a short production cycle, low energy consumption, few by-products, and a high-purity, odorless product, showing good industrial application prospects.

The invention discloses a synthesis method of mannitol carbonate sulfate, and belongs to the technical field of organic synthesis. The synthesis method provided by the invention comprises the following steps: reacting 1, 3, 4, 6-tetrachloro-2, 5-hexanediol with chlorosulfonic acid in the presence of an acid-binding agent to obtain an intermediate solution as shown in a formula (II); formula (II); and mixing the intermediate solution as shown in the formula (II) with anhydrous carbonate, heating to a first set temperature for reaction, and then heating to a second set temperature for reaction in the presence of a phase transfer catalyst to obtain the mannitol carbonic sulfate. The whole process route is short, the yield is high, and the total yield of two steps reaches 88% or above; meanwhile, few by-products are generated, the purification difficulty is low, the reaction time is short, few hazardous wastes are generated, operation is easy and convenient, and industrial large-scale production is facilitated.

This invention discloses a microchannel continuous preparation method for S-(-)-bioprolol fumarate intermediates, belonging to the field of medicinal chemistry technology. The method includes dissolving 4-isopropoxyethoxymethylphenol and a base in a solvent to provide a mixture; and contacting R-epoxychloropropane with the mixture in a microchannel reactor to react and form [[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]methyl]ethylene oxide. This invention overcomes the shortcomings of low reaction yield and long reaction time in existing technologies. By synergistically adjusting the material concentration, flow rate, residence time, and other reaction conditions, it improves reaction efficiency, shortens the reaction cycle, and increases the molar yield to over 70%. It significantly surpasses traditional batch reactions in terms of reaction efficiency, reaction time, and byproduct control.