This invention discloses a two-dimensional
hydrogen germanene
nanosheet, its preparation method, and its applications. The two-dimensional
hydrogen germanene
nanosheet has an ultrathin
layered structure, with covalently modified
hydrogen atoms on its surface, a lateral dimension of 100–300 nm, and a thickness of 5–10 nm. When activated by a specific
wavelength laser, the two-dimensional hydrogen germanene
nanosheet can photoexcite and generate
singlet oxygen to destroy bacterial biofilms and kill
bacteria. Simultaneously, it consumes local
oxygen to create a staged hypoxic microenvironment, thereby inhibiting excessive inflammatory responses. After the
light exposure ends, as the local
oxygen level naturally recovers, it can further enhance the infection clearance function of immune cells, achieving continuous clearance of residual infection. This invention, through staged dynamic regulation of
oxygen partial pressure, synergistically integrates direct bactericidal and
immune clearance processes, ensuring antibacterial strength while reducing the risk of
tissue damage and infection recurrence. It is suitable for the safe and
effective treatment of
implant-related
biofilm infections.