The invention discloses a preparation method of a hollow spherical
inorganic oxide based on self-
assembly, which comprises the following steps: (1) mixing a passivating agent with an
inorganic oxide precursor, performing
passivation protection on the
inorganic oxide precursor in a
transesterification or
chelation reaction mode, adding water or an
aqueous solution with the pH value of 4-14 for pre-crosslinking, and performing
vacuum drying to obtain the hollow spherical inorganic
oxide based on self-
assembly; a solution A containing an amphiphilic composite precursor is obtained; (2) mixing the solution A with a non-polar compound to prepare a solution B, finally dispersing the solution B in water or an
aqueous solution with the pH value of 4-14 to form an oil-in-water structure, then stirring to react for more than 6 hours, and then washing and
drying to obtain a hollow spherical
oxide precursor; and (3) calcining the hollow spherical
oxide precursor to obtain the hollow spherical inorganic oxide. The method does not need an interface agent, a hard template or a high-temperature and high-pressure environment, and has the advantages of low cost, expandability, simple preparation, greenness and safety.