4256 results about "Carbonyl group" patented technology

Described herein are sorbents functionalized with polyamines having oxygen-containing units selected from carbonyl units, hydroxyl units, and combinations thereof, methods of making same, and methods of using same.

The invention provides a carbonyl reductase mutant. The carbonyl reductase mutant is obtained by performing single-point mutation or multi-point combined mutation on the 17th site, the 40th site and the 64th site of an amino acid sequence as shown in SEQ ID NO.1. The invention also provides a coding gene, a recombinant vector containing the coding gene, a co-expression engineering bacterium and an application of the co-expression engineering bacterium. Compared with a wild type enzyme, the carbonyl reductase mutant has high activity and high stereoselectivity, the enzyme activity can reach more than two times that of the wild type enzyme, the catalytic efficiency on a substrate precursor ketone is remarkably improved, the yield of a statin drug intermediate and chiral alcohol synthesized by an enzyme method of the carbonyl reductase mutant is remarkably improved, and the yield of a rosuvastatin intermediate (3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R) is remarkably improved. The highest yields of the (3R, 5R)-6-chloro-3, 5-dihydroxyhexanoic acid tert-butyl ester and the atorvastatin intermediate (3R, 5R)-6-cyano-3, 5-dihydroxyhexanoic acid tert-butyl ester reach 99% and 97.6% respectively, e.e. Is larger than 99%, and the method has high industrial application value.

The invention discloses a carbonyl reductase, a mutant and an application of the carbonyl reductase in synthesis of a chiral alcohol compound. The carbonyl reductase mutant is obtained by performing single-site or multi-site mutation on the 96th site, the 145th site, the 202nd site or the 206th site of the amino acid sequence of the carbonyl reductase LbCR derived from lactobacillus brevis as shown in SEQ ID No.2. The activity and stability of the carbonyl reductase LbCR mutant are obviously improved, and the carbonyl reductase LbCR mutant has a wide substrate spectrum. Compared with a wild type, the mutant LbCRM4 has the advantages that the enzyme activity is improved by 86.3 times, the substrate conversion rate is greater than 99%, the e.e.p value of the product is always kept at 99.5% or above, the space time yield reaches 1288.9 g / L / d, and the half-life period at 40 DEG C is 101.4 h and is improved by 83.5 times. The LbCR mutant has an industrial application prospect.

Embodiments of the present invention provide methods and intermediates for the large scale preparation of 2, 4, 6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl] benzamide hemisuccinate, as well as formulations and product forms prepared by these methods. Embodiments of the present invention further provide for the preparation of lamidetan acetate (2, 4, 6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl] benzamide acetate) and / or a pharmaceutical composition thereof, and / or the use of lamidetan acetate and formulations thereof in subcutaneous drug delivery.

The invention relates to a saccharomyces cerevisiae strain for efficiently synthesizing cordycepin as well as a construction method and application of the saccharomyces cerevisiae strain, and belongs to the technical field of microbial genetic engineering. The construction method provided by the invention comprises the following steps: carrying out multi-copy genome integrated expression on heterologous codon optimized 2 '-carbonyl-3'-deoxyadenosine reductase genes and 3 '-adenosine monophosphate phosphohydrolase genes, so as to increase the dosage of key enzymes; and supplementing the defective gene of the engineering strain to obtain the saccharomyces cerevisiae strain B5U3 with high yield of cordycepin. According to the obtained saccharomyces cerevisiae strain for efficiently synthesizing the cordycepin, the cordycepin yield reaches 2.92 g / L after shake flask fermentation, the cordycepin yield reaches 7.5 g / L after fermentation in a fermentation tank, and a foundation is laid for safer and more reliable industrial production of the cordycepin.

The specification relates to a wash-off label (100, 200) comprising a face (101, 301) and a pressure sensitive adhesive (102, 302) adjoined to the face, wherein the face (101, 301) comprises corona discharged filmic material and the pressure sensitive adhesive (102, 302) has a composition including at least one acrylic polymer comprising acrylic monomer(s) and / or non-acrylic comonomer(s) having a carbonyl group capable of undergoing a crosslinking reaction, amount of the acrylic monomer(s) and / or non-acrylic comonomer(s) having a carbonyl group capable of undergoing a crosslinking reaction being from 0.1 to 5 wt. % of monomer composition, and a crosslinking agent with dihydrazide functionality, amount of the crosslinking agent being from 20 to 150% with respect to the amount of the carbonyl groups capable of undergoing a crosslinking reaction. The wash-off label (100, 200) is detachable from a surface when exposed to an alkaline washing solution at a temperature of 85 degrees C. the detachability being such that the pressure sensitive adhesive (102, 302) remains attached to the face (101, 301). Further, the specification relates to a labelled item and use of the wash-off label for labelling an item. Still further, the specification relates to a label laminate web and a method of manufacturing the wash-off label as well as to a pressure sensitive adhesive composition for a wash-off label.

The invention provides starch-based hard carbon and a preparation method thereof, a negative electrode plate, a sodium ion battery and electric equipment, and relates to the technical field of new energy. According to the preparation method disclosed by the invention, hydroxyl and hydrogen atoms in the starch are consumed through organic acid esterification, so that a molten state is not formed in the subsequent oxidation crosslinking and carbonization processes, the structure and strength of a carbon skeleton are improved, and functional groups and doped atoms are more easily introduced; in the oxidation cross-linking process, oxygen-containing functional groups mainly containing carbonyl are mainly introduced, and the cross-linking degree is enhanced, so that phosphorus and nitrogen atoms are better doped in subsequent carbonization, a better spherical structure is formed, and the subsequent carbonization yield is further improved. The starch-based hard carbon material prepared by the method has the advantages that the starch-based hard carbon material is mixed with the phosphorus source and the nitrogen source for carbonization, the pore-forming process and the phosphorus-nitrogen atom doping process can be directly completed in the heating process, and open pores are changed into closed pores in the high-temperature and constant-temperature process, so that the prepared starch-based hard carbon material has excellent structure and surface groups and heteroatoms, and the dynamic performance of the starch-based hard carbon material is further optimized.

The invention discloses a high-performance carbonyl reductase mutant and application thereof in synthesis of a series of chiral alcohols. The high-performance carbonyl reductase mutant is obtained by performing the following mutations on an amino acid sequence as shown in SEQ ID NO.2: the 69th alanine mutates into any one of lysine, leucine, aspartic acid or asparagine, and the 69th alanine mutates into any one of lysine, leucine, aspartic acid or asparagine; and / or the 100th glycine is mutated into any one of glutamic acid, serine, lysine or asparagine. Compared with a wild type enzyme, the thermal stability and the catalytic activity of the obtained mutant are remarkably improved, particularly, single point mutants Mut-A69N, Mut-G100E and Mut-G100N and a combined mutant Mut-A69N-G100N show excellent relative enzyme activity, thermal stability and substrate tolerance. The mutant has high catalytic activity and stability to various chiral alcohols, and the contradiction that the traditional carbonyl reductase is easy to inactivate at high temperature and the catalytic efficiency is difficult to achieve at the same time is solved. The invention provides an efficient and stable enzyme catalysis tool for green biological preparation of chiral drug intermediates.

The invention provides a liposome preparation and a preparation method thereof, the liposome preparation comprises an ion pairing agent, phospholipid or a derivative thereof, sterol, a lipid molecule derivative and a drug compound, the ion pairing agent comprises at least one of a compound (I) and a compound (II), and the compound (II) comprises at least one of a compound (III) and a compound (III). Structures in the compound (I) and the compound (II) contain a plurality of functional groups (such as amide, carbonyl, thioether and the like), so that abundant binding sites are provided for drug molecules, and the compound (I) and the compound (II) can interact with different types of drug compounds (such as fat-soluble and water-soluble drugs); the liposome preparation is allowed to be combined with various drug molecules through hydrogen bonds, hydrophobic interaction or electrostatic interaction, and the liposome preparation adapts to physicochemical properties of different drugs. The compound (I) and the compound (II) further comprise different hydrophobic groups (such as alkyl chains) and hydrophilic groups (such as sulfonic acid, carboxylic acid and the like), so that the liposome preparation has the amphiphilic characteristic, not only can encapsulate hydrophobic drugs, but also can encapsulate hydrophilic drugs, and the variety and range of encapsulated drugs are improved.

The invention provides a synthesis method of 6-(t-butyloxycarboryl)-3, 6-diazabicyclo [3.1. 1] heptane, which comprises the following steps: starting from N-benzyl-2, 6-piperidinedione, firstly forming a dibromide 1, then forming a bridge ring intermediate 2 under alkaline conditions, then removing benzyl to obtain an intermediate 3, then reducing dicarbonyl to form free amine 4, and finally synthesizing the 6-(t-butyloxycarboryl)-3, 6-diazabicyclo [3.1. 1] heptane. Then performing Boc protection on amino to obtain an intermediate 5, and performing debenzylation to form a target product. According to the synthesis method, few impurities are generated, and the product is easy to purify and high in purity, so that the total yield is increased, the unit cost is effectively reduced, and large-scale industrial production is facilitated.

The invention discloses a multi-effect repair type collagen and application thereof, and belongs to the technical field of synthetic biology. Transdermal peptide TD-1, a transmembrane region of human XVII type collagen, an extracellular sixteenth non-collagen region, an extracellular fifteenth collagen region and a coding gene of a His tag are selected to be connected in series, and a gene sequence is optimized through pichia pastoris codon selection preference; and then the T-COL17R3 is constructed and expressed to obtain the T-COL17R3. Efficacy experiments prove that compared with similar products sold in the market, T-COL17R3 not only has excellent transdermal performance, but also has better cell proliferation and migration promoting capability, better capability of resisting early saccharification product ketoamine and later saccharification product dicarbonyl compounds, better capability of scavenging free radicals and resisting elastase, and can be used for preparing the anti-epidermal drug. In addition, synthesis of melanin in B16-F10 cells can be reduced, so that T-COL17R3 has excellent application potential in development of pharmaceutical compositions or skin care products with repairing, anti-wrinkle and firming or whitening and brightening effects.

To provide a thermosetting resin composition that exhibits sufficiently low dielectric properties and offers superior heat resistance for use in printed wiring boards, and an active ester resin that yields the same.SOLUTION: Provided is an active ester resin composed of polyaryloxy units and polyarylcarbonyl units, the active ester resin having, as the polyaryloxy units, allyl group-containing units represented by the following formula, where R1 is a hydrocarbon group having 1 to 12 carbon atoms; R2 is H or a hydrocarbon group having 1 to 12 carbon atoms; X is a bonding site with a polyarylcarbonyl unit or an allyl group; 1 to 99 mol% of all X's are allyl groups; i is an integer of 0 to 3; and n is a repeating number with an average value of 0.1 to 5.SELECTED DRAWING: Figure 1

The invention discloses a carbonyl reductase mutant as well as a preparation method and application thereof, and belongs to the technical field of enzyme engineering. According to the invention, on the basis of carbonyl reductase BcKRED from Bacillus cereus, a series of dominant mutants are obtained through a method of directed evolution in the field of enzyme engineering. The carbonyl reductase dominant mutant obtained by the invention has high catalytic activity, thermal stability and chiral selectivity reversed with wild-type carbonyl reductase. A green and efficient way is provided for industrial production of chiral alcohol by taking carbonyl reductase as a biocatalyst, and the method has a wide application prospect.

The invention discloses polyrotaxane with controllable cyclodextrin coverage rate as well as a preparation method and application of the polyrotaxane, and belongs to the technical field of polyrotaxane materials. The preparation method comprises the following steps: dissolving alpha-cyclodextrin, 3-hydroxyadamantane-1-carboxylic acid and polyethylene glycol diamine in deionized water, refrigerating and assembling to form quasi-polyrotaxane, and blocking to obtain polyrotaxane; wherein the polyethylene glycol diamine is prepared from polyethylene glycol and N, N '-carbonyldiimidazole, and the cyclodextrin coverage rate of the polyrotaxane is directionally regulated and controlled by regulating and controlling the mass ratio of the alpha-cyclodextrin to the 3-hydroxyadamantane-1-carboxylic acid, the adding sequence of the 3-hydroxyadamantane-1-carboxylic acid and the refrigerating and assembling time. Based on the mechanism that 3-hydroxyadamantane-1-carboxylic acid and polyethylene glycol compete in a cyclodextrin cavity, polyrotaxane with a cyclodextrin coverage rate of 0.5-2.5% is synthesized, and a polymer based on the polyrotaxane has better ductility and mechanical properties.

Provided is a polyamide resin, which is a copolymer of a biodegradable polyamide, such as polyamide 2 to polyamide 4, and another polyamide, the polyamide resin having enhanced biodegradability. The polyamide resin contains a structural unit represented by Formula (1) and another polyamide structural unit, and a difference between a degree of randomness determined based on a proportion of each structural unit as determined by 1H-NMR measurement when structural units are assumed to have an ideal random sequence and a degree of randomness determined based on a proportion of carbonyl carbon of an amide group linking different structural units with respect to a total peak integrated value for carbonyl carbon as determined by 13C-NMR measurement is 0.10 or less, where in Formula (1), x is an integer of 1 or greater and 3 or less.

The invention discloses an all-solid-state composite dry conductive agent and a preparation method thereof, and belongs to the technical field of batteries. The all-solid-state composite dry conductive agent is prepared by the following steps: uniformly mixing carbon nanotubes, high-dispersion carbon black and graphene to obtain a primary mixture; then preparing a uniformly dispersed glue solution from the composite dispersant and water; and then adding the primary mixture into the glue solution, uniformly mixing, sanding, homogenizing, drying and crushing to obtain the product, the high-dispersion carbon black is obtained by oxidizing carbon black to form active groups such as carboxyl and hydroxyl on the surface of the carbon black, halogenating acyl and then reacting with lithium 2, 5-diaminobenzene sulfonate. The preparation method comprises the following steps: grafting histidine ester into carboxymethyl cellulose by using propylene glycol diglycidyl ester as a cross-linking agent, then introducing allyl-1, 3-sultone, then copolymerizing with lithium 2-acrylamido-2-methylpropanesulfonate and 3-aminobenzoic acid allyl ester protected by fluorenylmethoxycarbonyl, and then deprotecting to obtain the composite dispersant.

The invention relates to the technical field of batteries, in particular to a porous composite diaphragm, a preparation method thereof and a secondary battery. The porous composite diaphragm comprises a base membrane, a first coating and a second coating, the first coating and the second coating are oppositely arranged on the two surfaces of the base film; the first coating layer and the second coating layer comprise a copolymer containing a first monomer unit and a second monomer unit; the first monomer unit contains a cyano group on a side chain, and the second monomer unit contains a carbonyl group on a side chain; in the copolymer, the molar ratio of the second monomer unit is 1-20%; the first coating and the second coating comprise skeleton structures and first-class pore structures formed between the skeleton structures, and second-class pore structures are formed on bodies of the skeleton structures; and the average pore diameter of the first-type pore structure is greater than that of the second-type pore structure. According to the porous composite diaphragm, the lithium ion conductivity can be improved while the bonding performance with a pole piece is improved.

The invention discloses a high-transdermal recombinant humanized XVII type collagen as well as a preparation method and application thereof, and belongs to the technical field of synthetic biology. According to the preparation method, transdermal peptide TD-1, different functional fragments of human XVII type collagen and coding genes of His tags are selected to be connected in series, gene sequences are optimized through pichia pastoris codon selection preference firstly, and then the high-transdermal recombinant humanized XVII type collagen is obtained; and then the recombinant humanized XVII type collagen T-COL17-NC16 and the recombinant humanized XVII type collagen T-COL17 are constructed by expression of the recombinant humanized XVII type collagen T-COL17. Effect experiments prove that compared with similar products sold in the market, the skin-care product has more excellent transdermal performance, can improve cell proliferation and migration ability, also has obvious ability of resisting early saccharification product ketoamine and late saccharification product dicarbonyl compounds, better ability of scavenging free radicals and resisting elastase, and can be used for preparing the skin-care product. Moreover, synthesis of melanin in B16-F10 cells can be reduced, and the compound is expected to become a novel functional biological raw material to be applied to the fields of pharmaceutical compositions or skin care products and the like.

The invention belongs to the technical field of printing materials, and provides a thermal printing material with a cleaning function and a preparation method and application thereof. The thermal printing material comprises a base material, a thermal imaging layer and a protective layer which are sequentially stacked, the protective layer is prepared from a first film forming material, a second film forming material and a cleaning function material, and the cleaning function material comprises rare earth oxide. The first film-forming material is at least one of modified polyvinyl alcohol, styrene acrylic resin, polyurethane resin, polyacrylic resin, styrene maleic anhydride copolymer and waterborne epoxy resin, and the second film-forming material is a carbonyl compound and / or an amino compound. The thermal printing material provided by the invention can clean a thermal printing head while printing, the thermal printing head is kept clean for a long time, the service life is long, the printing effect of an output information image is not influenced, and the thermal printing material has the characteristics of high-transparency appearance, clear image, high density and no scratch.

The invention relates to the technical field of dielectric materials, and discloses a composite dielectric material and a preparation method and application thereof.The composite dielectric material comprises filler and a base material, the filler is modified barium titanate, and the base material is cyanoethyl cellulose; the modified barium titanate comprises a barium titanate core and a shell, the shell comprises a polymer containing an epoxy group, the core and the shell are connected through a covalent bond, and an infrared spectrum test shows that in an infrared spectrogram of the modified barium titanate, characteristic peaks of the epoxy group and carbonyl respectively exist at 910 + / -10 cm <-1 > and 1720 + / -10 cm <-1 >. Epoxy groups in the modified barium titanate filler can react with hydroxyl groups in a cyanoethyl cellulose matrix material to form covalent linkage, compatibility of the filler and a matrix is improved, meanwhile, a potential well is formed, migration of carriers can be limited, and the composite material has good dielectric performance and energy storage performance.

The invention provides an imine covalent organic polymer and a preparation method thereof, a negative electrode material and a potassium ion battery. The preparation method comprises the following steps: carrying out first mixing on raw materials including a carbonyl-containing first organic compound, an amino-containing second organic compound and a dispersion liquid to obtain a mixed liquid; carrying out in-situ polymerization reaction on the mixed solution to obtain an imine covalent organic polymer; wherein the first organic compound is nitro-substituted or non-substituted pyrene-4, 5, 9, 10-tetraketone; the second organic compound is selected from any one or more of C6-C12 aromatic amine compounds, C6-C12 heteroaromatic amine compounds and amino-substituted C4-C6 cyclic compounds, and the number of amino groups in each molecule of the second organic compound is greater than or equal to 2. The covalent organic polymer obtained by the preparation method can solve the problem that the structure is easily stacked and is easily dissolved in electrolyte to be damaged when the covalent organic polymer is used as a negative electrode material.

The invention belongs to the technical field of antibiosis and wound healing promotion, and relates to double-response (near-infrared light and hydrogen peroxide double-response photo-thermal / carbon monoxide therapy) antibacterial hydrogel as well as preparation and application thereof. The invention relates to a double-response antibacterial hydrogel. The antibacterial hydrogel is prepared from the following components: drug-loaded nano particles and a hydrogel matrix. The drug-loaded nano particles are prepared by loading dimanganese decacarbonyl (MnCO) into cavities of hollow mesoporous copper sulphide nano particles (HMCuS NPs) and coating the surfaces of the particles with a polydopamine layer (PDA). According to the invention, CO / PTT synergistic treatment of bacterial infected wounds is realized, and the antibacterial effect is significantly improved. An in-vitro antibacterial experiment result shows that the antibacterial hydrogel shows extremely strong inhibition capability on escherichia coli and staphylococcus aureus, and the problem of drug resistance caused by a bacterial biofilm is effectively solved.

The invention discloses a composite diaphragm, a preparation method thereof and a secondary battery. The composite diaphragm comprises a base diaphragm, the polymer coating is arranged on at least one surface of the base membrane, and the polymer coating comprises a cross-linked polymer which is formed by in-situ polymerization of a first monomer and a second monomer and has a network structure; wherein the first monomer is a monomer at least comprising a carbon-carbon double bond and an ester functional group; the second monomer is a monomer at least comprising a carbon-carbon double bond and a carbonyl functional group. Compared with the prior art, the composite diaphragm disclosed by the invention is applied to the lithium ion battery, and when the battery is overheated or short-circuited and other abnormal conditions, the polymer coating forms a compact cross-linked polymer network, so that the defect that the traditional polyolefin substrate diaphragm is easy to break at high temperature is overcome, the occurrence of thermal runaway of the battery is effectively inhibited, and the service life of the battery is prolonged. The electrochemical reaction of the battery can be stopped, and the safety of the battery is remarkably improved.

The invention provides a separation method of a catalyst for preparing butyraldehyde through propylene carbonylation, and relates to the technical field of chemical synthesis. The separation method comprises the following steps: carrying out flash evaporation separation and low-pressure evaporator evaporation on a material obtained by carrying out a propylene carbonylation reaction on propylene and synthesis gas as raw materials, obtaining a gas-phase material from a collecting tank of a low-pressure evaporator, and outputting a liquid-phase catalyst solution; the gas-phase material is subjected to condensation and gas-liquid separation, crude butyraldehyde is output, and obtained non-condensable gas returns to a liquid distribution chamber of the low-pressure evaporator; wherein the catalyst is acetylacetone triphenyl phosphorus silicification carbonyl rhodium, and the operation temperature of the low-pressure evaporator is 85-95 DEG C. By controlling the circulating air volume and the evaporation temperature, high-temperature deactivation of the catalyst is prevented, the service life of the catalyst is prolonged, and the process cost is reduced; the process flow is simplified, and the method is suitable for large-scale process production.

The invention relates to a method for producing microparticles comprising at least one organic active compound encapsulated by a shell of an organic wall material, the method comprising i. Providing a water-immiscible liquid containing the organic active compound to be encapsulated and at least one first shell-forming compound (SFC1); ii. Emulsifying the water-immiscible liquid obtained in step i. In an aqueous medium to obtain an oil-in-water (o / w) emulsion of the water-immiscible liquid in the aqueous medium; iii. Adding at least one second shell-forming compound (SFC2) to the aqueous medium or to the emulsion obtained in step ii. Prior to or during performing step ii., thereby obtaining an aqueous suspension of the microparticles; wherein the first shell-forming compound (SFC1) or the second shell-forming compound (SFC2) has 1, 2, 3, 4, 5 or 6, in particular 1, 2, 3 or 4, in particular 1, 2 or 3 first reactive groups (RG1) selected from isocyanate groups, isothiocyanate groups, carbonyl halide groups and carboxylic anhydride groups, per molecule, and the other shell-forming compound has 1, 2, 3, 4, 5 or 6, in particular 1, 2, 3 or 4, per molecule, in particular 1, 2 or 3 second reactive groups (RG2) selected from the group consisting of hydroxyl, thiol and primary amino groups, the first shell-forming compound (SFC1) or the second shell-forming compound (SFC2) having only one reactive group and the other shell-forming compound having 1, 2, 3, 4, 5 or 6, in particular 1, 2, 3 or 4, in particular 1, 2 or 3 reactive groups. The invention also relates to microparticles obtainable by this process and to the use thereof.

The invention relates to the field of automobile part manufacturing, and particularly discloses a barrier layer direct bonding type TPE material for an automobile air conditioner pipeline system and a preparation method and application of the barrier layer direct bonding type TPE material. The TPE material is prepared from the following raw materials: a thermoplastic elastomer TPE, PA, EVOH, polyether block amide, a glycidyl methacrylate grafted olefin copolymer elastomer, a toughening compatilizer, composite modified montmorillonite, a cold-resistant additive, an antioxidant and paraffin oil. Wherein the composite silane coupling agent, lauric acid and N, N '-carbonyldiimidazole are adopted to modify the nano-montmorillonite, so that the dispersity of nano-montmorillonite particles is improved, the formation of aggregates is effectively reduced, and the mechanical property of the material is enhanced; the polyether block amide, the glycidyl methacrylate grafted olefin copolymer elastomer and the toughening compatilizer have a synergistic effect, so that good adhesiveness of the TPE material and the barrier layer is realized.

The invention relates to the technical field of biology, and discloses a carbonyl reductase mutant and application thereof in enzymatic synthesis of chiral alcohol. The amino acid sequence as shown in SEQ ID NO.2 is subjected to mutation that 36th lysine is mutated into any one of aspartic acid, threonine and valine, or / and 125th histidine is mutated into any one of lysine, serine and leucine, or 170th histidine is mutated into any one of lysine, cysteine and leucine. The carbonyl reductase mutants, especially single-site mutants Mut-T75K, Mut-T75D and Mut-E216M and a combined mutant Mut-T75K-E216M, with activity improved to different extents compared with that of a wild type are obtained, have excellent relative enzyme activity, thermal stability and substrate tolerance, have relatively high activity and stability for various chiral alcohols, and can be used for preparing the carbonyl reductase mutants. The catalyst has the advantages of high catalytic activity, high thermal stability, strong substrate tolerance, easiness in fermentation and the like.

Disclosed is an additive for a non-aqueous electrolyte solution, which contains a cyclic sulfone compound represented by formula (1). X1 represents a sulfonyl group or a carbonyl group, and Z represents a monovalent group represented by formula (21), (22), (23) or (24). # imgabs0 #

The invention discloses a hard carbon material and a preparation method thereof, a negative plate and a battery, at least part of the surface of the hard carbon material comprises oxygen-containing functional groups, the oxygen-containing functional groups comprise first oxygen-containing functional groups and second oxygen-containing functional groups, the molar percentage sigma of the first oxygen-containing functional groups to the oxygen-containing functional groups is 62% lt; sigma < = 95%; wherein the first oxygen-containing functional group is carbonyl and / or hydroxyl; the second oxygen-containing functional group is a quinonyl group and / or an ether bond. The hard carbon material provided by the invention has more reversible sodium storage active sites, so that the specific capacity and the first-circle coulombic efficiency of the battery are favorably improved.

The invention provides cellulose-based electronic carrier tape paper and a preparation method thereof, and the preparation method comprises the following steps: step (1): soaking a first wood pulp board in water until fibers are swelled, and pulping to obtain pulp; step (2), enabling the basalt nanosheet to react with polyvinylpyrrolidone, so as to obtain a carbonyl modified basalt nanosheet; (3) soaking the second wood pulp board in water until the second wood pulp board is completely defibered to obtain paper pulp, grinding the paper pulp, and carrying out micro-jet nano-homogenization treatment to obtain a cellulose nano-fibril suspension; and (4) uniformly mixing the cellulose nanofibril suspension, carbonyl modified basalt nanosheets and an antistatic agent with the slurry prepared in the step (1), forming a paper sample to obtain a wet paper sheet, and drying to obtain the cellulose-based electronic carrier tape paper. The cellulose-based electronic carrier tape paper prepared by the invention is obviously superior to the traditional electronic carrier tape paper in the aspects of environmental protection, cost, electrostatic protection and mechanical property.