414 results about "Carbonyl group" patented technology

Disclosed herein is a compound that is (R)-(2-(3-((((2-ethylbutanoyl)oxy)methoxy)carbonyl)-2-hydroxyphenyl)-1-propionamidoethyl)boronic acid citrate coordination complex, or a pharmaceutically acceptable salt or solvate thereof. Also disclosed herein are methods of treating a bacterial with a compound that is (R)-(2-(3-((((2-ethylbutanoyl)oxy)methoxy)carbonyl)-2-hydroxyphenyl)-1-propionamidoethyl)boronic acid citrate coordination complex, or a pharmaceutically acceptable salt or solvate thereof in combination with ceftibuten.

The present application provides a photosensitive resin composition, dry film resist, photosensitive dry film and application thereof. The photosensitive resin composition comprises 45-60 parts of alkali-soluble resin, 35-50 parts of photopolymerization monomer, 2.5-5 parts of photoinitiator and 0.1-0.8 parts of sensitizer; the sensitizer is a compound shown in the general formula, R1 represents methylene or carbonyl, n represents 0 or 1; R2 represents phenyl, and any hydrogen atom on R2 is optionally substituted by methoxy, C1-C 10 alkyl, phenyl, benzyl or phenoxy. The sensitizer of the present application can make the product have better photosensitivity and resolution. Moreover, based on the above specific weight parts of alkali-soluble resin, photopolymerization monomer, photoinitiator and sensitizer, the comprehensive performance of the product of the present application is better.

The present invention relates to a novel polymorph of (1R,2R,3aS,3bR,10aS,10bR,11S,12aS)-5,10b-difluoro-1-(((fluoromethyl)thio)carbonyl)-11-hydroxyl-2,10a,12a-trimethyl-7-phenyl-1,2,3,3a,3b,7,10,10a,10b,11,12,12a-dodecylhydrocyclapenta[5,6]napththo[1,2-F]indazole-1-furan-2-carboxylate ester as shown in formula (I), a preparation method therefor, and a use thereof. The crystal form of the present invention has characteristics such as a significant pharmaceutical effect, good stability, high yield, and high purity, and is beneficial for the selection and design of a drug administration route and the determination of a drug preparation process parameter, thereby improving drug production quality.

The present disclosure pertains to improved methods of preparing high melting dicarboxylic acids or oxo-acids (e.g., carboxylic acid / aldehydes) by ozonolysis of their esters. For example, the present disclosure provides methods for preparing brassylic acid by way of the ozonolysis of erucic acid ester, the method comprising the steps of converting the erucic acid to an ester, performing ozonolysis on the ester, and converting the resulting brassylate ester product to brassylic acid.

The present invention relates to a thermoplastic composition comprising, monophasic polypropylene, 0.01 – 5 wt.% of non-aromatic polyester having an average M / E ratio of at least 10, wherein M is the number of backbone carbon atoms in the polyester not including the carbonyl carbons and E is the number of ester groups in the polyester, and 0 - 5 wt.% of optional further components. Such compositions who an improved strain at break.

This invention discloses a cross-linked copolymer coating for negative electrodes, its preparation method, and its application, relating to the field of solid-state battery negative electrode protection technology. The coating is formed by in-situ copolymerization of a precursor composition consisting of carbonate monomers with unsaturated double bonds, hydroxyl-rich natural polymer derivatives, lithium salts, and an initiator. The rigid cellulose skeleton in the copolymer regulates the degree of polymerization of the carbonate monomers through a hydrogen bond network, forming a protective layer with a rigid-flexible block structure, resulting in a uniform and dense SEI film. The hydrogen bond anchoring effect of high-density hydroxyl and carbonyl groups inhibits polycarbonate segment degradation and improves interfacial chemical stability. The three-dimensional hydrogen bond network endows the coating with excellent mechanical strength and flexibility, synergistically buffering volume changes and inhibiting lithium dendrite growth. This preparation process is simple and controllable, effectively reducing the probability of battery short circuits and improving safety performance and cycle stability.

The application discloses a preparation method of a lithium ion battery adhesive and the product. The preparation method of the adhesive comprises the following steps: first, taking a bisphenol A type diether dianhydride and a functional group-containing diamine into a polar aprotic solvent to perform a polycondensation reaction, adding a condensation activator into the obtained polyamide acid solution, and uniformly blending to obtain the adhesive; wherein the functional group-containing diamine is composed of 50-80 mol% of amide diamine monomers and the balance of 2-(4-aminophenyl)-5-aminobenzimidazole in terms of molar percentage, the amide diamine monomers are 4,4'-diaminobenzanilide and / or N,N'-bis(4-aminophenyl)terephthalamide; and the activator is one or a combination of two or more selected from N,N'-carbonyldiimidazole, N,N'-thiocarbonyldiimidazole and diimidazolylbenzene. The adhesive is applied to a lithium battery positive / negative slurry to further manufacture a battery, and the battery has good battery characteristics.

The present invention provides, in part, novel small molecule inhibitors of PHD, having a structure according to Formula (I), and sub-formulas thereof: Formula (I) or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for treatment or prevention of diseases including heart (e.g. ischemic heart disease, congestive heart failure, and valvular heart disease), lung (e.g., lung inflammation, pneumonia, acute lung injury, pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease), respiratory (e.g.,respiratory infection, acute respiratory distress syndrome), liver (e.g. acute liver failure and liver fibrosis and cirrhosis), and kidney (e.g. acute kidney injury and chronic kidney disease) disease, inflammatory bowel disease (IBD), ischemic reperfusion injury (e.g., stroke), retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), and white matter injury (WMI).

The present invention addresses the problem of providing a medicine that, despite of being a non-ergot dopamine agonist (DA), reduces the risk of the drowsiness side effect, and exhibits an excellent therapeutic effect on neurodegenerative disorders such as Parkinson's disease (PD). The present invention relates to a pharmaceutical composition for treating neurodegenerative diseases such as Parkinson's disease, the pharmaceutical composition comprising 1-{[(4aR,6R,8aR)-2-amino-3-cyano-8-methyl-4,4a,5,6,7,8,8a,9-octahydrothieno[3,2-g]quinolin-6-yl]carbonyl}-3-[2-(dimethylamino)ethyl]-1-propylurea or a pharmacologically acceptable salt thereof. The pharmaceutical composition is characterized by being orally administered at a daily dose of 0.25 mg to 2 mg in terms of free form.

The objective of the present invention is to provide a method for producing a carbonyl halide safely and efficiently. The method for producing a carbonyl halide according to the present invention is characterized in comprising the step of irradiating a light to a halomethane having 1 or more halogeno groups selected from the group consisting of chloro, bromo and iodo in the presence of oxygen and ozone.

This invention belongs to the field of wastewater treatment, specifically relating to a composition, treatment agent, and application for treating oily wastewater and oily sludge. The composition comprises component A and component B, with a mass ratio of (40-100):(5-8). Component A consists of cyclodextrin, sodium alginate, and glycerol; component B is acrylamide. This invention uses cyclodextrin, sodium alginate, glycerol, and acrylamide as main components, containing functional groups such as polycarboxyl, polyhydroxy, carbonyl, and amino groups. It utilizes hydrogen bonding, covalent bonding, and electrostatic interactions between these functional groups to achieve rapid treatment of wastewater or sludge. Experiments show that this composition has good acid resistance and adsorption capacity, achieving the removal of oil and suspended solids from acidic oily wastewater and sludge without pre-oxidation or pH adjustment, effectively reducing treatment costs and simplifying the treatment process.

The present application relates to a kind of water-based sprayable self-drying type acrylate adhesive and its preparation method, belong to polymer adhesive technical field.First, the core layer emulsion formed by hard monomer and multi-functional crosslinking monomer is prepared;Then drop the shell monomer including soft monomer, hydrophilic functional monomer and the functional monomer containing beta-dicarbonyl structure on it, form core-shell structure emulsion;Finally, by pH adjustment, add rheological modifier, film-forming aid and the coordination crosslinking agent containing polyvalent metal ions are prepared.The present application combines core-shell structure with beta-dicarbonyl / metal ion room temperature coordination crosslinking system, wherein the core layer provides rigid support, shell layer promotes rapid film formation, functional monomer and metal ion form strong coordination bond network after moisture volatilization.At the same time, self-made bifunctional monomer containing phosphate and silane significantly improves the universal adhesion of adhesive to different substrates.The prepared adhesive has excellent spray atomization, self-drying, high bonding strength and stability.

The application discloses a method and device for improving detoxification replacement efficiency of materials containing carbonyl substances, and belongs to the technical field of carbonylation metallurgy safety production. The application adopts the mode of hot nitrogen gas and cold nitrogen gas alternately passivating replacement, replaces the traditional single cold nitrogen gas continuous purging process, and adopts multiple pressure increase-pressure release pulse type operation for each round of replacement; the supporting device is provided with a parallel hot nitrogen gas supply unit and a cold nitrogen gas supply unit, a DCS interlocking control system and an annular tangent air inlet pipeline at the bottom of a storage bin. The application greatly improves the replacement efficiency and completeness of the materials containing carbonyl substances, shortens the replacement time by more than 80%, avoids problems such as material hardening, channeling and burning of material bags caused by continuous high temperature, guarantees continuous, stable and safe operation of carbonylation metallurgy production, and reduces production cost.

A lithium ion battery includes a cathode including a cathode active material; an anode including silicon, a conductive carbon, lithium metal, or a combination of any two or more thereof; a separator; and an electrolyte including a lithium sulfonylimide salt, a dicarbonyl solvent, and a fluorinated ether solvent.

This invention discloses a method for preparing the DPP1 inhibitor bresocarte, belonging to the field of pharmaceutical synthesis. Specifically, the method includes the following steps: N-tert-butoxycarbonyl-L-4-bromophenylalanine reacts with methanesulfonyl chloride or 4-nitrobenzenesulfonyl chloride in the presence of a base, followed by amination substitution to obtain intermediate 1; then, it undergoes dehydration in the presence of trifluoroacetic anhydride to obtain intermediate 2; next, it undergoes a coupling reaction with pinacol diboronate to obtain intermediate 3; then, it undergoes a coupling reaction with bromide compound 4 to obtain intermediate 5; then, it undergoes cyclization with di-tert-butyl dicarbonate in the presence of sodium methoxide to obtain intermediate 6; then, it undergoes deprotection in the presence of hydrogen chloride to obtain intermediate 7; next, it undergoes condensation with compound 8 to obtain intermediate 9; finally, it undergoes deprotection in the presence of hydrogen chloride to obtain the inhibitor bresocarte. This method provides a new synthetic approach, with low overall cost, simple operation, high yield, and suitability for industrial production.

This invention relates to the use of at least one organic dialkyl dicarbonate ester for reducing the nitrogen content in an aqueous polyurethane-polyurea dispersion containing at least one polyurethane-polyurea and at least one nitrogen compound, wherein the nitrogen compound is selected from hydrazine, amines, and mixtures thereof, wherein the amine has at least one primary and / or secondary amino group, is free of carbonyl groups, and has a molecular weight of 31 to 1000 g / mol. The invention also relates to a method for producing an aqueous polyurethane-polyurea dispersion with reduced nitrogen content, to aqueous polyurethane-polyurea dispersions obtained or obtainable by the method according to the invention, and to articles, cosmetics, coatings, adhesive layers, coating formulations, adhesive formulations, and / or cosmetic formulations thus obtainable.

This invention relates to the field of chemical synthesis technology, specifically disclosing a method for preparing vinyl ethylene carbonate. The method uses glycidyl as a starting material, first converting it to glycidaldehyde via a mild oxidation reaction with high selectivity. Then, using a cross-linked imidazole polymeric ionic liquid as a catalyst, glycidaldehyde undergoes an atom-economical cycloaddition reaction with carbon dioxide to construct a cyclic carbonate intermediate. Finally, under catalytic conditions, a condensation reaction introduces a vinyl functional group to obtain the vinyl ethylene carbonate product. This invention uses widely available, low-toxicity, and inexpensive glycidyl instead of highly toxic raw materials, and utilizes greenhouse gas carbon dioxide as a carbonyl source for resource utilization. The process route is highly atom-economical, the reaction conditions are mild, and the catalyst is easy to separate, recover, and recycle, effectively solving the prominent problems of high raw material toxicity, expensive catalysts, and difficult byproduct treatment in traditional preparation techniques.

This invention provides a strain derived from Clostridium difficile (Clostridium difficile) Clostridioides difficile This invention relates to mutants of glutamate dehydrogenase and their preparation, including single-site, two-site, or multi-site mutants. The invention effectively solves the problems of inactivity or low activity of glutamate dehydrogenase in the biocatalytic transformation of 2-carbonyl-4-(hydroxymethylphosphono)butyric acid as a substrate, and provides a continuous chemical method for the synthesis of 2-carbonyl-4-(hydroxymethylphosphono)butyric acid using a microchannel reactor throughout the entire process.

The present invention provides a carbonyl reductase mutant, preparation method and use thereof, and a preparation method of ethyl (R)-6-hydroxy-8-chlorooctanoate. The carbonyl reductase mutant is a carbonyl reductase with amino acid mutation; the carbonyl reductase comprises an amino acid sequence as set forth in SEQ ID NO: 2; the amino acid mutation includes E101V, F214R or E101V / F214R. In the present invention, by introducing mutations on the basis of the original carbonyl reductase sequence, the enzyme activity is improved, the stereoselectivity is improved, and ethyl (R)-6-hydroxy-8-chlorooctanoate can be obtained with high yield and high purity under relatively mild conditions, which reduces the production cost and is suitable for industrial production.

This invention relates to the solid form of propionic acid (1R,3S)-3-[3-({[3-(methoxymethyl)-1-methyl-1H-pyrazol-5-yl]carbonyl}amino)-1H-pyrazol-5-yl]cyclopentyl ester, pharmaceutical compositions comprising such solid forms, and the use of such solid forms and pharmaceutical compositions for the treatment of cancer.

One aspect of the present invention is a compound of formula (I) for use as a medicament [Formula 1] JPEG2023528073000334.jpg41120[In the formula, Ring A is a 5- or 6-membered aromatic or heteroaromatic ring, and the aromatic or heteroaromatic ring is selected from the group consisting of F, Cl, Br, I, CN, alkoxy, NR 11 R 11 , OH, alkyl, haloalkyl, aralkyl, aryl, and heteroaryl, wherein the aryl and heteroaryl substituents may further be selected from F, Cl, Br, I, CN, alkoxy, NR 11 R 11 substituted with one or more substituents each independently selected from , OH, alkyl, haloalkyl, and aralkyl; Y is C=N-OH and CR 10 R 10 ' is selected from R 10 and R 10 each ' is independently selected from H, F, alkyl, and haloalkyl; R1, R4, and R5 are each independently selected from H, F, Cl, Br, and I; R2 and R3 are each independently selected from H, F, Cl, Br, I, CN, methoxy, and haloalkyl; R 11 and R 11 ' are each independently H, alkyl, haloalkyl, COR 12 , and SO2R 13 Selected from R 12 and R 13 and R are both alkyl], or a pharmaceutically acceptable salt or solvate thereof. A further aspect of the present invention relates to compounds of formula (I) for use in the fields of immuno-oncology, immunology and related applications, and to compounds of formula (I) per se.

The application discloses a rhodium-catalyzed desymmetrization hydroformylation method for constructing polychiral center carbon ring nucleosides. The method for constructing polychiral center carbon ring nucleosides comprises the following steps: under the condition of an inert atmosphere, an acetylacetone dicarbonyl rhodium metal precursor and a chiral ligand are added into an organic solvent to prepare a catalyst solution, the catalyst solution is mixed with a substrate, and a reaction is carried out under the condition of a hydrogen atmosphere and a carbon monoxide atmosphere; after the reaction is completed, filtration and purification are carried out, and polychiral center cycloalkyl aldehyde is obtained; and the aldehyde group is converted to obtain the polychiral center carbon ring nucleosides. The method for constructing polychiral center carbon ring nucleosides has the advantages of high selectivity, wide substrate compatibility, high reaction efficiency, easy conversion of products, and the like. The whole reaction process can obtain polychiral center cycloalkyl aldehyde in one step with extremely high enantioselectivity and diastereoselectivity, the aldehyde group is converted, polychiral center carbon rings can be obtained with high yield, high dr value and high ee value, and the method is simple and easy to operate.

Disclosed in the present invention are a method and system for preparing an oxime via an ammoximation reaction. The method comprises: (1) mixing a carbonyl compound, ammonia, and a circulating catalyst slurry at a specific feed ratio of the carbonyl compound to the circulating catalyst slurry to obtain a mixed stream, and then bringing the mixed stream into contact with hydrogen peroxide for an ammoximation reaction to obtain a reaction slurry; (2) mixing the reaction slurry with an organic solvent and then performing two-phase separation to obtain an oxime-containing organic phase and a catalyst-containing aqueous phase; (3) optionally, washing the organic phase obtained in step (2) with optional water and then performing separation to obtain an organic solvent and an oxime product; and (4) filtering the aqueous phase obtained in step (2) and then returning same to step (1) to provide at least part of the circulating catalyst slurry. The method and system for preparing an oxime according to the present invention significantly prolong the service life of a catalyst, improve the operating stability of a system, reduce the consumption of catalyst, and improve the quality of the prepared oxime product.

The present application relates to a kind of perovskite solar cells and its passivation method, the electron blocking layer is made of acyl chloride group derivative, on the one hand, the carbonyl group in acyl chloride group can be coordinated with the Pb 2+ Ion forms Lewis acid-base pair, thereby significantly reduce the defect state density of perovskite surface.Let go of group Cl ‑ Ion can increase the grain size of perovskite, improve the crystalline quality of perovskite layer.In addition, acyl chloride group and perovskite component reaction generates electron blocking layer cesium acetate, reduces the charge recombination at interface, while it can promote energy level gradient arrangement, effectively improve the separation and extraction capacity of carrier, successfully improve the photoelectric conversion efficiency and stability of carbon-based hole-free all-inorganic perovskite solar cell, and significantly reduce the hysteresis effect.The present application process is simple and has universality, is conducive to promoting the commercialization of perovskite, has wide market demand and application prospect.

One embodiment of the present invention relates to an eco-friendly polyimide-based film containing no perfluoroalkyl group, and provides a polyimide-based film comprising an imide repeating unit and / or an amide repeating unit, wherein the imide repeating unit is formed by a reaction of a diamine compound and a dianhydride compound, the amide repeating unit is formed by a reaction of a diamine compound and a dicarbonyl compound, the dianhydride compound comprises a dianhydride compound containing a methyl group and / or a dianhydride compound containing no methyl group, and the polyimide-based film has a static folding value of 110° or less on the basis of a thickness of 50 μm.

This disclosure discloses a millimeter-wave antenna device and a millimeter-wave antenna base station, belonging to the field of antenna technology. The millimeter-wave antenna device includes a transmitting module, a receiving module, an radome with wave transmission characteristics, and a base with electromagnetic wave shielding characteristics. The radome is fixedly connected to the base to form a cavity, and the transceiver modules are located inside the cavity and spaced apart on the base. An absorbing material layer is provided on the side of the radome facing the base, and the projection of the absorbing material layer onto the base lies between the transceiver modules. The absorbing material layer comprises the following components in parts by weight: 10-60 parts thermoplastic resin, 40-85 parts absorbing powder, and 2-15 parts toughening agent, wherein the absorbing powder includes carbonyl iron powder, and the particle size D50 of the carbonyl iron powder is 1μm-6μm. The absorbing material layer has strong normal and wide-angle absorption efficacy for millimeter waves in the 24.25GHz-29.5GHz frequency band, effectively reducing millimeter wave reflection interference from the base and improving signal isolation between the transceiver modules.

This invention discloses a method for synthesizing p-methylaminobenzoylglutamate diethyl ester. Using p-methylaminobenzoic acid and diethyl glutamate hydrochloride as raw materials, and carbonyl diimidazole as an ester activator, the specific synthesis method involves dissolving carbonyl diimidazole in a solvent under inert gas protection, stirring, adding p-methylaminobenzoic acid to generate the active ester, then adding diethyl glutamate hydrochloride and reacting. The mixture is then concentrated, cooled, water is added dropwise, filtered, and dried to obtain p-methylaminobenzoylglutamate diethyl ester. This method is simple, convenient, low-cost, and has a high yield, showing great promise for industrialization.

This invention provides the ketone reductase RasADH-E189D and its applications. The RasADH-E189D enzyme was obtained through site-directed mutagenesis, and its amino acid sequence is shown in SEQ ID NO.4. RasADH-E189D can efficiently and stereoselectively catalyze the asymmetric reduction reaction of aryl-substituted alkenyl 3,5-dicarbonyl esters, thereby preparing high-purity chiral aryl-substituted alkenyl β-hydroxy esters, which has important application value in the field of chiral drug synthesis.

This invention belongs to the field of cycloazinone preparation technology, and provides a high-yield cycloazinone synthesis process, including the following steps: Step 1: N-ethoxycarbonyl-N,N,N-trimethylguanidine and a solid-phase catalyst are added to toluene and stirred evenly. Under nitrogen protection, the temperature is raised to 40-60°C, and a cyclohexyl isocyanate toluene solution is added dropwise. Stirring is continued for 2-4 hours. The solid-phase catalyst is recovered by filtration, and the mixture is concentrated under reduced pressure to obtain N-cyclohexylcarbamoyl-N-ethoxycarbonyl-N,N,N-trimethylguanidine; Step 2: Under nitrogen protection, the temperature is raised to 50-60°C, and the N-cyclohexylcarbamoyl-N-ethoxycarbonyl-N,N,N-trimethylguanidine toluene solution is added dropwise to a sodium methoxide toluene solution and stirred for 1-2 hours. The temperature is lowered to room temperature, and glacial acetic acid is added for neutralization. After washing, the mixture is concentrated under reduced pressure, and a crystallizing agent is added. The temperature is lowered to 0-5°C, and the mixture is stirred for crystallization for 2-4 hours. After filtration and washing, the mixture is dried under vacuum to obtain the finished cycloazinone.

The application discloses a kind of SBS modified asphalt based on TAIC-MMA copolymer regeneration and preparation method thereof, belong to road engineering material field, include: S1: after aging asphalt is preheated at 135 ℃, under the first shear condition, incorporate ESO, continue 10-15min to induce nucleophilic ring-opening reaction of epoxy group in ESO and carbonyl in aging asphalt;S2: continue to incorporate TAIC / MMA mixture under the second shear condition, after stirring at 135 ℃ for 20 minutes, initiator BPO is added, continue to stir to make the free radical produced by decomposition of BPO initiate in-situ copolymerization and dynamic crosslinking reaction of TAIC and MMA;S3: the mixture obtained in S2 is carried out heat swelling at 70 ℃, namely obtained.The application uses ESO as colloidal stabilizer, uses triallyl isocyanurate as the crosslinking agent of SBS network structure reconstruction, uses the ester group side chain in MMA to enhance the interfacial compatibility with asphalt matrix by steric hindrance effect, by molecular level synergistic effect, finally realize the comprehensive promotion of aging asphalt cement rheological property, durability and mechanical property.