5754 results about "Carbonyl group" patented technology

The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

The invention discloses a carbonyl reductase mutant and a method for catalytically synthesizing high-concentration glassine by using the carbonyl reductase mutant, and belongs to the field of biological catalysis. According to the invention, a one-pot method is adopted to catalyze beta-acetone xyloside to synthesize high-concentration boine, carbonyl reductase CnMDR coded enzyme and rational design of a substrate pocket key are combined with multiple sites, beneficial mutations are combined, dominant mutant enzyme recombinant bacteria are used as a catalyst, beta-acetone xyloside is used as a substrate, and formate dehydrogenase variants and NAD + kinase are introduced at the same time, so that the high-concentration boine is synthesized. The NADP < + >-NADPH coenzyme is driven to circulate, the yield of the synthesized boine is 200g / L, and the conversion rate is gt; the ee value of the product is gt; the invention provides a one-pot efficient low-cost method for synthesizing the boine, only a trace amount (0.3 mM) of coenzyme needs to be added, byproducts in a reaction system are easy to separate, and great convenience is provided for industrial large-scale production.

Described herein are sorbents functionalized with polyamines having oxygen-containing units selected from carbonyl units, hydroxyl units, and combinations thereof, methods of making same, and methods of using same.

The invention relates to a high-temperature-resistant nylon engineering plastic and a preparation method thereof, and belongs to the technical field of high polymer materials. The high-temperature-resistant nylon engineering plastic comprises the following components in parts by weight: 80-120 parts of nylon resin, 4-6 parts of inorganic filler, 4-6 parts of glass fiber, 2-10 parts of a heat-resistant modifier, 1-2 parts of a coupling agent, 1-3 parts of polyethylene wax, 0.5-1.5 parts of an antioxidant and 1-2 parts of a flame retardant, carbonyl and maleimide groups of the heat-resistant modifier strengthen intermolecular interaction and improve the glass transition temperature and the melting point, intermediate products 1 and 2 strengthen high temperature resistance, in addition, sulfonyl attracts electrons to strengthen thermal stability, tetrahydrofuran ring and acrylate are resistant to decomposition, and stability and water resistance are improved; boron and nitrogen of the flame retardant cooperate, a B-O-C carbon layer is formed at high temperature, flame-retardant gas is released, the flame-retardant property is remarkably improved, and the high-temperature-resistant nylon engineering plastic prepared by the preparation method has good high-temperature-resistant and water-resistant effects and also has excellent flame-retardant property.

The invention provides a carbonyl reductase mutant. The carbonyl reductase mutant is obtained by performing single-point mutation or multi-point combined mutation on the 17th site, the 40th site and the 64th site of an amino acid sequence as shown in SEQ ID NO.1. The invention also provides a coding gene, a recombinant vector containing the coding gene, a co-expression engineering bacterium and an application of the co-expression engineering bacterium. Compared with a wild type enzyme, the carbonyl reductase mutant has high activity and high stereoselectivity, the enzyme activity can reach more than two times that of the wild type enzyme, the catalytic efficiency on a substrate precursor ketone is remarkably improved, the yield of a statin drug intermediate and chiral alcohol synthesized by an enzyme method of the carbonyl reductase mutant is remarkably improved, and the yield of a rosuvastatin intermediate (3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R) is remarkably improved. The highest yields of the (3R, 5R)-6-chloro-3, 5-dihydroxyhexanoic acid tert-butyl ester and the atorvastatin intermediate (3R, 5R)-6-cyano-3, 5-dihydroxyhexanoic acid tert-butyl ester reach 99% and 97.6% respectively, e.e. Is larger than 99%, and the method has high industrial application value.

The invention relates to the technical field of optical sensing, in particular to a copper-carbon quantum dot nano-enzyme and a preparation method and application thereof. Poria cocos and Cu < 2 + > are taken as raw materials, and the copper-carbon quantum dots with excellent peroxidase activity are prepared by adopting a one-pot hydrothermal method and can be used for sensitively, accurately and selectively detecting glyphosate. Cu < 2 + > is combined with oxygen-rich and nitrogen-rich components in poria cocos to generate an oxidation-reduction reaction, CuCDs with Cu < 2 + > / Cu < + > are obtained, Cu < 2 + > doping changes electron cloud distribution of the CDs, the electron transmission capability of the CuCDs is enhanced, and Cu < 2 + > and the CDs have a synergistic effect to generate three ROS (. OH,. O2 <-> and < 1 > O2), so that excellent peroxidase activity is exerted. The glyphosate is chelated with hydroxyl, amino, carbonyl, carboxyl and Cu on the surface of the CuCDs to occupy active sites, so that the active sites are poisoned, the peroxidase activity of the CuCDs is selectively inhibited, and a powerful choice is provided for simply, quickly, sensitively and selectively detecting the glyphosate.

The invention discloses a carbonyl reductase, a mutant and an application of the carbonyl reductase in synthesis of a chiral alcohol compound. The carbonyl reductase mutant is obtained by performing single-site or multi-site mutation on the 96th site, the 145th site, the 202nd site or the 206th site of the amino acid sequence of the carbonyl reductase LbCR derived from lactobacillus brevis as shown in SEQ ID No.2. The activity and stability of the carbonyl reductase LbCR mutant are obviously improved, and the carbonyl reductase LbCR mutant has a wide substrate spectrum. Compared with a wild type, the mutant LbCRM4 has the advantages that the enzyme activity is improved by 86.3 times, the substrate conversion rate is greater than 99%, the e.e.p value of the product is always kept at 99.5% or above, the space time yield reaches 1288.9 g / L / d, and the half-life period at 40 DEG C is 101.4 h and is improved by 83.5 times. The LbCR mutant has an industrial application prospect.

Embodiments of the present invention provide methods and intermediates for the large scale preparation of 2, 4, 6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl] benzamide hemisuccinate, as well as formulations and product forms prepared by these methods. Embodiments of the present invention further provide for the preparation of lamidetan acetate (2, 4, 6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl] benzamide acetate) and / or a pharmaceutical composition thereof, and / or the use of lamidetan acetate and formulations thereof in subcutaneous drug delivery.

The invention relates to a saccharomyces cerevisiae strain for efficiently synthesizing cordycepin as well as a construction method and application of the saccharomyces cerevisiae strain, and belongs to the technical field of microbial genetic engineering. The construction method provided by the invention comprises the following steps: carrying out multi-copy genome integrated expression on heterologous codon optimized 2 '-carbonyl-3'-deoxyadenosine reductase genes and 3 '-adenosine monophosphate phosphohydrolase genes, so as to increase the dosage of key enzymes; and supplementing the defective gene of the engineering strain to obtain the saccharomyces cerevisiae strain B5U3 with high yield of cordycepin. According to the obtained saccharomyces cerevisiae strain for efficiently synthesizing the cordycepin, the cordycepin yield reaches 2.92 g / L after shake flask fermentation, the cordycepin yield reaches 7.5 g / L after fermentation in a fermentation tank, and a foundation is laid for safer and more reliable industrial production of the cordycepin.

The invention discloses a method and a device for synthesizing a metal precursor organic carbonyl cobalt compound, which are particularly suitable for synthesizing and preparing dicarbonyl cyclopentadienyl cobalt and (3, 3-dimethyl-1-butyne) hexacarbonyl cobalt. The method comprises the following steps: S01-S07, weighing the following raw materials: 120 parts of activated carbon, 250 parts of water, 3-9.1 parts of gold chloride, 118.9-129.8 parts of cobalt salt, a 40%-80% hydrazine hydrate aqueous solution, a 30% sodium hydroxide aqueous solution, 500 parts of dichloromethane and 69.4 parts of a cyclopentadiene monomer; the preparation method comprises the following steps: adding activated carbon, gold chloride, cobalt salt and water into a reaction kettle, starting stirring, controlling the temperature at 10-15 DEG C, dropwise adding a 40% hydrazine hydrate aqueous solution, and slowly heating to 50-55 DEG C after dropwise adding; and filtering the reaction liquid, drying the filtered solid, and putting into a reaction kettle. According to the invention, cobalt salt with wide source and low price is used as a raw material to synthesize the carbonyl cobalt compound, and the carbonyl cobalt compound does not need to be synthesized by taking cobalt octacarbonyl with high price and the like as a carbonyl cobalt source to react with corresponding organic matters.

The specification relates to a wash-off label (100, 200) comprising a face (101, 301) and a pressure sensitive adhesive (102, 302) adjoined to the face, wherein the face (101, 301) comprises corona discharged filmic material and the pressure sensitive adhesive (102, 302) has a composition including at least one acrylic polymer comprising acrylic monomer(s) and / or non-acrylic comonomer(s) having a carbonyl group capable of undergoing a crosslinking reaction, amount of the acrylic monomer(s) and / or non-acrylic comonomer(s) having a carbonyl group capable of undergoing a crosslinking reaction being from 0.1 to 5 wt. % of monomer composition, and a crosslinking agent with dihydrazide functionality, amount of the crosslinking agent being from 20 to 150% with respect to the amount of the carbonyl groups capable of undergoing a crosslinking reaction. The wash-off label (100, 200) is detachable from a surface when exposed to an alkaline washing solution at a temperature of 85 degrees C. the detachability being such that the pressure sensitive adhesive (102, 302) remains attached to the face (101, 301). Further, the specification relates to a labelled item and use of the wash-off label for labelling an item. Still further, the specification relates to a label laminate web and a method of manufacturing the wash-off label as well as to a pressure sensitive adhesive composition for a wash-off label.

The invention provides starch-based hard carbon and a preparation method thereof, a negative electrode plate, a sodium ion battery and electric equipment, and relates to the technical field of new energy. According to the preparation method disclosed by the invention, hydroxyl and hydrogen atoms in the starch are consumed through organic acid esterification, so that a molten state is not formed in the subsequent oxidation crosslinking and carbonization processes, the structure and strength of a carbon skeleton are improved, and functional groups and doped atoms are more easily introduced; in the oxidation cross-linking process, oxygen-containing functional groups mainly containing carbonyl are mainly introduced, and the cross-linking degree is enhanced, so that phosphorus and nitrogen atoms are better doped in subsequent carbonization, a better spherical structure is formed, and the subsequent carbonization yield is further improved. The starch-based hard carbon material prepared by the method has the advantages that the starch-based hard carbon material is mixed with the phosphorus source and the nitrogen source for carbonization, the pore-forming process and the phosphorus-nitrogen atom doping process can be directly completed in the heating process, and open pores are changed into closed pores in the high-temperature and constant-temperature process, so that the prepared starch-based hard carbon material has excellent structure and surface groups and heteroatoms, and the dynamic performance of the starch-based hard carbon material is further optimized.

The invention provides a leaching agent for removing thallium and beryllium in lithium slag and application. The leaching agent comprises a first leaching agent and a second leaching agent. The first leaching agent is an organic acid solution, and organic acid comprises carboxyl and at least one group of hydroxyl, sulfydryl, carbonyl and sulfonic acid group; the organic acid is single organic acid or mixed organic acid; the second leaching agent comprises a cationic agent and a reducing agent, the cationic agent can form at least one of K < + >, NH4 < + >, Mg < 2 + >, Na < + > and Fe < 3 + > in an aqueous solution, and the reducing agent comprises an inorganic reducing agent and / or an organic reducing agent. Organic acid in the first leaching agent can destroy the crystal structure of the lithium slag, and meanwhile groups such as carboxyl and hydroxyl can be complexed with thallium and beryllium ions so that the thallium and beryllium ions can be dissolved out more easily. On the basis, cations in the second leaching agent and the reducing solution accelerate the release of thallium and beryllium through ion exchange and reduction effects. The leaching agent can remove thallium and beryllium in the lithium slag at the same time, and the removal rate of thallium and beryllium is high.

The invention discloses a high-performance carbonyl reductase mutant and application thereof in synthesis of a series of chiral alcohols. The high-performance carbonyl reductase mutant is obtained by performing the following mutations on an amino acid sequence as shown in SEQ ID NO.2: the 69th alanine mutates into any one of lysine, leucine, aspartic acid or asparagine, and the 69th alanine mutates into any one of lysine, leucine, aspartic acid or asparagine; and / or the 100th glycine is mutated into any one of glutamic acid, serine, lysine or asparagine. Compared with a wild type enzyme, the thermal stability and the catalytic activity of the obtained mutant are remarkably improved, particularly, single point mutants Mut-A69N, Mut-G100E and Mut-G100N and a combined mutant Mut-A69N-G100N show excellent relative enzyme activity, thermal stability and substrate tolerance. The mutant has high catalytic activity and stability to various chiral alcohols, and the contradiction that the traditional carbonyl reductase is easy to inactivate at high temperature and the catalytic efficiency is difficult to achieve at the same time is solved. The invention provides an efficient and stable enzyme catalysis tool for green biological preparation of chiral drug intermediates.

The invention discloses a preparation method of a dual PDE3 / 4 inhibitor Encephaline. The preparation method comprises the following steps: carrying out a sizuki coupling reaction on initial raw materials of a compound shown as a formula 1 and a compound shown as a formula 2 to obtain a compound shown as a formula 3, carrying out intramolecular cyclization to obtain a compound shown as a formula 4, converting carbonyl into a compound shown as a formula 5 by using POCl3, and carrying out an alkylation reaction on the compound shown as a formula 5 and a compound shown as a formula 6 to obtain a compound shown as a formula 7. Wherein the acyl imine of the compound as shown in the formula 7 and a compound as shown in a formula 8 are subjected to substitution reaction to obtain the product Encephaline. The selected raw materials are easy to obtain, the operation method is simple and convenient, the product yield is high, and the method is suitable for batch production.

Methods for treating immune thrombocytopenia comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (PRN1008) and pharmaceutically acceptable salts thereof are disclosed. Pharmaceutical compositions comprising at least one compound chosen from PRN1008 and pharmaceutically acceptable salts thereof are also disclosed.

Disclosed is a printing ink for heat-sensitive recording media, which is (A) or (B) below: (A) a heat-sensitive color-developing printing ink containing a leuco dye, a color developer, a vinylpyrrolidone-vinyl acetate copolymer, and a solvent, wherein the color developer is at least one selected from the group consisting of an N,N'-diaryl urea-based compound represented by general formula (1) (in the formula, R0 represents a C1-12 alkyl group, a C7-12 aralkyl group, or a C6-12 aryl group. The aralkyl group and the aryl group may be substituted with a C1-12 alkyl group, a C1-12 alkoxy group, a C6-12 aryl group, or a halogen atom. A plurality of R0s may be the same or different. A1 represents a hydrogen atom or a C1-4 alkyl group. A plurality of A1s may be the same or different.), a compound represented by general formula (2) (in the formula, R1 to R5 are the same or different, and represent a hydrogen atom, a halogen atom, a nitro group, an amino group, an alkyl group, an alkoxy group, an aryloxy group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an alkylcarbonylamino group, an arylcarbonylamino group, an alkylsulfonylamino group, an arylsulfonylamino group, a monoalkylamino group, a dialkylamino group, or an arylamino group.), and 5-(N-3-methylphenyl-sulfonamide)-N',N''-bis-(3-methylphenyl)-isophthalic acid diamide; and (B) a protective layer printing ink for heat-sensitive recording media, the protective layer printing ink containing an adhesive, a slipperiness imparting agent, and a solvent, wherein the adhesive is a polyvinyl acetal resin, and the slipperiness imparting agent is an alkyl phosphate ester and / or a salt thereof.

The invention discloses an isoxazoline compound as shown in a formula (I) and application thereof. R1, R2 and R3 can be selected from halogen atoms, cyano groups, nitryl groups, C1-C3 halogenated alkyl groups and the like; q can be independently selected from A1 to A6; l1 and L2 may be selected from a carboxyl group, a C1-C6 alkoxycarbonyl group, a hydroxyl-substituted C1-C8 alkyl group, and the like; z1, Z2 may be selected from a hydrogen atom, a C1-C6 alkyl group, a C3-C5 cycloalkyl group, or C (O) M, wherein M is a C1-C6 alkyl group, a C2-C6 alkenyl group, or the like; the isoxazoline compound provided by the invention has no cross resistance with existing insecticides, has the advantages of quick pesticide effect, low dosage and the like, and particularly has an excellent control effect on rice-resistant chilo suppressalis, plutella xylostella, aphid and the like. The invention also provides an isoxazoline compound as a pesticide acceptable salt, a composition and an application of the isoxazoline compound. # imgabs0 #

The invention provides a gas for plasma etching, a gas combination, an etching method and semiconductor equipment, which belong to the field of plasma etching, and are mainly characterized in that one or more of carbonyl halide, aldehyde halide and carboxyl halide are provided as process gases in the etching process to excite and form plasma, and the plasma is used as a plasma source. According to the method, the to-be-etched layer is etched, so that the problem of upper and lower inconsistency caused by large difference between the bottom etching rate and the middle etching rate when a high-aspect-ratio hole or groove is formed by etching to a certain degree is solved, the morphology of high-aspect-ratio etching is remarkably improved, the collimation is ensured, and the effectiveness of the semiconductor structure is improved.

The invention provides a liposome preparation and a preparation method thereof, the liposome preparation comprises an ion pairing agent, phospholipid or a derivative thereof, sterol, a lipid molecule derivative and a drug compound, the ion pairing agent comprises at least one of a compound (I) and a compound (II), and the compound (II) comprises at least one of a compound (III) and a compound (III). Structures in the compound (I) and the compound (II) contain a plurality of functional groups (such as amide, carbonyl, thioether and the like), so that abundant binding sites are provided for drug molecules, and the compound (I) and the compound (II) can interact with different types of drug compounds (such as fat-soluble and water-soluble drugs); the liposome preparation is allowed to be combined with various drug molecules through hydrogen bonds, hydrophobic interaction or electrostatic interaction, and the liposome preparation adapts to physicochemical properties of different drugs. The compound (I) and the compound (II) further comprise different hydrophobic groups (such as alkyl chains) and hydrophilic groups (such as sulfonic acid, carboxylic acid and the like), so that the liposome preparation has the amphiphilic characteristic, not only can encapsulate hydrophobic drugs, but also can encapsulate hydrophilic drugs, and the variety and range of encapsulated drugs are improved.

The invention provides a synthesis method of 6-(t-butyloxycarboryl)-3, 6-diazabicyclo [3.1. 1] heptane, which comprises the following steps: starting from N-benzyl-2, 6-piperidinedione, firstly forming a dibromide 1, then forming a bridge ring intermediate 2 under alkaline conditions, then removing benzyl to obtain an intermediate 3, then reducing dicarbonyl to form free amine 4, and finally synthesizing the 6-(t-butyloxycarboryl)-3, 6-diazabicyclo [3.1. 1] heptane. Then performing Boc protection on amino to obtain an intermediate 5, and performing debenzylation to form a target product. According to the synthesis method, few impurities are generated, and the product is easy to purify and high in purity, so that the total yield is increased, the unit cost is effectively reduced, and large-scale industrial production is facilitated.

The invention discloses a multi-effect repair type collagen and application thereof, and belongs to the technical field of synthetic biology. Transdermal peptide TD-1, a transmembrane region of human XVII type collagen, an extracellular sixteenth non-collagen region, an extracellular fifteenth collagen region and a coding gene of a His tag are selected to be connected in series, and a gene sequence is optimized through pichia pastoris codon selection preference; and then the T-COL17R3 is constructed and expressed to obtain the T-COL17R3. Efficacy experiments prove that compared with similar products sold in the market, T-COL17R3 not only has excellent transdermal performance, but also has better cell proliferation and migration promoting capability, better capability of resisting early saccharification product ketoamine and later saccharification product dicarbonyl compounds, better capability of scavenging free radicals and resisting elastase, and can be used for preparing the anti-epidermal drug. In addition, synthesis of melanin in B16-F10 cells can be reduced, so that T-COL17R3 has excellent application potential in development of pharmaceutical compositions or skin care products with repairing, anti-wrinkle and firming or whitening and brightening effects.

To provide a thermosetting resin composition that exhibits sufficiently low dielectric properties and offers superior heat resistance for use in printed wiring boards, and an active ester resin that yields the same.SOLUTION: Provided is an active ester resin composed of polyaryloxy units and polyarylcarbonyl units, the active ester resin having, as the polyaryloxy units, allyl group-containing units represented by the following formula, where R1 is a hydrocarbon group having 1 to 12 carbon atoms; R2 is H or a hydrocarbon group having 1 to 12 carbon atoms; X is a bonding site with a polyarylcarbonyl unit or an allyl group; 1 to 99 mol% of all X's are allyl groups; i is an integer of 0 to 3; and n is a repeating number with an average value of 0.1 to 5.SELECTED DRAWING: Figure 1

The invention provides a synthesis method of bis (hydroxyethyl) amino propyl hydroxyethyl oleylamine, which comprises the following steps: taking N-tert-butyloxycarbonyl-1, 3-propane diamine and ethylene oxide according to a set proportion, and reacting in a first organic solvent to obtain a first intermediate; reacting the first intermediate with a hydrochloric acid solution according to a set ratio to obtain a second intermediate; and taking the second intermediate, 1-bromo-cis-9-octadecene and alkali according to a set ratio to react in a second organic solvent to obtain a compound bis (hydroxyethyl) amino propyl hydroxyethyl oleylamine, and synthesizing the bis (hydroxyethyl) amino propyl hydroxyethyl oleylamine by adopting a green and environment-friendly method.

The invention discloses a carbonyl reductase mutant as well as a preparation method and application thereof, and belongs to the technical field of enzyme engineering. According to the invention, on the basis of carbonyl reductase BcKRED from Bacillus cereus, a series of dominant mutants are obtained through a method of directed evolution in the field of enzyme engineering. The carbonyl reductase dominant mutant obtained by the invention has high catalytic activity, thermal stability and chiral selectivity reversed with wild-type carbonyl reductase. A green and efficient way is provided for industrial production of chiral alcohol by taking carbonyl reductase as a biocatalyst, and the method has a wide application prospect.

There is provided a fluorine-containing copolymer comprising tetrafluoroethylene unit, hexafluoropropylene unit and perfluoro (propyl vinyl ether) unit, wherein the copolymer has a content of hexafluoropropylene unit of 9.4 to 10.1% by mass with respect to the whole of the monomer units, a content of perfluoro (propyl vinyl ether) unit of 0.8 to 1.78 by mass with respect to the whole of the monomer units, a melt flow rate at 372° C. of 4.5 to 8.5 g / 10 min, and a total number of a carbonyl group-containing terminal group, —CF═CF2 and —CH2OH per 106 main-chain carbon atoms of 90 or less.

Methods for treating children, adolescents and adults with persistent or chronic immune thrombocytopenia comprising administering at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

The invention discloses polyrotaxane with controllable cyclodextrin coverage rate as well as a preparation method and application of the polyrotaxane, and belongs to the technical field of polyrotaxane materials. The preparation method comprises the following steps: dissolving alpha-cyclodextrin, 3-hydroxyadamantane-1-carboxylic acid and polyethylene glycol diamine in deionized water, refrigerating and assembling to form quasi-polyrotaxane, and blocking to obtain polyrotaxane; wherein the polyethylene glycol diamine is prepared from polyethylene glycol and N, N '-carbonyldiimidazole, and the cyclodextrin coverage rate of the polyrotaxane is directionally regulated and controlled by regulating and controlling the mass ratio of the alpha-cyclodextrin to the 3-hydroxyadamantane-1-carboxylic acid, the adding sequence of the 3-hydroxyadamantane-1-carboxylic acid and the refrigerating and assembling time. Based on the mechanism that 3-hydroxyadamantane-1-carboxylic acid and polyethylene glycol compete in a cyclodextrin cavity, polyrotaxane with a cyclodextrin coverage rate of 0.5-2.5% is synthesized, and a polymer based on the polyrotaxane has better ductility and mechanical properties.

Provided is a polyamide resin, which is a copolymer of a biodegradable polyamide, such as polyamide 2 to polyamide 4, and another polyamide, the polyamide resin having enhanced biodegradability. The polyamide resin contains a structural unit represented by Formula (1) and another polyamide structural unit, and a difference between a degree of randomness determined based on a proportion of each structural unit as determined by 1H-NMR measurement when structural units are assumed to have an ideal random sequence and a degree of randomness determined based on a proportion of carbonyl carbon of an amide group linking different structural units with respect to a total peak integrated value for carbonyl carbon as determined by 13C-NMR measurement is 0.10 or less, where in Formula (1), x is an integer of 1 or greater and 3 or less.

There is provided a fluorine-containing copolymer comprising tetrafluoroethylene unit, hexafluoropropylene unit and perfluoro (propyl vinyl ether) unit, wherein the copolymer has a content of hexafluoropropylene unit of 8.5 to 9.5% by mass with respect to the whole of the monomer units, a content of perfluoro (propyl vinyl ether) unit of 1.2 to 1.88 by mass with respect to the whole of the monomer units, a melt flow rate at 372°° C. of 9.0 to 15.0 g / 10 min, and a total number of a carbonyl group-containing terminal group, —CF═CF2 and —CH2OH per 106 main-chain carbon atoms of 100 or less.