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61 results about "Haloalkane" patented technology

The haloalkanes (also known as halogenoalkanes or alkyl halides) are a group of chemical compounds derived from alkanes containing one or more halogens. They are a subset of the general class of halocarbons, although the distinction is not often made. Haloalkanes are widely used commercially and, consequently, are known under many chemical and commercial names. They are used as flame retardants, fire extinguishants, refrigerants, propellants, solvents, and pharmaceuticals. Subsequent to the widespread use in commerce, many halocarbons have also been shown to be serious pollutants and toxins. For example, the chlorofluorocarbons have been shown to lead to ozone depletion. Methyl bromide is a controversial fumigant. Only haloalkanes which contain chlorine, bromine, and iodine are a threat to the ozone layer, but fluorinated volatile haloalkanes in theory may have activity as greenhouse gases. Methyl iodide, a naturally occurring substance, however, does not have ozone-depleting properties and the United States Environmental Protection Agency has designated the compound a non-ozone layer depleter. For more information, see Halomethane. Haloalkane or alkyl halides are the compounds which have the general formula "RX" where R is an alkyl or substituted alkyl group and X is a halogen (F, Cl, Br, I).

Synthesis method of allyl phosphonic acid diester

The invention discloses a synthesis method of allyl phosphonic acid diester. According to the method, phosphorous acid diester and an allyl chloride compound are used as raw materials and react in the presence of a specific transition metal catalyst and alkali under the conditions of normal pressure and 45-60 DEG C to obtain the allyl phosphonic acid diester. The method has the advantages of mild reaction conditions, simple operation, high product yield (90-99%), no by-product, no generation of halogenated alkane gas and easy industrial production, and is suitable for the fields of polymer flame retardants, electronic materials, pesticide and medicine intermediates and the like.
Owner:SUZHOU LEAD BIOTECH CO LTD

A method for synthesizing a dialkylphosphinic ester

This invention discloses a method for synthesizing dialkylphosphinates, belonging to the field of organic synthesis technology. The method uses hypophosphite and haloalkanes as starting materials. First, a hypophosphite is generated through a heated and pressurized reaction under the action of a phase transfer catalyst. The obtained hypophosphite does not require complex purification; it is directly reacted with an olefin under heated and pressurized conditions in the presence of a free radical initiator to obtain the target product, dialkylphosphinate. The method of this invention uses inexpensive and readily available raw materials, has a simple process route, includes only two core reactions, operates under mild conditions, is safe and convenient, produces few and easily treatable byproducts, has a high product yield, and is simple to purify. It is very suitable for large-scale industrial production, providing an economical and efficient synthetic route for the preparation of high-performance halogen-free flame retardants.
Owner:ZHEJIANG WANSHENG CO LTD

Degradable Gemini morpholine quaternary ammonium salt, and preparation method and application thereof

The application discloses a degradable gemini morpholine quaternary ammonium salt. The application further discloses a preparation method of the degradable gemini morpholine quaternary ammonium salt, comprising the following steps: S1, performing N-alkylation reaction on morpholine and halogenated alkane to obtain N-alkyl morpholine; S2, performing reaction on substance A and halogenated acetyl halide to obtain substance B; S3, continuously performing N-alkylation reaction on the N-alkyl morpholine and the substance B to obtain the degradable gemini morpholine quaternary ammonium salt. The application further discloses application of the degradable gemini morpholine quaternary ammonium salt in a bactericide and in preparation of a medicine for treating helicobacter pylori infection. The gemini morpholine quaternary ammonium salt has a good effect of killing helicobacter pylori; the gemini morpholine quaternary ammonium salt can be degraded in an alkaline environment, can avoid drug resistance of helicobacter pylori to the gemini morpholine quaternary ammonium salt, and can make the degradation product be rapidly discharged out of the body.
Owner:UNIV OF SCI & TECH OF CHINA

Polyethylene catalysts and methods for their preparation and ultra-high molecular weight polyethylene and methods for their preparation

This invention relates to the field of catalysts, specifically to a polyethylene catalyst and its preparation method, as well as ultra-high molecular weight polyethylene and its preparation method. The method includes the following steps: (1) under diluent conditions, a magnesium halide precursor, an alcohol compound, and a first internal electron donor undergo a first contact reaction to obtain a first reaction solution; (2) a second internal electron donor is added to the first reaction solution to undergo a second contact reaction to obtain a second reaction solution; (3) a titanium precursor is added to the second reaction solution to undergo a third contact reaction to obtain a third reaction solution; (4) a haloalkane is added to the third reaction solution, followed by a third internal electron donor to undergo a fourth contact reaction. The catalyst prepared by this invention exhibits good catalytic performance.
Owner:PETROCHINA CO LTD

Process for the modification of a beta-ketimine ligand precursor and products thereof

This invention relates to a simple method for modifying β-ketoimine ligand precursors, wherein L... Ph The reaction involves a lithium compound with H2 solution; then a haloalkane is added for C-C coupling; followed by the addition of an acid solution to complete the modification of the β-ketoimine ligand precursor, yielding a terminally alkylated ketoimine. This invention relates to a simple method for modifying β-ketoimine ligand precursors, specifically involving the removal of the proton at the α-position of the β-ketoimine ligand precursor from commercially available n-butyllithium to form a deprotonated β-ketoimine lithium compound, followed by C-C coupling to achieve alkylation at the α-position of the ketocarbonyl group, thus providing a convenient modification of the β-ketoimine ligand precursor.
Owner:SUZHOU UNIV

Method for continuously preparing alkyl phosphonic acid diaryl ester

The invention relates to a method for continuously preparing alkyl diaryl phosphonate, which comprises the following steps of: a, reacting trialkyl phosphite and triaryl phosphite in a high-temperature section filled with a solid catalyst to obtain a reaction product; and b, removing low-fraction byproducts in the reaction product in the step a through reduced pressure distillation or fractionation at the outlet of the high-temperature section, feeding the residual product into a cooling section, collecting a crude product of the alkyl diaryl phosphonate at the outlet of the cooling section, and carrying out post-treatment to obtain the alkyl diaryl phosphonate. A continuous catalytic reaction is carried out through the solid catalyst filled in the tubular reactor, and an intermittent reaction is changed into a continuous reaction, so that the liquid holdup is greatly reduced, and the safety coefficient of production is improved; a traditional halogenated alkane catalyst is not used, so that the risk that the temperature rise is out of control is effectively reduced; according to the method, the reaction time is shortened while the reaction yield is not reduced, and the production efficiency is improved.
Owner:NINGBO PUDUOKIKE TECH DEV CO LTD

A preparation method of a phenylbutyric acid nitrogen mustard NO donor prodrug delivery system and a medicine for treating tumors

This invention provides a chlorambucil NO donor prodrug having the structure shown in Formula (I) or a pharmaceutically acceptable salt thereof: Formula (I). It involves reacting chlorambucil with a dihaloalkane to obtain a halochlorambucil intermediate; reacting the halochlorambucil intermediate with silver nitrate to obtain the chlorambucil NO donor prodrug. This invention applies the chlorambucil NO donor prodrug to the preparation of drugs for treating tumors, such as melanoma, lymphoma, leukemia, or breast cancer. This nanosystem exhibits good NO release levels under light irradiation. Cellular experiments have demonstrated its good antitumor effect, providing a new strategy for multimodal combined antitumor therapy.
Owner:CHINA THREE GORGES UNIV

Process for producing hydro(chloro)fluorocarbon compounds

A process is provided which includes contacting a haloalkane reactant with a fluorination agent in the liquid phase, in the presence of a catalyst, under conditions which are free of or substantially free of a superacid, to produce a product stream including a haloalkane product, preferably a hydro(chloro)fluorocarbon.
Owner:THE CHEMOURS CO FC LLC

Analysis method for determining halogenated alkane impurities in tigliptin hydrobromide

PendingCN121703338AComponent separationHydrobromideAlkane
The invention discloses an analysis method for determining halogenated alkane impurities in tigliptin hydrobromide, and relates to the technical field of quality analysis. In order to solve the problem of detection of halogenated alkane impurities in tigliptin hydrobromide, the invention provides a convenient, efficient and accurate detection method. The method comprises the following steps: preparing a test solution and an impurity reference solution, and detecting by adopting a gas chromatographic method; the method can be used for accurately determining the content of halogenated alkane in tigliptin hydrobromide, plays a guiding role in development of a synthesis process, and contributes to establishment of quality standards of tigliptin hydrobromide bulk drugs.
Owner:HSING PHARMACEUTICALS CO LTD

Method for synthesizing trans-isopentenyl substituted indolone through nickel catalysis

PendingCN121990970Aachieve synthesishigh activityOrganic chemistryAlkaneKetone
The invention relates to a method for synthesizing trans-isopentenyl substituted indolone under the catalysis of transition metal nickel. Specifically, a metal nickel catalyst (Ni (cod) 2) and tricyclohexylphosphine (PCy3) are used as ligands, C3 unsubstituted indolone is used as a nucleophilic reagent to react with isoprene, and a trans-isopentenyl substituted indolone product is obtained. And then taking the product as a reaction raw material, and carrying out nucleophilic substitution reaction on the product and halogenated alkane under an alkaline condition to obtain the 3, 3-disubstituted indolone with divergent functional groups. According to the invention, isoprene is used as a reaction precursor, a trans-isopentenyl substituted indolone product is obtained with high activity and selectivity, a nucleophilic substitution reaction is relayed, and a new strategy is provided for flexibly and conveniently introducing functional groups with different steric hindrances and electrical properties.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES

Heating control method for vehicle and system thereof

PendingUS20260131635A1Air-treating devicesCompression machinesThermodynamicsChlorofluorocarbon
Disclosed are a method for controlling heating of an HVAC system for an electric vehicle and an HVAC system thereof. According to various embodiments, in an operation of the HVAC system including a main heating unit in which a first refrigerant circulates and an auxiliary heating unit in which a second refrigerant circulates, at least one of the first refrigerant and the second refrigerant may comprise at least one of: a natural refrigerant; a hydrofluorocarbon (HFC)-based refrigerant; a hydrofluoroolefin (HFO)-based refrigerant; a hydrochlorofluorocarbon (HCFC)-based refrigerant; a hydrocarbon-based refrigerant that is not a natural refrigerant; and a halon or a perfluorocarbon (PFC)-based refrigerant.
Owner:SK ON CO LTD +1

Methods for manufacturing haloolefins

A method for producing haloolefins, wherein, in the presence of silicon oxide and alkali metal elements, haloalkanes containing fluorine atoms and having 2 to 4 carbon atoms are converted into haloolefins containing fluorine atoms and having 2 to 4 carbon atoms in the gas phase.
Owner:AGC INC

A process for the preparation of 4,6-dichloropyrimidine

The application provides a preparation method of 4,6-dichloropyrimidine, which uses 4,6-dihydroxypyrimidine as a starting reaction raw material, halogenated alkane or nitrobenzene as a solvent, triphosgene as a chlorinating reagent, and an organic phosphine as a catalyst, and a morpholine derivative is selected as a cocatalyst. The catalyst and the cocatalyst can be used repeatedly, an acid binding agent is not required in the reaction process, the reaction time is about 3 hours, the product yield is not less than 95.0%, and the method is an efficient and green and environmental 4,6-dichloropyrimidine preparation method.
Owner:CAC NANTONG CHEM

Halogenated alkane dehalogenase hld-1405, encoding gene and application thereof

ActiveCN120924518BBacteriaHydrolasesAlkaneHaloalkane dehalogenase
This invention discloses a haloalkane dehalogenase HLD-1405, its encoding gene, and its applications, belonging to the field of biotechnology. The amino acid sequence of this haloalkane dehalogenase HLD-1405 is shown in SEQ ID NO.2, and its encoding gene is shown in SEQ ID NO.1. This haloalkane dehalogenase HLD-1405 exhibits high catalytic activity towards 1,3-dibromopropane, with optimal operating conditions of 40℃ / pH 9.0, and retains 100% activity in 20% methanol. This haloalkane dehalogenase HLD-1405 can efficiently degrade short-chain haloalkanes and also has the ability to degrade pollutants such as DDT and hexachlorocyclohexane (HCH), showing great application potential in the treatment of stubborn pollutants and suitable for environmental bioremediation and industrial catalysis.
Owner:HUNAN NORMAL UNIVERSITY

Cyclic preparation method of spirolactone key material

The invention relates to a cyclic preparation method of a spirolactone key material, and belongs to the technical field of medicines. According to the method, resource utilization is carried out on a byproduct compound 2 generated in the production process of a spirolactone intermediate 1, and the byproduct compound 2 is converted into a spirolactone key material compound 1 under the acidic condition. The reaction is carried out in an organic solvent or an aqueous medium, the acidic aqueous solution is selected from hydrochloric acid, sulfuric acid, trifluoroacetic acid, acetic acid, nitric acid or phosphoric acid, the concentration range is 0.1-6 mol / L, the reaction temperature is 0-100 DEG C, the reaction time is 0.5-96 hours, and the feeding molar ratio of the compound 2 to the acid is 1: 0.5-1: 10. The organic solvent can be selected from ethers, alcohols, esters or haloalkanes. The obtained compound 1 can be used as a raw material for preparing spirolactone, and a final product is obtained through an oxygen bridge reaction, an esterification reaction, a decarboxylation reaction, an etherification reaction, a dehydrogenation reaction and a thioation reaction. The method provided by the invention realizes cyclic utilization of production byproducts, improves the utilization rate of raw materials, reduces the production cost, reduces waste discharge, and has a good industrial application prospect.
Owner:ZHEJIANG LANGHUA PHARMA

A method for preparing cyanamide and thiols

This invention belongs to the technical field of organic synthesis and discloses a method for preparing cyanamide and thiols. The method involves reacting arylthiourea with a haloalkane in the presence of a base or a base and a copper salt using an aprotic organic solvent as the reaction medium to obtain cyanamide and thiols; the structure of the arylthiourea is Formula IV, and the structure of the cyanamide is Formula I. The method of this invention is simple to operate, operates under mild conditions, and can rapidly and efficiently obtain structurally diverse cyanamide and thiols, exhibiting high functional group compatibility.
Owner:SOUTH CHINA UNIV OF TECH

Process for producing hydrochloro(fluoro)carbon compounds

Provided herein is a process involving contacting a haloalkane reactant with an olefin in the presence of a catalyst system to produce a product stream including a haloalkane insertion product, wherein the product stream contains less than about 10 wt.% of byproduct telomers, oligomers, dimers and / or other polymeric products, as well as compositions produced by this process.
Owner:THE CHEMOURS CO FC LLC

Synthesis method of borohydride anion B11H14-

PendingCN121269631AMetal hydridesAlkaneOrganic solvent
The invention discloses a synthesis method of a borohydride anion B11H14 <->. According to the synthesis method, hydroboron and halogenated hydrocarbon are taken as raw materials and are fully pyrolyzed in an organic solvent to prepare precursor salt, the precursor salt and quaternary ammonium salt are subjected to an ion exchange reaction, so that inorganic hydroboron is converted into organic quaternary ammonium salt, and then a poor solvent is adopted to achieve the purpose of crystallization and purification. According to the method, B11H14-can be efficiently synthesized, the yield can reach 70% or above, and the purity of B11H14-can reach 99.5% or above after repeated crystallization. The method is suitable for preparing the quaternary ammonium salt compound corresponding to high-purity B11H14-on a hectogram scale.
Owner:XIAN MODERN CHEM RES INST

Method for converting hydrocarbon raw materials and device THEREOF

The present disclosure relates to the field of hydrocarbon raw material conversion, in particular to a method for converting hydrocarbon raw materials and a device thereof. The method comprises the following steps: 1) reacting a gaseous hydrocarbon raw material with a halogen to produce a haloalkane and a hydrogen halide; 2) reacting the haloalkane provided in step 1) with an active metal to produce a first unsaturated hydrocarbon and a first metal halide; and 3) reacting the hydrogen halide provided in step 1) with an active metal to produce a second metal halide and hydrogen. In an electrochemical system of the present disclosure, hydrocarbon raw materials can be converted into high-value products such as hydrogen, ethylene, acetylene, propylene, graphite, etc.
Owner:SHANGHAI TECH UNIV

Compositions and methods for reducing greenhouse gas

The present disclosure provides consumable compositions comprising a haloalkane and a medium chain triglyceride, methods of preparing the consumable composition, and methods of administering the consumable compositions.
Owner:RUMIN8 PTY LTD

A quaternary ammonium carbamate salt, its preparation method and application

This invention belongs to the field of antibacterial materials technology, specifically relating to a urethane quaternary ammonium salt, its preparation method, and its application. The preparation method includes the following steps: reacting a compound containing a -NH-COO- group with a haloalkane under the action of a catalyst to undergo a quaternization reaction, thereby obtaining the urethane quaternary ammonium salt. The preparation method of this invention is simple, low in cost, and the obtained quaternary ammonium salt antibacterial agent exhibits good antibacterial properties.
Owner:FUJIAN MEDICAL UNIV

Process for the preparation of a homogeneous catalyst and process for the hydroesterification of vinyl acetate using the homogeneous catalyst

PendingCN122301944AAlkanePolymer science
This invention belongs to the field of organic chemical engineering, specifically relating to a method for preparing a homogeneous catalyst and a method for preparing 3-acetoxypropionate by using the homogeneous catalyst in the hydrogen esterification reaction of vinyl acetate. The method for preparing the homogeneous catalyst of this invention includes the following steps: (1) in a first organic solvent, a dihaloalkane and a dialkylphosphine borane complex are reacted under alkaline conditions to generate a dialkylphosphine ligand borane complex; (2) in a first alcohol, the dialkylphosphine ligand borane complex is heated to remove borane, yielding a dialkylphosphine ligand; (3) in a second organic solvent, the dialkylphosphine ligand and a metal precursor are mixed to obtain a solution containing the homogeneous catalyst. The homogeneous catalyst of this invention can be applied to the hydrogen esterification reaction of vinyl acetate, and the homogeneous catalyst and its ligands are easy to synthesize. Using the homogeneous catalyst of this invention to catalyze the hydrogen esterification reaction of vinyl acetate, the conversion rate of the reaction raw materials is >99%, the yield of the straight-chain ester product can reach 62%, and the selectivity can reach 71%.
Owner:SHANGHAI PUJING CHEM NEW MATERIALS

A bifunctional polymer-based ammonia adsorbent and a method for preparing the same

The application discloses a kind of dual-functional polymer-based ammonia adsorbent and preparation method thereof, which can efficiently adsorb low-concentration ammonia.The application is prepared by the following steps: first, quaternary ammonium reaction of vinyl imidazole and functional halogenated alkane, then chelation reaction of metal chloride, so that the product is dual-functional, then free radical copolymerization reaction of di-vinyl benzene, to obtain dual-functional polymer-based ammonia adsorbent with porous structure.The obtained polymer-based adsorbent contains weak acidic group and metal ion, and has ultra-high adsorption capacity for low-concentration ammonia (adsorption capacity for 3 vol.% ammonia can be as high as 10.8 mol / kg), and excellent regeneration performance and ammonia adsorption selectivity.The dual-functional polymer of the application has high adjustability of functional groups, and has good industrial application potential.
Owner:FUZHOU UNIV

Method for producing halogenated alkene and method for producing silicon tetrafluoride

A method for producing a halogenated alkene, the method comprising converting a halogenated alkane represented by formula (1) into a halogenated alkene represented by formula (2) and a compound represented by formula (3) in a gas phase in the presence of silicon oxide and an alkali metal element. R1-R3 each independently represent a hydrogen atom, a fluorine atom, a methyl group, a fluorinated methyl group, an ethyl group, or a fluorinated ethyl group, and the number of carbon atoms in each of formulae (1)-(3) is 2-4.
Owner:AGC INC

Low-damage fracturing fluid for coal rock gas well and preparation method of low-damage fracturing fluid

The invention discloses a low-damage fracturing fluid for a coal rock gas well and a preparation method of the low-damage fracturing fluid, and relates to the technical field of petrochemical engineering. When the low-damage fracturing fluid for the coal rock gas well is prepared, firstly, allyl phosphorus dichloride and 4-(dimethylaminomethyl) phenol react to prepare a double-bond di-tert-amine intermediate; reacting the double-bond di-tert-amine intermediate with halogenated alkane to prepare a gemini quaternary ammonium hydrophobic monomer; the preparation method comprises the following steps: reacting N, N '-ethylenediamine disuccinic acid with allyl glycidyl ether to prepare a metal chelating monomer; acrylamide, acrylic acid, fumaric acid, a metal chelating monomer and a gemini quaternary ammonium hydrophobic monomer are copolymerized to prepare modified polyacrylamide; and mixing the modified polyacrylamide with water and an auxiliary agent to prepare the low-damage fracturing fluid for the coal rock gas well. The prepared low-damage fracturing fluid for the coal rock gas well has the advantages of being low in damage, capable of expanding pores and increasing permeability, anti-swelling, resistant to temperature and shear and resistant to salt.
Owner:SICHUAN LEICHILIO PETROLEUM TECHNOLOGY CO LTD

A fiber-reinforced asphalt mixture and its preparation and use

The application discloses a kind of mixed fiber recycled asphalt mixture and preparation and application thereof, belong to bituminous material technical field, the mixed fiber recycled asphalt mixture, by mass parts, including new aggregate 50~95 parts, asphalt mixture recycling material 5~60 parts, new asphalt 2~5 parts, fiber 0.1~0.5 parts, regenerant 0.01~0.5 parts and penetration type regenerant 0.005~0.05 parts;The penetration type regenerant is the quaternary ammonium salt structure that amino-containing pyridine is obtained by reaction with halogenated alkane through door Shu Er Jintu reaction;Add regenerant and penetration type regenerant and the aging asphalt in asphalt mixture recycling material, make asphaltene in aging asphalt depolymerization, so that aging asphalt is regenerated;Add fiber to enhance the high-temperature performance, water stability and fatigue performance of recycled asphalt mixture.
Owner:THE FIRST ENGINEERING COMPANY OF CCCC FOURTH HARBOUR ENGINEERING CO LTD

Fine-grain tungsten target material and preparation method thereof

The invention relates to the field of sputtering targets for semiconductor manufacturing, and particularly provides a fine-grain tungsten target and a preparation method thereof.The preparation method comprises the steps that 1, halogenated alkane is pre-activated and then subjected to chemical vapor deposition with hydrogen and tungsten hexafluoride on a substrate, and a carbon-doped tungsten material is formed; and (2) the carbon-doped tungsten material is subjected to annealing treatment at the temperature of 1500-2100 DEG C, and the fine-grain tungsten target material is obtained. The preparation method is simple in process, and the prepared tungsten target material has high purity, high density and an equiaxed fine grain structure.
Owner:XIAMEN TUNGSTEN CO LTD

A labeled probe for quantifying protein dynamics

ActiveCN121159473BOrganic chemistryBiological testingAlkaneHaloalkane dehalogenase
The present application relates to the technical field of chemical genetics marking, in particular to a kind of probe for marking quantifying protein dynamics.The probe includes the compound of the following structural formula: the compound contains halogenated alkane chain, can be specifically covalently combined with halogenated alkane dehalogenase-HaloTag label protein.It is combined with the fusion protein containing HaloTag in cell with the purpose of protein, with high specificity and stability, low toxicity, with good biocompatibility and strong anti-photobleaching ability in live cell imaging.The compound has the nature of space limited emission effect, through HaloTag bridge, can sensitively mark and respond to the spatial dynamic change of any single protein molecule in cell physiological process, and then realize the quantification and visualization of protein dynamics in method, for recording physiological activity under different time scales.
Owner:BEIJING NORMAL UNIV AT ZHUHAI