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106 results about "Haloalkane" patented technology

The haloalkanes (also known as halogenoalkanes or alkyl halides) are a group of chemical compounds derived from alkanes containing one or more halogens. They are a subset of the general class of halocarbons, although the distinction is not often made. Haloalkanes are widely used commercially and, consequently, are known under many chemical and commercial names. They are used as flame retardants, fire extinguishants, refrigerants, propellants, solvents, and pharmaceuticals. Subsequent to the widespread use in commerce, many halocarbons have also been shown to be serious pollutants and toxins. For example, the chlorofluorocarbons have been shown to lead to ozone depletion. Methyl bromide is a controversial fumigant. Only haloalkanes which contain chlorine, bromine, and iodine are a threat to the ozone layer, but fluorinated volatile haloalkanes in theory may have activity as greenhouse gases. Methyl iodide, a naturally occurring substance, however, does not have ozone-depleting properties and the United States Environmental Protection Agency has designated the compound a non-ozone layer depleter. For more information, see Halomethane. Haloalkane or alkyl halides are the compounds which have the general formula "RX" where R is an alkyl or substituted alkyl group and X is a halogen (F, Cl, Br, I).

Preparation method and application of oil-soluble heteropolyacid ionic liquid catalyst

The invention discloses a preparation method and application of an oil-soluble heteropolyacid ionic liquid catalyst. The catalyst is composed of organic cations and inorganic anions, the cations are one of quaternary ammonium, imidazole and pyridine cations containing long-chain alkyl, the anions are heteropolyacid anions, the long-chain alkyl enables the catalyst to have good oil solubility, the catalyst can be efficiently dispersed in the waste grease, heteropolyacid provides active sites, and the catalyst can be used for treating the waste grease. Nano-scale active particles are formed after in-situ vulcanization, and the catalytic hydrogenation effect is achieved. The invention also provides a preparation method of the oil-soluble heteropolyacid ionic liquid catalyst, the catalyst can be prepared from tertiary amine and halogenated hydrocarbon through three-step reaction of alkylation, anion exchange and acid-base neutralization, the preparation process is simple, a highly toxic reagent is avoided, and the cost is low. The catalyst provided by the invention can be used for catalytic hydroisomerization of various waste oils and fats, has the characteristics of high conversion rate, low coking rate and high product calorific value, and has relatively high industrial application potential.
Owner:FUZHOU UNIV

Synthesis method of allyl phosphonic acid diester

The invention discloses a synthesis method of allyl phosphonic acid diester. According to the method, phosphorous acid diester and an allyl chloride compound are used as raw materials and react in the presence of a specific transition metal catalyst and alkali under the conditions of normal pressure and 45-60 DEG C to obtain the allyl phosphonic acid diester. The method has the advantages of mild reaction conditions, simple operation, high product yield (90-99%), no by-product, no generation of halogenated alkane gas and easy industrial production, and is suitable for the fields of polymer flame retardants, electronic materials, pesticide and medicine intermediates and the like.
Owner:SUZHOU LEAD BIOTECH CO LTD

Full-bio-based multifunctional antibacterial nylon material as well as preparation method and application thereof

PendingCN120944103AAlkaneCarboxylic acid
The invention discloses a full-bio-based multifunctional antibacterial nylon material as well as a preparation method and application thereof, relates to the technical field of high-molecular polymers, and solves the problems that the preparation process of a nylon material in the prior art depends on petroleum resources, the function is single and the application scene is limited. The method comprises the following steps: reacting an aminocaprolactam solution with corresponding aldehyde / carboxylic acid / halogenated alkane, and purifying to obtain a cyclic lysine derivative monomer M; the preparation method comprises the following steps: mixing and heating a cyclic lysine derivative monomer M, an initiator and a catalyst, reacting, and purifying to obtain a nylon material PM; and carrying out quaternization reaction on the nylon PM solution and alkyl halide, and purifying to obtain the full-bio-based multifunctional nylon material P. The preparation method completely abandons the use of petroleum-based raw materials, realizes the multifunctional synergistic effect of antibacterial property, biocompatibility, antibacterial biofilm property, thermosensitivity and the like, and can be applied to the fields of antibacterial materials, biomedical materials, antibacterial biofilms and thermosensitivity materials.
Owner:CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES

Trichlorbacterium and application thereof in bioremediation of pollutants

The invention relates to the field of environmental microbial remediation, in particular to a strain of trichlorobacterium and application thereof in bioremediation of pollutants. According to the present invention, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, and the bacillus subtilis is bacillus subtilis. The strain NB-12 obtained by the invention is a strain of self-synthesized cobalamin screened from river bottom sediments, is suitable for extensive industrial production and degrades a plurality of halogenated alkanes in the environment.
Owner:SHENYANG INST OF APPL ECOLOGY CHINESE ACAD OF SCI

A method for synthesizing a dialkylphosphinic ester

This invention discloses a method for synthesizing dialkylphosphinates, belonging to the field of organic synthesis technology. The method uses hypophosphite and haloalkanes as starting materials. First, a hypophosphite is generated through a heated and pressurized reaction under the action of a phase transfer catalyst. The obtained hypophosphite does not require complex purification; it is directly reacted with an olefin under heated and pressurized conditions in the presence of a free radical initiator to obtain the target product, dialkylphosphinate. The method of this invention uses inexpensive and readily available raw materials, has a simple process route, includes only two core reactions, operates under mild conditions, is safe and convenient, produces few and easily treatable byproducts, has a high product yield, and is simple to purify. It is very suitable for large-scale industrial production, providing an economical and efficient synthetic route for the preparation of high-performance halogen-free flame retardants.
Owner:ZHEJIANG WANSHENG CO LTD

Purification method for fluoroolefin having structure of =CF2 or =CHF, high-purity fluoroolefin, and production method therefor

ActiveUS12410112B2Halogenated hydrocarbon preparationHaloalkeneAlkane
Impurities are removed from a fluoroolefin having a structure of ═CF2 or ═CHF that has been obtained by a dehydrohalogenation reaction and that contains haloalkene, haloalkane, and / or haloalkyne impurities.Provided are: a method of purifying a fluoroolefin having a structure of ═CF2 or ═CHF, comprising bringing a fluoroolefin having a structure of ═CF2 or ═CHF that has been obtained by a dehydrohalogenation reaction and that contains at least one of haloalkane, haloalkene, and / or haloalkyne impurities into contact with a solid adsorbent to remove the impurities through adsorption; a high-purity fluoroolefin; and a production method therefor.
Owner:KANTO DENKA IND CO LTD

Degradable Gemini morpholine quaternary ammonium salt, and preparation method and application thereof

The application discloses a degradable gemini morpholine quaternary ammonium salt. The application further discloses a preparation method of the degradable gemini morpholine quaternary ammonium salt, comprising the following steps: S1, performing N-alkylation reaction on morpholine and halogenated alkane to obtain N-alkyl morpholine; S2, performing reaction on substance A and halogenated acetyl halide to obtain substance B; S3, continuously performing N-alkylation reaction on the N-alkyl morpholine and the substance B to obtain the degradable gemini morpholine quaternary ammonium salt. The application further discloses application of the degradable gemini morpholine quaternary ammonium salt in a bactericide and in preparation of a medicine for treating helicobacter pylori infection. The gemini morpholine quaternary ammonium salt has a good effect of killing helicobacter pylori; the gemini morpholine quaternary ammonium salt can be degraded in an alkaline environment, can avoid drug resistance of helicobacter pylori to the gemini morpholine quaternary ammonium salt, and can make the degradation product be rapidly discharged out of the body.
Owner:UNIV OF SCI & TECH OF CHINA

Polyethylene catalysts and methods for their preparation and ultra-high molecular weight polyethylene and methods for their preparation

This invention relates to the field of catalysts, specifically to a polyethylene catalyst and its preparation method, as well as ultra-high molecular weight polyethylene and its preparation method. The method includes the following steps: (1) under diluent conditions, a magnesium halide precursor, an alcohol compound, and a first internal electron donor undergo a first contact reaction to obtain a first reaction solution; (2) a second internal electron donor is added to the first reaction solution to undergo a second contact reaction to obtain a second reaction solution; (3) a titanium precursor is added to the second reaction solution to undergo a third contact reaction to obtain a third reaction solution; (4) a haloalkane is added to the third reaction solution, followed by a third internal electron donor to undergo a fourth contact reaction. The catalyst prepared by this invention exhibits good catalytic performance.
Owner:PETROCHINA CO LTD

Method for removing probenecid sodium halogenated alkyl toxic impurities

The invention relates to a method for removing halogenated alkyl toxic impurities in probenecid sodium, which is characterized by comprising the following steps of: 1, heating and hydrolyzing excessive halogenated alkyl under an alkaline condition to remove the halogenated alkyl toxic impurities; 2, organic solvent extraction and removal; 3, adsorption removal by a specific adsorption column; after the treatment by the method, the residue of haloalkane is reduced to be not detected from 15-100ppm, and the limit requirements of related genotoxic impurities in Chinese drug registration regulations and ICH guidance principles are completely met.
Owner:ANHUI KANGZHENG KANGYUAN PHARM CO LTD

A process for the preparation of r-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxaldehyde

The present application relates to a kind of preparation methods of R-(+)-2,2-dimethyl-1,3-dioxolane-4-formaldehyde, belong to the technical field of pharmaceutical intermediates synthesis.In order to solve the existing wastewater pollution and the problem of low selectivity, provide a kind of preparation method of R-(+)-2,2-dimethyl-1,3-dioxolane-4-formaldehyde, the method includes the action of catalytic amount of phase transfer catalyst quaternary ammonium salt and oxidant, the oxidant is selected from PCC or BPCC, in halogenated alkane solvent, substrate formula II compound double ketone-D-mannitol is converted into product formula I compound R-(+)-2,2-dimethyl-1,3-dioxolane-4-formaldehyde by catalytic oxidation reaction.The present application has the effect of high product yield and purity quality, product yield reaches more than 95%, purity reaches more than 99.5%, also greatly reduces the generation of a large amount of wastewater, the advantage of environment-friendly.
Owner:JIANGSU BAJU PHARM CO LTD

Process for the modification of a beta-ketimine ligand precursor and products thereof

This invention relates to a simple method for modifying β-ketoimine ligand precursors, wherein L... Ph The reaction involves a lithium compound with H2 solution; then a haloalkane is added for C-C coupling; followed by the addition of an acid solution to complete the modification of the β-ketoimine ligand precursor, yielding a terminally alkylated ketoimine. This invention relates to a simple method for modifying β-ketoimine ligand precursors, specifically involving the removal of the proton at the α-position of the β-ketoimine ligand precursor from commercially available n-butyllithium to form a deprotonated β-ketoimine lithium compound, followed by C-C coupling to achieve alkylation at the α-position of the ketocarbonyl group, thus providing a convenient modification of the β-ketoimine ligand precursor.
Owner:SUZHOU UNIV

Halon purification method

There is provided a halon purification method capable of simply, safely, and efficiently removing mixed bromine molecules to obtain high purity halon. The halon purification method is a method for removing bromine molecules from crude halon containing halon and the bromine molecules, and the method includes: a contact step of bringing the crude halon into contact with an absorbing liquid containing an aqueous solution containing metal iodide to obtain a mixed liquid containing the crude halon and the absorbing liquid; and a separation step of separating the halon from the mixed liquid to obtain the halon and the absorbing liquid having absorbed the bromine molecules.
Owner:RESONAC CORP

Method for continuously preparing alkyl phosphonic acid diaryl ester

The invention relates to a method for continuously preparing alkyl diaryl phosphonate, which comprises the following steps of: a, reacting trialkyl phosphite and triaryl phosphite in a high-temperature section filled with a solid catalyst to obtain a reaction product; and b, removing low-fraction byproducts in the reaction product in the step a through reduced pressure distillation or fractionation at the outlet of the high-temperature section, feeding the residual product into a cooling section, collecting a crude product of the alkyl diaryl phosphonate at the outlet of the cooling section, and carrying out post-treatment to obtain the alkyl diaryl phosphonate. A continuous catalytic reaction is carried out through the solid catalyst filled in the tubular reactor, and an intermittent reaction is changed into a continuous reaction, so that the liquid holdup is greatly reduced, and the safety coefficient of production is improved; a traditional halogenated alkane catalyst is not used, so that the risk that the temperature rise is out of control is effectively reduced; according to the method, the reaction time is shortened while the reaction yield is not reduced, and the production efficiency is improved.
Owner:NINGBO PUDUOKIKE TECH DEV CO LTD

A preparation method of a phenylbutyric acid nitrogen mustard NO donor prodrug delivery system and a medicine for treating tumors

This invention provides a chlorambucil NO donor prodrug having the structure shown in Formula (I) or a pharmaceutically acceptable salt thereof: Formula (I). It involves reacting chlorambucil with a dihaloalkane to obtain a halochlorambucil intermediate; reacting the halochlorambucil intermediate with silver nitrate to obtain the chlorambucil NO donor prodrug. This invention applies the chlorambucil NO donor prodrug to the preparation of drugs for treating tumors, such as melanoma, lymphoma, leukemia, or breast cancer. This nanosystem exhibits good NO release levels under light irradiation. Cellular experiments have demonstrated its good antitumor effect, providing a new strategy for multimodal combined antitumor therapy.
Owner:CHINA THREE GORGES UNIV

Disubstituted 4, 4 '-bipyridine derivative, preparation method thereof and electro-catalytic material

The invention relates to a disubstituted 4, 4 '-bipyridine derivative as well as a preparation method and an electro-catalytic material thereof. The compound has the following structural general formula: in the formula, R1 is C2-6 alkyl, and R2 is C3-6 alkenyl. The preparation method comprises the following steps: mixing halogenated alkane and 4, 4 '-dipyridyl in an organic solvent for reaction, carrying out solid-liquid separation on a reaction system, and precipitating an intermediate compound from filtrate; redissolving the intermediate compound, and adding halogenated olefin for reaction; and collecting a precipitation product, and drying to obtain the 4, 4 '-bipyridine derivative. The electro-catalytic material is used for electro-catalytic oxygen evolution reaction and comprises foamed nickel and a disubstituted 4, 4 '-bipyridine derivative loaded on the foamed nickel. Compared with the prior art, the disubstituted 4, 4 '-bipyridine derivative and the electrocatalytic material prepared by the invention have relatively small overpotential voltage and resistance in an alkaline electrolyte environment, and can be used for an electrocatalytic oxygen evolution process of electrolyzed water.
Owner:UNIV OF SHANGHAI FOR SCI & TECH

A positively charged quaternary ammonium salt polymer catalyst and its preparation method and application

The invention belongs to the field of water treatment, and more particularly to a positively charged quaternary ammonium salt polymer catalyst and its preparation method and application. The catalyst provided by the present invention is made of a positively charged quaternary ammonium salt precursor through polymerization and anion exchange, and the positively charged quaternary ammonium salt precursor is the reaction product of acrylate and halogenated alkane; the acrylate is one or more of dimethylaminoethyl acrylate, dimethylaminoethyl methacrylate and 3 (dimethylamino) ethyl acrylate; the halogenated alkane is one or more of undecane bromide, dodecane bromide, tetradecane bromide, hexadecane bromide, eicosane bromide, dodecane chloride, tetradecane chloride and hexadecane chloride. The catalyst provided by the present invention has good stability and antibacterial properties, can efficiently and selectively catalyze the degradation of organic pollutants by peroxide, has important practical significance for removing wastewater rich in organic pollutants, and has a wide range of applications in water pollution control and water environment restoration.
Owner:UNIV OF SCI & TECH OF CHINA

A catalytic synthesis method of chiral polysubstituted hydrogenated quinolines

The application discloses a catalytic synthesis method of chiral polysubstituted hydrogenated quinoline compounds, and belongs to the field of organic synthesis. The application comprises the following steps: at 0-40 DEG C, alcohol or halogenated alkane is used as a solvent, a copper metal catalyst and a chiral ligand are added, and reaction is carried out under nitrogen protection for 0.5-2 hours; the temperature is lowered to-60-0 DEG C; then, o-aminophenyl nitrone, propargyl alcohol ester and alkali are sequentially added; and reaction is carried out for 6-48 hours, so as to obtain a chiral polysubstituted hydrogenated quinoline compound shown in formula 1 or 2. The application realizes, for the first time, synthesis of chiral polysubstituted hydrogenated quinoline compounds by using o-aminophenyl nitrone and propargyl alcohol ester as reactants, and by using a cheap copper metal catalyst and a chiral ligand, the method is simple in operation, low in cost, and has excellent enantioselectivity and diastereoselectivity.
Owner:OCEAN UNIV OF CHINA

Process for producing hydro(chloro)fluorocarbon compounds

A process is provided which includes contacting a haloalkane reactant with a fluorination agent in the liquid phase, in the presence of a catalyst, under conditions which are free of or substantially free of a superacid, to produce a product stream including a haloalkane product, preferably a hydro(chloro)fluorocarbon.
Owner:THE CHEMOURS CO FC LLC

Analysis method for determining halogenated alkane impurities in tigliptin hydrobromide

The invention discloses an analysis method for determining halogenated alkane impurities in tigliptin hydrobromide, and relates to the technical field of quality analysis. In order to solve the problem of detection of halogenated alkane impurities in tigliptin hydrobromide, the invention provides a convenient, efficient and accurate detection method. The method comprises the following steps: preparing a test solution and an impurity reference solution, and detecting by adopting a gas chromatographic method; the method can be used for accurately determining the content of halogenated alkane in tigliptin hydrobromide, plays a guiding role in development of a synthesis process, and contributes to establishment of quality standards of tigliptin hydrobromide bulk drugs.
Owner:HSING PHARMACEUTICALS CO LTD

Method for synthesizing trans-isopentenyl substituted indolone through nickel catalysis

PendingCN121990970Aachieve synthesishigh activityOrganic chemistryAlkaneKetone
The invention relates to a method for synthesizing trans-isopentenyl substituted indolone under the catalysis of transition metal nickel. Specifically, a metal nickel catalyst (Ni (cod) 2) and tricyclohexylphosphine (PCy3) are used as ligands, C3 unsubstituted indolone is used as a nucleophilic reagent to react with isoprene, and a trans-isopentenyl substituted indolone product is obtained. And then taking the product as a reaction raw material, and carrying out nucleophilic substitution reaction on the product and halogenated alkane under an alkaline condition to obtain the 3, 3-disubstituted indolone with divergent functional groups. According to the invention, isoprene is used as a reaction precursor, a trans-isopentenyl substituted indolone product is obtained with high activity and selectivity, a nucleophilic substitution reaction is relayed, and a new strategy is provided for flexibly and conveniently introducing functional groups with different steric hindrances and electrical properties.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES

Degradable gemini morpholine quaternary ammonium salt as well as preparation method and application thereof

The invention discloses a degradable gemini morpholine quaternary ammonium salt. The invention also discloses a preparation method of the degradable gemini morpholine quaternary ammonium salt, and the preparation method comprises the following steps: S1, morpholine and halogenated alkane are subjected to an N-alkylation reaction to obtain N-alkyl morpholine; s2, reacting the substance A with halogenated acetyl halide to obtain a substance B; s3, N-alkyl morpholine and the substance B are continuously subjected to an N-alkylation reaction, and the degradable gemini morpholine quaternary ammonium salt is obtained. The invention also discloses application of the degradable dimeric morpholine quaternary ammonium salt as a bactericide in preparation of drugs for treating helicobacter pylori infection. The gemini morpholine quaternary ammonium salt disclosed by the invention has a good effect of killing helicobacter pylori; and the gemini morpholine quaternary ammonium salt can be degraded in an alkaline environment, so that the drug resistance of helicobacter pylori to the gemini morpholine quaternary ammonium salt can be avoided, and the degradation product can be quickly discharged out of the body.
Owner:UNIV OF SCI & TECH OF CHINA

Heating control method for vehicle and system thereof

PendingUS20260131635A1Air-treating devicesCompression machinesThermodynamicsChlorofluorocarbon
Disclosed are a method for controlling heating of an HVAC system for an electric vehicle and an HVAC system thereof. According to various embodiments, in an operation of the HVAC system including a main heating unit in which a first refrigerant circulates and an auxiliary heating unit in which a second refrigerant circulates, at least one of the first refrigerant and the second refrigerant may comprise at least one of: a natural refrigerant; a hydrofluorocarbon (HFC)-based refrigerant; a hydrofluoroolefin (HFO)-based refrigerant; a hydrochlorofluorocarbon (HCFC)-based refrigerant; a hydrocarbon-based refrigerant that is not a natural refrigerant; and a halon or a perfluorocarbon (PFC)-based refrigerant.
Owner:SK ON CO LTD +1

Halogenated alkane dehalogenase HLD-1405 as well as coding gene and application thereof

ActiveCN120924518ABacteriaHydrolasesAlkaneHaloalkane dehalogenase
The invention discloses halogenated alkane dehalogenase HLD-1405 as well as a coding gene and application thereof, and belongs to the technical field of biology. The amino acid sequence of the halogenated alkane dehalogenase HLD-1405 is as shown in SEQ ID NO. 2, and the coding gene of the halogenated alkane dehalogenase HLD-1405 is as shown in SEQ ID NO. 1. The halogenated alkane dehalogenase HLD-1405 has high catalytic activity on 1, 3-dibromopropane, the optimum action condition is 40 DEG C / pH 9.0, and the activity of the halogenated alkane dehalogenase HLD-1405 in 20% methanol is kept 100%. The haloalkane dehalogenase HLD-1405 can efficiently degrade short-chain haloalkane, has the capability of degrading pollutants such as DDT and hexachlorocyclohexane, has great application potential in treatment of stubborn pollutants, and is suitable for bioremediation and industrial catalysis of environmental pollution.
Owner:HUNAN NORMAL UNIVERSITY

Pyrroloyl piperidylamine compound and method for detecting genotoxic impurities of pyrroloyl piperidylamine compound

The invention belongs to the technical field of medical analysis, and discloses a pyrrole acyl piperidylamine compound and a method for detecting genotoxic impurities of the pyrrole acyl piperidylamine compound. Specifically, the invention relates to analysis and limit determination of four genotoxic impurities in a pyrroloyl piperidylamine new drug (code name compound 1) for resisting drug-resistant bacterium infection. According to the method, a liquid chromatography-mass spectrometry technology is adopted, octadecyl bonded silica gel is used as a stationary phase, a mixed solution of methanol and an ammonium acetate acidic aqueous solution is used as a mobile phase, and triple quadrupole mass spectrometry is used as a detector for analysis and determination. The genotoxic impurities comprise halogenated alkanes, halogenated olefins, carbamates and azo oxides. The method has relatively good specificity and sensitivity, can be used for accurately and quantitatively determining the genotoxic impurities, and is simple and rapid to operate. The method provides a method basis for quality control of the compound 1, and has important application value for quality control and safety guarantee in a new drug research and development process.
Owner:INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI

A process for the preparation of a diazabicyclooctene compound

ActiveCN118772145BOrganic chemistry methodsAlkaneAnnulation
The application discloses a preparation method of a diazabicyclooctene compound. Specifically, the method comprises the following steps: performing ring formation reaction of compound 3 and triphosgene in a solvent under the action of a base, as shown in the following formula, and the solvent is a halogenated alkane solvent, and the base is triethylamine. The preparation method has a short synthesis route, reduces consumption of raw materials, and improves overall yield.
Owner:SHANGHAI INST OF PHARMA IND CO LTD +1

Methods for manufacturing haloolefins

A method for producing haloolefins, wherein, in the presence of silicon oxide and alkali metal elements, haloalkanes containing fluorine atoms and having 2 to 4 carbon atoms are converted into haloolefins containing fluorine atoms and having 2 to 4 carbon atoms in the gas phase.
Owner:AGC INC

A modified metal-organic framework material, its preparation method and application

This invention relates to the field of catalyst technology for the hydrogenation of carbon dioxide to methanol, and discloses a modified metal-organic framework material and its preparation method and application. The method includes: (1) reacting a first inorganic metal compound, an aromatic organic acid, an organic acid, and a first organic solvent, followed by solid-liquid separation to obtain product I; (2) mixing product I, a second organic solvent, and a second inorganic metal compound, followed by solid-liquid separation to obtain product II; (3) mixing product II, a second organic solvent, and a metal-organic compound, followed by solid-liquid separation to obtain product III; (4) reacting product III, a Lewis acid compound, a second organic solvent, and a modifier; wherein the first inorganic metal compound and the second inorganic metal compound are different, the aromatic organic acid and the organic acid are different, and the modifier is selected from at least one of haloalkanes, alcohols, and alkenes. The material prepared by this method exhibits a methanol selectivity greater than 95% and a CO2 conversion rate greater than 25%.
Owner:CHN ENERGY NEW ENERGY TECHNOLOGY RESEARCH INSTITUTE CO LTD +2

A process for the preparation of 4,6-dichloropyrimidine

The application provides a preparation method of 4,6-dichloropyrimidine, which uses 4,6-dihydroxypyrimidine as a starting reaction raw material, halogenated alkane or nitrobenzene as a solvent, triphosgene as a chlorinating reagent, and an organic phosphine as a catalyst, and a morpholine derivative is selected as a cocatalyst. The catalyst and the cocatalyst can be used repeatedly, an acid binding agent is not required in the reaction process, the reaction time is about 3 hours, the product yield is not less than 95.0%, and the method is an efficient and green and environmental 4,6-dichloropyrimidine preparation method.
Owner:CAC NANTONG CHEM