High polymer quaternary ammonium salt antibacterial agent preparation method and application

A technology of antibacterial agents and quaternary ammonium salts, applied in botany equipment and methods, applications, biocides, etc., can solve the problems of high cost, complicated preparation process, poor thermal stability and processing performance, and achieve low cost and high preparation Simple process and good stability

Active Publication Date: 2016-11-23
成都康钧生物科技有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of these antibacterial agents is generally complicated, the thermal stability and processing performance are poor, and the cost is high, making it difficult to apply polyethyleneimine (PEI) on a large scale. Polyethyleneimine (PEI) is a water-soluble polyamine with a large amount of Amino N atom

Method used

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  • High polymer quaternary ammonium salt antibacterial agent preparation method and application
  • High polymer quaternary ammonium salt antibacterial agent preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Dissolve 1 g of polyethyleneimine in 5 mL of tetrahydrofuran, and dissolve 2 mL of short-chain halogenated hydrocarbon 1 (bromohexane) in 5 mL of tetrahydrofuran. The polyethyleneimine solution was added dropwise to the hexylbromide solution. Maintain stirring at 50°C for 24h. After the reaction, the product was precipitated with ether, and finally dried under reduced pressure to obtain quaternized polyethyleneimine 1.

Embodiment 2

[0019] Dissolve 1 g of polyethyleneimine in 5 mL of tetrahydrofuran, and dissolve 4 mL of short-chain halogenated hydrocarbon 2 (methyl iodide) in 5 mL of tetrahydrofuran. Add the polyethyleneimine solution dropwise into the iodomethane solution, and keep stirring at 50°C for 24h. After the reaction, the solvent tetrahydrofuran and unreacted methyl iodide were removed by rotary evaporation, and finally the quaternized polyethyleneimine 2 was obtained by drying under reduced pressure.

experiment example 3

[0021] The antibacterial agent (quaternized polyethyleneimine 1) prepared in Example 1 of the present invention was subjected to a bacterial liquid co-culture antibacterial experiment. The bacteria used for detection was Escherichia coli ATCC 25922. In this experiment, the equal concentration dilution method was used to determine the minimum inhibitory concentration. The specific method is as follows: the material to be tested is dissolved in deionized water with an initial concentration of 4096 μg / mL. Then, dilute to 1 μg / mL in a 96-well plate. In the experimental group, 70 μg of different concentrations of antibacterial materials were added to each well. 70 μg of deionized water was added to the control group. Dilute the cultured Escherichia coli to about 2×10 6 CFU / mL. Subsequently, 70 μg of culture medium containing bacteria was added to each well of the experimental group and the control group. Incubate the 96-well plate with slight shaking at 37°C for 20 hours, and ...

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Abstract

The invention provides a high polymer quaternary ammonium salt antibacterial agent preparation method and application, and belongs to the technical field of antibacterial agents. The antibacterial agent is prepared by conducting a quaterization reaction on large molecular weight polyethyleneimine (b-PEI) and short-chain haloalkane. The high polymer quaternary ammonium salt antibacterial agent prepared through the method has an efficient, lasting and broad-spectrum antibacterial property, has the advantages of being high in safety, simple in preparation process and the like, can serve as an antibacterial additive and has a potential commercial application prospect in the fields of medical treatment, sanitation and environmental protection.

Description

technical field [0001] The invention relates to a polymer quaternary ammonium salt antibacterial agent, a preparation method and application, and belongs to the technical field of antibacterial agents. Background technique [0002] In recent years, with the development of science and technology and the improvement of people's living standards, people's requirements for hygiene and health have become higher and higher, and people have begun to pay more and more attention to the development and application of high-performance antibacterial agents. [0003] There are many kinds of antibacterial agents, which can be divided into three categories: inorganic antibacterial agents, organic antibacterial agents and natural antibacterial agents. Most of the fungicides currently used for water body or medical disinfection are small molecular substances. Small molecule fungicides not only leave residual toxicity, have short antibacterial time, but also cause environmental pollution. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/04A01N33/12A01P1/00
CPCA01N33/12C08G73/0226
Inventor 徐福建罗旭胡杨李杨张桢焱
Owner 成都康钧生物科技有限公司
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