199 results about "Large molecular weight" patented technology

The invention provides a layer-by-layer self-assembled nanofiltration membrane and a preparation method and application thereof.The layer-by-layer self-assembled nanofiltration membrane comprises a base membrane and a self-assembled coating formed on the base membrane, and the self-assembled coating at least comprises an initial alternating coating and a separation alternating coating; the molecular weight cutoff of the base membrane is not less than 500kDa; the initial alternate coating is formed by alternately assembling a large-molecular-weight cationic polyelectrolyte layer and an anionic polyelectrolyte layer, and the separation alternate coating is formed by alternately assembling a small-molecular-weight cationic polyelectrolyte layer and an anionic polyelectrolyte layer; the initial alternating coating is formed on the base membrane, and a high-molecular-weight cationic polyelectrolyte layer in the initial alternating coating adopts cationic polyelectrolyte with the number-average molecular weight not less than 500kDa; and the small-molecular-weight cationic polyelectrolyte layer in the separation alternate coating is cationic polyelectrolyte with the number-average molecular weight not exceeding 100kDa. The layer-by-layer self-assembled nanofiltration membrane provided by the invention has more excellent permeability and micropollutant rejection rate.

The invention discloses a low-cost large-molecular-weight fish scale collagen extraction method, and belongs to the technical field of fish scale collagen. The method comprises the following steps: (1) pretreatment: repeatedly freezing and storing fish scales and unfreezing and redissolving the fish scales; 2) impurity protein removal: taking out the fish scales, and removing fish silver; soaking in a sodium chloride solution, washing and drying; 3) extracting fish scale collagen, namely extracting the dried fish scales for 1-4 hours at 40-100 DEG C according to a solid-liquid ratio of 1: (5-20) by adopting a hydrothermal extraction mode, carrying out solid-liquid separation, and collecting fish scale collagen extract liquids in different molecular weight intervals; and 4) freeze-drying the collagen extract liquid to obtain a fish scale collagen solid product. According to the method, acid or alkali solution pretreatment is not needed, and a sodium chloride salt solution is used for mildly removing impure protein. And the structure of the fish scale collagen is relatively completely maintained while the relatively high yield is ensured.

The present invention discloses an injectable human collagen soft tissue filling material and a preparation method thereof, belonging to the technical field of biomedical materials. The injectable human collagen soft tissue filling material comprises pretreated recombinant human collagen and an osmotic pressure regulator, and the injectable human collagen soft tissue filling material is in an isotonic state; the pretreatment of the recombinant human collagen is processed by isoelectric precipitation and centrifugal separation process; the preparation method thereof comprises filtering and sterilizing the raw materials, pretreatment, and homogenizing the pretreated recombinant human collagen and the osmotic pressure regulator. The injectable human collagen soft tissue filling material of the present invention is mainly human collagen, has a large molecular weight and a triple helix structure, and has a uniform particle size distribution, which can play a filling and supporting effect; the preparation process thereof is simple and convenient, without special processing technology, and will not introduce toxic and harmful residual substances, so that the product performance is stable.

The invention relates to the technical field of proton exchange membranes, and provides a covalent grafted heteropoly acid modified perfluorosulfonic acid membrane as well as a preparation method and application thereof. According to the invention, polypropylene glycol monoalkyl ether and Keggin type vacancy heteropoly acid are subjected to covalent grafting, and then the obtained covalent grafted heteropoly acid is used as an additive to modify the perfluorosulfonic acid membrane, so that the leakage problem of heteropoly acid in the proton exchange membrane can be effectively relieved, and meanwhile, the excellent proton conduction performance of heteropoly acid is also retained; moreover, the polypropylene glycol monoalkyl ether has relatively large molecular weight, so that the heteropoly acid can be anchored more firmly in the perfluorosulfonic acid membrane, and the proton conduction capability of the heteropoly acid is fully exerted. The result of the embodiment shows that the covalent grafted heteropoly acid modified perfluorosulfonic acid membrane provided by the invention shows excellent proton conduction performance and chemical stability, and has a wide application prospect.

The invention discloses a preparation method of a doxorubicin-loaded ginseng selenium polysaccharide nano-carrier with immunoregulation and liver cancer cell inhibition functions, and aims to solve the problems of toxic injury of tissues and organs and inhibition of an immune system caused by an antitumor drug doxorubicin. According to the invention, deoxycholic acid is grafted on the ginseng selenium polysaccharide, so that the ginseng selenium polysaccharide is hydrophobized and forms an amphiphilic polysaccharide polymer, and the limitations of large molecular weight, low bioavailability and the like of the ginseng selenium polysaccharide are overcome. The self-assembled ginseng selenium polysaccharide nanoparticles are used as carriers for delivering antitumor drugs, so that the self-assembled ginseng selenium polysaccharide nanoparticles have an immunoregulation effect and can effectively improve side effects such as immunosuppression caused by the antitumor drugs; and the carrier also has a pH sensitive response release characteristic, so that the targeting effect of the medicine in a tumor area is enhanced, and the innovative carrier has a good clinical application prospect.

The present invention discloses a pectin methylesterase mutant ΔDdPemA, its encoding gene, preparation method, and application. The pectin methylesterase mutant ΔDdPemA is obtained by mutating the amino acid at position 200 in the center of the substrate binding pocket of the wild-type pectin methylesterase DdPemA from a high-molecular-weight, branched valine to a low-molecular-weight alanine, and by mutating the amino acid at position 339 at the substrate inlet and outlet of the substrate binding pocket from a high-molecular-weight, branched valine to a basic lysine. The amino acid sequence and nucleotide sequence of the wild-type pectin methylesterase DdPemA are SEQ ID NO. 1 and SEQ ID NO. 2, respectively. The mutant enzyme provided by the present invention has significantly improved enzyme activity under weakly acidic conditions, solving the problem of insufficient catalytic activity of the wild-type pectin methylesterase under weakly acidic conditions and creating favorable conditions for the application of the enzyme in the fields of food, textiles, and feed processing.

The invention belongs to the technical field of cosmetics, and particularly relates to an EGCG-DNA sodium composition with anti-oxidation and anti-aging effects and application of the EGCG-DNA sodium composition. The EGCG-DNA sodium composition is prepared from the following components in parts by weight: 0.5 to 2 parts of EGCG-DNA inclusion, and 0.5 to 2 parts of PDRN (Protein Deoxyribose Nucleic Acid) from rose. An EGCG-DNA sodium inclusion is wrapped by adopting a specific nano wrapping technology, the problems that DNA sodium is large in molecular weight and impermeable and EGCG is unstable are solved, then the rose-sourced DNA sodium is matched with one another and has a synergistic effect in a preferable dosage range, free radicals are effectively resisted, and the skin aging problem is solved.

The invention discloses an efficient extraction method of large-molecular-weight astragalus polysaccharide, which belongs to the technical field of plant extraction, and comprises the following steps: cleaning astragalus, filtering, and crushing; the preparation method comprises the following steps: mixing a beta-1, 3-glucanase aqueous solution and trehalose ethylene diamine, and stirring for 10-30 minutes to obtain an enzyme protection system; soaking the radix astragali powder in a citric acid solution, adding an enzyme protection system, applying a bipolar pulsed electric field, and reacting at 40-60 DEG C for 30-40 minutes; adjusting the concentration of the ethanol to 40-50%, standing, centrifuging and collecting crude astragalus polysaccharide; purifying, decolorizing, concentrating, freeze-drying and crushing the crude astragalus polysaccharide to obtain refined astragalus polysaccharide; the mass ratio of the trehalose ethylene diamine to the beta-1, 3-glucanase is (15: 1) to (30: 1). The enzyme protection system maintains the activity of the enzyme, the enzyme and the pulsed electric field act synergistically, the extraction time is shortened, and the extraction rate is increased while the astragalus polysaccharide with large molecular weight is obtained.

The invention discloses a silk fibroin solution injection capable of forming gel in situ and a preparation method and application thereof.The preparation method comprises the following steps that a regenerated silk fibroin solution with the molecular weight of 100 kDa-250 kDa and a hydrogen bond breaker are evenly mixed to obtain a mixed solution, the mixed solution is subjected to quick-freezing supercooling crystallization and vacuum drying to obtain silk fibroin powder, and the silk fibroin powder is dried to obtain the silk fibroin solution injection capable of forming gel in situ. And sterilizing and dissolving in normal saline to obtain the silk fibroin solution injection. A hydrogen bond breaker is introduced into a high-molecular-weight regenerated silk fibroin solution, a beta folding structure between silk fibroin molecules is inhibited, damage to the silk fibroin molecules in the freeze-drying process is reduced through a quick-freezing and supercooling crystallization method, and aggregation of the silk fibroin molecules is further reduced; after redissolving, an injection is formed and injected into local tissues, the micromolecular hydrogen bond breaker quickly diffuses, and the large molecular weight regenerated silk fibroin recovers hydrogen bond interaction and then forms hydrogel in situ through physical crosslinking, so that in-vivo in-situ gelling of the silk fibroin is realized.

The invention relates to an anti-tarnish anti-aging agent and a preparation method and application thereof, the anti-tarnish anti-aging agent has a structure as shown in the following formula (I): # imgabs0 #, the anti-aging agent provided by the invention has similar processability and equivalent processing safety compared with the existing anti-aging agent 4020, but has the outstanding characteristics of large molecular weight, more lasting aging resistance, good compatibility with rubber, difficult blooming and no surface tarnish after long-term use compared with the existing anti-aging agent 4020.

The organic phosphonic acid polymer flame retardant is prepared by taking organic phosphinic acid containing alkylene as an initiator, and the organic phosphonic acid polymer flame retardant is high in phosphine content and convenient to synthesize. The synthesized organic phosphonic acid polymer flame retardant can provide better flame retardant property under the condition of lower additive amount, and as the organic phosphonic acid polymer flame retardant is a polymer, has large molecular weight and does not contain metal ions, a better bicontinuous phase is formed in resin, so that the resin has higher retention rate of mechanical property and electrical property, and the flame retardant has better flame retardant property. The flame retardant can be widely applied to the technical field of flame retardants.

The invention relates to preparation and application of a desoxyribonucleic acid and desoxyribonucleic acid derivative transdermal delivery system, and belongs to the technical field of biological medicine and skin care products. Desoxyribonucleic acid and derivatives thereof have the effects of resisting aging, repairing and the like, but are difficult to penetrate through a skin barrier due to large molecular weight and strong polarity. According to the invention, hydroxyethyl chitosan, desoxyribonucleic acid and derivatives thereof are combined through electrostatic interaction to form the nano-composite. The compound is small in particle size and can promote transdermal absorption through hair follicle or cuticle gaps. The preparation method is simple, does not need an auxiliary reagent, and comprises the step of mixing a hydroxyethyl chitosan solution and a deoxyribonucleic acid derivative solution. Experiments show that the compound significantly enhances the transdermal efficiency, and has the effects of promoting cell repair and proliferation and resisting inflammation. The composition can be used for skin care products, and is high in safety and wide in application prospect.

The invention relates to an SBS molecular structure active repairing agent, an SBS modified asphalt reaction regenerant and a preparation method. The SBS molecular structure active repairing agent has a spheroidic stereo configuration, multiple conformational numbers, a large molecular weight and a large number of terminal active isocyanate groups; the SBS modified asphalt reaction regenerant is prepared from the following raw materials in percentage by weight: 25 to 35 percent of SBS molecular structure activity repairing agent, 65 to 75 percent of aromatic hydrocarbon oil and 0.1 to 0.2 percent of catalyst. The three-dimensional functional hyperbranched SBS modified asphalt reaction regenerant disclosed by the invention not only can supplement light components lost in the aging process of matrix asphalt and balance the proportion of light and heavy components in aged asphalt, but also can efficiently reconstruct a three-dimensional network cross-linked structure of degraded SBS in asphalt through the reaction of an SBS molecular structure active repairing agent and the degraded SBS, so that the service life of the asphalt is prolonged. The physical-rheological property of the aged SBS modified asphalt can be obviously recovered, and the aging resistance of the regenerated SBS modified asphalt can be improved.

The invention discloses an auxiliary open fire heating device for improving the surface quality of extruded plastics. The auxiliary open fire heating device comprises a bracket base device and a fire jetting combustion furnace tray device and is characterized in that the bracket base device comprises a base and a support frame, and the support frame is mounted on the base; the fire jetting combustion furnace tray device comprises a gas inlet valve, a gas guide pipe and nozzle devices; the gas inlet valve is mounted at an inlet of the gas guide pipe; the nozzle devices are mounted on the gas guide pipe; and the fire jetting combustion furnace tray device is mounted on the bracket base device through the support frame. The auxiliary open fire heating device has the advantages of simplicity, convenience and feasibility and also has the advantages of being convenient to use, high in efficiency, high in practicability, light in structure and convenient to mount, disassemble and operate. Generally, when large-molecular-weight plastics of a molecular chain net structure, such as organosilane crosslinked polyethylene, are processed and produced, the auxiliary open fire heating device is directly mounted on a nose of the existing extruder by using magnetic absorption and utilizes open fire to carry out auxiliary open fire heating on a forming die orifice and an extruded wire so as to improve the poor surface quality of the extruded product.

The invention relates to a method for high-yield preparation of an icodextrin bulk drug by a single enzyme system, which comprises the following steps: gelatinizing starch at high temperature, adding alpha-thermoamylase for hydrolysis, carrying out ultrafiltration separation on primary enzymatic hydrolysate to obtain high-molecular-weight dextrin and alpha-thermoamylase, returning the high-molecular-weight dextrin and the alpha-thermoamylase to a gelatinization tank for secondary enzymolysis, and combining ultrafiltration permeates of the secondary enzymatic hydrolysate and the primary enzymatic hydrolysate, and performing molecular weight screening by ultrafiltration to obtain icodextrin of which the weight-average molecular weight and the number-average molecular weight simultaneously meet the requirements of alpha-1, 6 glucosidic bonds. On the basis of a traditional icodextrin manufacturing process, the working procedures of recovering macromolecular dextrin and performing secondary enzymolysis are added, and the yield can reach 85-91%. Particularly, new amylase does not need to be additionally added in the secondary enzymolysis, the original amylase is continuously used, new equipment is not added, the production cost increase is small, and the preparation efficiency is high.

The invention discloses high-heat-resistance low-dielectric-loss resin as well as a preparation method and application thereof, and relates to the technical field of resin materials. The high-heat-resistance and low-dielectric-loss resin is prepared through the curing reaction of the alicyclic epoxy resin and the active ester; the core of the method is that alicyclic epoxy resin is subjected to curing reaction with active ester by utilizing the characteristics of small molecular weight, high crosslinking density and no glyceryl ether structure, so that the defects of large molecular weight, low crosslinking density, low Tg, low cost and the like of resin formed by bisphenol A type epoxy resin, phenolic aldehyde type epoxy resin and the active ester in the prior art are effectively overcome. And electrical defects caused by a glyceryl ether-containing structure of part of resin are overcome. The prepared high-heat-resistance low-dielectric-loss resin has high heat resistance and excellent electrical performance, the manufacturing process is simple and easy to operate, and the high-heat-resistance low-dielectric-loss resin can be applied to the electronic field of copper-clad plates and the like and has wide application prospects.

The present invention relates to a sulfonium sulfonate photoacid generator represented by Formula I, a synthesis method thereof, and a photoresist composition containing the photoacid generator. The photoacid generator of the present invention has a relatively large molecular weight, which can reduce diffusion of the photoacid generator during use, thereby improving the process window and edge roughness of the photoresist. Furthermore, the photoacid generator of the present invention is simple to prepare, and a high-purity product can be obtained through a simple recrystallization step. Furthermore, the photoacid generator of the present invention significantly improves the edge roughness and DOF of the resulting photolithographic pattern compared to existing photoacid generators for ArF lithography.

The present invention provides a coating for polycarbonate, a preparation method and application thereof, and a filter device, belonging to the technical field of coating technology for filter devices. The coating for polycarbonate comprises the following components in parts by weight: 10-20 parts of polyhydroxy acrylate resin, 1-10 parts of isocyanate curing agent, 0-20 parts of infrared absorber, 1-10 parts of ultraviolet absorber, 0.1-5 parts of surfactant, and 60-80 parts of composite solvent; wherein, the composite solvent comprises a solvent with a large molecular weight and a solvent with a small molecular weight; the molecular weight of the solvent with a large molecular weight is ≥90 g / mol, and the molecular weight of the solvent with a small molecular weight is <90 g / mol. The coating for polycarbonate of the present invention solves the problems that the solvent in the coating corrodes the PC, resulting in a large haze and easy whitening, the PC is not resistant to UV and is prone to yellowing and powdering, and the viscosity of the coating is large, and it is easy to occur flow marks, peeling, vertical stripes and other problems.

The invention relates to the field of macromolecules, and discloses a polymer as well as a preparation method and application thereof. The polymer has a chemical structural unit as shown in a formula 1. Compared with polyester, the polymer disclosed by the invention has the characteristics of higher degradation rate in a water environment, large molecular weight and good heat resistance or mechanical property, and can be applied to the fields of degradable packaging materials, drug controlled release carriers and the like.

The invention provides polyimide and a preparation method thereof. The preparation method comprises the following steps: adding a sodium hydroxide aqueous solution into a monomer solution containing a dianhydride monomer and an aprotic solvent, mixing, adding diisocyanate, carrying out a polymerization reaction to obtain a reaction product system, and precipitating from the reaction product system to obtain polyimide, wherein the feeding time of the diisocyanate is 4 to 5 hours; in the monomer solution, the molar concentration of the dianhydride monomer is 0.5-0.6 mol / L; the obtained polyimide has the advantages of high specific concentration viscosity, high molecular weight and excellent high temperature resistance.

The invention discloses waterborne acrylic resin and a preparation method thereof, and belongs to the technical field of acrylic resin processing. Comprising the following components in parts by mass: 44-55 parts of deionized water, 0.5-3 parts of a carboxyl-containing monomer, 0-17 parts of a hydroxyl-containing monomer, 5-35 parts of an acrylate monomer, 5-20 parts of an ethylene monomer, 5-10 parts of a reactive diluent, 0.1-5 parts of a chain transfer agent, 0.5-2.5 parts of an initiator, 0-10 parts of a solvent and 1-3 parts of a neutralizer. According to the invention, accurate regulation and control of key properties of the resin are realized by adjusting the monomer ratio and the type and dosage of the chain transfer agent: the number-average molecular weight covers 25,000-80,000, the glass-transition temperature is adjustable in the range of 25-80 DEG C, and different scene requirements of high hardness, high chemical resistance and the like are met; meanwhile, the hydrophobic core layer guarantees the mechanical strength, the semi-hydrophilic and semi-oleophylic shell layer improves the water dispersion stability, and the problem that high Tg / large molecular weight and dispersity of traditional water-based resin are difficult to consider at the same time is solved.

1. Name of the product in this design: Integrated High Performance Liquid Chromatograph. 2. Application of this design: It is mainly used for instruments and equipment for analyzing organic compounds with high boiling points, low volatility, unstable temperature, and large molecular weight. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention relates to the technical field of organic synthesis, and discloses a double-center non-metallocene catalyst and a preparation method thereof, and a butene-1-based elastomer and a preparation method thereof. Wherein the double-center non-metallocene catalyst comprises a structure as shown in a formula I; in the formula I, R1-R5 are independently selected from H or C1-C8 alkyl groups, R6 is selected from C1-C5 alkyl groups, aryl groups or aryl groups containing C1-C5 alkyl substituent groups, and R7 is selected from methyl and / or ethyl. When the double-center non-metallocene catalyst provided by the invention is used for catalyzing a polymerization reaction of butene-1 and long-chain alpha-olefin, the insertion rate of an alpha-olefin monomer with large steric hindrance can be increased, and the growth of a polymerization chain is facilitated; and the butene-1-based elastomer material with large molecular weight, narrow molecular weight distribution, low glass transition temperature and high random copolymerization unit content can be prepared.

The invention relates to the technical field of biological medicine, in particular to a TREM-1 targeted fluorescent molecular probe as well as a preparation method and application thereof, and discloses a fluorescent molecular probe named as' TREM-1 targeted fluorescent molecular probe as well as a preparation method and application thereof '. The invention aims to solve the problems of large molecular weight, poor pharmacokinetic performance, limited tissue penetration, high imaging background and poor imaging timeliness of the existing antibody fluorescent probe. The probe comprises a TREM-1 targeting module (TDM), a near-infrared fluorescence reporter group, a dark quenching group and a conformational sensitive connecting arm (CSL). The fluorescence of the probe is quenched before the probe is combined with TREM-1, and after the probe is combined with a target spot, TDM specific binding induces CSL conformation rearrangement, so that a reporter group and a quenching group are spatially separated, fluorescence resonance energy transfer (FRET) is relieved, and fluorescence activation is realized. According to the invention, rapid, high-contrast and low-background fluorescence imaging of atherosclerotic plaques is realized, and the probe is small in molecular size, strong in tissue penetrability and rapid in-vivo clearing.

The invention relates to the technical field of olefin polymerization, in particular to a catalyst component for preparing a propylene polymer, the propylene polymer and a synthesis method of the propylene polymer. When the melt index of the propylene polymer is 2g / 10min to 20g / 10min, the z-average molecular weight of the propylene polymer is greater than or equal to 1,000,000; when the isotacticity of the propylene polymer is greater than or equal to 96%, mmmm% in boiling heptane insoluble substances is greater than or equal to 89%; the bending elastic modulus of the propylene polymer is greater than or equal to 1.3 GPa, the tensile yield stress is greater than or equal to 32 MPa, and the cantilever beam notch impact strength is greater than or equal to 40 J / m; the polymer contains a part of molecules with particularly large molecular weight, and the part of macromolecules have relatively regular molecular chains, so that the polymer is excellent in rigid-tough balance, and particularly high in modulus.

The invention belongs to the technical field of biological detection, and particularly relates to a detection method and a detection kit for oxidized low-density lipoprotein. The invention provides a novel application of quaternary ammonium salt chitosan in a kit, and particularly relates to application of quaternary ammonium salt chitosan with different molecular weights in an immunoturbidimetry detection process of oxidized low-density lipoprotein. When high-molecular-weight quaternized chitosan with the molecular weight of 100-200 kDa and low-molecular-weight quaternized chitosan with the molecular weight of 30-50 kDa are used as components of the oxidized low-density lipoprotein detection kit, the quaternized chitosan with different molecular weights can react with citrate radicals to form gel particles with different mechanical strengths; the content of the oxidized low-density lipoprotein can be detected through immunoturbidimetry, and the sensitivity and the linear range of the oxidized low-density lipoprotein detection kit are greatly improved and widened by using the quaternized chitosan with different molecular weights.

The application provides a layer-by-layer self-assembly nanofiltration membrane, a preparation method and application thereof. The layer-by-layer self-assembly nanofiltration membrane comprises a base film and a self-assembly coating layer formed on the base film, wherein the self-assembly coating layer comprises at least a starting alternating coating layer and a separation alternating coating layer; the molecular weight cut-off of the base film is not less than 500 kDa; the starting alternating coating layer is alternately assembled by a high-molecular-weight cationic polyelectrolyte layer and an anionic polyelectrolyte layer; the separation alternating coating layer is alternately assembled by a low-molecular-weight cationic polyelectrolyte layer and an anionic polyelectrolyte layer; the starting alternating coating layer is formed on the base film, and the high-molecular-weight cationic polyelectrolyte layer in the starting alternating coating layer adopts a cationic polyelectrolyte with a number-average molecular weight of not less than 500 kDa; and the low-molecular-weight cationic polyelectrolyte layer in the separation alternating coating layer adopts a cationic polyelectrolyte with a number-average molecular weight of not more than 100 kDa. The layer-by-layer self-assembly nanofiltration membrane has more excellent permeability and micro-pollutant rejection rate.

The invention provides segmented aliphatic polycarbonate capable of introducing an unsaturated functional group. The segmented aliphatic polycarbonate has a structure as shown in a formula I, r1 is selected from substituent groups on side chains after ring-opening copolymerization of epoxy compounds as shown in formulas 101-108 and dioxo ring carbon or cyclic anhydride; the structure of R2 is formed after ring opening of cyclic anhydride and an epoxy compound; n and m are both non-zero natural numbers. According to the polymer, a polyester domain is introduced on the basis of high-molecular-weight aliphatic polycarbonate for segmentation, and a polymer chain is converted into a sectional structure, so that the mechanical property of the polymer can be greatly adjusted. # imgabs0 #

The present invention relates to a polymeric microparticle with dual size pores, and a preparation method therefor. The polymeric microparticle is formed by cross-linking at least partially cross-linkable oligomer materials, including rigid nanoparticles, wherein at least one of the rigid nanoparticles has a non-spherical shape in a solution. The polymeric microparticles have two sets of pores having distinctive sizes distributed inside, wherein the first set of pores are macropores larger in size, and the second set of pores are gel pores that are smaller in size and formed internal structural ordering at least in regions. While ensuring the ordering of molecules and pores of the original polymeric microparticles, the present invention allows for a second, larger pores within the polymeric microparticles, which can improve the permeability of the separation matrice and enable use in separation for larger molecular weight biomolecules, and thereby expanded the separation range of the polymeric microparticles in chromatographic analysis. In addition, ordered pore arrangement, which is formed locally inside the microparticle, provides excellent mechanical properties and separation effect.

The invention relates to a specifically degraded KIM1 liposome, preparation thereof and application of the specifically degraded KIM1 liposome in preparation of medicines for treating kidney diseases, and belongs to the technical field of biological medicines. According to the invention, a KIM1 targeting polypeptide and an E3 ubiquitin ligase ligand (such as lenalidomide) are respectively modified on the surface of a liposome. The lipidosome capable of specifically degrading the KIM1 can be rapidly enriched in a damaged kidney after renal injury occurs, and the KIM1 protein level in the damaged kidney is degraded by 75%. Meanwhile, the druggability problems of poor solubility, low bioavailability and the like caused by large molecular weight of the compound in the PROTAC drug development process are avoided, and the technical problems that drugs are difficult to prepare and kidney injury drugs are lacked in the prior art are solved.