89 results about "Triazine derivative" patented technology

The invention relates to the field of pouring sealants, and discloses a modified epoxy resin pouring sealant and a preparation method thereof, the pouring sealant comprises epoxy resin, a modified inorganic filler, a modified additive and an auxiliary agent; the modified inorganic filler is prepared by grafting a quaternized s-triazine derivative and an inorganic filler; the quaternized s-triazine derivative is prepared through the steps that 3, 5-diaminophenylboronic acid, cyanuric chloride, 3-chloropropyltrimethoxysilane and 1, 4-butanediamine are sequentially subjected to substitution to prepare a s-triazine derivative, then the s-triazine derivative reacts with N, N-dimethyl-1, 3-diaminopropane, and bromoethane is used for quaternization treatment. The modified additive is prepared from a modified bismaleimide monomer prepared from maleic anhydride and 5 (6)-amino-1-(4-aminophenyl)-1, 3, 3-trimethylindane and 1-methyl-4-isopropyl cyclohexene through a self-stabilization precipitation polymerization method, the prepared pouring sealant is high in tensile strength, good in impact resistance and good in mechanical property, and the prepared pouring sealant has the advantages of being good in mechanical property, good in mechanical property and good in mechanical property. Meanwhile, good heat resistance, flame retardance, dielectricity and antibacterial activity are achieved.

The invention discloses a triazine desulfurizer and a preparation method thereof, and belongs to the technical field of gas purification. The triazine desulfurizer is mainly prepared from the following raw materials in percentage by weight: 20 to 50 weight percent of triazine derivative, 10 to 15 weight percent of sterically hindered amine, 3 to 7 weight percent of stabilizer, 1 to 3 weight percent of synergist, 0.5 to 1.5 weight percent of penetrant, 0.5 to 1.5 weight percent of inhibitor, 1 to 2 weight percent of additive and the balance of water, the preparation method of the triazine derivative comprises the following steps: adding 2-(diphenylphosphino) ethylamine into a toluene solvent, adding a paraformaldehyde aqueous solution in batches under a stirring condition, and reacting for 2-8 hours to obtain the triazine derivative. According to the triazine desulfurizer and the preparation method thereof provided by the invention, the triazine derivative and the sterically hindered amine are taken as a host, and the stabilizer, the synergist, the penetrant, the inhibitor and the assistant are compounded, so that the scaling trend of the triazine desulfurizer in an oil and gas well can be slowed down, the dissolution rate of hydrogen sulfide and the mass transfer rate in a solution are increased, and the desulfurization reaction is promoted; the desulfurization effect and the desulfurization rate are improved, and meanwhile, a very good scale inhibition effect is also achieved.

The invention provides a liquid sulfur removal agent and a preparation method thereof, and belongs to the technical field of natural gas hydrogen sulfide removal treatment.The liquid sulfur removal agent comprises, by weight, 36-66% of s-triazine derivatives, 5-8% of sulfolane, 2-5% of a pH control agent, 10-12% of a stabilizer, 5-8% of a scale inhibitor, 1-2% of a bactericide and the balance deionized water; wherein the s-triazine derivative is selected from a mixture of hexahydro-1, 3, 5-triacetyl-hexahydros-triazine, 1, 3, 5-triacetyl-hexahydros-triazine and 1, 3, 5-triazinane-2, 4-diketone, and the structural formula of the s-triazine derivative is shown in the description. The liquid sulfur removal agent is high in sulfur removal efficiency, good in corrosion inhibition and sterilization performance and not prone to scaling.

Disclosed in the present invention are a triazine derivative, a preparation method therefor and the use thereof, belonging to the technical field of drug synthesis. Specifically, disclosed in the present invention are a triazine derivative represented by general formula (I), a pharmaceutical composition containing the triazine derivative, and the use thereof in the preparation of an anthelmintic drug for humans or animals. The general structural formula (I) of the triazine derivative is shown as follows. The triazine derivative of the present invention has a significant effect in resisting zoonotic helminths such as nematodes and heartworms, and has a broad application prospect.

Provided herein is a compound of formula (I) wherein R1, R2, n, X, Q, L, m, R3 and p are as defined herein, which compounds are useful in the treatment of diseases characterized by impaired neurotrophin and / or other trophic factor signaling, such as Alzheimer's disease and the like.

The present invention relates to specific deuterated spirocarbazole-triazine derivatives, mixtures and formulations comprising the same, and to electronic devices comprising these compounds, in particular organic electroluminescent devices comprising these compounds as matrix material, electron transport material or hole blocking material.

The invention relates to an extraction agent and an extraction method, and relates to the technical field of wet extraction of industrial solid waste, and the extraction agent comprises the following components in parts by mass: an extraction main agent, an anti-impurity stabilizer and an extraction aid; the extraction main agent comprises di (2-ethylhexyl) phosphate and mono (2-ethylhexyl) phosphate, the impurity-resistant stabilizer comprises an imidazoline derivative, a triazine derivative and dimethyl methylphosphonate, and the extraction assistant comprises isooctyl alcohol; the extraction method comprises the steps of ash ball preparation, impurity removal, extraction and the like. According to the extraction agent and the extraction method, interference impurities such as trace heavy metal ions, sulfides and cyanides generated due to component fluctuation in the purified ash of the calcium carbide furnace are selectively chelated, the impurities are prevented from being combined with the extraction main agent, and then the anti-interference stability of the extraction agent under the condition that the impurity content of the purified ash of the calcium carbide furnace fluctuates is improved; and the control difficulty in the production process is reduced.

The invention discloses a TADF luminescent material and a preparation method thereof, and relates to the technical field of organic optoelectronics, the molecular structure of the material comprises a phenyl triazine derivative electron-deficient core as an electron acceptor and a carbazole or tert-butyl carbazole electron-rich group as an electron donor; an aggregation-induced emission mechanism is introduced into the thermally activated delayed fluorescence material, so that the aggregation-induced quenching problem of a traditional thermally activated delayed fluorescence material and the exciton annihilation effect under high brightness are effectively solved, and meanwhile, the defect that a traditional aggregation-induced emission molecule is low in electroluminescence efficiency is overcome; the material can be used for preparing a non-doped organic electroluminescent device, the process is simplified, the cost is reduced, and the material has application potential in the field of intelligent response materials.

The invention belongs to the technical field of optical adhesives, and discloses an upper and lower glass substrate bonding sealant and application thereof, the sealant comprises the following raw materials: urethane acrylate, isobornyl acrylate, a photoinitiator, a cross-linking agent, a multifunctional stabilizer, modified nano silicon dioxide and a polymerization inhibitor; the multifunctional stabilizer is a triazine derivative containing a hindered phenol antioxidant structure, a benzotriazole ultraviolet light absorber structure and a long-chain alkyl structure; the modified nano silicon dioxide is core-shell nanoparticles formed by in-situ growth of nano cerium dioxide on the surface of mesoporous silicon dioxide loaded with a hindered amine light stabilizer; the liquid optical sealant is prepared from polyurethane acrylate and isobornyl acrylate, and the multifunctional stabilizer and the modified nano silicon dioxide are compounded, so that the liquid optical sealant has optical transparency, bonding sealing performance, weather-resistant stability and mechanical enhancement, and is adaptive to the fitting scene of upper and lower glass substrates.

The invention belongs to the technical field of photoresist, and particularly relates to a triazinyl negative photoresist composition for an organic insulating film, which comprises the following components in parts by mass: 30-100 parts of a polymer containing a triazine structure; 5-65 parts of an unsaturated compound containing an olefinic bond; 0.005 to 10 parts of a surface active agent; 0.005 to 10 parts of an adhesion promoter; 0.005 to 30 parts of a free radical polymerization initiator; and 100 to 2000 parts of a solvent. According to the invention, a polyfunctional group triazine derivative participates in a free radical addition reaction, a poly (methyl) acrylate polymer containing a triazine structure is synthesized, and by regulating and controlling the type and number of functional groups of monomers participating in the reaction and the alkyl chain length and introducing aryl or naphthenic base, the polyfunctional group-containing poly (methyl) acrylate polymer is obtained. The hydrophilic-hydrophobic property, the temperature resistance and the chemical resistance of the polymer can be accurately adjusted.

Cyclopropyl N-[(S)-[3-[1-(2,2-difluoropropylcarbamoyl)-3-hydroxy-3-methyl- cyclobutyl]imidazo[1,2-b][1,2,4]triazin-6-yl]-[4- (trifluoromethyl)cyclohexyl]methyl]carbamate, or a pharmaceutically acceptable salt thereof, being a potent modulator of human IL-17 activity, is accordingly of benefit in the treatment and / or prevention of various human ailments, including inflammatory and autoimmune disorders.

N-[(S)-[3-[1-(2,2-difluoropropylcarbamoyl)-3-hydroxy-3-methyl- cyclobutyl]imidazo[1,2-b][1,2,4]triazin-6-yl]-[4-(trifluoromethyl)cyclohexyl]methyl]-4-5 methyl-1,2,5-oxadiazole-3-carboxamide, or a pharmaceutically acceptable salt and / or solvate thereof, being a potent modulator of human IL-17 activity, is accordingly of benefit in the treatment and / or prevention of various human ailments, including inflammatory and autoimmune disorders.

A medical rubber part in which non-elution characteristics are maintained even after sterilization with gamma ray, a packaging article for the medical rubber part, and a medical rubber composition for manufacturing the medical rubber part can be provided or implemented. The medical rubber composition can contain or comprise: a (a) base polymer containing a halogenated isobutylene-isoprene rubber; a (b) polyethylene; and a (c) triazine derivative as a crosslinking agent. A proportion of the triazine derivative contained per 100% by mole of a halogen of the halogenated isobutylene-isoprene rubber contained in the (a) base polymer can be 1% by mole to 15% by mole.

The invention relates to the technical field of medicine synthesis, in particular to a synthesis method and application of a 4H-pyrido [1, 2-a] pyrimidine-4-one-1, 3, 5-triazine derivative. The structure of the target compound is shown as a formula I. The preparation method of the 4H-pyrido [1, 2-a] pyrimidine-4-ketone-1, 3, 5-triazine derivative comprises the following step: reacting a compound shown in a formula I with a compound shown in a formula II in the presence of acetonitrile, secondary amine and anhydrous potassium carbonate to obtain the 4H-pyrido [1, 2-a] pyrimidine-4-ketone-1, 3, 5-triazine derivative. The 4H-pyrido [1, 2-a] pyrimidine-4-ketone-1, 3, 5-triazine derivative disclosed by the invention has a relatively good anti-tumor effect, and is characterized by relatively strong tumor cell growth inhibition activity.

There is provided a compound of formula I, (I) wherein R1 and R2 are as defined herein, which compounds are useful in the treatment of diseases characterised by impaired signalling of neurotrophins and / or other trophic factors, such as Alzheimer's disease and the like.

This research focuses on the preparation and application of guanidine-based ionic porous organic polymers for gold extraction from water, belonging to the field of porous organic polymer materials. Four guanidine-based ionic covalent organic framework materials (Ionic-COF-X, X:Cl) with different counterions were synthesized by reacting ionic guanidine hydrochloride monomers as organic linkers with aromatic ring-substituted triazine derivative ligands (TFBT), followed by anion exchange. ‑ ,Br ‑ AcO ‑ and SO4 2‑ A guanidine-based porous ionic polymer material (PiP-1) was obtained by reacting an ionic guanidine hydrochloride monomer as an organic linker with an aromatic ring-substituted benzimidazole derivative ligand (BDBI). PiP-1 was then applied to the adsorption and removal of gold ions in solution. It exhibited extremely high saturation adsorption capacity, rapid adsorption kinetics, high selectivity, and recyclability, showing potential for gold adsorption in practical applications.

The invention discloses a mixed type triazinyl crude oil desulfurizing agent which is prepared from the following raw materials in percentage by mass: 40-70% of triazine derivative, 10-30% of alkaline additive, 5-15% of dispersing agent, 2-10% of surfactant and the balance of solvent. The preparation method of the desulfurizer comprises the following steps: 1, weighing raw materials; 2, mixing, heating and stirring the weighed triazine derivative and the solvent; 3, sequentially adding an alkaline auxiliary agent, a dispersing agent and a surfactant, maintaining the temperature, and continuously stirring; 4, cooling to room temperature, and filtering; 5, performing reduced pressure distillation to obtain a finished product. According to the desulfurizing agent, more active intermediates are generated through the synergistic effect of the added alkaline auxiliary agent and the triazine derivative, the activity of the desulfurizing agent is improved, and the dispersing agent and the surfactant are added to promote dispersion stability of triazine-based particles and improve the contact efficiency with sulfide, so that the desulfurizing efficiency of the desulfurizing agent is improved; the reaction temperature and the addition amount are reduced, and the application range of the desulfurizing agent is expanded.

The present disclosure relates to antibody-drug conjugates, wherein the drug is a pyrazolo[1,5-a][1,3,5]triazine derivative or a pyrazolo[1,5-a]pyrimidine derivative. In particular, the drug may be a 2-substituted 8-halogeno-N4-(4-(pyridine-2-yl)benzyl)pyrazolo[1,5-a][1,3,5]triazine-2,4-diamine. Such antibody-drug conjugates are particularly useful in treating proliferative diseases, including cancer.

The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Furthermore, the present invention provides a crystalline form useful as an active pharmaceutical ingredient, and a pharmaceutical composition comprising the same.A compound represented by Formula (I):wherein Y is N or the like; R1 is substituted or unsubstituted aromatic heterocyclyl or the like; R2 is substituted or unsubstituted aromatic carbocyclyl or the like; R3 is substituted or unsubstituted aromatic heterocyclyl or the like; —X— is —NH— or the like; m is 1 or the like; R5a is each independently a hydrogen atom or the like; R5b is each independently a hydrogen atom or the like; n is 1 or the like; R4a is each independently a hydrogen atom or the like; and R4b is each independently a hydrogen atom or the like,or a pharmaceutically acceptable salt thereof.

N-[(S)-(4, 4-difluorocyclohexyl) {3-[1-(2, 2-difluoropropylcarbamoyl)-3-hydroxy-3-methylcyclobutyl] imidazo [1, 2-b] [1, 2, 4] triazin-6-yl} methyl]-4-methyl-1, 2, 5-oxadiazole-3-carboxamide, or a pharmaceutically acceptable salt thereof, is a potent modulator of human IL-17 activity, and is therefore of benefit in the treatment and / or prevention of a variety of human diseases, such as, for example, human IL-17. Inflammatory and autoimmune disorders are included.

The invention provides a strong-conjugation high-polarity ultraviolet absorbent as well as a preparation method and application thereof. According to the invention, a triazine derivative structure of a hyperconjugated system of (para-ester-triazine-BP-2-triazine-para-ester) is designed, the conjugated system is extended, charges in molecules are transferred, an ultraviolet absorption spectrum is widened, and an ultraviolet light absorber with a strong absorption effect on UVA and UVB is formed. The para-ester is introduced into the ultraviolet absorbent, and the vinyl sulfone group of the para-ester can be subjected to Michael addition reaction with amino (-NH2) in nylon to form a stable covalent bond, so that the ultraviolet absorbent is firmly combined on nylon fibers, and the washability is enhanced.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of a 1, 2, 4-triazine derivative. The 1, 2, 4-triazine derivative is prepared by taking a compound I and an amine compound (a compound II and / or an acid salt thereof) as initial raw materials, taking dimethyl sulfoxide as a solvent and an oxidizing agent and carrying out one-step efficient oxidation tandem cyclization reaction in the presence of a halogen simple substance. The preparation method provided by the invention has the advantages of simple steps, high yield, avoidance of use of highly corrosive hydrobromic acid and highly toxic selenium dioxide, mild reaction conditions and low production cost, and is suitable for large-scale production. Moreover, according to the preparation method provided by the invention, no unstable intermediate is generated, byproducts are few, and the high-purity 1, 2, 4-triazine derivative can be obtained through simple post-treatment steps.

The present invention provides a compound of formula (I) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective SGK1 inhibitors. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of treating disorders associated with serum and glucocorticoid regulated kinase 1 (SGK1) activity, such as cardiovascular disorders, fibrotic diseases, metabolic diseases, immune and inflammatory diseases, nervous system disorders and cancer, by using the compounds and pharmaceutical compositions.

Compounds are provided which can inhibit KRAS G12D. Also provided are pharmaceutical compositions and medical uses of the same, including the use in treating or preventing conditions such as cancers.

The application discloses a compound taking triazine derivatives as a core and an application thereof, and belongs to the technical field of semiconductors. The structure of the compound provided by the application is shown in general formula (1). The compound provided by the application contains a triazine parent nucleus structure, has suitable HOMO and LUMO energy levels, and has a high triplet energy level (T1). When the compound is applied to an OLED device, the driving voltage of the device can be effectively reduced, and the current efficiency and service life of the device are improved.

The invention relates to the technical field of synthesis of flame retardants, in particular to a preparation method and application of a phosphorus-containing triazine derivative flame retardant. The method comprises the following steps: by taking 1, 3, 5-triacryloylhexahydro-1, 3, 5-triazine as a raw material and 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide as a reaction reagent, reacting at the reaction temperature of 110-120 DEG C for 2-4 hours, thereby obtaining the phosphorus-containing triazine derivative flame retardant. And carrying out Michael addition reaction to prepare the phosphorus-containing triazine derivative, and purifying to obtain the refined phosphorus-containing triazine derivative. And carrying out melt blending on the obtained phosphorus-containing triazine derivative and polyethylene glycol terephthalate (PET). The preparation method has the advantages of simple process, mild conditions and the like, the synthesized product has the advantages of efficient flame retardance, compatibility, mechanical property maintenance, environmental friendliness and the like, the high-performance flame-retardant PET material can be prepared by introducing the flame-retardant PET material into a PET matrix, and the requirements in the fields of electronics, automobiles, buildings and the like are met.

The present disclosure provides compounds of Formula I, pharmaceutical salts thereof, and / or solvates of any of the foregoing which are useful for treating diseases and conditions related to mutant KIT and PDGFRa and present an advantageously non-brain penetrant profile for treating diseases and conditions related to mutant KIT and PDGFRa. The present disclosure also provides methods for treating gastrointestinal stromal tumors and systemic mastocytosis.