145 results about "Triazine derivative" patented technology

The present invention provides a pharmaceutical composition comprising a compound exhibiting coronavirus proliferation inhibitory activity.A pharmaceutical composition comprising a compound represented by the formula: wherein Y is N; R1 is substituted or unsubstituted aromatic heterocyclyl; R2 is substituted or unsubstituted 6-membered aromatic carbocyclyl; R3 is substituted or unsubstituted aromatic heterocyclyl; —X— is —NH—; m is 0 or 1; R5a is a hydrogen atom; R5b is a hydrogen atom; n is 1; R4a is a hydrogen atom; and R4b is a hydrogen atom, or a pharmaceutically acceptable salt thereof.

The invention belongs to the technical field of high polymer materials, and discloses a corrosion-resistant buried polyolefin drainage pipe and a preparation method thereof.The corrosion-resistant buried polyolefin drainage pipe is prepared from, by mass, 100-120 parts of high-density polyethylene, 20-30 parts of ABS resin, 5-10 parts of plasticizer, 10-15 parts of modified boron nitride, 0.5-2 parts of composite flame retardant, 0.1-0.5 part of antioxidant, 3-5 parts of calcium stearate and 1-3 parts of PE wax; the modified boron nitride is a triazine derivative which is grafted on the surface of hexagonal boron nitride and contains a plurality of benzisothiazolinone units; the composite flame retardant is compounded by a phosphorus-containing Schiff base flame retardant and DOPO according to the mass ratio of 1: (2-4); the high-density polyethylene is used as a matrix, the modified boron nitride is added, so that the corrosion resistance of the material is improved, the phosphorus-containing Schiff base flame retardant is compounded with DOPO, the flame retardance of the material is improved, and meanwhile, the dosage of DOPO is reduced.

The present invention relates to novel compounds for the treatment, alleviation or prevention of a group of diseases, disorders and abnormalities which are responsive to the modulation or inhibition of the activation of a component of the NLRP3 inflammasome pathway. In particular, the component of the inflammasome pathway is a NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome. More particularly, the compounds of the present invention have the capability to modulate the NLRP3 inflammasome pathway. Further, the compounds of the present invention are suitable for the treatment, alleviation or prevention of a group of diseases, disorders and abnormalities which are responsive to the modulation, in particular decrease, of IL-1 beta and / or IL-18 levels.

The invention relates to the field of pouring sealants, and discloses a modified epoxy resin pouring sealant and a preparation method thereof, the pouring sealant comprises epoxy resin, a modified inorganic filler, a modified additive and an auxiliary agent; the modified inorganic filler is prepared by grafting a quaternized s-triazine derivative and an inorganic filler; the quaternized s-triazine derivative is prepared through the steps that 3, 5-diaminophenylboronic acid, cyanuric chloride, 3-chloropropyltrimethoxysilane and 1, 4-butanediamine are sequentially subjected to substitution to prepare a s-triazine derivative, then the s-triazine derivative reacts with N, N-dimethyl-1, 3-diaminopropane, and bromoethane is used for quaternization treatment. The modified additive is prepared from a modified bismaleimide monomer prepared from maleic anhydride and 5 (6)-amino-1-(4-aminophenyl)-1, 3, 3-trimethylindane and 1-methyl-4-isopropyl cyclohexene through a self-stabilization precipitation polymerization method, the prepared pouring sealant is high in tensile strength, good in impact resistance and good in mechanical property, and the prepared pouring sealant has the advantages of being good in mechanical property, good in mechanical property and good in mechanical property. Meanwhile, good heat resistance, flame retardance, dielectricity and antibacterial activity are achieved.

The invention discloses a triazine desulfurizer and a preparation method thereof, and belongs to the technical field of gas purification. The triazine desulfurizer is mainly prepared from the following raw materials in percentage by weight: 20 to 50 weight percent of triazine derivative, 10 to 15 weight percent of sterically hindered amine, 3 to 7 weight percent of stabilizer, 1 to 3 weight percent of synergist, 0.5 to 1.5 weight percent of penetrant, 0.5 to 1.5 weight percent of inhibitor, 1 to 2 weight percent of additive and the balance of water, the preparation method of the triazine derivative comprises the following steps: adding 2-(diphenylphosphino) ethylamine into a toluene solvent, adding a paraformaldehyde aqueous solution in batches under a stirring condition, and reacting for 2-8 hours to obtain the triazine derivative. According to the triazine desulfurizer and the preparation method thereof provided by the invention, the triazine derivative and the sterically hindered amine are taken as a host, and the stabilizer, the synergist, the penetrant, the inhibitor and the assistant are compounded, so that the scaling trend of the triazine desulfurizer in an oil and gas well can be slowed down, the dissolution rate of hydrogen sulfide and the mass transfer rate in a solution are increased, and the desulfurization reaction is promoted; the desulfurization effect and the desulfurization rate are improved, and meanwhile, a very good scale inhibition effect is also achieved.

The invention provides a liquid sulfur removal agent and a preparation method thereof, and belongs to the technical field of natural gas hydrogen sulfide removal treatment.The liquid sulfur removal agent comprises, by weight, 36-66% of s-triazine derivatives, 5-8% of sulfolane, 2-5% of a pH control agent, 10-12% of a stabilizer, 5-8% of a scale inhibitor, 1-2% of a bactericide and the balance deionized water; wherein the s-triazine derivative is selected from a mixture of hexahydro-1, 3, 5-triacetyl-hexahydros-triazine, 1, 3, 5-triacetyl-hexahydros-triazine and 1, 3, 5-triazinane-2, 4-diketone, and the structural formula of the s-triazine derivative is shown in the description. The liquid sulfur removal agent is high in sulfur removal efficiency, good in corrosion inhibition and sterilization performance and not prone to scaling.

Disclosed in the present invention are a triazine derivative, a preparation method therefor and the use thereof, belonging to the technical field of drug synthesis. Specifically, disclosed in the present invention are a triazine derivative represented by general formula (I), a pharmaceutical composition containing the triazine derivative, and the use thereof in the preparation of an anthelmintic drug for humans or animals. The general structural formula (I) of the triazine derivative is shown as follows. The triazine derivative of the present invention has a significant effect in resisting zoonotic helminths such as nematodes and heartworms, and has a broad application prospect.

The present invention relates to novel compounds for the treatment, alleviation or prevention of a group of diseases, disorders and abnormalities which are responsive to the modulation or inhibition of the activation of a component of the NLRP3 inflammasome pathway. In particular, the component of the inflammasome pathway is a NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome. More particularly, the compounds of the present invention have the capability to modulate the NLRP3 inflammasome pathway. Further, the compounds of the present invention are suitable for the treatment, alleviation or prevention of a group of diseases, disorders and abnormalities which are responsive to the modulation, in particular decrease, of IL-1 beta and / or IL-18 levels.

The invention relates to the technical field of materials, and discloses a high-flame-retardancy low-smoke halogen-free cable sheath material and a preparation method thereof.The cable sheath material is prepared by taking a polyvinyl base material as a main raw material and taking a flexibilizer, a flame retardant and the like as auxiliary materials through mixing and extrusion processes; wherein the flame retardant is prepared by cross-linking galactomannan by using a triazine derivative containing a phosphorus flame-retardant element in the structure as a cross-linking agent, the galactomannan can be used as a carbon source, a triazine ring can be used as a nitrogen source, and the phosphorus flame retardant can be used as an acid source, so that a three-element integrated intumescent flame-retardant system can be formed, and the flame-retardant effect is good when combustion occurs. An expanded carbon layer can be rapidly formed on the surface of the sheath material, the expanded carbon layer can effectively isolate oxygen, heat and a fire source, then the flame retardant property of the sheath material is effectively improved, the aerogel structure has rich pores, smoke formed by combustion can be effectively absorbed, and the flame retardant property of the sheath material is improved. Therefore, low-smoke halogen-free modification of polyethylene is realized.

The invention relates to the technical field of epoxy resin, in particular to an optical epoxy resin molding compound and a preparation method and application thereof. The coating comprises the following components: a colorant, epoxy resin, an antioxidant, a curing agent and an auxiliary agent, the color agent comprises an ultraviolet absorbent and a blue light absorbent; the epoxy resin comprises triazine skeleton epoxy resin. The toner comprises an ultraviolet absorbent and a blue light absorbent, and the epoxy resin comprises triazine skeleton epoxy resin, so that light rays below 460 nm can be effectively shielded, the transmittance of light rays above 500 nm reaches 85% or above, and meanwhile, excellent high-temperature resistance is achieved; the ultraviolet absorbent comprises a triazine ultraviolet absorbent, and the blue light absorbent comprises a triazine derivative structure of an isoindolinone heterocyclic skeleton, so that the numerical value of 460 nm light transmittance / 500 nm light transmittance can be reduced to 0.5 or below.

The invention discloses a corrosion inhibitor capable of resisting H2S and CO2 corrosion at high temperature and a preparation method thereof, and belongs to the technical field of synthesis of corrosion inhibitors, and the corrosion inhibitor is finally obtained by dissolving a triazine derivative in an organic solvent, adding a halide for reaction, firstly performing vacuum concentration after the reaction is finished, then adding an anti-solvent for precipitation, performing suction filtration and washing. According to the corrosion inhibitor capable of resisting H2S and CO2 corrosion at the high temperature and the preparation method of the corrosion inhibitor, a triazine ring, a benzene ring, a naphthalene ring, hydroxyl, sulfydryl, cyano, amino and the like are introduced into corrosion inhibitor molecules, the binding energy of the molecules and metal Fe atoms is increased, binding is firmer, the corrosion inhibitor is of a quaternary ammonium salt structure, and the corrosion inhibitor can be used for resisting H2S and CO2 corrosion at the high temperature. Due to the excellent water solubility, the corrosion inhibitor can form a homogeneous mixture with water to be in full contact with the surface of steel, so that the corrosion inhibition rate is higher than 90% under the working conditions that the temperature is higher than 90 DEG C, the degree of mineralization is higher than 18000 mg / L and CO2 and H2S are rich, and the corrosion inhibitor has a good anti-corrosion effect on carbon steel and is small in dosage and free of pollution to the environment.

Provided herein is a compound of formula (I) wherein R1, R2, n, X, Q, L, m, R3 and p are as defined herein, which compounds are useful in the treatment of diseases characterized by impaired neurotrophin and / or other trophic factor signaling, such as Alzheimer's disease and the like.

The present invention relates to specific deuterated spirocarbazole-triazine derivatives, mixtures and formulations comprising the same, and to electronic devices comprising these compounds, in particular organic electroluminescent devices comprising these compounds as matrix material, electron transport material or hole blocking material.

The invention relates to an extraction agent and an extraction method, and relates to the technical field of wet extraction of industrial solid waste, and the extraction agent comprises the following components in parts by mass: an extraction main agent, an anti-impurity stabilizer and an extraction aid; the extraction main agent comprises di (2-ethylhexyl) phosphate and mono (2-ethylhexyl) phosphate, the impurity-resistant stabilizer comprises an imidazoline derivative, a triazine derivative and dimethyl methylphosphonate, and the extraction assistant comprises isooctyl alcohol; the extraction method comprises the steps of ash ball preparation, impurity removal, extraction and the like. According to the extraction agent and the extraction method, interference impurities such as trace heavy metal ions, sulfides and cyanides generated due to component fluctuation in the purified ash of the calcium carbide furnace are selectively chelated, the impurities are prevented from being combined with the extraction main agent, and then the anti-interference stability of the extraction agent under the condition that the impurity content of the purified ash of the calcium carbide furnace fluctuates is improved; and the control difficulty in the production process is reduced.

The invention discloses a TADF luminescent material and a preparation method thereof, and relates to the technical field of organic optoelectronics, the molecular structure of the material comprises a phenyl triazine derivative electron-deficient core as an electron acceptor and a carbazole or tert-butyl carbazole electron-rich group as an electron donor; an aggregation-induced emission mechanism is introduced into the thermally activated delayed fluorescence material, so that the aggregation-induced quenching problem of a traditional thermally activated delayed fluorescence material and the exciton annihilation effect under high brightness are effectively solved, and meanwhile, the defect that a traditional aggregation-induced emission molecule is low in electroluminescence efficiency is overcome; the material can be used for preparing a non-doped organic electroluminescent device, the process is simplified, the cost is reduced, and the material has application potential in the field of intelligent response materials.

The invention discloses a kind of preparation method of 1,2,4-benzotriazine derivatives, 1-(trifluoromethanesulfonyl)-1H-benzotriazole compound shown in formula II structure, bromoacetophenone compound shown in formula III structure, acid binding agent are added to reaction solvent and react and prepare.The present invention directly obtains 1,2,4-benzotriazine derivative I by the [5+1] cycloaddition tandem reaction of bromoacetophenone compound and 1-(trifluoromethanesulfonyl)-1H-benzotriazole.This reaction raw materials, catalyst and solvent are all commercialized and cheap and easy to obtain, reaction process is green and environmentally friendly, reaction conditions are mild, operation is convenient, substrate application range is wider, applied research is practical, with good application prospect.The method is suitable for industrialized production, solves the defect that reaction conditions are harsh in prior art, reaction reagent is expensive, reaction environment is unfriendly and is difficult to industrialized production.

The application provides a preparation method of a polysubstituted 1,3,5-triazine, and chemical formula 1 and biuret are reacted in a solvent under the action of a catalyst to generate an intermediate chemical formula 3, and the chemical formula 3 is reacted in a solvent under the action of an acid binding agent to generate chemical formula 4. Compared with the prior art, the two-step reaction is stable, the metal ion content is controlled in the ppb level, the application range is wide, and the method can be applied to multiple fields such as photoelectricity, chemical industry, medicine and agriculture.

The invention belongs to the technical field of optical adhesives, and discloses an upper and lower glass substrate bonding sealant and application thereof, the sealant comprises the following raw materials: urethane acrylate, isobornyl acrylate, a photoinitiator, a cross-linking agent, a multifunctional stabilizer, modified nano silicon dioxide and a polymerization inhibitor; the multifunctional stabilizer is a triazine derivative containing a hindered phenol antioxidant structure, a benzotriazole ultraviolet light absorber structure and a long-chain alkyl structure; the modified nano silicon dioxide is core-shell nanoparticles formed by in-situ growth of nano cerium dioxide on the surface of mesoporous silicon dioxide loaded with a hindered amine light stabilizer; the liquid optical sealant is prepared from polyurethane acrylate and isobornyl acrylate, and the multifunctional stabilizer and the modified nano silicon dioxide are compounded, so that the liquid optical sealant has optical transparency, bonding sealing performance, weather-resistant stability and mechanical enhancement, and is adaptive to the fitting scene of upper and lower glass substrates.

The invention belongs to the technical field of photoresist, and particularly relates to a triazinyl negative photoresist composition for an organic insulating film, which comprises the following components in parts by mass: 30-100 parts of a polymer containing a triazine structure; 5-65 parts of an unsaturated compound containing an olefinic bond; 0.005 to 10 parts of a surface active agent; 0.005 to 10 parts of an adhesion promoter; 0.005 to 30 parts of a free radical polymerization initiator; and 100 to 2000 parts of a solvent. According to the invention, a polyfunctional group triazine derivative participates in a free radical addition reaction, a poly (methyl) acrylate polymer containing a triazine structure is synthesized, and by regulating and controlling the type and number of functional groups of monomers participating in the reaction and the alkyl chain length and introducing aryl or naphthenic base, the polyfunctional group-containing poly (methyl) acrylate polymer is obtained. The hydrophilic-hydrophobic property, the temperature resistance and the chemical resistance of the polymer can be accurately adjusted.

Cyclopropyl N-[(S)-[3-[1-(2,2-difluoropropylcarbamoyl)-3-hydroxy-3-methyl- cyclobutyl]imidazo[1,2-b][1,2,4]triazin-6-yl]-[4- (trifluoromethyl)cyclohexyl]methyl]carbamate, or a pharmaceutically acceptable salt thereof, being a potent modulator of human IL-17 activity, is accordingly of benefit in the treatment and / or prevention of various human ailments, including inflammatory and autoimmune disorders.

N-[(S)-[3-[1-(2,2-difluoropropylcarbamoyl)-3-hydroxy-3-methyl- cyclobutyl]imidazo[1,2-b][1,2,4]triazin-6-yl]-[4-(trifluoromethyl)cyclohexyl]methyl]-4-5 methyl-1,2,5-oxadiazole-3-carboxamide, or a pharmaceutically acceptable salt and / or solvate thereof, being a potent modulator of human IL-17 activity, is accordingly of benefit in the treatment and / or prevention of various human ailments, including inflammatory and autoimmune disorders.

A medical rubber part in which non-elution characteristics are maintained even after sterilization with gamma ray, a packaging article for the medical rubber part, and a medical rubber composition for manufacturing the medical rubber part can be provided or implemented. The medical rubber composition can contain or comprise: a (a) base polymer containing a halogenated isobutylene-isoprene rubber; a (b) polyethylene; and a (c) triazine derivative as a crosslinking agent. A proportion of the triazine derivative contained per 100% by mole of a halogen of the halogenated isobutylene-isoprene rubber contained in the (a) base polymer can be 1% by mole to 15% by mole.

The invention relates to the technical field of medicine synthesis, in particular to a synthesis method and application of a 4H-pyrido [1, 2-a] pyrimidine-4-one-1, 3, 5-triazine derivative. The structure of the target compound is shown as a formula I. The preparation method of the 4H-pyrido [1, 2-a] pyrimidine-4-ketone-1, 3, 5-triazine derivative comprises the following step: reacting a compound shown in a formula I with a compound shown in a formula II in the presence of acetonitrile, secondary amine and anhydrous potassium carbonate to obtain the 4H-pyrido [1, 2-a] pyrimidine-4-ketone-1, 3, 5-triazine derivative. The 4H-pyrido [1, 2-a] pyrimidine-4-ketone-1, 3, 5-triazine derivative disclosed by the invention has a relatively good anti-tumor effect, and is characterized by relatively strong tumor cell growth inhibition activity.

The present invention relates to a compound selected from novel triazine derivative compound, a pharmaceutically or sitologically acceptable salt thereof, a solvate thereof, or a stereoisomer thereof, and a use thereof. With a potent antibacterial effect, the amphiphilic triazine compound according to the present invention can be safely and effectively used as an excellent antibacterial composition and a therapeutic composition for microbial infectious diseases.

There is provided a compound of formula I, (I) wherein R1 and R2 are as defined herein, which compounds are useful in the treatment of diseases characterised by impaired signalling of neurotrophins and / or other trophic factors, such as Alzheimer's disease and the like.

This research focuses on the preparation and application of guanidine-based ionic porous organic polymers for gold extraction from water, belonging to the field of porous organic polymer materials. Four guanidine-based ionic covalent organic framework materials (Ionic-COF-X, X:Cl) with different counterions were synthesized by reacting ionic guanidine hydrochloride monomers as organic linkers with aromatic ring-substituted triazine derivative ligands (TFBT), followed by anion exchange. ‑ ,Br ‑ AcO ‑ and SO4 2‑ A guanidine-based porous ionic polymer material (PiP-1) was obtained by reacting an ionic guanidine hydrochloride monomer as an organic linker with an aromatic ring-substituted benzimidazole derivative ligand (BDBI). PiP-1 was then applied to the adsorption and removal of gold ions in solution. It exhibited extremely high saturation adsorption capacity, rapid adsorption kinetics, high selectivity, and recyclability, showing potential for gold adsorption in practical applications.

The invention belongs to the technical field of organic electroluminescent functional materials and devices, and particularly relates to a triazine derivative containing pyridine and carbazole substituent groups and application of the triazine derivative. According to the invention, pyridine and carbazole are introduced to a substituent group of triazine, so that a conjugated system of the material is enhanced, and the electron transport performance and thermal stability of the compound are improved. The organic electroluminescent device prepared from the organic electronic material has the advantages of lower driving voltage, higher external quantum efficiency and longer service life.

There is provided herein a compound of formula I,wherein R1, R2, n, X, Q, L, m, R3 and p are as defined herein, which compounds are useful in the treatment of treatment of diseases characterised by impaired signalling of neurotrophins and / or other trophic factors, such as Alzheimer's disease and the like.