The invention designs a preparation method and application of a polymer hollow microcapsule. The method comprises the following steps of using nano cellulose as an emulsifier of a Pickering emulsion,adding an initiator, a monomer and a cross-linking agent into a discontinuous phase of the emulsion, afterwards, using the Pickering emulsion as a template, and preparing the polymer hollow microcapsule through the polymerization and cross linking reactions, in a liquid drop of the emulsion, of the monomer. The nano cellulose used in the method has advantages of being good in biocompatibility, wide in source, low in cost, green and environmental friendly, and the like; the range of a polymer to which the method is applicable is wide; hydrophobic and hydrophilic polymer monomers can be selectedand used; an environmental stimuli-responsive polymer or a polymer with a special function, such as a pH (potential of Hydrogen)-response, temperature-response or conducting polymer and the like, canbe selected and used; moreover, the method is simple, convenient and quick; reaction conditions are simple; the polymer hollow microcapsule is adjustable in particle size, low in cost and easy in quantity production and the obtained polymer hollow microcapsule can be used for the entrapment and the controlled release of a medicine and can be widely applied to the fields of medicines, agricultureand the like.