The invention discloses multistage spray and fluidized drying equipment and relates to multistage spray and fluidized drying equipment with upward air exhausting. The multistage spray and fluidized drying equipment is satisfactory drying equipment applicable to various materials with different features, such as dairy products, mirco-encapsulated essence, coffee mate, yolk powder and fruit and vegetable powder. The multistage spray and fluidized drying equipment comprises a multistage spray drying tower, an in-tower fluidized bed, a cyclone separator, a bag-type dust collector, an external fluidized bed, a main tower air supply fan, a main tower air supply filter, a main tower air supply heater, an in-tower fluidized bed air supply fan, an in-tower fluidized bed air supply heater, an internal fluidized bed air supply filter, an external fluidized bed air supply fan, an external fluidized bed air supply heater, an external fluidized bed air supply filter, a bag-type dust collector off-gas exhausting machine, a bag-type dust collector fine-powder air supply fan, a bag-type dust collector fine-powder air supply filter, a main tower star-shaped discharging valve, a bag-type dust collector star-shaped discharging valve, a product powder distributor, a feed feeding and metering pump, a feed solution buffer tank and a waste heat recoverer.