756 results about "Guanidine" patented technology

The present invention relates to a compound represented by formula (I):

in which at least one of R³ and R⁴ is a group represented by formula (A):

where the structural variables are as defined herein. The compounds are useful for blocking sodium channels.

The present invention relates to compounds represented by formula (I):

in which at least one of R³ and R⁴ is a group represented by formula (A):

where the structural variables are defined herein. The compounds are useful for blocking sodium channels.

A solvent that reversibly converts from a nonionic liquid mixture to an ionic liquid upon contact with a selected trigger, e.g., contact with CO₂, is described. In preferred embodiments, the ionic solvent is readily converted back to the nonionic liquid mixture. The nonionic liquid mixture includes an amidine or guanidine or both, and water, alcohol, or a combination thereof. Single component amine solvents that reversibly convert between ionic and non-ionic states are also described. Some embodiments require increased pressure to convert; others convert at 1 atmosphere.

The present invention relates to guanidine compounds of the general formula I

corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof. The present compound further relates to the use of guanidine compounds as binding partners for 5-HT5 receptors for the treatment of diseases which are modulated by a 5-HT5 receptor activity, in particular for the treatment of neurodegenerative and neuropsychiatric disorders as well as the associated signs, symptoms and dysfunctions.

The present invention is directed towards an electrocoating composition comprising a cyclic guanidine.

Reversible switchable surfactants are provided. A surfactant is the salt of an amidine or guanidine having at least one R group that is a hydrophobic moiety selected from the group consisting of higher aliphatic moiety, higher siloxyl moiety, higher aliphatic/siloxyl moiety, aliphatic/aryl moiety, siloxyl/aryl moiety, and aliphatic/siloxyl/aryl moiety. The other R groups are smaller moieties such as H, C₁ to C₄ aliphatic or the like. The surfactant is turned on by a gas that liberates hydrogen ions, such as, for example, carbon dioxide, which liberates hydrogen ions in the presence of water. The surfactant is turned off by exposure to a flushing gas and/or heating. When “on” the surfactants are useful to stabilize emulsions, and when “off” they are useful to separate immiscible liquids or a liquid and a solid. The surfactants find uses in polymerization and in the oil industry.

The invention provides an antibacterial master batch based on a guanidinium polymer and a preparation method thereof. The antibacterial master batch comprises the following blended components: a matrix resin, a composite antibacterial agent and a dispersant, wherein, on the basis of 100 parts by weight of the matrix resin, the composite antibacterial agent is 10 to 30 parts by weight, the dispersant is 2 to 10 parts by weight, the matrix resin is at least one selected from the group consisting of low-density polyethylene and high-melt index polypropylene, and the composite antibacterial agentis a polyguanidine/polysilicate composite antibacterial agent and is prepared by mixing an aqueous solution of water-soluble polyguanidine inorganic acid salt or organic acid salt with an aqueous solution of water-soluble silicate and adding an aqueous solution of water-soluble metal salt. The antibacterial master batch is used for antimicrobial modification of polypropylene, and addition amount of the antibacterial master batch is 2 to 10 wt % of the matrix material polypropylene; prepared modified polypropylene has the advantages of high antibacterial efficiency, a white color, good washingfastness, etc.

Disclosed is an electrode whose surface includes an organic/inorganic composite porous coating layer comprising heat-absorbing inorganic particles and a binder polymer, wherein the heat-absorbing inorganic particle is at least one particle selected from the group consisting of antimony-containing compounds, metal hydroxides, guanidine-based compounds, boron-containing compounds and zinc tartrate compounds. A separator using the heat-absorbing inorganic particles as a component for forming or coating the separator, and an electrochemical device including the electrode and/or the separator are also disclosed. The separator using the heat-absorbing inorganic particles as a component for forming or coating the separator can ensure excellent thermal safety and minimizes degradation of the quality of a battery.

There is provided a series of substituted acyl guanidines of Formula (Ik)

or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R₂, R₃, R₄, R₅, R₂₅, R₂₆ and R₂₇ as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

The invention relates to multiple kinds of alkaline ionic liquids as well as preparation methods and application thereof. The alkaline ionic liquid provided by the invention mainly comprises a cation X<+> and an anion Y<->, wherein the precursor of the cation X<+> is choline, phosphine, guanidine or amine; and the precursor of the anion Y<-> is imidazole, phenol or alcohol. The alkaline ionic liquid is prepared from the precursors of the cation and anion at room temperature in a certain ratio. The ionic liquid synthesized in the invention can be applied to the absorption of acidic gases such as carbon dioxide and sulfur dioxide, the absorption and desorption effects are good and the ionic liquid can be recycled.

The inventions relate to antiseptic agents and the method for producing thereof and can be used as a broad-spectrum disinfectant in medicine, veterinary medicine, agriculture etc.

The method for producing of biocidal polyguanidine that comprises condensation polymerization of hexamethylenediamine with guanine salt additionally uses hydrazine hydrate during the condensation polymerization process, at the following ratio of components, mass %:

• • hexamethylenediamine 20-55
  • guanidine salt 25-65
  • hydrazine hydrate the rest.

Biocidal polyguanidine obtained by means of the above-mentioned method, with the following formula:

where

• • n—the number of links A in a single unit of the polymer chain, n=1-3;
  • m—the number of links B in a single unit of the polymer chain, m=2-10;
  • z—the number of single units in the polymer chain, z=4-20;
  • Acid—an acid.

The inventions allow obtaining a biocidal polyguanidine with high level of broad-spectrum antimicrobial activity.

The invention provides a preparation method for crustacean guanidine containing antimicrobial. The crustacean guanidine containing antimicrobial is compounded after the reaction of crustacean guanidine, chitosan, and surfactant. The preparation method has the procedure that the chitosan is dissolved in the acid containing water, when the temperature rises to 20-60 DEG C under stirring for 0.5-5 hour reaction, then the crustacean guanidine is added for 0.1-2 hours full reaction, and finally the surfactant evenly added and stired; and then the crustacean guanidine containing antimicrobial is made. The crustacean guanidine containing antimicrobial in the textile has the application that the padding process is used to ensure that the textile possesses antibiotic, moisturizing, and skin protecting functions. The application in the agriculture is realized by diluting the crustacean guanidine containing antimicrobial proportionately into operating liquid of definite consistence, then applying the operating liquid to the crops or fruit trees in the means of spray or irrigation. The crustacean guanidine containing antimicrobial can inhibit the microorganisms, can destroy virus, can preserve moisture, and can increase the yield.

The invention relates to a composition comprising polymerizable material and an anionic photocatalyst. The photocatalyst is a photolabile compound able to liberate a strong base having a pK.sub.a .gtoreq.12. The catalyst can be illustrated by the structural formula Z-A wherein Z is a photolabile group and A is a strong base, for example, a nitrogen containing compound such as, a secondary amine, a guanidine or amidine and Z is covalently bound to A.

Nondetonable, or low detonation sensitivity, substantially nontoxic liquid monopropellants are provided. The liquid propellants are formed from aqueous solutions of solid oxidizers in liquid oxidizers and water soluble liquid fuels and formulated to have a freezing point less than −10° C. Liquid oxidizers may be inorganic or organic aqueous solutions, with hydrogen peroxide being preferred. Preferred solid oxidizers are water soluble nitrates including ammonium dinitramide, aminoguanidine dinitrate, ammonium nitrate, hydroxylamine nitrate, hydrazine nitrate, guanidine nitrate and aminoguanidine nitrate. Preferred liquid fuels are water soluble alcohols, amines and amine nitrates, hydroxyethyl hydrazine, hydroxyethylhydrazine nitrate, cyanoguanidine, guanidines, aminoguanidines, triaminoguanidines, and their nitrate salts, ethanolamine dinitrate, ethylenediamine dinitrate, polyvinyl nitrate, and aziridine.

The invention provides a new chitosan derivate-chitosan biguanide muriate, its preparation and usage, in which, the repeat unit is 2-biguanide glucose muriate, the substitution degree of guanidine is 15-50%, and the molecular weight is 0.5-25 ten thousand. This invention uses the reaction of chitosan and dicyandiamide to prepare chitosan biguanide muriate, and has advantages of mild reaction conditions and fewer side effects. The product has good antibacterial activity and water solubility, and can be widely used in medicine, textile industry, agriculture and other fields.

The present invention relates to cyclic guanidines, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.

This disclosure relates to reagents, compositions, methods for stabilising RNA in an RNA-containing sample by contacting the sample with guanidine and a metal ion to form a stabilised RNA-containing composition in which the metal ion is present at a concentration which is no more than 20 mM, and the metal ion is derived from a metal other than from a Group 1 or Group 2 metal.

The invention relates to the field of inorganic materials, in particular to a high-specific-surface-area mesoporous graphite-phase carbon nitride material and a preparation method thereof. The graphite-phase carbon nitride material which is yellow powder is 5-28nm in pore diameter, 120-220m<2>/g in specific surface area and 0.4-0.7cm<3>/g in pore volume. The preparation method includes: dispersing guanidine hydrochloride solution on nano SiO2 microspheres or mesoporous silicon oxide materials, stirring, drying, calcining in an inert atmosphere, and removing a mould plate to obtain the mesoporous graphite-phase carbon nitride material. The raw material guanidine hydrochloride is low in cost and safe, the preparation method is simple, and the product is high in specific surface area. Further, adjustment of pore volume and specific surface area of the mesoporous graphite-phase carbon nitride material can be realized by adjusting usage of template agent.