The present invention discloses a health sterilization wet tissue, which comprises a nonwoven fabric adopted as a carrier of a health sterilization emulsion, wherein a weight ratio of the health sterilization emulsion to the carrier is 0.5-5:1, and the health sterilization emulsion comprises, by weight, 80-99% of deionized water, 0.1-3% of polyhexamethyleneguanidine hydrochloride, 0.1-2% of 1,2-propylene glycol, 0.01-0.5% of vitamin E, 0.05-1% of a flavor, 0.003-0.1% of EDTA-4Na, 0.01-6% of aloe gel lyophilized powder (200:1), and the balance of citric acid or sodium citrate. The health sterilization wet tissue has the following characteristics that: bactericdal power can achieve 90%, bacterial can be effectively killed, and effects of skin moisturizing and protection, tender, smooth and soft skin protection, pleasant aroma, and no side effect are provided. In addition, the health sterilization emulsion production method has characteristics of simple operation and high production efficiency.