Patents
Literature
4 results about "Vibrio cholerae" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Vibrio cholerae is a Gram-negative, comma-shaped bacterium. The bacterium's natural habitat is brackish or saltwater. Some strains of V. cholerae cause the disease cholera. V. cholerae is a facultative anaerobe and has a flagellum at one cell pole as well as pili. V. cholerae can undergo respiratory and fermentative metabolism. When ingested, V. cholerae can cause diarrhoea and vomiting in a host within several hours to 2–3 days of ingestion. V. cholerae was first isolated as the cause of cholera by Italian anatomist Filippo Pacini in 1854, but his discovery was not widely known until Robert Koch, working independently 30 years later, publicized the knowledge and the means of fighting the disease.
A detection reagent, kit and method for Vibrio cholerae O139 biotype double virulence gene by loop-mediated isothermal amplification
ActiveCN116397036BEfficient detectionspecificMicrobiological testing/measurementMicroorganism based processesVibrio choleraeMicrobiology
This invention relates to the field of biomedical detection technology, providing a reagent, kit, and detection method for detecting *Vibrio cholerae* serogroup O139 using loop-mediated isothermal amplification (LAMP). This invention targets the synergistic regulation of the tcpA and hlyA genes in *Vibrio cholerae* serogroup O139, designing LAMP detection primers and establishing a LAMP detection method based on isothermal amplification. These LAMP detection primers or loop primers show promising applications not only against *Vibrio cholerae* serogroup O139 but also against other nosocomial infection bacteria. The LAMP primers for detecting *Vibrio cholerae* serogroup O139 can be used to detect *Vibrio cholerae* serogroup O139 in clinical patients or for outpatient screening. The kit of this invention can effectively and specifically detect single-reaction, single-copy, or higher copies of *Vibrio cholerae* serogroup O139. Compared to the "gold standard" real-time quantitative PCR, the kit of this invention offers higher accuracy and sensitivity, completing the detection within 30 minutes.
Owner:ZHEJIANG UNIV
Use of micafungin in the manufacture of a medicament for inhibiting fungi
ActiveCN121264471BBroad spectrum antifungal effectHave inhibitory effectBiocideFungicidesAntifungalAntibiosis
The application discloses application of micafungin in preparation of a medicine for inhibiting fungi, and application of combination of micafungin and trifloxystrobin in preparation of the medicine for inhibiting fungi, especially for inhibiting Magnaporthe grisea. It is found by the application that micafungin has an inhibiting effect on Magnaporthe grisea. The combination of micafungin and trifloxystrobin has a synergistic effect, can overcome the drug resistance of Magnaporthe grisea with trifloxystrobin resistance, and improve the antibacterial effect on Magnaporthe grisea. It is found by the application that micafungin has a broad-spectrum antifungal effect, and has an inhibiting effect on other fungi such as Botrytis cinerea, Vibrio cholerae and Aspergillus niger in addition to Magnaporthe grisea.
Owner:CHINA NAT RICE RES INST
Specific primer combinations for detecting pathogenic microorganisms associated with glacial meltwater dissemination
Owner:NORTHWEST INST OF ECO ENVIRONMENT & RESOURCES CAS
Bacillus subtilis gene expression regulation and control tool based on I-F3 type CRISPR (clustered regularly interspaced short palindromic repeats) system
The invention discloses a bacillus subtilis gene expression regulation and control tool based on an I-F3 type CRISPR (clustered regularly interspaced short palindromic repeats) system, and belongs to the field of gene engineering. The CRISPRi inhibition capability of a VchQCas system derived from Vibrio cholera in bacillus subtilis WS9C is verified through expression optimization, and a VcaQCas system with high CRISPRi regulation and control efficiency and PAM broad-spectrum property is identified and obtained from QCascade systems of eight types of I-F3 on the basis of bioinformatics methods such as gene mining and CRISPR element prediction. And then, the targeting preference of the system in the bacillus subtilis WS9C and the PAM suitability are analyzed in detail. The bacillus subtilis provided by the invention provides a new gene expression regulation strategy as a foreign protein expression host, and also provides reference for site selection of gene regulation.
Owner:JIANGNAN UNIV