124 results about "Antimicrobial compound" patented technology

The invention relates to the technical field of anti-yellowing, in particular to anti-yellowing lining cloth with a hot melt coating and a preparation method of the anti-yellowing lining cloth. Composite carbon dots, an anti-yellowing agent and a composite chitosan solution are adopted to prepare finishing liquid for finishing the lining cloth; the preparation method comprises the following steps: selecting furfural and urea as a carbon source and a nitrogen source, performing one-step hydrothermal synthesis to obtain a nitrogen-doped furfural-based carbon dot, and grafting an amino-terminated polyimidazolium salt antibacterial compound to obtain a composite carbon dot; wherein the amino-terminated polyimidazolium salt antibacterial compound is an amino-terminated halogen-free polyimidazolium salt antibacterial compound which is prepared by taking ethylenediamine, butyric acid, glyoxal and formaldehyde as raw materials based on amine-aldehyde polycondensation and has good biocompatibility; the preparation method comprises the following steps: by taking polybutylene adipate, toluene diisocynate and isophorone diisocyanate as main monomers, polypropylene oxide triol as a crosslinking monomer, 2, 2-dimethylolpropionic acid and 4, 4 '-diaminodiphenyl disulfide as chain extenders and composite carbon dots as an end-capping reagent, adding water and emulsifying to obtain the waterborne polyurethane hot melt adhesive.

A nanomedicine composition, preparation method, and use thereof, comprising: a negatively charged nanophospholipid disk and an antimicrobial compound; wherein the negatively charged nanophospholipid disk comprises a negatively charged phospholipid layer and a membrane scaffold protein, wherein the negatively charged phospholipid layer is formed by mixing a neutral phospholipid and a negatively charged phospholipid in a molar ratio of approximately 5:5-7:3. The nanomedicine composition provided herein reduces the toxicity of the antimicrobial compound while enhancing its antimicrobial efficacy, and has great potential for expansion into clinical applications.

A method of selectively inhibiting pathogenic microbes includes: providing an antimicrobial compound that is functional having a structure of Formula 1, or derivative thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof; and contacting a microbe with the compound such that the microbe is selectively inhibited;

Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment of bacterial infections, such as pneumonia

There is provided an antimicrobial composition comprising: an antimicrobial compound; and a population of metal nanoparticles. Also described is a method of producing such an antimicrobial composition, a coating or treatment for a surface or substrate comprising such an antimicrobial composition, and a medical device comprising such a coating or treatment.

Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment of bacterial infections, such as pneumonia.

The invention discloses block polyol as well as a preparation method and application thereof, and belongs to the technical field of polymer polyol. An antibacterial compound containing a conjugated ring structure is directly embedded into a polyol molecular chain through a polymerization reaction, and the block polyol is applied to synthesis of a polyurethane material. According to the method, through covalent bonding of an antibacterial structure block and polybasic acid, stable existence of an antibacterial functional group in a polyurethane main chain is realized, and the defect that the antibacterial property is weakened or environmental pollution is caused due to migration and surface grafting of an antibacterial agent is avoided; an effective solution is provided for developing a polyurethane material with excellent antibacterial property and biological safety.

The invention relates to a microbial biofilm cultivation method comprising the use of a soft agar hydrogel substrate and one or more stains for detection and / or quantification of one or more microbial components and / or characteristics. The invention further relates to the use of the microbial biofilm cultivation method for screening of one or more antimicrobial compounds.

This application relates to bioabsorbable cationic steroidal antimicrobial (CSA) compounds or salts thereof having a structure of formula I, II or III: formula (I), formula (II) or formula (III), wherein R1-R 18 At least one of them (e.g., R) 18 This includes monoglycerides or diglycerides of fatty acids linked by ester bonds, and R1-R 18 At least one of them (e.g., R3, R7, and R) 12 ) is an amino acid linked to the steroid backbone via an ester bond or an amide bond, wherein: R 18 It has the following structure: -R 19 -(C=O)-O-C-CR 20 -CR 21 , where R 19 The radical is omitted or selected from alkyl, alkenyl, ynyl, and aryl, and R 20 and R 21 Independently selected from hydroxyl, alkylcarboxyl, and aminoalkylcarboxyl groups, provided that R 20 and R 21 At least one of them is an alkyl carboxyl group, R3, R7 and R 12 It has the following structure: R 24 R 23 N-R 22 -(C=O)-X-, where R 22 It is a substituted or unsubstituted alkyl group, X is oxygen or nitrogen, and R is... 23 and R 24 It is independently hydrogen, alkyl, alkenyl, alkynyl, or aryl. (I)(II)(III)

The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I):or a pharmaceutically acceptable salt thereof, wherein:Q is fluoro, chloro, bromo, or iodo;each of s, b, and n is independently an integer from about 10 to about 100; andeach of v, j, p, z, q, x and m is independently an integer from 1 to about 20.

The present invention relates to the use of a compound X selected from the group consisting of compounds of formula (I), glyceryl ethers, sorbitan esters and isosorbide esters, as an antimicrobial agent against a microorganism causing dental caries, a microorganism causing dental plaque or a microorganism causing gingivitis, wherein R is selected from saturated hydrocarbon chains having 5 to 23 carbon atoms, unsaturated hydrocarbon chains having 5 to 23 carbon atoms, and mixtures thereof.

An article comprising a compound of Formula I, wherein: R1 represents H or a C1-C12 hydrocarbon group that is optionally substituted or a water solubilising functional group; R2 represents a C1 or more hydrocarbon group that is optionally substituted; R3 represents H or a C1-12 hydrocarbon group that is optionally substituted; X represents O, NH, S or PH; and L represents a linker group, and wherein the article comprises: a) an underlying substrate and a surface layer, and the surface layer comprises the compound; and / or b) the compound dispersed in a binder.

The present invention relates to an antimicrobial composite comprising a cationic antimicrobial compound and a bacterial enzyme degradable anionic copolymer wherein the bacterial enzyme degradable anionic copolymer and the cationic antimicrobial compound are linked to each other by electrostatic interaction. The invention also relates to a pharmaceutical composition comprising the antibacterial composite; a method of treating a subject suffering from a bacterial and / or fungal infection, comprising the step of administering to the subject a therapeutically effective amount of an antibacterial composite or pharmaceutical composition; the use of an antimicrobial composite in the preparation of a medicament for the treatment of bacterial and / or fungal infections in a subject in need of an antimicrobial composite; the use of the antibacterial composite or pharmaceutical composition for the treatment of bacterial and / or fungal infections; the invention also provides a method for preparing the antibacterial composite material.

A nanodiamond-reinforced nanofiber scaffold system for skin regeneration, consisting of a multilayered, electrospun nanofiber matrix formed from one or more biocompatible polymers selected from polycaprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA), chitosan, gelatin or collagen, wherein nanodiamonds are present in an amount of 0.1 to 5 wt.-% are incorporated and surface-functionalized with oxygen, hydroxyl, or carboxyl groups to ensure homogeneous dispersion within the polymer matrix, the scaffold being characterized by a controlled fiber diameter in the range of 100 to 800 nm, an interconnected porosity between 60 and 90%, a tensile strength of 2 to 10 MPa, a degradation time of 2 to 8 weeks, and the ability to improve cell adhesion, proliferation, and migration of fibroblasts and keratinocytes, while simultaneously exhibiting antioxidant activity, reduced formation of reactive oxygen species, and the optional incorporation of bioactive agents selected from growth factors, antioxidants, or antimicrobial compounds to accelerate wound healing and skin tissue regeneration.

This disclosure relates to a cephalosporin antibacterial compound and a method for preparing the same. This cephalosporin antibacterial compound exhibits antibacterial activity against a variety of bacteria, including Gram-negative bacteria.

The present application relates to a kind of targeting bacterial UDP-N-acetylglucosamine enolpyruvate transaminase antibacterial compound and its application, the antibacterial compound is S-(4-chlorobenzyl) chloro isothiourea, its chemical structure is as shown in formula I: I;Or its pharmaceutically acceptable salt, stereoisomer, solvate, crystal form, isotopically labeled or prodrug.The antibacterial compound of the present application can effectively inhibit the growth of klebsiella pneumoniae, including carbapenem-resistant klebsiella pneumoniae and high virulence klebsiella pneumoniae;It also has good bacteriostatic effect on escherichia coli and pseudomonas aeruginosa;It is expected to be applied to the clinical treatment of infection caused by drug-resistant klebsiella pneumoniae and high virulence klebsiella pneumoniae and other pathogenic bacteria, and has important clinical significance and social benefits.

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

The invention relates to a preparation method of a cephalosporin antibacterial compound and an intermediate thereof. Specifically, the invention relates to a method for preparing a cephalosporin antibacterial compound and an intermediate thereof by using a continuous flow microchannel reactor, and the preparation process can realize continuous automatic production and is high in industrial operability.

To provide needleless access connectors having a valve that can resist bacterial growth, and in particular, needleless access connectors having access ports with an antimicrobial resistant valve.SOLUTION: A valve including an antimicrobial agent can be used with needleless access connectors. The valve can have an insert that includes an antimicrobial coating thereon, and / or the valve can have physical features, such as a series of tunnels or groves or a patterned surface, containing an antimicrobial formulation, and / or the valve can be made of a material that includes an antimicrobial agent.SELECTED DRAWING: Figure 2A

The invention relates to the technical field of tobacco antibacterial substances, in particular to a fatty acid derivative and a preparation method thereof, an antibacterial compound and a pesticide. The fatty acid derivative is selected from compounds represented by the following structural formula: wherein R is selected from phenyl or CX, and X represents halogen. The fatty acid derivative has a good inhibition effect on phytophthora nicotianae, and can be used as a pesticide for preventing and treating tobacco black shank, so that the selection of antibacterial drugs and pesticides is expanded.

The application discloses a new antibacterial compound and a preparation method and application thereof, and the new antibacterial compound is obtained by fermenting endophytic fungi (Epicoccum latusicollum) under stress of pathogenic fungi (Fusarium oxysporum), filtering, discarding mycelia, enriching the fermentation liquor by using a macroporous adsorption resin, and adopting high performance liquid preparation separation, and the chemical name of the new compound is (6E,8E)-13-acetoxy-3-hydroxy-8,10,12,14-tetramethylhexadeca-6,8-dienoic acid. The new compound obtained by fermenting endophytic fungi under stress of pathogenic fungi has significant antibacterial activity, and the application provides a scientific basis for mining endophytic fungi antibacterial natural compounds based on stress effects.

Provided herein are inhibitors of LpxH, pharmaceutical compositions comprising said inhibitory compounds, and methods for using said LpxH inhibitory compounds for the treatment of infectious disease.

Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

The present invention discloses an antibacterial compound of Formula 1 or pharmaceutically acceptable salt thereof:wherein X is CH, S, CH—NH2;R1 is C1-C8 alkyl, substituted alkyl, alkyl amine, substituted amine; preferably R1 is methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, methyl amine, ethylamine, propylamine, isopropyl amine, isobutylamine, N-ethylprop-2-yn-1-amine, N-isopropyl propane-1,3-diamine, N1-isopropyl ethane-1,3-diamine, 1-butyl-2-methylguanidine, N1-ethyl-N1-propylethane-1,2-diamine, cyclobutyamine, phosphate, sulphate;R2 is hydrogen, alkyl, substituted alkyl; preferably R2 is methyl, propyl, isopropyl;R3 is hydrogen, alkyl, substituted alkyl; and preferably R3 is methyl, propyl, isopropyl.The Formula 1 or pharmaceutically acceptable salt thereof is an imidazole glycerol phosphate dehydratase (IGPD) inhibitor and treats or prevents or ameliorates tuberculosis.

This disclosure relates to a cephalosporin antibacterial compound and a method for preparing the same. This cephalosporin antibacterial compound exhibits antibacterial activity against a variety of bacteria, including Gram-negative bacteria.

The invention discloses a bridged ring phloroglucinol antibacterial compound as well as a preparation method and application thereof, and belongs to the field of medicinal chemistry and anti-infection pharmacy. The structural general formula of the bridged ring phloroglucinol antibacterial compound is shown in the specification. The preparation method specifically comprises the following steps: (1) preparing a compound B by taking methyl iodide, sodium methoxide and a compound A as raw materials; (2) preparing a compound C by taking diisobutylaluminium hydride, the compound B, 2, 6-dimethyl pyridine and trifluoromethanesulfonic anhydride as raw materials; (3) preparing a compound D by taking palladium acetate, triphenylphosphine, the compound C, triethylamine and formic acid as raw materials; and (4) preparing a target product by taking the compound D, hexafluoroisopropanol, p-toluenesulfonic acid, the compound E, chiral phosphoric acid and ytterbium trifluoromethanesulfonate as raw materials. The compound disclosed by the invention shows high selectivity, low drug resistance risk and a potential new action mechanism, and provides a new leading structure and a technical path for overcoming drug resistance of existing antibacterial drugs.

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

This disclosure relates to temporary antimicrobial eluting adhesive spacer implants (1) and components, kits, and methods for forming said spacer implants. Particularly preferred disclosures relate to modular spacers, components, and kits, and methods of manufacturing them, wherein the modular nature of said spacers allows for selection of spacers of specific desired lengths and specific selection of antimicrobial compounds and dosages, as well as the parts and processes for forming them.

A composition comprising a solubiliser, at least one preservative, at least one liquid emollient and at least one antimicrobial agent, wherein the composition comprises thymol and carvacrol. The antimicrobial agent may comprise essential oils, active ingredients derived from essential oils or synthetic equivalents thereof and, optionally, additional antimicrobial compounds. The composition may comprise thymol, carvacrol, levulinic acid and lauric acid. The composition may be used for intra-anal douching and may be used to reduce the risk of the transmission of sexually transmitted diseases (STDs) and / or sexually transmitted infections (STIs). The composition may be essentially free of water and may be provided as a single unit dosage formulation. Alternatively, the composition may further comprise water and may be provided as a single unit dosage or multi-dosage formulation. Methods of making the composition that is essentially free of water and the composition further comprising water are also disclosed.