76 results about "Antimicrobial compound" patented technology

The invention relates to a microbial biofilm cultivation method comprising the use of a soft agar hydrogel substrate and one or more stains for detection and / or quantification of one or more microbial components and / or characteristics. The invention further relates to the use of the microbial biofilm cultivation method for screening of one or more antimicrobial compounds.

This application relates to bioabsorbable cationic steroidal antimicrobial (CSA) compounds or salts thereof having a structure of formula I, II or III: formula (I), formula (II) or formula (III), wherein R1-R 18 At least one of them (e.g., R) 18 This includes monoglycerides or diglycerides of fatty acids linked by ester bonds, and R1-R 18 At least one of them (e.g., R3, R7, and R) 12 ) is an amino acid linked to the steroid backbone via an ester bond or an amide bond, wherein: R 18 It has the following structure: -R 19 -(C=O)-O-C-CR 20 -CR 21 , where R 19 The radical is omitted or selected from alkyl, alkenyl, ynyl, and aryl, and R 20 and R 21 Independently selected from hydroxyl, alkylcarboxyl, and aminoalkylcarboxyl groups, provided that R 20 and R 21 At least one of them is an alkyl carboxyl group, R3, R7 and R 12 It has the following structure: R 24 R 23 N-R 22 -(C=O)-X-, where R 22 It is a substituted or unsubstituted alkyl group, X is oxygen or nitrogen, and R is... 23 and R 24 It is independently hydrogen, alkyl, alkenyl, alkynyl, or aryl. (I)(II)(III)

The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I):or a pharmaceutically acceptable salt thereof, wherein:Q is fluoro, chloro, bromo, or iodo;each of s, b, and n is independently an integer from about 10 to about 100; andeach of v, j, p, z, q, x and m is independently an integer from 1 to about 20.

The present invention relates to the use of a compound X selected from the group consisting of compounds of formula (I), glyceryl ethers, sorbitan esters and isosorbide esters, as an antimicrobial agent against a microorganism causing dental caries, a microorganism causing dental plaque or a microorganism causing gingivitis, wherein R is selected from saturated hydrocarbon chains having 5 to 23 carbon atoms, unsaturated hydrocarbon chains having 5 to 23 carbon atoms, and mixtures thereof.

The present invention relates to an antimicrobial composite comprising a cationic antimicrobial compound and a bacterial enzyme degradable anionic copolymer wherein the bacterial enzyme degradable anionic copolymer and the cationic antimicrobial compound are linked to each other by electrostatic interaction. The invention also relates to a pharmaceutical composition comprising the antibacterial composite; a method of treating a subject suffering from a bacterial and / or fungal infection, comprising the step of administering to the subject a therapeutically effective amount of an antibacterial composite or pharmaceutical composition; the use of an antimicrobial composite in the preparation of a medicament for the treatment of bacterial and / or fungal infections in a subject in need of an antimicrobial composite; the use of the antibacterial composite or pharmaceutical composition for the treatment of bacterial and / or fungal infections; the invention also provides a method for preparing the antibacterial composite material.

This disclosure relates to a cephalosporin antibacterial compound and a method for preparing the same. This cephalosporin antibacterial compound exhibits antibacterial activity against a variety of bacteria, including Gram-negative bacteria.

The present application relates to a kind of targeting bacterial UDP-N-acetylglucosamine enolpyruvate transaminase antibacterial compound and its application, the antibacterial compound is S-(4-chlorobenzyl) chloro isothiourea, its chemical structure is as shown in formula I: I;Or its pharmaceutically acceptable salt, stereoisomer, solvate, crystal form, isotopically labeled or prodrug.The antibacterial compound of the present application can effectively inhibit the growth of klebsiella pneumoniae, including carbapenem-resistant klebsiella pneumoniae and high virulence klebsiella pneumoniae;It also has good bacteriostatic effect on escherichia coli and pseudomonas aeruginosa;It is expected to be applied to the clinical treatment of infection caused by drug-resistant klebsiella pneumoniae and high virulence klebsiella pneumoniae and other pathogenic bacteria, and has important clinical significance and social benefits.

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

The invention relates to a preparation method of a cephalosporin antibacterial compound and an intermediate thereof. Specifically, the invention relates to a method for preparing a cephalosporin antibacterial compound and an intermediate thereof by using a continuous flow microchannel reactor, and the preparation process can realize continuous automatic production and is high in industrial operability.

The invention relates to the technical field of tobacco antibacterial substances, in particular to a fatty acid derivative and a preparation method thereof, an antibacterial compound and a pesticide. The fatty acid derivative is selected from compounds represented by the following structural formula: wherein R is selected from phenyl or CX, and X represents halogen. The fatty acid derivative has a good inhibition effect on phytophthora nicotianae, and can be used as a pesticide for preventing and treating tobacco black shank, so that the selection of antibacterial drugs and pesticides is expanded.

The application discloses a new antibacterial compound and a preparation method and application thereof, and the new antibacterial compound is obtained by fermenting endophytic fungi (Epicoccum latusicollum) under stress of pathogenic fungi (Fusarium oxysporum), filtering, discarding mycelia, enriching the fermentation liquor by using a macroporous adsorption resin, and adopting high performance liquid preparation separation, and the chemical name of the new compound is (6E,8E)-13-acetoxy-3-hydroxy-8,10,12,14-tetramethylhexadeca-6,8-dienoic acid. The new compound obtained by fermenting endophytic fungi under stress of pathogenic fungi has significant antibacterial activity, and the application provides a scientific basis for mining endophytic fungi antibacterial natural compounds based on stress effects.

Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

The present invention discloses an antibacterial compound of Formula 1 or pharmaceutically acceptable salt thereof:wherein X is CH, S, CH—NH2;R1 is C1-C8 alkyl, substituted alkyl, alkyl amine, substituted amine; preferably R1 is methyl, ethyl, propyl, butyl, pentyl, isopropyl, isobutyl, methyl amine, ethylamine, propylamine, isopropyl amine, isobutylamine, N-ethylprop-2-yn-1-amine, N-isopropyl propane-1,3-diamine, N1-isopropyl ethane-1,3-diamine, 1-butyl-2-methylguanidine, N1-ethyl-N1-propylethane-1,2-diamine, cyclobutyamine, phosphate, sulphate;R2 is hydrogen, alkyl, substituted alkyl; preferably R2 is methyl, propyl, isopropyl;R3 is hydrogen, alkyl, substituted alkyl; and preferably R3 is methyl, propyl, isopropyl.The Formula 1 or pharmaceutically acceptable salt thereof is an imidazole glycerol phosphate dehydratase (IGPD) inhibitor and treats or prevents or ameliorates tuberculosis.

This disclosure relates to a cephalosporin antibacterial compound and a method for preparing the same. This cephalosporin antibacterial compound exhibits antibacterial activity against a variety of bacteria, including Gram-negative bacteria.

The invention discloses a bridged ring phloroglucinol antibacterial compound as well as a preparation method and application thereof, and belongs to the field of medicinal chemistry and anti-infection pharmacy. The structural general formula of the bridged ring phloroglucinol antibacterial compound is shown in the specification. The preparation method specifically comprises the following steps: (1) preparing a compound B by taking methyl iodide, sodium methoxide and a compound A as raw materials; (2) preparing a compound C by taking diisobutylaluminium hydride, the compound B, 2, 6-dimethyl pyridine and trifluoromethanesulfonic anhydride as raw materials; (3) preparing a compound D by taking palladium acetate, triphenylphosphine, the compound C, triethylamine and formic acid as raw materials; and (4) preparing a target product by taking the compound D, hexafluoroisopropanol, p-toluenesulfonic acid, the compound E, chiral phosphoric acid and ytterbium trifluoromethanesulfonate as raw materials. The compound disclosed by the invention shows high selectivity, low drug resistance risk and a potential new action mechanism, and provides a new leading structure and a technical path for overcoming drug resistance of existing antibacterial drugs.

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

This disclosure relates to temporary antimicrobial eluting adhesive spacer implants (1) and components, kits, and methods for forming said spacer implants. Particularly preferred disclosures relate to modular spacers, components, and kits, and methods of manufacturing them, wherein the modular nature of said spacers allows for selection of spacers of specific desired lengths and specific selection of antimicrobial compounds and dosages, as well as the parts and processes for forming them.

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.

Pharmaceutical formulations for topical dental administration or medical (e.g., implant) treatments are disclosed, comprising an effective amount of at least one antimicrobial compound; at least one peroxide source compound; and at least one gel agent. Methods for treating oral anatomical structures are also disclosed. The pharmaceutical formulations and methods of treatment provide oral anatomical benefits to patients, including, for example, reduction or halting of gum recession; reduction or halting of bone recession; reduction or halting of bone loss; reduction or elimination of pain; reduction or elimination of bleeding; reduction or elimination of swelling; enhanced bone regeneration; enhanced soft tissue repair; or combinations thereof.

The present disclosure relates to compositions and related apparatuses that provide effective microbial inhibiting headspace concentrations of allyl isothiocyanate, citral, thymol, linalool, terpineol, eugenol, or a combination of any two or more thereof.

The present application belongs to the field of compounds, and particularly relates to a multifunctional compound with fire-retardant, hydrophobic and antibacterial properties and a preparation method thereof; the obtained compound can be used as a fire-retardant, hydrophobic and antibacterial functional surfactant in the field of materials such as foams and emulsion coatings. 17 The present application provides a preparation method of a compound, which comprises: subjecting a substance with a structural formula of formula I R-CH2-OH to an esterification reaction or an ester exchange reaction with an organic phosphorus compound to obtain the compound; wherein R in formula I is a fluorine-containing alkane with C4-C 17 The present application provides a compound with hydrophobic fire-retardant and antibacterial properties and a preparation method thereof; the obtained compound can be used as a surfactant, which can be further used in foaming or polymer emulsion, and can impart excellent hydrophobic, fire-retardant and antibacterial properties to the surface of a foam material or a coating material while using a smaller amount.

The invention provides a preparation method and application of methyl 2-hydroxyphenylacetate. The methyl 2-hydroxyphenylacetate is separated from a fermentation culture of streptomyces wetland 13-3 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No. 22830. According to the method, the compound methyl 2-hydroxyphenylacetate is obtained from streptomycete for the first time, verification proves that the methyl 2-hydroxyphenylacetate has broad-spectrum antibacterial activity on various plant pathogenic fungi, particularly, the inhibitory activity on aspergillus fumigatus, colletotrichum truncatum, rhizoctonia solani, verruca verrucosa and magnaporthe oryzae is higher than that of amphotericin B, and the methyl 2-hydroxyphenylacetate can be used for preparing antibacterial agent drugs and has broad-spectrum antibacterial activity. A novel natural antibacterial compound is provided for the fields of agriculture and medicine, and the method is simple and convenient to operate, high in purification efficiency and environment-friendly.

Antibacterial compound represented by structural formula I, (I); Or a pharmaceutically acceptable salt thereof is provided herein, wherein R1 in the formula is as defined herein. Additionally, a pharmaceutical composition comprising a compound of structural formula I is provided.

Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment of bacterial infections, such as pneumonia.

It suppresses odors caused by mold. [Solution] A method for suppressing mold-derived odors, comprising the step of applying an antimicrobial compound to mold at a concentration below the minimum inhibitory concentration for mold growth.

The invention relates to a method and device for analysing antimicrobial compound susceptibility of pathogenic microorganisms in body fluid samples. The method includes the steps of providing at least one body fluid sample, filtering the at least one body fluid sample through at least one catch filter which is configured for capturing at least a fraction of pathogenic microorganisms from the at least one body fluid sample if present in the body fluid sample, applying at least one antimicrobial compound to at least part of the at least one catch filter, in particular to the fraction of pathogenic microorganisms, such that at least a fraction of the captured pathogenic microorganisms extracellularly secrete antimicrobial responsive biomolecules, analysing the extracellularly secreted antimicrobial responsive biomolecules and determining at least one susceptibility characteristic thereof, and comparing at least one determined susceptibility characteristic with at least one reference characteristic corresponding to the at least one determined susceptibility characteristic thereby determining the susceptibility of at least part of the captured pathogenic microorganisms to the at least one antimicrobial compound.

Compositions comprising 2-hydroxycarboxylic acid for dysregulating the metabolism of planktonic bacteria and their use. This disclosure provides compositions for dysregulating the metabolism of planktonic bacteria, the compositions comprising preferred enantiomers of 2-hydroxycarboxylic acid. This disclosure further provides compositions for dysregulating the metabolism of planktonic bacteria, the compositions comprising preferred enantiomers of 2-hydroxycarboxylic acid and antimicrobial compounds. Dysregulation of the metabolism of planktonic bacteria can be measured, among other examples, by a decrease in the MIC of concomitant antimicrobial agents, an enhancement of in vivo antimicrobial effects, or aerobic respiration of metabolically active cells (reduction of non-fluorescent resazurin to highly fluorescent resorphine), which can lead to sensitization of planktonic bacteria to antimicrobial compounds and / or disruption of resistance of planktonic bacteria to antimicrobial compounds.

Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs). The boronic acid derivatives disclosed herein can be used in combination with various antibiotics to treat resistant bacteria.

The subject matter described herein is directed to antibacterial compounds and methods of isolating the compounds from extracts of Thuja arborvitae.