316 results about "Antimicrobial compound" patented technology

Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

Cephalosporin compounds represented by formula I-1, I-2 or I-3, pharmaceutical compositions containing the same, and uses as antibacterial agents. #imgabs0#

Provided here are antimicrobial compositions comprising an alkylene glycol ester and at least one antimicrobial compound, wherein suitably said alkylene glycol ester and said antimicrobial compound are present in the antimicrobial composition in beneficial weight ratios. Also provided are methods for increasing the efficacy of antimicrobial compounds and methods for reducing the minimum amount of antimicrobial compound needed for effective preservation activity in end-use formulations.

The invention discloses a medicinal silica gel desiccant with high adsorption speed and a preparation method thereof, and belongs to the technical field of desiccant preparation. The medicinal silica gel desiccant with high adsorption speed is prepared from the following components in parts by weight: 50-65 parts of silica gel, 4-8 parts of calcium chloride, 3-6 parts of magnesium sulfate, 3-7 parts of ferric oxide, 1-4 parts of an antibacterial compound, 5-10 parts of a modified surfactant, 1-2 parts of potassium hydroxide, 10-30 parts of ice water, 2-4 parts of acrylic acid, 2-4 parts of acrylamide and 0.4-0.8 part of sodium carboxymethyl starch. 0.2 to 0.3 part of benzoin dimethyl ether, 0.005 to 0.015 part of polyethylene glycol diacrylate and 1 to 2 parts of methanol. The silica gel desiccant prepared by the method has excellent antibacterial performance, adsorption rate and adsorption capacity.

The invention relates to the technical field of anti-yellowing, in particular to anti-yellowing lining cloth with a hot melt coating and a preparation method of the anti-yellowing lining cloth. Composite carbon dots, an anti-yellowing agent and a composite chitosan solution are adopted to prepare finishing liquid for finishing the lining cloth; the preparation method comprises the following steps: selecting furfural and urea as a carbon source and a nitrogen source, performing one-step hydrothermal synthesis to obtain a nitrogen-doped furfural-based carbon dot, and grafting an amino-terminated polyimidazolium salt antibacterial compound to obtain a composite carbon dot; wherein the amino-terminated polyimidazolium salt antibacterial compound is an amino-terminated halogen-free polyimidazolium salt antibacterial compound which is prepared by taking ethylenediamine, butyric acid, glyoxal and formaldehyde as raw materials based on amine-aldehyde polycondensation and has good biocompatibility; the preparation method comprises the following steps: by taking polybutylene adipate, toluene diisocynate and isophorone diisocyanate as main monomers, polypropylene oxide triol as a crosslinking monomer, 2, 2-dimethylolpropionic acid and 4, 4 '-diaminodiphenyl disulfide as chain extenders and composite carbon dots as an end-capping reagent, adding water and emulsifying to obtain the waterborne polyurethane hot melt adhesive.

A nanomedicine composition, preparation method, and use thereof, comprising: a negatively charged nanophospholipid disk and an antimicrobial compound; wherein the negatively charged nanophospholipid disk comprises a negatively charged phospholipid layer and a membrane scaffold protein, wherein the negatively charged phospholipid layer is formed by mixing a neutral phospholipid and a negatively charged phospholipid in a molar ratio of approximately 5:5-7:3. The nanomedicine composition provided herein reduces the toxicity of the antimicrobial compound while enhancing its antimicrobial efficacy, and has great potential for expansion into clinical applications.

A method of selectively inhibiting pathogenic microbes includes: providing an antimicrobial compound that is functional having a structure of Formula 1, or derivative thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof; and contacting a microbe with the compound such that the microbe is selectively inhibited;

The current invention relates to an antimicrobial composite material comprising a cationic antimicrobial compound, and a bacterial-enzyme-degradable anionic copolymer, wherein the bacterial-enzyme-degradable anionic copolymer and the cationic antimicrobial compound are attached to one another through electrostatic interaction. The current invention also relates to a pharmaceutical composition comprising the antimicrobial composite material, a method of treating a subject suffering from a microbial and / or fungal infection comprising the steps of administering to the subject a therapeutically effective amount of the antimicrobial composite material or the pharmaceutical composition, use of the antimicrobial composite material in the manufacture of a medicament to treat a microbial and / or fungal infection in a subject in need thereof, the antimicrobial composite material or the pharmaceutical composition for use in the treatment of a microbial and / or fungal infection, and a method of manufacture of the antimicrobial composite material.

Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment of bacterial infections, such as pneumonia

There is provided an antimicrobial composition comprising: an antimicrobial compound; and a population of metal nanoparticles. Also described is a method of producing such an antimicrobial composition, a coating or treatment for a surface or substrate comprising such an antimicrobial composition, and a medical device comprising such a coating or treatment.

A compound can have a structure of Formula A, or derivative thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof:wherein ring A is a phenyl, indolyl, naphthyl, or benzothiazolyl; X is S, SO, or SO2; Y is a linker or bond; Z is CH, CR2, or N; Z1 is C or N to form an imidazopyridine; each Z2, Z3, or Z4 is independently CH, CR2, or N; each Z5 or Z6 is C or CH; each R1, R2, and R3 is independently a substituent, and at least one of R1, R2, or R3 is a substituent other than a hydrogen; m is 0, 1, 2, 3, or 4; and n is 0 or a positive integer. The compounds can have specific substituent patterns.

The present invention relates to antimicrobial compounds isolated from Faecalibacterium prausnitzii supernatants, composition containing the compounds, and their use to inhibit bacterial growth or prevent bacterial infection, inhibit the virulence of N bacteria such as E. coli, and to treat diseases such as irritable bowel disease, Crohn's disease, and ulcerative colitis.

Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment of bacterial infections, such as pneumonia.

The invention discloses block polyol as well as a preparation method and application thereof, and belongs to the technical field of polymer polyol. An antibacterial compound containing a conjugated ring structure is directly embedded into a polyol molecular chain through a polymerization reaction, and the block polyol is applied to synthesis of a polyurethane material. According to the method, through covalent bonding of an antibacterial structure block and polybasic acid, stable existence of an antibacterial functional group in a polyurethane main chain is realized, and the defect that the antibacterial property is weakened or environmental pollution is caused due to migration and surface grafting of an antibacterial agent is avoided; an effective solution is provided for developing a polyurethane material with excellent antibacterial property and biological safety.

An 6-(4,5-bis(4-bromophenyl)-2-(4-methoxyphenyl)-1H-imidazol-1-yl)hexanoic acid compound, its synthesis, and its use as an antimicrobial agent.

The invention relates to automatic disinfection of vascular access device connectors. The disclosure also relates to a coupling device for coupling a vascular access device to a medical device, which may include a body, a spring, and a housing. The body may include a distal end, a proximal end, and a lumen extending through the distal end and the proximal end. The proximal end of the body may include a connector. The housing may be coupled to the proximal end of the spring and may enclose the connector. The distal end of the spring may be coupled to the body. The housing may include a flap, which may include an antibacterial compound. When the housing is disposed in the proximal position, the tab may cover the connector, the antimicrobial compound may contact the connector, and the spring may not be compressed. In response to movement of the housing from the proximal position to the distal position, the spring may be compressed and the flap may open.

The invention relates to a microbial biofilm cultivation method comprising the use of a soft agar hydrogel substrate and one or more stains for detection and / or quantification of one or more microbial components and / or characteristics. The invention further relates to the use of the microbial biofilm cultivation method for screening of one or more antimicrobial compounds.

Provided herein are novel antibacterial compounds of Formula I. The compounds can be made through enzymatic oxidative dimerization in the presence of a suitable organism and one or more metal salts. Pathogenic bacteria exposed to the compound of Formula I do not develop resistance to these compounds even after prolonged exposure. Also provided herein are methods of treating bacterial infections, and method of killing or disinfecting bacteria.

This application relates to bioabsorbable cationic steroidal antimicrobial (CSA) compounds or salts thereof having a structure of formula I, II or III: formula (I), formula (II) or formula (III), wherein R1-R 18 At least one of them (e.g., R) 18 This includes monoglycerides or diglycerides of fatty acids linked by ester bonds, and R1-R 18 At least one of them (e.g., R3, R7, and R) 12 ) is an amino acid linked to the steroid backbone via an ester bond or an amide bond, wherein: R 18 It has the following structure: -R 19 -(C=O)-O-C-CR 20 -CR 21 , where R 19 The radical is omitted or selected from alkyl, alkenyl, ynyl, and aryl, and R 20 and R 21 Independently selected from hydroxyl, alkylcarboxyl, and aminoalkylcarboxyl groups, provided that R 20 and R 21 At least one of them is an alkyl carboxyl group, R3, R7 and R 12 It has the following structure: R 24 R 23 N-R 22 -(C=O)-X-, where R 22 It is a substituted or unsubstituted alkyl group, X is oxygen or nitrogen, and R is... 23 and R 24 It is independently hydrogen, alkyl, alkenyl, alkynyl, or aryl. (I)(II)(III)

A 3-(3-fluorophenyl)-5-(4-methoxybenzylthio)-4-phenyl-4H-1,2,4-triazole compound, its synthesis, and its use as an antimicrobial agent.

The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I):or a pharmaceutically acceptable salt thereof, wherein:Q is fluoro, chloro, bromo, or iodo;each of s, b, and n is independently an integer from about 10 to about 100; andeach of v, j, p, z, q, x and m is independently an integer from 1 to about 20.

The present invention relates to the use of a compound X selected from the group consisting of compounds of formula (I), glyceryl ethers, sorbitan esters and isosorbide esters, as an antimicrobial agent against a microorganism causing dental caries, a microorganism causing dental plaque or a microorganism causing gingivitis, wherein R is selected from saturated hydrocarbon chains having 5 to 23 carbon atoms, unsaturated hydrocarbon chains having 5 to 23 carbon atoms, and mixtures thereof.

A 3-(4-bromophenyl)-5-((2-isopropyl-5-methylphenoxy)methyl)-1.2.4-oxadiazole compound, its synthesis, and its use as an antimicrobial agent.

Disclosed herein are antibacterial compounds that accumulate in Gram-negative bacteria, methods of preparing the compounds, and methods of using the compounds to inhibit or kill microbes, and methods of treating microbial infections, such as Gram-negative bacterial infections. Compounds selected for conversion to potential Gram-negative antibacterial compounds were identified based on compounds having low globularity and low flexibility. Amine substituents were then strategically added to the selected compounds to provide compounds having antibacterial activity against Gram-negative bacteria.

An article comprising a compound of Formula I, wherein: R1 represents H or a C1-C12 hydrocarbon group that is optionally substituted or a water solubilising functional group; R2 represents a C1 or more hydrocarbon group that is optionally substituted; R3 represents H or a C1-12 hydrocarbon group that is optionally substituted; X represents O, NH, S or PH; and L represents a linker group, and wherein the article comprises: a) an underlying substrate and a surface layer, and the surface layer comprises the compound; and / or b) the compound dispersed in a binder.

The present invention relates to an antimicrobial composite comprising a cationic antimicrobial compound and a bacterial enzyme degradable anionic copolymer wherein the bacterial enzyme degradable anionic copolymer and the cationic antimicrobial compound are linked to each other by electrostatic interaction. The invention also relates to a pharmaceutical composition comprising the antibacterial composite; a method of treating a subject suffering from a bacterial and / or fungal infection, comprising the step of administering to the subject a therapeutically effective amount of an antibacterial composite or pharmaceutical composition; the use of an antimicrobial composite in the preparation of a medicament for the treatment of bacterial and / or fungal infections in a subject in need of an antimicrobial composite; the use of the antibacterial composite or pharmaceutical composition for the treatment of bacterial and / or fungal infections; the invention also provides a method for preparing the antibacterial composite material.

The invention discloses a method for preparing a plant disease-resistant agent by using a biomass carbon nano material and its application. The method uses a biomass material as a raw material, and sequentially sintering, cooling, ball milling, washing and reducing the biomass material to obtain a nano material-level plant disease-resistant agent. The content of O element on the outer surface of the nano material-level plant disease-resistant agent accounts for 18-22% of the total element content on the surface of the material, and the reduction process is carried out under a methane system. The invention reduces the content of O element on the outer surface of the biomass carbon nano material, so that the material itself can better promote the synthesis of hydrogen peroxide in plant tissues. Compared with other disease-resistant preparations of the same type, the amount of hydrogen peroxide produced by the biomass carbon nano material is increased by 98.09%. Because the content of hydrogen peroxide as an endogenous antibacterial compound in plants is increased, the disease resistance of plants is ultimately improved, and no damage is caused to plants and the environment.

A nanodiamond-reinforced nanofiber scaffold system for skin regeneration, consisting of a multilayered, electrospun nanofiber matrix formed from one or more biocompatible polymers selected from polycaprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA), chitosan, gelatin or collagen, wherein nanodiamonds are present in an amount of 0.1 to 5 wt.-% are incorporated and surface-functionalized with oxygen, hydroxyl, or carboxyl groups to ensure homogeneous dispersion within the polymer matrix, the scaffold being characterized by a controlled fiber diameter in the range of 100 to 800 nm, an interconnected porosity between 60 and 90%, a tensile strength of 2 to 10 MPa, a degradation time of 2 to 8 weeks, and the ability to improve cell adhesion, proliferation, and migration of fibroblasts and keratinocytes, while simultaneously exhibiting antioxidant activity, reduced formation of reactive oxygen species, and the optional incorporation of bioactive agents selected from growth factors, antioxidants, or antimicrobial compounds to accelerate wound healing and skin tissue regeneration.

A 5-((2-isopropyl-5-methylphenoxy)methyl)-3-(naphthalen-1-yl)-1,2,4-oxadiazole compound, having the formula I:can be used as an antimicrobial agent.