46 results about "Bacterial Disorder" patented technology

Disclosed are compounds of formula (I), which are of use in the treatment of bacterial diseases and infections, to compositions containing those compounds and to methods of treating bacterial diseases and infections using the compounds. In particular, the compounds are useful for the treatment of infection with, and diseases caused by, Clostridium difficile.

Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.

The invention relates to a florfenicol solid dispersoid and a preparation method thereof. The solid dispersoid comprises the components of: florfenicol and a carrier. The carrier combination is reasonable, a rapid supercritical gas expansion technology and a super micro powder technology are combined to be used, an organic solvent is not required, the solubility of a product in water is greatly improved, the bioavailability is effectively improved, and bacterial diseases (which are caused by sensitive bacteria) of beasts and birds can be effectively cured. Besides, the preparation process is simple and easy to operate, the product is harmless and environment-friendly, the curative effect is excellent, and the like.

The invention discloses a method for preparing a chelerythrine medicament and application thereof in prevention and treatment of bacterial diseases of aquatic animals. The medicament consists of chelerythrine and starch serving as an auxiliary material. The method for preparing the prevention and treatment agent comprises the following steps of: weighing chelerythrine extract (the purity is 80 percent) and starch serving as the auxiliary material, adding the chelerythrine extract and the starch into a mixer, and mixing the chelerythrine extract and the starch uniformly to obtain a preparation containing 5 to 20 percent chelerythrine. When the bacterial disease prevention and treatment agent is added into feed for feeding, the dosage is 200 to 250 mg/kg (according to the quantity of the chelerythrine for each kilogram of weight); the prevention and treatment agent added in the feed has low toxicity, does not affect the quality of aquatic products, has no residue or pollution, is not easy to generate medicament resistance, does not affect the feed and growth of the aquatic animals, has low dosage, and is widely applied in prevention and treatment of bacterial hemorrhage diseases of mandarin fish, weever, carp, grass carp, eel, porgy, flounder and the like.

The invention relates to the technical field of livestock medication and specifically relates to a compound formula of gallic acid and rhein, a preparation method and an application thereof. The compound formula is capable of preventing and treating viral and bacterial diseases of livestock. The compound formula of gallic acid and rhein comprises the following components in parts by weight: 75-80parts of gallic acid and 20-25 parts of rhein. An in vivo test proves that the compound formula of gallic acid and rhein has the function of preventing and controlling bird flu H9N2 subtype, bursal disease virus, chicken escherichia coli, and the like, and is capable of effectively killing pathogenic bacteria of animals, such as bovine escherichia coli, swine escherichia coli and swine bacillus cereus.

The invention discloses a multi-effect active iodine disinfectant, which is prepared from the following substances in percentages by weight: 1 to 12 percent of iodine, 0.1 to 2 percent of potassium iodate, 0.5 to 3 percent of potassium iodide, 20 to 50 percent of surfactant, 0.1 to 5 percent of organic acid, 5 to 30 percent of organic solvent, 0.5 to 5 percent of inorganic salt and the balance of purified water. The invention also provides a preparation method and application of the multi-effect active iodine disinfectant. The multi-effect active iodine disinfectant is mainly used for the disinfection of breeding houses, appliances, body surfaces and drinking water of livestock and poultry, the disinfection of a water body for aquaculture, the disinfection of an appliance for the aquaculture and the field of the prevention and the control on animal bacterial diseases in the aquaculture.

The invention discloses a compound microcapsule for treating bacterial disease of livestock and poultry and a preparation method thereof. The compound microcapsule mainly comprises the following components in part by weight: 10 to 20 parts of origano oil, 15 to 30 parts of levofloxacin and 30 to 60 parts of capsule material. The Chinese medicinal preparation origano oil is combined with the western medicine levofloxacin to prepare the compound microcapsule. The western medicine levofloxacin fast sterilizes, and the Chinese medicinal preparation origano oil assists sterilizing, and the origano oil and the levofloxacin can regulate body functions of the livestock and poultry and improves immunity at the same time. The compound microcapsule has the advantages of synergistic effects because of the combination of the Chinese medicinal preparation and the western medicine, obvious sterilizing effect, no toxic or side effect of the medicaments, and capability of treating both principal and secondary aspects of diseases. In addition, the compound microcapsule solves the problem of poor stability of the origano oil used as essential oil, and makes the origano oil easily and stably combined with the western medicine levofloxacin.

The invention provides a Cyrtomium fortunei and ebony traditional Chinese medicine composite. The composite is a mixture of the alcohol extract of Cyrtomium fortunei, the alcohol extract of ebony and cinnamic acid in a certain ratio or an extract prepared by carrying out alcohol extraction after ebony and Cyrtomium fortunei are mixed in a certain ratio, and the composite also contains conventional pharmaceutic adjuvants and excipients. The invention also provides a preparation method and application of the Cyrtomium fortunei and ebony traditional Chinese medicine composite. The Cyrtomium fortunei and ebony traditional Chinese medicine composite has good prevention and treatment effects on poultry bacterial diseases and virus diseases, especially poultry diseases caused by escherichia coli and chlamydia and poultry diseases caused by bursal disease viruses and avian influenza. Moreover, the Cyrtomium fortunei and ebony traditional Chinese medicine composite has available raw material, lower cost and convenient and easy preparation process.

The invention discloses a compound Chinese herbal medicine for inhibiting and killing aeromonas hydrophila as well as a preparation method and application of the compound Chinese herbal medicine. The compound Chinese herbal medicine consists of gallnut, sanguisorba officinalis root and rheum officinale, wherein the weight ratio of the gallnut, to the sanguisorba officinalis root to the rheum officinale is at 5 to 2 to 1. Meanwhile, the invention discloses a preparation method and application of the compound Chinese herbal medicine for inhibiting and killing aeromonas hydrophila. The compound Chinese herbal medicine disclosed by the invention achieves the reasonable development and utilization of compound Chinese herbal medicine resources; in culture of aquatic animals, the compound Chinese herbal medicine has a great significance in guaranteeing animal nutrition, promoting growth of the animals and improving the disease preventing and disease resisting capacities of the animals, and meanwhile the compound Chinese herbal medicine is also in line with the requirements of aquaculture in sustainable development; in order to reduce loss of the aquaculture industry caused by diseases, a medicine, which is relatively strong in effect and low in toxic and side effects, becomes particularly important in the prevention and control of the diseases; and by taking the aeromonas hydrophila as a research object, the compound Chinese herbal medicine, which is relatively good in antibacterial effect, is screened out, so that the invention provides reference for prevention and control practice of diseases in aquatic animals and fish bacterial diseases caused by the aeromonas hydrophila.

The invention relates to the field of preventing and treating aquatic farming animal diseases, in particular to an antibiotic and anti-inflammatory medicament for preventing and treating bacteria diseases of aquatic farming animals. The medicament comprises the following compositions in weight portion: 10 to 20 portions of mountain rhubarb, 15 to 25 portions of root of large-flowered skullcap, 1 to 5 portions of glucan, 5 to 15 portions of garlic, 3 to 8 portions of florfenicol and 50 to 90 portions of carrier, wherein the traditional Chinese medicine compositions are crushed into superfine powder, mixed with the glucan, the florfenicol and the carrier according to the mixing ratio and evenly stirred to prepare the medicament. The medicament has the good functions of treating bacteria diseases of aquatic farming animals, and addressing both the symptoms and root causes, thereby lowering the recurrence rate and the death rate of aquatic farming animal diseases; moreover, no medicament residue is existed.

Use of the compound Pulsatilla Saponin B4 represented by formula (I), or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating viral and/or bacterial diseases, and a medicament comprising the compound Pulsatilla Saponin B4 represented by formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient, wherein the disease is dairy cow mastitis.

The invention discloses a process for optimally extracting quercetin from perfoliote knotweed herb by using a Plackett-Burnman combined response surface method. According to the process, the extraction amount of quercetin in perfoliote knotweed herb is taken as an investigation index, and extraction research is performed by adopting the Plackett-Burnman combined response surface method, so the optimal extraction process for quercetin in perfoliote knotweed herb is obtained; i.e., the perfoliote knotweed herb is soaked in ethanol with a concentration of 59.92% and accounting for 25 times of thevolume of the perfoliote knotweed herb for 24 hours, and then reflux extraction is conducted for 3.4 hours twice; under the condition of the extraction process, the average extraction amount of quercetin is 0.34 mg/g. An extract prepared by optimizing the extraction process is high in antibacterial activity, the MIC of the extract to escherichia coli, staphylococcus aureus and salmonella is 3.12g/L, 6.24 g/L and 6.31 g/L respectively, and the MBC of the extract to escherichia coli, staphylococcus aureus and salmonella is 12.52 g/L, 24.08 g/L and 25.41 g/L respectively; and the quercetin canbe used for treating livestock and poultry bacterial diseases caused by escherichia coli, staphylococcus aureus and salmonella.

The invention belongs to the technical field of immunoenhancers, and particularly relates to an immunoenhancer and application thereof and fish feed for enhancing immunity. The immunoenhancer comprises the following components in parts by mass: 2,000-6,000 parts of clostridium butyricum, 15-45 parts of vitamin C and 5-30 parts of vitamin E, wherein the living bacterial count of the clostridium butyricum is larger than or equal to 10*10<8> CFU/mL. The immunoenhancer not only solves the problem of frequent occurrence of bacterial diseases in pelteobagrus fulvidraco pond culture, but also does not produce drug resistance, guarantees eating safety of cultured products and achieves significant economic, social and ecological benefits.

The invention relates to the use of a nasal spray made of cistus extracts for preventing and/or treating viral and/or bacterial oropharyngeal diseases.

Compounds of formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof,

pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds.

The invention provides a callicarpa bodinieri compound preparation as well as a preparation method and application thereof, and the callicarpa bodinieri compound preparation comprises a first medicinal material and a second medicinal material which account for 40-90wt% of the total weight of the callicarpa bodinieri compound preparation, a carrier accounting for 10 to 60 wt%; wherein the first medicinal material is a verbenaceae callicarpa plant medicinal material; the weight ratio of the first medicinal material to the second medicinal material is 1: 1-3: 1. Therefore, the compound preparation with a sustained and controlled release function is formed by the extract containing the verbenaceae callicarpa plant component and the high-molecular compound (carrier) through a certain process, so that the aim of preventing and treating bacterial diseases by utilizing the plant extract is fulfilled.

The invention discloses a preparation process of small molecular peptides, belonging to the field of fishery breeding, and comprises the following raw materials in parts by weight: 30 to 50 parts of soybean meal; 20 to 30 parts of corn; 10 to 15 parts of carrot powder, 20 to 30 parts of earthworm powder; 5 to 10 parts of adhesive for fish; 2 to 5 parts of San Huang powder; 2 to 5 parts of growth-promoting additive. The preparation method comprises the following steps of sterilizing corn and growth-promoting additive, then crushing the corn and the growth-promoting additive into powder, then stirring and mixing soybean meal, carrot powder, earthworm powder and San Huang powder with the corn and the growth-promoting additive, finally expanding and granulating to obtain pellet feed, finally spraying waterproof grease, drying and bagging to obtain target feed. The invention can clear away heat and toxic materials, resist bacteria and diminish inflammation, and is used for preventing and treating bacterial diseases such as liver and gallbladder, gill rot, hemorrhage, enteritis, skin rot and the like. At the same time, the invention can enhance the disease-resistant immune function of fish, improve the survival rate of fish and promote the growth of fish.