11 results about "Bacterial Disorder" patented technology

The application belongs to the technical field of biomedicine, and discloses a method for constructing a Channa argus bile stasis model. The application discloses application of rifampicin or a pharmaceutically acceptable salt thereof in construction of a fish liver injury model. The application discloses, for the first time, that the antibiotic rifampicin widely used in aquaculture is used to construct a fish liver injury model. The model is closer to the real scene of the use of a large amount of drugs when bacterial diseases break out in production practice. The injury type of the fish liver injury model is clearly directed to bile stasis, which fills the research blank of the disease model of the fish, and is different from common hepatocyte necrosis or fatty liver models.

This invention relates to the field of veterinary drug formulation and new feed additive technology, and proposes a compound emulsion based on hydroxypropyl chitosan-encapsulated essential oil-phytosterols, its preparation method, and its application. The compound emulsion is composed of the following raw materials in weight percentages: 10%–15% hydroxypropyl chitosan essential oil-encapsulated emulsion, 6%–9% phytosterol liposome dispersion, 6%–10% medium-chain triglycerides, 1.5%–2.5% beeswax, 2%–3% hydrogenated soybean lecithin, 3%–4% polysorbate 80, 0.3%–0.5% xanthan gum, 5%–7% glycerol, 3%–5% glucose, 0.05%–0.1% potassium sorbate, 0.005%–0.008% antioxidant, and the balance being water. This technical solution solves the problem of poor treatment efficacy for bacterial diseases in calves in related technologies.

The invention provides a total artificial breeding and breeding method for dwarf, which applies polypeptide with antibacterial activity to breeding and breeding stages of dwarf, so that bacterial diseases can be effectively prevented and controlled, and the survival rate of breeding and breeding is remarkably improved. One amino acid sequence of the polypeptide is SEQ ID NO: 2. According to the method, a complete technical system from polypeptide screening to feed additive development and covering of the whole process of seedling raising and dwarf cultivation is established, and an innovative integrated solution is provided for solving the problem of prevention and treatment of bacterial diseases in all stages of dwarf cultivation. The feed additive not only remarkably improves the seedling raising efficiency and the culture benefit, but also provides important technical support for replacing antibiotics and realizing sustainable development of green and healthy culture of mulinialateralis.

The invention belongs to the technical field of biological medicine, and particularly relates to a traditional Chinese medicine composition and application thereof in oral cavity. The invention provides a traditional Chinese medicine composition with a brand new formula. The traditional Chinese medicine composition comprises extracts prepared from Chinese olives, radix paeoniae alba, liquorice and sophora flowers through alcohol extraction. A research result shows that the obtained traditional Chinese medicine composition has an excellent effect of inhibiting the formation of the oral biofilm, the inhibition rate exceeds 90% and is obviously higher than that of a single traditional Chinese medicine composition or other traditional Chinese medicine compositions formed by different types and / or proportions, and the traditional Chinese medicine composition can be used for treating tooth bacterial diseases including decayed teeth and has an important application value in preparation of oral products.

The present invention relates to the use of a polyaminated fatty acid compound corresponding to formula (I), the pharmaceutically acceptable salts thereof and / or the solvates thereof as adjuvants for antibacterial agents, a pharmaceutical composition comprising at least said polyaminated fatty acid compound and at least one antibacterial agent, said pharmaceutical composition being used as a medicament, in particular as a medicament. The pharmaceutical composition is used for treating bacterial diseases or infectious diseases, especially bacterial diseases or infectious diseases caused by Gram-negative bacteria, and is used for killing holding bacteria cells or inhibiting the growth of the holding bacteria cells. A kit comprising a composition comprising said polyaminated fatty acid compound and a separate pharmaceutical composition comprising at least one antibacterial agent, as well as a polyaminated fatty acid compound corresponding to formula (I '-a), a pharmaceutically acceptable salt thereof and / or a solvate thereof.

The invention belongs to the technical field of biology, and particularly relates to antibacterial peptide based on pseudosciaena crocea RPL39 protein and application of the antibacterial peptide. The preparation method comprises the following steps: by taking a pseudosciaena crocea RPL39 protein as a template, intercepting a linear polypeptide of 12 amino acids, and carrying out amidation modification on a carboxyl terminal, so as to obtain the antibacterial peptide KRK12N: Lys-Thr-Phe-Arg-Ile-Lys-Arg-Phe-Leu-Ala-Lys-Lys-NH2; the method comprises the following steps: replacing threonine at the second site in an amino acid sequence of KRK12N with tryptophan, so as to obtain KRK12N-1: Lys-Trp-Phe-Arg-Ile-Lys-Arg-Phe-Leu-Ala-Lys-Lys-NH2; the method comprises the following steps: carrying out interchange on lysine at the sixth site and phenylalanine at the eighth site in an amino acid sequence of KRK12N-1, so as to obtain KRK12N-2: Lys-Trp-Phe-Arg-Ile-Phe-Arg-Lys-Leu-Ala-Lys-Lys-NH2, and carrying out interchange on lysine at the sixth site and phenylalanine at the eighth site in the amino acid sequence of KRK12N-1. The antibacterial peptide KRK12N, the antibacterial peptide KRK12N-1 and the antibacterial peptide KRK12N-2 have broad-spectrum bactericidal activity and can be used for specifically killing gram-positive bacteria and gram-negative bacteria. In addition, the antibacterial peptides KRK12N, KRK12N-1 and KRK12N-2 all have relatively weak hemolytic activity, relatively low cytotoxicity and good temperature, acid-base and salt ion stability. The antibacterial peptides KRK12N, KRK12N-1 and KRK12N-2 provided by the invention can be used for replacing antibiotics and are applied to prevention and treatment of bacterial diseases.

The invention relates to compounds that show antifungal and antibacterial properties in the context of treating plant and / or animal (e.g. human) diseases or infections. The invention relates to the use of a compound of formula (I) as an antifungal or antibacterial agent. The invention also relates to a compound of formula (I) for use in treating a fungal or bacterial disease or infection in a subject. Methods of producing a compound of formula (I) are also provided.

This application belongs to the technical field of traditional Chinese medicine compound formulas for poultry, and discloses a fermented traditional Chinese medicine compound, its preparation method, and its application. The fermented traditional Chinese medicine compound is obtained by fermenting a traditional Chinese medicine compound with Aspergillus niger. The traditional Chinese medicine compound comprises the following components by weight: 70-90 parts Coptis chinensis, 90-110 parts Scutellaria baicalensis, 110-130 parts Lonicera japonica, 90-110 parts Forsythia suspensa, 110-130 parts Pulsatilla chinensis, 90-110 parts Andrographis paniculata, 110-130 parts Taraxacum mongolicum, 70-90 parts Atractylodes lancea, 90-110 parts Atractylodes macrocephala, 90-110 parts Poria cocos, and 30-50 parts Glycyrrhiza uralensis. This application provides a fermented traditional Chinese medicine compound that, through fermentation with Aspergillus niger using a specific combination of traditional Chinese medicines, significantly improves the prevention and treatment efficacy of the traditional Chinese medicine combination against bacterial diseases in chickens.

A method for treating at least one of a bacterial disease and a viral disease according to an embodiment includes sequentially generating electrical stimulation at different frequencies, and sequentially applying the generated electrical stimulation at different frequencies to user's body through an electrode unit in contact with the body of a user who has the bacterial or viral disease.

The application belongs to the technical field of disease prevention and control of aquatic animals, and discloses application of a dimeric coumarin derivative in preparation of a drug for preventing and treating nocardiosis of aquatic animals. The dimeric coumarin derivative is 3,3'-(ethane-1,1-diyl)bis(4-hydroxy coumarin), which can be used as an active ingredient to prepare a drug for preventing and treating bacterial diseases of aquatic animals, and preferably in the form of feeding with the drug. Experiments prove that the derivative has an in-vitro minimum inhibitory concentration of about 3.125 μg / mL on Nocardia seriolae, and when the infected large-mouth bass is fed with the derivative at a concentration of 200 mg / kg and 2000 mg / kg, the survival rate of the large-mouth bass is 50-56% after 28 days, and the derivative has no obvious toxicity to the large-mouth bass within a feed concentration range of 100-3200 mg / kg, thereby effectively solving the problems of poor efficacy, residues and drug resistance of traditional antibiotics.