356 results about "Bacterial disease" patented technology

The invention belongs to the field of pesticide preparations, and particularly relates to an oil suspending agent containing pleuromutilin and a preparation method of the oil suspending agent. According to the invention, by optimizing the formula, the obtained oil suspending agent can effectively prevent and treat bacterial diseases, the dosage form of the oil suspending agent is more beneficial to application to spraying method pesticide application, and the embodiment verifies that the prevention and treatment effect on the bacterial diseases can reach 90% or above under the condition that the concentration of pleuromutilin is 200PPM. In addition, according to a traditional method, an active compound is obtained through fermentation, and then the active compound is mixed with a corresponding solvent and an auxiliary agent to be processed into a dosage form, so that the cost is high, and great pollution is brought. The method provided by the invention not only meets the control requirements on bacterial diseases, but also saves the energy and power cost from the aspect of process, reduces the use of solvents, is more beneficial to environmental protection, and thus has great economic benefits, environmental benefits and ecological benefits.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to quinolinone compounds, a preparation method and application of the quinolinone compounds in prevention and treatment of plant diseases. Compared with the prior art, the quinolinone compound is synthesized and applied to plant disease control, and the technical problem that the bacterial disease treatment effect of a chemical bactericide is reduced due to the fact that the resistance of original bacteria to the bactericide is enhanced in the plant bacterial disease treatment process is solved.

The invention relates to a microbial agent prepared based on a new strain of bacillus velezensis, which has the function of broad-spectrum antagonism of common pathogenic bacteria of aquatic products and can effectively prevent and / or treat bacterial diseases and / or fungal diseases of aquatic organisms including crustaceans and fishes. Meanwhile, the content of nitrite and ammonia nitrogen in aquaculture water can be effectively reduced, and the usage amount and residual quantity of antibiotics and chemical drugs in aquaculture are reduced.

The present application relates to a truncated pleuromutilin derivative containing an ester group, and a preparation method and use thereof. The structural formula is shown in Formula T: By testing the antibacterial activity of the truncated pleuromutilin derivative containing an ester group, it is proved that it has good antibacterial activity against plant bacterial diseases and is superior to truncated pleuromutilin. It can be used to prepare a plant pathogen control agent, and its preparation method is simple and the production cost is low.

The invention relates to a fluxazole amide composition and a preparation method thereof. More specifically, the present invention relates to synergistic compositions of fluoxazole amides and methods of preparing stable and non-phytotoxic formulations, the synergistic composition comprises fluoxazole amide or an agrochemically acceptable salt thereof, an insecticide selected from diamides, at least one or more compounds selected from insecticides, fungicides and plant health additives, and an agrochemically acceptable excipient. The invention further relates to pesticidal compositions for controlling harmful pests in plants, which can be formulated, are environmentally safe, exhibit high efficacy, and act on disease resistance management or delay the development of disease resistance by employing a variety of modes of action, plant tolerance against insect pests, mites, fungal and bacterial diseases and abiotic stress is increased and the overall health and vigor of the treated plant is improved.

The invention belongs to the field of molecular biology, and particularly relates to application of OsDOF3 protein or a coding gene thereof to improvement of rice broad-spectrum disease resistance and regulation of agronomic traits. According to the application, an OsDOF3 knockout mutant and an overexpression transgenic line are constructed under the background of susceptible rice, resistance phenotype analysis is performed by inoculating various pathogenic bacteria (including pyricularia oryzae, rhizoctonia solani and bacterial blight), and it is proved that OsDOF3 participates in regulation and control of an immunoreaction pathway of rice to fungal diseases (rice blast and sheath blight) and bacterial diseases (bacterial blight). Meanwhile, the application also finds that after a strong promoter ubi is adopted for driving, an overexpression material of the OsDOF3 is shorter than that of a wild plant, and the OsDOF3 influences normal growth and development of rice while stimulating plant immune response. The invention provides important gene resources and molecular theoretical basis for developing a new variety of broad-spectrum disease-resistant rice.

The invention belongs to the technical field of biology, and particularly relates to antibacterial peptide based on large yellow croaker CXCL8 protein and application of the antibacterial peptide. The preparation method comprises the following steps: by taking a large yellow croaker CXCL8 protein as a template, intercepting a linear polypeptide of 13 amino acids, and carrying out carboxyl terminal amidation modification, so as to obtain the antibacterial peptide AVV13N, and the amino acid sequence of the antibacterial peptide AVV13N is Ala-Arg-Trp-Val-Arg-Arg-Val-Leu-Lys-Lys-Met-Val-NH2; the antibacterial peptide AVK13N is obtained by interchanging lysine at the 11th site and valine at the 13th site in an amino acid sequence of the antibacterial peptide AVV13N, and the amino acid sequence of the antibacterial peptide AVK13N is Ala-Arg-Trp-Val-Arg-Arg-Val-Leu-Lys-Lys-Val-Met-Lys-NH2. The molecular weights of the antibacterial peptides AVV13N and AVK13N are both 1669.12 Da, the isoelectric points of the antibacterial peptides AVV13N and AVK13N are both 12.44, and the antibacterial peptides AVV13N and AVK13N are both alkaline polypeptides. The antibacterial peptides AVV13N and AVK13N have broad-spectrum bactericidal activity and can be used for specifically killing gram-positive bacteria and gram-negative bacteria. In addition, the antibacterial peptides AVV13N and AVK13N have relatively weak hemolytic activity, relatively low cytotoxicity and good temperature stability, pH value stability and salt ion stability. The antibacterial peptides AVV13N and AVK13N provided by the invention can replace antibiotics and are applied to prevention and treatment of bacterial diseases.

The invention provides an application of a penicillium strain in growth promotion and antibiosis, and particularly relates to an application of a penicillium strain with a preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.12767 in growth promotion and antibiosis. The penicillium strain can promote crop growth in Guangdong, Heilongjiang, Shandong and fields, can promote crop growth in fields and prevent and treat eubacterial diseases, is compatible with chemical drugs, can be suitable for soil in different areas and different environments to promote crop growth, and can prevent and treat eubacterial diseases.

The invention discloses application of quorum sensing quenching enzyme in prevention and control of vibrio corallinum pathogens. The quorum sensing quenching enzyme can remarkably inhibit coral bacterial diseases with different symptoms caused by different vibrio infections, can be used for preparing drugs or biological products for preventing and treating coral vibrio infections, and is used for preventing and controlling coral early pathogens.

The present invention provides a system for differential delivery of live BALO. The system comprises: a carrier comprising a polysaccharide hydrocolloid; and BALO immobilized within the carrier wherein the BALO is present in a physiological state selected from the group consisting of leech plastid, leech cyst and AP, which is present at a cell density of at least about 1.0 * 108 PFU / g carrier wherein the polysaccharide hydrocolloid is in the form of a wet or dry gel, and wherein the carrier preserves the viability and lysolytic efficacy of the immobilized BALO. Further provided are methods for making the systems for differential delivery of live BALO, as well as methods for using the same, e.g., for treating phytopathogenic bacterial diseases in plants or crops.

The invention belongs to the technical field of biology, and particularly discloses a high-temperature-resistant antibacterial protein Cystatin B sourced from marine fish as well as a preparation method and application of the high-temperature-resistant antibacterial protein Cystatin B. The high-temperature-resistant antibacterial protein Cystatin B is derived from pomfret, and the amino acid sequence of the high-temperature-resistant antibacterial protein Cystatin B is as shown in SEQ ID NO. 1; the nucleotide sequence of the gene for coding the high-temperature-resistant antibacterial protein Cystatin B is as shown in SEQ ID NO.2, and the sequences of primers adopted for cloning the gene are as shown in SEQ ID NO.3-4. The high-temperature-resistant antibacterial protein Cystatin B has a remarkable antibacterial effect on gram-negative bacteria such as escherichia coli, vibrio parahaemolyticus and edwardsiella tarda as well as gram-positive bacteria such as staphylococcus aureus; and after being treated at the temperature of 100 DEG C, the antibacterial agent still can keep relatively high antibacterial activity. The antibacterial protein is simple in preparation method, can replace traditional antibiotics, and can quickly and efficiently prevent and treat various common bacterial diseases in aquaculture.

The present invention discloses a Bacillus Velez, a microbial agent and an application thereof in the prevention and treatment of pathogenic bacteria and diseases, and relates to the technical field of the prevention and treatment of pathogenic bacteria and diseases. The Bacillus Velez provided by the present invention exhibits a strong inhibitory effect on the growth of pathogenic bacteria hyphae. It has a significant antagonistic effect on a variety of pathogens and a strong blocking effect on the infection cycle of pathogens. Based on the above characteristics, the Bacillus Velez provided by the present invention can be developed into a biocontrol agent and a biological pesticide, and can be applied to agricultural production and pesticide research. Therefore, the present invention provides a good strain resource for the future development of microbial agents for the biological prevention and treatment of edible fungi diseases.

The invention discloses a culture method for improving sebastes schlegeli fry quality, which comprises the following steps: collecting sebastes schlegeli breeder seed fields in advance, artificially breeding parents by using net cages on the sea, performing nutrition rejuvenation on the parents, and obtaining offspring fry by using a method of manually squeezing fry; reasonable culture density is controlled according to different seedling specifications, and natural plant active ingredients easy to absorb are screened to be matched with common microecologics and the like for use, so that disinfection and drug use are avoided; controlling the flowing speed of aquaculture water in different growth stages. The method integrates nutrition rejuvenation, artificial farrowing, pollution-free water quality regulation and control and offspring seed behavior state regulation and control, solves the problems that parent germplasm is poor, dead offspring seeds or offspring seed activity is insufficient, growth is slow, stress resistance is poor and the like in the offspring seed breeding process, and is high in operation controllability in the breeding period, high in offspring seed survival rate and remarkable in growth promoting immune effect; the method has good prevention and treatment effects on bacterial diseases, realizes pollution-free seedling breeding, can reduce disease occurrence and death rate, reduces feed coefficient, and effectively improves culture economic benefits.

The invention belongs to the field of prevention and control of bacterial diseases of aquatic animals, and discloses an acid-resistant broad-spectrum vibrio parahaemolyticus bacteriophage LVPP58 and application of the acid-resistant broad-spectrum vibrio parahaemolyticus bacteriophage LVPP58 in vibrio disease prevention and control, and the preservation number of the bacteriophage is CCTCC M 2025322. The bacteriophage is a broad-spectrum vibrio parahaemolyticus bacteriophage, not only can split vibrio parahaemolyticus, but also can split vibrio alginolyticus, the bacteriophage LVPP58 is stable in titer at the pH of 3-11 and the temperature of 30-60 DEG C, the bacteriophage and antibiotics are combined for use, a synergistic effect can be generated, the treatment effect is enhanced, the occurrence rate of drug resistance is reduced, and a new strategy is provided for solving the problem of bacterial drug resistance.

The Bacillus velezensis M173 was deposited with the Guangdong Microbial Culture Collection Center with a deposit number of GDMCC No. 61434. After being prepared into a seed-coating agent, Bacillus velezensis M173 can promote the growth and germination of plants and significantly improve the control effect on pathogens. Moreover, Bacillus velezensis M173 can relieve the condition of dead seedlings of crops at seedling stage after being applied to the crops. In particular, both pot experiments and field experiments prove that the Bacillus velezensis M173 of the present invention has a significant control effect on fungal and bacterial diseases, in particular, bacterial wilt and stem rot. Therefore, the Bacillus velezensis M173 of the present invention has broad application prospects.

The invention belongs to the technical field of pesticides, and particularly relates to a bactericidal composition containing isofetamid and benziothiazolinone, the active ingredients of the bactericidal composition comprise (A) isofetamid and (B) benziothiazolinone, the weight ratio of the component (A) to the component (B) is 15: 1-1: 15, and the total weight of isofetamid and benziothiazolinone accounts for 5-90% of the weight of the composition. In combination with actual application requirements, the bactericidal composition can be prepared into any one of an emulsion in water, a microemulsion, a suspending agent, water dispersible granules and wettable powder, and is used for preventing and treating common fungal and bacterial diseases in agricultural production.

The invention belongs to the field of biological agriculture, and particularly relates to bacillus amyloliquefaciens as well as a fungicide and application thereof. The invention discloses bacillus amyloliquefaciens B26 which is preserved in China General Microbiological Culture Collection Center on November 6, 2024, and the preservation number is CGMCC No.32519. The strain has a broad-spectrum antibacterial effect on fungal diseases and bacterial diseases, particularly has a remarkable antagonistic effect on tobacco wildfire germs, and can be used for preparing a bacillus amyloliquefaciens strain. The bacillus amyloliquefaciens B26 is used for preventing and treating the tobacco wildfire disease, it is found that the strain has an obvious preventing and treating effect on the tobacco wildfire disease, and a fungicide of the bacillus amyloliquefaciens B26 also has a good preventing and treating effect on the tobacco wildfire disease in a pot experiment. And a new scheme is provided for plant disease prevention and treatment, especially for green prevention and treatment of tobacco wildfire.

The invention relates to the field of agricultural pest control, and discloses a composite pest control agent based on a plant extract as a core. Comprising 15%-25% of honeysuckle extract, 10%-20% of podophyllum hexandrum extract, 15%-25% of camellia peel extract, 10%-20% of wikstroemia indica extract, 10%-20% of senecio scandens extract, 10%-20% of lycoris radiate extract, 1%-3% of a synergist, 5%-10% of an emulsifier and a solvent. According to the invention, a plurality of plant extracts are fused, and effective prevention and control of a plurality of fungi, bacterial diseases and pests are realized through accurate optimization of the ratio. Compared with a current technology which only adopts a single plant extract, the method has the advantages that the comprehensive prevention and treatment efficiency is remarkably improved, the problems of limited prevention and treatment range and poor multi-pest control effect are successfully solved, and the blank in the research and application field of the compound plant extract prevention and treatment agent is filled.

The present invention belongs to the field of molecular biology technology, and specifically relates to the use thereof of the disease resistance gene PPARalpha and its encoded protein in half-smooth tongue sole (Cynoglossus semilaevis). The present invention provides the application of PPARalpha gene and protein in making products for preventing and treating fish bacterial diseases. The overexpression of PPARalpha gene significantly improves the anti-infection ability of half-smooth tongue sole, reduces the mortality after bacterial infection. In addition, it improves the oxidative stress level of fish and the ability to metabolize toxic substances, regulates apoptosis and energy metabolism pathways in the immune process. Therefore, the products containing PPARalpha gene can be used to prevent and treat bacterial diseases in fish and reduce economic losses caused by pathogenic bacterial infections in aquaculture.

The invention provides acinetobacter for culturing prawns in saline-alkali water and application of the acinetobacter. The preservation number of the provided acinetobacter is CGMCC (China General Microbiological Culture Collection Center) No.36066. The acinetobacter soilis strain provided by the invention has remarkable comprehensive application advantages, can still keep higher growth activity and metabolic capability in a low-temperature environment, and continuously plays a water body purification function. Ammonia nitrogen and nitrite nitrogen in a water body can be efficiently degraded, the environment of the aquatic water body is remarkably improved by promoting the nitrogen circulation process, and harm caused by nitrogen pollution is reduced. In addition, the strain can effectively inhibit and prevent reproduction of pathogenic vibrios and reduce the occurrence risk of bacterial diseases of aquatic animals. The strain is high in safety, does not cause poison or stress reaction to bred animals even under the condition of high-concentration use, and has good ecological safety and environmental friendliness.

The invention discloses bacillus subtillis ZKY07 for preventing and controlling bacterial diseases of pachyrhizua angulatus and application of the bacillus subtillis ZKY07. According to the invention, a strain ZKY07 which has an antagonistic effect on two pathogenic bacteria of the Pachyrhizua angulatus bacterial wilt is screened from strains separated from dendrobium leaves and is used for biological control of the Pachyrhizua angulatus bacterial wilt, and the preservation number of bacillus subtillis ZKY07 is GDMCC No: 64618. Through determination, the ZKY07 has a good antagonistic effect on ralstonia solanacearum causing pogostemon cablin bacterial wilt, ralstonia solanacearum causing peanut bacterial wilt, ralstonia solanacearum causing tomato bacterial wilt, Klebsiella variicola causing banana sheath rot, fusarium asiaticum causing peanut fruit rot and sclerotium rolfsii causing peanut southern blight. The strain ZKY07 has the effects of producing protease, producing cellulase, dissolving potassium, dissolving organophosphorus and fixing nitrogen. The invention provides an excellent biological control means for the bacterial wilt of the pueraria thomsonii.

The present invention belongs to the technical field of rapid detection of drug sensitivity for bacteria. Disclosed are an enrichment culture medium, and a preparation method therefor and the use thereof. The enrichment culture medium comprises the following raw materials in parts by mass: 15.0-20.0 parts of tryptone, 3.5-5.5 parts of peptone, 1.5-3.5 parts of glucose, 5.0-6.5 parts of yeast extract, 2.0-2.5 parts of dipotassium phosphate, 2.0-3.5 parts of disodium hydrogen phosphate, 1.0-1.5 parts of monopotassium phosphate, 2.5-7.5 parts of sodium chloride, 12.0-18.0 parts of proteose peptone, 15.0-22.0 parts of beef heart infusion powder, 8.0-12.0 parts of soya peptone, 1.0-5.0 parts of 0.1% nicotinamide adenine dinucleotide (NAD), 30-100 parts of newborn calf serum inactivated at 56°C for 30 min, 2.0-4.0 parts of mannitol, 3.0-5.0 parts of sodium pyruvate, 0.23-0.45 parts of cycloheximide, 0.8-2.0 parts of 0.05% bromothymol blue, 2.5-4.5 parts of 0.1% methylene blue, and 1000 parts of distilled water, with the pH value of 6.8-7.5. The enrichment culture medium is used to screen effective therapeutic drugs for bacterial diseases in poultry, and is convenient to use and has a single enrichment effect superior to that of respective selective enrichment broths of target bacteria. Therefore, the culture medium can realize rapid proliferation of common pathogenic bacteria in poultry.

The invention relates to paenibacillus strongly ZKSW001 as well as a fungicide and application thereof, and belongs to the technical field of microorganisms. The paenibacillus pumilus ZKSW001 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.36076, the preservation date is September 25, 2025, and the address of the preservation institution is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The invention also provides application of the paenibacillus strongly ZKSW001 in inhibition of harmful bacteria in soil, prevention and treatment of root-knot nematode and promotion of plant growth. The paenibacillus strongly ZKSW001 disclosed by the invention not only can promote the growth of crops and realize weight loss and efficiency improvement, but also can control the occurrence of soil-borne fungal and bacterial diseases, and can inhibit the growth of root-knot nematode. Chemical pesticide application can be reduced, pesticide residues are reduced, and sustainable development of agricultural economy is promoted.

The invention discloses a derivative containing chiral thioether and sulfone units as well as a preparation method and application of the derivative. The derivative containing the chiral thioether and the sulfone unit is applied to preparation of medicaments for preventing and treating rice bacterial leaf blight, rice bacterial leaf streak, citrus canker, tobacco bacterial wilt, muskmelon bacterial leaf blight, tomato bacterial wilt, watermelon fruit rot, Chinese cabbage soft rot, peach tree shot hole disease and cabbage black rot fungus. The invention further discloses application of the derivative containing the chiral thioether and sulfone unit to preparation of medicaments for preventing and treating rice bacterial leaf blight, rice bacterial leaf streak, citrus canker, tobacco bacterial wilt, muskmelon bacterial leaf blight, tomato bacterial wilt, watermelon fruit rot and cabbage black rot. The derivative containing chiral thioether and sulfone units has the characteristics of broad bactericidal spectrum and high activity, has excellent prevention and treatment effects on bacterial diseases, and is simple and feasible in preparation steps and low in production cost.

The invention relates to the technical field of pesticide bactericides, and particularly discloses a bactericide containing atomic copper and zinc oxide. Transition metal copper is anchored in defect sites on the surface of nano-zinc oxide in a monatomic form to obtain composite powder, the composite powder and an auxiliary agent are mixed and stirred and then subjected to coarse crushing, fine grinding, spraying and granulation, and the bactericide containing atomic copper and zinc oxide is obtained. The bactericide provided by the invention solves the waste caused by clusters and crystal lattices of copper ions, achieves the effect of supplementing copper and zinc at the same time through disposable use, greatly reduces the cost, saves copper resources, enables the utilization rate of copper to be high, reduces the pollution of heavy metals to the environment, and efficiently prevents and removes insect pests, bacterial diseases and fungal diseases of crops; the bactericidal composition can be applied to most crops, is high in bactericidal speed and lasting in prevention and treatment effect, and can be compounded with various agricultural agents for use.

The invention discloses application of a licoflavone compound in resisting food-borne pathogenic bacteria and dairy cow mastitis pathogenic bacteria. The licoflavone compound has the advantages that the licoflavone compound can be used for treating food-borne bacterial diseases caused by food-borne bacteria such as escherichia coli, bacillus cereus, listeria monocytogenes and salmonella enteritidis; food-borne fungal diseases caused by food-borne fungi such as aspergillus flavus, penicillium expansum and monilinia coerulea; the licochalcone A shows certain inhibitory activity on dairy cow mastitis pathogenic bacteria caused by streptococcus agalactiae, streptococcus dysgalactiae, escherichia coli and staphylococcus aureus, and particularly has an obvious inhibitory effect on food-borne pathogenic bacteria and dairy cow mastitis pathogenic bacteria by three licochalcone A with different contents. The compound disclosed by the invention is simple in structure and relatively high in safety, and is expected to be developed into a novel antibacterial drug.

The invention discloses a preparation method of a recombinant lactic acid bacteria preparation for expressing antibacterial peptide and interleukin 22 (IL-22) and application of a composite microecological preparation composed of the antibacterial peptide and the interleukin 22 in prevention and treatment of animal bacterial infection diseases. The probiotic preparation provided by the invention comprises lactic acid bacteria, antibacterial peptide and interleukin, the recombinant lactic acid bacteria preparation can be taken orally without generating toxicity to an organism, and the recombinant lactic acid bacteria preparation can be colonized in intestinal tracts and secrete the antibacterial peptide and IL-22. The antibacterial peptide secreted by the recombinant lactic acid bacteria can punch bacterial cell membranes to cause bacterial death, does not cause generation of drug-resistant bacteria, and can reduce or replace the use of antibiotics; iL-22 secreted by the recombinant lactic acid bacteria can promote the repair of damaged tissues of intestinal tracts, activate the immune system of the organism and enhance the resistance; the probiotic effect of lactic acid bacteria can regulate the balance of intestinal flora of the organism, promote nutrient absorption and enhance the immunity of the organism. The preparation provided by the invention has the advantages of innovativeness, good safety, no toxic or side effect, simple administration mode, remarkable effect and the like, can effectively reduce the use of antibiotics, and provides a new solution for preventing and treating bacterial diseases in animal husbandry.

The present invention discloses the application of isoquinoline-3-carboxylic acid in preventing and controlling plant bacterial diseases. The isoquinoline-3-carboxylic acid provided by the present invention has an obvious inhibitory effect on plant bacterial diseases, and the plant bacterial diseases are Ralstonia solanacearum, Acidovorax avenae subsp. Citrulli, Pseudomonas syringae pv. actinidiae, Pectobacterium carotovorum subsp. carotovorum, Xanthomonas oryzae pv. oryzae, Xanthomonas oryzae pv. oryzicola, Alternaria brassicae, Xanthomonas citri subsp. citri, Pectobacterium carotovorum subsp. carotovorum, Xanthomonas fragariae, Pseudomonas syringae pv. lachrymans, Dickeya dadantii, Xanthomonas axonopodis pv. mangiferaeindicae. The isoquinoline-3-carboxylic acid of the present invention has protective and therapeutic effects on Acidovorax avenae subsp. Citrulli.

The present invention discloses the application of coumarin-3-carboxylic acid in preventing and treating plant bacterial diseases. The coumarin-3-carboxylic acid provided by the present invention has a significant inhibitory effect on plant bacterial diseases. The plant bacterial diseases are oryzae bacterial leaf blight, oryzae bacterial leaf streak, citrus canker, cantaloupe bacterial fruit spot, tomato bacterial wilt, strawberry bacterial angular leaf spot, cabbage black rot, cabbage soft rot, potato soft rot, mango bacterial angular leaf spot, cassava bacterial wilt, cucumber bacterial angular leaf spot, kiwifruit canker and banana bacterial soft rot. The coumarin-3-carboxylic acid provided by the present invention has protective and therapeutic effects on melon bacterial fruit spot.

The invention discloses a bactericidal composition containing cuaminosulfate and benziothiazolinone, the composition contains cuaminosulfate and benziothiazolinone, and the weight part ratio of cuaminosulfate to benziothiazolinone in the composition is (1: 8)-(32: 1). The bactericidal composition containing cuaminosulfate and benziothiazolinone is used for preventing and treating bacterial diseases. According to the invention, cuaminosulfate and benziothiazolinone are compounded for use, the synergistic effect is obvious, the development of drug resistance of diseases can be delayed, the service life of the pesticide can be prolonged, the control effect of effective components of the pesticide can be obviously improved, the number of times of pesticide application is reduced, the pesticide application amount is reduced, and the environmental pressure is relieved, so that the effects of main prevention and comprehensive control are achieved; the requirement of national'zero increase 'of pesticides is met.