284results about How to "Low cytotoxicity" patented technology

The invention relates to the technical field of antibacterial peptides, and particularly discloses a marine antibacterial peptide and application thereof, and the amino acid sequence of the marine antibacterial peptide is as shown in SEQ ID NO.1: MWKLPKWRNGRRRGFKIPRW. The marine antibacterial peptide CD109 provided by the invention has an inhibition effect on staphylococcus aureus, acinetobacter baumannii, pseudomonas aeruginosa and klebsiella pneumoniae, and has extremely low cytotoxicity.

The invention relates to the technical field of antibacterial peptide application, in particular to an antibacterial peptide for inhibiting drug-resistant staphylococcus aureus and application of the antibacterial peptide. The antibacterial peptide is obtained by performing N-terminal acetylation modification and C-terminal amidation modification on polypeptide as shown in SEQ ID NO.1. The invention further discloses a preparation method of the antibacterial peptide. The antibacterial peptide provided by the invention is a novel cationic antibacterial peptide, the minimum inhibitory concentrations of the antibacterial peptide to pathogenic bacteria staphylococcus aureus ATCC12600 and staphylococcus aureus ATCC33591 are respectively 4 [mu] g / mL and 32 [mu] g / mL, the biological safety is extremely high, and due to the characteristics, the antibacterial peptide shows extremely high medical drug antibacterial value, and can be used for preparing the antibacterial peptide. Alternative medicinal resources are provided for clinically resisting the two human pathogenic bacteria in the future.

The invention belongs to the technical field of biological medicines, and relates to an antibacterial polypeptide, a composition and application thereof. The amino acid sequence of the antibacterial polypeptide is as shown in SEQ ID NO. 1: KWKIKWPVKWFKM-NH2. The invention also discloses a preparation method of the antibacterial polypeptide. Experiments show that the antibacterial polypeptide disclosed by the invention has broad-spectrum antibacterial activity on gram-positive bacteria and / or gram-negative bacteria, and also has low cytotoxicity and low hemolysis. The antibacterial polypeptide provided by the invention consists of 14 amino acids, is relatively short in peptide chain, small in molecular weight and easy to artificially synthesize, is a micromolecular polypeptide with extremely high application value, can be used for preparing a novel antibacterial agent, and has a wide application prospect.

The invention provides a hydrogel composition. The hydrogel composition is prepared from the following components in percentage by weight: 0.5 to 15 percent of an adhesion component, 0.5 to 10 percent of a moisturizing component, 0.01 to 5 percent of a bioactive component, 0.01 to 5 percent of a physical crosslinking agent, 0.01 to 2 percent of a flavoring component, 0.01 to 2 percent of an antimicrobial component and the balance of medical purified water, wherein the bioactive component comprises at least one of lipoic acid, tea polyphenol, lactic acid bacteria extract and metabiotics; the antimicrobial component comprises at least one of copper ions, benzyl alcohol, p-hydroxyacetophenone, sodium methyl hydroxybenzoate and sodium ethyl hydroxybenzoate. According to the hydrogel composition disclosed by the invention, the low-concentration antimicrobial component is introduced, so that the antimicrobial component has more stable and effective bactericidal activity and can be more stably adhered to a wound, and the hydrogel composition can have better antibacterial performance and a function of promoting wound healing without additionally adding antibiotics.

The invention relates to a preparation method of an antibacterial film. The preparation method comprises the following steps: preparing and forming an m-SiO2-SH-Ag-HA composite material; and blending the m-SiO2-SH-Ag-HA composite material into a membrane material, so as to form the antibacterial membrane. The hydrophilic HA in the antibacterial film formed by the preparation method can coat the outer side of m-SiO2-SH-Ag through electrostatic interaction to form an electrostatic barrier, effectively prevent the release of Ag < + > and play roles in stabilization, protection and slow release on one hand, and can increase the hydrophilicity of the surface of the film and effectively inhibit the early adhesion of bacteria on the other hand. When the target bacteria appear, HA coated on the surface of the m-SiO2-SH-Ag-HA is degraded by secreting hyaluronidase, so that the exposure and release of Ag < + > are promoted. The antibacterial film disclosed by the invention can release sterilization components through enzymatic initiation to realize on-demand antibiosis, and toxic and side effects and resource waste caused by uncontrollable continuous release of Ag < + > to the environment are avoided.

The invention is applicable to the technical field of polypeptides, and provides a novel antibacterial peptide GG25 and application thereof, and the amino acid sequence of the antibacterial peptide GG25 is as shown in SEQ ID No.1. The molecular weight of the novel antibacterial peptide GG25 is 2890.52 Da, and the novel antibacterial peptide GG25 has antibacterial activity on escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, enterococcus faecalis, salmonella typhimurium, methicillin-resistant staphylococcus aureus, staphylococcus aureus, staphylococcus epidermidis, listeria monocytogenes and bacillus subtilis; the hemolytic activity is low, the cytotoxicity is small, and the escherichia coli and methicillin-resistant staphylococcus aureus are not easily induced to generate drug resistance; in addition, the gelatin chitosan food coating containing GG25 also has a good beef preservation effect, and can be applied to the fields of food, animal husbandry, medicine and the like.

The invention discloses a pyrenyl Schiff base fluorescent derivative, a fluorescent probe, a preparation method of the pyrenyl Schiff base fluorescent derivative and application of the pyrenyl Schiff base fluorescent probe in biological imaging, and belongs to the technical field of fluorescent probes. The pyrenyl Schiff base fluorescent probe capable of specifically detecting the zinc ions is prepared through two-step chemical reaction of Suzuki coupling reaction and aldehyde amine condensation reaction, and the pyrenyl Schiff base fluorescent probe has good recoverability and low cytotoxicity, is high in practicability and low in cost, and can be applied to detection of the zinc ions. In addition, the sensor has excellent ion selectivity to zinc ions, extremely high sensitivity, good Stokes displacement and visual sensing performance, and detection of exogenous zinc ions and endogenous zinc ions in cells and tissues is realized through biological imaging. The problems of difficult synthesis process, slow response speed, high detection cost, non-ideal biological imaging effect and the like of the conventional fluorescent derivative are solved.

The invention belongs to the technical field of biology, and particularly relates to antibacterial peptide based on large yellow croaker CXCL8 protein and application of the antibacterial peptide. The preparation method comprises the following steps: by taking a large yellow croaker CXCL8 protein as a template, intercepting a linear polypeptide of 13 amino acids, and carrying out carboxyl terminal amidation modification, so as to obtain the antibacterial peptide AVV13N, and the amino acid sequence of the antibacterial peptide AVV13N is Ala-Arg-Trp-Val-Arg-Arg-Val-Leu-Lys-Lys-Met-Val-NH2; the antibacterial peptide AVK13N is obtained by interchanging lysine at the 11th site and valine at the 13th site in an amino acid sequence of the antibacterial peptide AVV13N, and the amino acid sequence of the antibacterial peptide AVK13N is Ala-Arg-Trp-Val-Arg-Arg-Val-Leu-Lys-Lys-Val-Met-Lys-NH2. The molecular weights of the antibacterial peptides AVV13N and AVK13N are both 1669.12 Da, the isoelectric points of the antibacterial peptides AVV13N and AVK13N are both 12.44, and the antibacterial peptides AVV13N and AVK13N are both alkaline polypeptides. The antibacterial peptides AVV13N and AVK13N have broad-spectrum bactericidal activity and can be used for specifically killing gram-positive bacteria and gram-negative bacteria. In addition, the antibacterial peptides AVV13N and AVK13N have relatively weak hemolytic activity, relatively low cytotoxicity and good temperature stability, pH value stability and salt ion stability. The antibacterial peptides AVV13N and AVK13N provided by the invention can replace antibiotics and are applied to prevention and treatment of bacterial diseases.

The invention belongs to the technical field of medicines, and discloses a substituted oxadiazole-aniline compound, a preparation method thereof, a pharmaceutical composition taking the compound as an active component, and application of the substituted oxadiazole-aniline compound and the pharmaceutical composition in treatment and / or prevention of infectious diseases caused by coronavirus. Specifically, the invention relates to a compound shown as a formula (I) and an isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the compound disclosed by the invention, and R1, R2, R3, R4 and n are described in the specification. The invention aims to prepare a new compound with anti-coronavirus activity, and the new compound can be used as a potential new drug for treatment or prophylactic treatment of infectious diseases caused by viruses, especially pneumonia diseases caused by coronaviruses. # imgabs0 #

The invention provides a probe for simultaneously detecting gamma-glutamyltranspeptidase and peroxynitrite and a preparation method of the probe. The probe provided by the invention can realize the effect of simultaneously detecting gamma-glutamyltranspeptidase and peroxynitrite, and has high sensitivity and specificity; meanwhile, the probe also has the advantages of low cytotoxicity and fast reaction. Therefore, the probe provided by the invention has potential application value in early diagnosis and in-situ monitoring of AKI, and is expected to become a powerful tool for evaluating kidney injury and oxidative stress states.

The invention discloses a novel fluorescent probe based on triphenylamine and a preparation method and application thereof, the preparation method comprises the following steps: S1, dissolving 4-methoxyaniline and 1-bromo-4-iodobenzene in a solvent A, and then adding copper iodide, 1, 10-phenanthroline and potassium tert-butoxide for reaction to obtain a compound 1; s2, dissolving the compound 1 obtained in the step S1, (5-formylthiophene-2-yl) boric acid and anhydrous potassium carbonate in a solvent B, and then adding PdCl2 (dppf) for reaction to obtain a compound 2; and S3, dissolving the compound 2 obtained in S2 and malononitrile in a solvent C, and then adding triethylamine for reaction to obtain the TPA-CN probe. The TPA-CN probe is used for monitoring exogenous and endogenous SO2 and viscosity change in living cells. According to the invention, dual imaging of SO2 and viscosity in a biological system and a food sample can be realized.

The invention belongs to the technical field of biological medicine, and particularly relates to an iron ion carrier and a preparation method and application thereof. The iron ion carrier disclosed by the invention has the advantages that the iron ion carrier disclosed by the invention can have relatively good binding activity with iron ions and ferrous ions, and has relatively low cytotoxicity and relatively long in-vivo drug half-life period.

The invention belongs to the field of immunology, and particularly relates to amplification of NK cells, in particular to a method for amplifying NK cells by using NK92 cells as trophoblast cells, which specifically uses NK92 cells secreting IL-21, IL-15 and IL-18 as trophoblast cells and PBMC as seed cells to directionally amplify and activate natural killer cells, and comprises the following steps: transfecting an NK92 cell strain through lentivirus; the NK92 cell strain capable of stably expressing IL-21, IL-15 and IL-18 is obtained; then obtaining monoclonal cells of NK92 cells through flow sorting and limit dilution methods, finally culturing and amplifying, preparing NK92 trophoblasts through irradiation, and mixing the NK92 trophoblasts with PBMC (peripheral blood mononuclear cells) for culturing so as to prepare the NK cells. According to the method, the NK cells can be efficiently amplified and activated, and the activated NK cells can improve the immunity of the organism, so that tumor and virus infection is resisted. The invention has wide application in medicine.

The invention discloses a cationic polyester, comprising a copolymer of monomer C, monomer S and monomer M, wherein the copolymer terminal group is modified with a group E; the monomer C comprises cholesterol; the monomer S comprises an organic acid having at least two carboxyl groups at the terminal group; the monomer M comprises a compound containing two hydroxyls and at least one secondary amine or tertiary amine; and the compound modified with the group E comprises at least one primary amine, secondary amine or tertiary amine group. The in vitro cell-level mRNA delivery efficiency of the cationic polyester of the invention is significantly better than that of the existing commonly used commercial gene transfection reagents, and the cytotoxicity is lower; the cationic polyester is soluble in ethanol, and is easy to be industrialized and clinically applied in preparations, and therefore has great practical application prospects.

The invention relates to a near-infrared small-molecule fluorescent dye with a pentadecamethine conjugated chain and a preparation method and application thereof, the near-infrared small-molecule fluorescent dye has a structure as shown in a general formula A, and is a novel dye matrix based on two benzoindole structures connected by a pentadecamethine chain, the functional dye molecule with the absorption and emission peak wavelength in the near-infrared region is obtained through regulation and control of substituent groups on a parent structure, and different substituent groups can be introduced to a fifteen-membered methine chain and an indole N atom. The absorption and emission wavelength is in a near-infrared region of 1100-1300nm, and the material has the characteristics of high brightness, excellent light stability, low cytotoxicity, simplicity and convenience in synthesis, easiness in structure modification and the like. After water-soluble modification, the polymer can be widely applied to the biomedical fields of tumor targeting imaging, living body angiography and the like. General formula A # imgabs0 #

The invention relates to a silicon-doped hydroxyapatite (at) MnO2 composite material and a preparation method and application thereof.The preparation method comprises the following steps that a permanganate solution is added into a silicon-doped hydroxyapatite suspension for a reaction, and the mass ratio of silicon-doped hydroxyapatite to permanganate is (5-8.75): (0.01-0.024); and after the reaction is finished, carrying out post-treatment to obtain the silicon-doped hydroxyapatite (at) MnO2 composite material. According to the preparation method, the permanganate solution is doped into the silicon-doped hydroxyapatite suspension for reaction, the permanganate solution can be decomposed and grow on the silicon-doped hydroxyapatite, a core-shell structure with the silicon-doped hydroxyapatite as a core and MnO2 as a shell is formed, and the obtained silicon-doped hydroxyapatite and MnO2 composite material is uniform in morphology, high in specific surface area and high in specific surface area. And a uniform shell layer is formed by controlling the dosage ratio of the permanganate to the silicon-doped hydroxyapatite, so that low cytotoxicity or even no cytotoxicity is ensured, and remarkable thermal response performance is achieved.

The invention discloses an antibacterial peptide and application thereof. The antibacterial peptide comprises one or more of an antibacterial peptide PFK with an amino acid sequence as shown in SEQ ID NO: 1, an antibacterial peptide PVK with an amino acid sequence as shown in SEQ ID NO: 2 and an antibacterial peptide PIK with an amino acid sequence as shown in SEQ ID NO: 3. The antibacterial peptides PFK, PVK and PIK disclosed by the invention have antibacterial effects on porphyromonas gingivalis, streptococcus mutans, acinetobacter baumannii, escherichia coli and staphylococcus aureus, and the antibacterial peptides PFK, PVK and PIK have relatively low hemolytic activity and relatively low cytotoxicity, so that the antibacterial peptides PFK, PVK and PIK can be used for preparing biological antibacterial preparations, anti-infection drugs or oral products.

The invention relates to dexcamphanol or fenchol ester derivatives of 2-hydroxynicotinic acid and pharmaceutical application of the dexcamphanol or fenchol ester derivatives, and belongs to the technical field of biological medicine. The structural general formula of the derivative disclosed by the invention is # imgabs0 #, wherein R1 is selected from-H,-Cl, alkyl with 1 to 8 carbon atoms,-CF3,-CF2H,-CN,-SCH3,-OH,-CHO,-CH2OH,-CH2NH2,-COOH, halogenated phenyl or-NR4R5; r4 and R5 are independently selected from-H or-CH3; r2 is selected from-H, alkyl with 1-6 carbon atoms, and acyl or carbamoyl with 2-7 carbon atoms; r3 is selected from # imgabs1; # X is selected from-CH = or-N =. The derivative disclosed by the invention has a good inflammation inhibition effect; and under the condition of high concentration, the compound has lower cytotoxicity and is safer. The compound can be used for preparing medicines for treating inflammation and inflammation-related diseases such as cerebral apoplexy, neuropathic pain, depression and senile dementia.

The invention belongs to the technical field of biomedical materials, and particularly relates to a carboxymethyl chitin composite material for an articular cavity and a preparation method of the carboxymethyl chitin composite material. The carboxymethyl chitin composite material for the articular cavity is prepared by selecting carboxymethyl chitin, hyaluronic acid, sodium alginate and chitosan which are good in biocompatibility as raw materials and performing functional modification treatment respectively, and through the synergistic effect of all the components, the elasticity modulus of the composite material is effectively improved, the swelling rate is reduced, and the joint cavity is more stable. And meanwhile, the composite material also has proper viscosity and degradation performance, and can meet application requirements.

The invention discloses temperature-sensitive antibacterial hydrogel based on ultra-small-particle-size copper nanoparticles and a preparation method of the temperature-sensitive antibacterial hydrogel, and relates to the technical field of biomedical materials. The preparation method of the temperature-sensitive antibacterial hydrogel comprises the step of uniformly mixing the gel matrix, the stabilizer, the pH buffer solution and the ultra-small-particle-size copper nanoparticles to prepare the temperature-sensitive antibacterial hydrogel. The preparation method of the copper nanoparticles with the ultra-small particle size comprises the following steps that lactoferrin is dissolved in water, copper sulfate pentahydrate is added, an alkali solution is added to adjust the pH of the solution to be 8-14, then a reducing agent is added for a reaction, dialysis and drying treatment are conducted, and the copper nanoparticles with the ultra-small particle size are obtained. The hydrogel has good injectability, can release the copper nanoparticles under specific conditions and rapidly sterilize, in addition, the hydrogel is convenient to synthesize and simple to operate, has good biocompatibility, shows relatively low cytotoxicity to cells, and has relatively great application potential in the process of treating skin wound infection.

The invention discloses an o-benzoyl sulfimide derivative pure organic long-afterglow material as well as a preparation method and application of the o-benzoyl sulfimide derivative pure organic long-afterglow material. The preparation method of the material comprises the following step: carrying out one-step reaction on o-benzoyl sulfonyl imide and corresponding halogenated hydrocarbon or acyl chloride to synthesize the N-site modified long afterglow material of the o-benzoyl sulfonyl imide. The invention has the following characteristics: (1) the raw materials are cheap and easily available, and the synthesis process is mature; (2) the material is long in afterglow life and high in quantum efficiency; and (3) the material has low cytotoxicity and good biocompatibility, and has great potential in the fields of long afterglow display and drug anti-counterfeiting.

The present invention discloses an antimicrobial peptide and its application, wherein the antimicrobial peptide comprises one or more of an antimicrobial peptide PFK having an amino acid sequence as shown in SEQ ID NO: 1, an antimicrobial peptide PVK having an amino acid sequence as shown in SEQ ID NO: 2, and an antimicrobial peptide PIK having an amino acid sequence as shown in SEQ ID NO: 3. The antimicrobial peptides PFK, PVK and PIK of the present invention have antimicrobial effects on Porphyromonas gingivalis, Streptococcus mutans, Acinetobacter baumannii, Escherichia coli and Staphylococcus aureus, and the antimicrobial peptides PFK, PVK and PIK have low hemolytic activity and low cytotoxicity, and can be used to prepare biological antimicrobial preparations, anti-infective drugs or oral products.

The invention discloses a membrane-rupturing antibacterial peptide and application thereof. On the basis of an artificial intelligence screening method, a membrane-rupturing antibacterial peptide KLAKLLKLLLWAQNELDQKK is identified from a proteome of toads, the membrane-rupturing antibacterial peptide has three positive charges, and 50% of amino acid is hydrophobic amino acid. Through experimental tests, the antibacterial peptide can inhibit the growth of 10 different strains including gram negative strains and gram positive strains; meanwhile, the semi-maximum hemolysis concentration and the semi-maximum cytotoxicity concentration of the antibacterial peptide are both greater than 128 mu g / mL, and the antibacterial peptide has good biological safety. The antibacterial peptide plays an antibacterial role by destroying cell membranes, has the characteristic that the drug resistance of bacteria is not easily caused, and is an ideal development object of antibacterial drugs and antibacterial products such as disinfectants, detergents and feed additives.

The invention discloses a preparation method of novel pH-sensitive DHA (at) ZIF-8NPs and application of the novel pH-sensitive DHA (at) ZIF-8NPs in preparation of a medicine for treating sarcopenia-osteoporosis, and relates to the technical field of research and development of the medicine for treating sarcopenia-osteoporosis. The preparation method comprises the following steps: step 1, dissolving 75 mg of zinc nitrate hexahydrate in 2.5 ml of deionized water to obtain a solution I, dissolving 165 mg of 2-methylimidazole in 4.5 ml of methanol to obtain a solution II, and dissolving 10 mg of DHA in 0.5 ml of DMF to obtain a solution III; step 2, adding the solution I into a mixture of the solution II and the solution III while stirring at room temperature, and obtaining a mixed solution after the synthetic solution becomes turbid rapidly for 3 minutes; step 3, centrifuging the mixed solution for 10 minutes at the rotating speed of 12000 rpm, so as to obtain DHA (at) ZIF-8NPs; 4, washing DHA (at) ZIF-8NPs with methanol for three times to completely remove unreacted reagents, and collecting all supernate for measuring the packaging efficiency and the drug loading content of DHA; and step 5, finally, performing freeze drying on the DHA (at) ZIF-8NPs, and performing low-temperature storage.

The invention relates to the technical field of microbial probiotic preparations, in particular to a sodium alginate multifunctional composite microsphere as well as a preparation method and application thereof. The sodium alginate multifunctional composite microspheres are obtained by dissolving the carbohydrate vesicles, the traditional Chinese medicine nanoparticles and the probiotics in a sodium alginate solution and then dropwise adding the solution into a calcium chloride solution through an ionic cross-linking effect. According to the invention, the amphiphilic xylooligosaccharide-cystamine derivative with H2S response is synthesized through a click reaction on the basis of prebiotic xylooligosaccharide. And the amphipathic saccharide vesicles are obtained through self-assembly by virtue of hydrophilic and hydrophobic effects. Sanguinarine iodide prepared by purification, separation and reflux and baicalin are self-assembled in an aqueous solution through a non-covalent bond, and the traditional Chinese medicine nanoparticles are prepared through ultrasonic treatment. An in-vitro simulated release experiment proves that the sodium alginate multifunctional composite microsphere is relatively low in release rate under an acidic condition, so that substances are favorably delivered to intestinal tracts; and the release of encapsulated substances can be better realized in neutral and alkaline environments.

The invention discloses an oligopeptide for treating neonatal bacterial meningitis and a preparation method of the oligopeptide, and belongs to the technical field of biological medicines. The invention successfully designs and prepares small molecular mimic peptides capable of effectively blocking escherichia coli from invading into the brain based on a lactam cyclization technology, the small molecular mimic peptides are named as EC-MP-1 and EC-MP-2, and animal level research proves that the mimic peptides disclosed by the invention can inhibit the invasion of E44 escherichia coli to HBMEC; cell and molecular level researches prove that the mimic peptide disclosed by the invention can play an effective therapeutic role. A new thought is provided for prevention and treatment of neonatal meningitis, and reliable scientific data is accumulated for subsequent development and clinical application of micromolecule polypeptide drugs.

The application provides a method for inducing poly-podophylli rhizoma by using clump buds, comprising the following steps: S1, cutting stem segments from a podophylli rhizoma mother plant, soaking and cleaning to obtain explants; S2, disinfecting and cleaning the explants, inoculating into a clump bud induction medium to obtain podophylli rhizoma clump buds; S3, inoculating the clump buds into doubling liquid I, washing with a liquid clump bud induction medium after culture, and then transferring into doubling liquid II; S4, taking out the clump buds, cleaning, inoculating into a clump bud induction medium, and then inoculating into a bud proliferation medium; S5, waiting until 1-2 cm, screening out potential mutant strains through phenotypes, inoculating into the bud proliferation medium for subculture, and obtaining mutant plants; and S6, rooting culture of the mutant plants, and after root systems grow, planting and raising seedlings, and then poly-podophylli rhizoma plants are obtained. In the research, suitable concentration of colchicine is used for induction treatment twice, and through stage concentration switching and intermittent recovery strategies, the poly-ploid induction efficiency and explant survival are effectively considered.

The invention discloses a compound with a triazolopyridine structure as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The compound has a brand-new chemical structure, the unique skeleton and the optimized molecular weight endow the compound with excellent patent medicine potential, hydroxyl and other functional groups in the compound provide a wide space for chemical modification, and the development prospect of diversified pharmacological activity derivatives is indicated; the compound significantly inhibits uric acid activity, has efficacy superior to that of a traditional drug benzbromarone, has lower cytotoxicity, and is an ideal uric acid-reducing drug candidate; the synthetic route is simple, the conditions are mild, the raw materials are easy to obtain, industrial production is facilitated, the high purity of the product is ensured through an efficient separation means, a powerful guarantee is provided for clinical medication safety, and novel uric acid lowering drugs are expected to be developed.

A ferritin fusion protein according to an embodiment includes a cancer-targeting peptide and a peptide to be cleaved in a cancer cell linked to an outer surface thereof. The ferritin fusion protein may enable efficient cancer-targeting treatment by releasing an anticancer drug specifically in a cancer cell, has excellent anticancer efficacy, and can effectively reduce toxicity to a normal cell, thereby minimizing side effects of anticancer treatment.

The invention discloses an amidino sulfonamide derivative or a pharmaceutical salt thereof, the structural general formula of the amidino sulfonamide derivative is as shown in the specification: # imgabs0. The amidino sulfonamide derivative provided by the invention not only has excellent anti-inflammatory activity, but also has lower toxicity.