61 results about "Pogostemon" patented technology

The invention discloses a substance-based quality detection method for Xiaohuang powder, and belongs to the technical field of quality detection of traditional Chinese medicines. According to the method, standard control of a classic famous prescription is realized by constructing a multi-dimensional quality control system. The method comprises the following steps: firstly, carrying out specific identification on gardenia, divaricate saposhnikovia root, liquorice and pogostemon cablin in the prescription by adopting a thin-layer chromatography; meanwhile, a multi-index component content determination method is established, and the contents of five components including geniposide, cimicifugin, 5-O-methylvisammioside, liquiritin and glycyrrhizic acid are synchronously determined by applying a high performance liquid chromatography (HPLC). Through a system quality control strategy combining qualitative identification and quantitative analysis, not only is a quality standard system of the substance reference of the Xiaohuang powder perfected, but also reliable technical guarantee is provided for ensuring the stability and consistency of product quality. The establishment of the method establishes a standardized method system for the substance-based quality control of the classical famous prescription Xiaohuang powder.

The invention provides a pogostemon cablin cold stress response transcription factor and application thereof in resisting cold and increasing pogostemon cablin alcohol content, and belongs to the technical field of gene engineering. The terpene metabolism cold response transcription factor PatbZIP6 and / or PatMYB5 is obtained through screening, the transcription factor obtained through screening can remarkably improve synthesis accumulation of patchouli alcohol through a genetic transformation method, the cold resistance of patchouli is improved, and the transcription factor can be used for breeding new varieties of patchouli.

The present invention discloses a compound microbial agent for alleviating continuous cropping obstacles of traditional Chinese medicine crops and its application. The compound microbial agent of the present invention contains Bacillus amyloliquefaciens Y34, Serratia marcescens Y35, Bacillus amyloliquefaciens Y40 and Streptomyces SD; it can be applied to improve soil, eliminate diseases of Polygonatum odoratum, Pogostemon cablin and Cynanchum stauntonii, and promote crop growth. The compound microbial agent of the present invention can reduce soil-borne diseases during the planting process of traditional Chinese medicine, alleviate continuous cropping obstacles of traditional Chinese medicine, improve the yield and quality of traditional Chinese medicine, and has important application value especially in the cultivation and production of traditional Chinese medicine crops such as Polygonatum odoratum and Pogostemon cablin.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a pharmaceutical composition for treating rhinitis and a preparation method and application thereof. The invention provides a pharmaceutical composition for treating rhinitis. The pharmaceutical composition is prepared from the following components in parts by mass: 12-15 parts of astragalus membranaceus, 9-12 parts of codonopsis pilosula, 9-12 parts of houttuynia cordata, 6-9 parts of divaricate saposhnikovia root, 9-12 parts of bighead atractylodes rhizome, 6-9 parts of radix bupleuri, 6-9 parts of ginger processed pinellia, 6-9 parts of fructus forsythiae, 6-9 parts of radix angelicae, 6-9 parts of fried semen armeniacae amarae, 6-9 parts of cocklebur fruit, 6-9 parts of isatis root, 6-9 parts of pogostemon cablin, 3-6 parts of rhodiola rosea, 2-4 parts of schizonepeta, 3-6 parts of dried ginger, 3-5 parts of Chinese date and 3-6 parts of liquorice. The composition provided by the invention is effective for both allergic rhinitis and chronic sinusitis, can relieve acute symptoms and improve chronic inflammation, and overcomes the defect of insufficient pertinence of the existing traditional Chinese medicine compound.

The invention discloses a pogostemon cablin essential oil clathrate compound preparation device, and relates to the technical field of medicine preparation, the pogostemon cablin essential oil clathrate compound preparation device comprises a kettle body, the bottom of the kettle body is an arc-shaped lower sealing head structure; the flow guide cone is arranged in the center of the bottom of the kettle body, and baffles are vertically arranged on the inner wall of the kettle body in a circumferential array mode; the stirring assembly is arranged in the kettle body, and the stirring assembly is used for being matched with the flow guide cone and the baffle and is used for guiding liquid in the kettle body to circularly flow up and down; the outer circulation high-shearing assembly comprises a high-speed shearing device, a suction inlet assembly is arranged at the side bottom of the kettle body and communicated with a feeding port of the high-speed shearing device, and a backflow port is formed in the side wall of the kettle body and communicated with a discharging port of the high-speed shearing device; an outer circulation passage is formed between the kettle body and the high-speed shearing device; the ultrasonic-assisted assembly is arranged near the suction inlet assembly; and the essential oil injection pipe is arranged in the flow guide cone.

This invention relates to the field of external moxibustion devices in traditional Chinese medicine, and in particular to a moxa stick for clearing dampness using the thunder-fire method, and its preparation method. The moxa stick comprises moxa wool, compound Chinese herbal powder, and moxa leaf paper; the compound Chinese herbal powder includes principal, assistant, adjuvant, and guiding herbs; the principal herbs include Evodia rutaecarpa, Cinnamomum cassia, and Ligusticum chuanxiong; the assistant herbs include stir-fried Atractylodes lancea, Poria cocos, Polyporus umbellatus, Alisma plantago-aquatica, stir-fried Atractylodes macrocephala, Astragalus membranaceus, and Amomum villosum; the adjuvant herbs include stir-fried Phellodendron chinense, Sophora flavescens, Artemisia capillaris, Gardenia jasminoides, Akebia quinata, Pinellia ternata, Centella asiatica, and Rosa laevigata root; the guiding herbs include Angelica dahurica, Pogostemon cablin, Angelica sinensis, Paeonia lactiflora, Glycyrrhiza uralensis, and Nelumbo nucifera leaf. This invention, guided by compound formulation theory, material innovation, process optimization, and packaging design, provides a thunder-fire moxa stick with strong targeted dampness-clearing properties, stable combustion performance, safety, portability, and controllable quality, showing promising application prospects.

The invention provides a traditional Chinese medicine composition formula for improving intestinal flora and application thereof, and relates to the technical field of traditional Chinese medicine, and the traditional Chinese medicine composition formula is prepared from the following raw materials: bighead atractylodes rhizome, poria cocos, pericarpium citri reticulatae, fructus amomi, fried malt, fried rice sprout, lotus seed, gordon euryale seed, dandelion, agastache rugosus, eupatorium, fried white hyacinth bean, medicated leaven, semen raphani and astragalus membranaceus. According to the invention, the number of beneficial bacteria in intestinal tracts can be increased, multi-target regulation of intestinal flora can be carried out, growth of harmful bacteria can be inhibited, diversity of intestinal flora can be improved, structural balance of flora can be recovered, the effect is comprehensive, and the effect is remarkable; the used raw materials are all medicinal and edible or common traditional Chinese medicines, are high in safety and have no obvious toxic or side effects; the traditional Chinese medicine composition is suitable for different types of intestinal flora disorder patients, and especially has a good treatment effect on functional dyspepsia, inflammatory diseases, irritable bowel syndrome and other diseases.

The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a homologous medicine and food traditional Chinese medicine composition with anti-fatigue effect, its preparation method and uses. The traditional Chinese medicine composition is processed from the following raw materials by weight: 10-30 parts of wine-processed polygonatum sibiricum, 10-20 parts of Chinese yam, 10-20 parts of green tea, 5-10 parts of mint, and 5-10 parts of pogostemon cablin. The preparation method is also disclosed, and it is made into granules. The medicine of the present invention is derived from traditional Chinese medicine that is both medicine and food, has both effectiveness and no toxic and side effects, is used for the prevention and improvement of qi deficiency and blood deficiency symptoms caused by fatigue, can effectively improve the fatigue state, and the preparation process of the present invention is reliable, has good reproducibility, and a high granule forming rate.

The invention relates to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition which comprises the following raw materials: radix angelicae, radix scutellariae, herba ephedrae, flos magnoliae, scalded semen armeniacae amarae, rhizoma belamcandae, herba pogostemonis and radix platycodonis. The invention further provides a traditional Chinese medicine mixture prepared from the traditional Chinese medicine composition and a preparation method of the traditional Chinese medicine mixture. The invention also provides application of the traditional Chinese medicine composition, the traditional Chinese medicine mixture or the preparation method in preparation of medicines for preventing and / or treating acute respiratory system infection. According to the traditional Chinese medicine composition, the traditional Chinese medicine mixture and the preparation method of the traditional Chinese medicine composition and the traditional Chinese medicine mixture, the curative effect on acute respiratory system infection is obvious, and no side effect exists.

The invention discloses an N-terminal truncation of pogostemon cablin alcohol synthase PcPTS, and a coding gene and application thereof, the N-terminal truncation of pogostemon cablin alcohol synthase PcPTS is prepared by the following method: carrying out N-terminal 12 amino acid truncation on wild type pogostemon cablin alcohol synthase PcPTS to obtain the N-terminal truncation of pogostemon cablin alcohol synthase PcPTS; compared with wild-type patchouli alcohol synthase, the N-terminal truncated body of the patchouli alcohol synthase PcPTS has higher catalytic activity, can remarkably improve the yield of patchouli alcohol in an artificial yeast cell factory, and is more beneficial to being applied to industrial production. Experiments show that the yield of the patchouli alcohol of the recombinant strain reaches 19.58 + / -2.79 mg / L and is increased by 35.1% compared with that of a wild strain (14.50 + / -0.89 mg / L).

The invention provides a composition. The composition comprises extracts of one or more of borneol (blumea balsamifera), lysimachia tricolor, myrrh, tea trees, lemons, thyme, rosemary, cistanche, cynomorium songaricum, herba epimedii, mint, peach kernels, radix cyathulae, pogostemon cablin, pumpkin seeds, curcuma zedoary, rhizoma acori graminei and turmeric. The invention further provides a cream prepared from the extract (plant essential oil), and the cream is suitable for being smeared on the skin of the perineum or the prostate area and used for relieving prostate discomfort, especially prostatitis symptoms. The invention further provides a combined treatment method, namely the cream is combined with a quantum resonance instrument, and local stimulation with a certain frequency is applied, so that the transdermal absorption and anti-inflammatory effects of the medicine are enhanced, and the overall curative effect is improved.

The invention relates to the field of cosmetics, in particular to a skin care composition containing pogostemon cablin, a preparation method of the skin care composition and cosmetics. The invention provides a skin care composition containing pogostemon cablin, which is prepared from the following components in percentage by mass: 10-25% of tea tree oil, 10-25% of pogostemon cablin, 10-25% of pogostemon cablin, 10-25% of pogostemon cablin, 10-25% of 15-30% of pogostemon cablin volatile oil; and 50 to 65% of evening primrose oil. According to the composition disclosed by the invention, all the components generate a synergistic effect, so that the inhibition effect on a propionibacterium acnes S21016 strain and staphylococcus aureus is improved; the anti-inflammatory effect is realized. The propionibacterium acnes and the staphylococcus aureus are closely related to the acnes; by inhibiting growth and reproduction of propionibacterium acnes and staphylococcus aureus bacteria, the effect of treating the acnes through bacteriostasis and sterilization is achieved.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and a preparation method and application thereof. The traditional Chinese medicine composition provided by the invention comprises astragalus membranaceus, cinnamon, semen cassiae, lotus leaves, poria cocos, lophatherum gracile, malt, hawthorn, rose, pogostemon cablin, sophora flower, semen torreya and emblic leafflower fruit. The formula takes the effects of tonifying spleen and promoting diuresis, soothing liver and regulating qi, and removing food retention and dissolving turbidity as the core, and has multiple effects of promoting urination and relieving stasis. The traditional Chinese medicine composition provided by the invention can regulate and control abnormal signal pathways of fatty liver and atherosclerosis; the compound has no obvious inhibition effect on a hepatic cell line HepG2 and has an inhibition effect on a hepatic stellate cell line LX2; the obvious lipid-lowering effect is achieved on a HepG2 high-lipid model; liver fat accumulation and liver injury in a TAA-induced zebrafish fatty liver model can be remarkably improved.

The invention discloses a pharmaceutical composition for rhinitis health care and respiratory tract circulation improvement and a preparation method thereof.The pharmaceutical composition is prepared from pogostemon cablin, osmanthus fragrans, geranium, wild chrysanthemum flowers, semen armeniacae amarae, astragalus membranaceus, pericarpium citri reticulatae, platycodon grandiflorum, mint and menthol through processing and liquefying, and through the synergistic effect of all the pharmaceutical ingredients, the pharmaceutical composition has the effects of inducing resuscitation with fragrance, dissolving turbidity and dredging resuscitation; the condition of unsmooth ventilation of the nose can be effectively improved, and uncomfortable symptoms such as nasal obstruction can be relieved; the spreading and descending of lung qi are regulated, and the normal physiological function of the respiratory tract is maintained; the whole resistance of the body and local qi and blood nourishing of the nose are enhanced, and repair and regeneration of nose tissues are promoted; the invasion of external heat toxin to the nose is resisted, and the inflammatory response is relieved. Long-term use of the nasal mask can significantly promote respiratory tract microcirculation, enhance the immune defense function of the nose, and effectively prevent occurrence and recurrence of nasal diseases.

This invention provides a traditional Chinese medicine preparation for treating or relieving functional constipation in children, belonging to the field of traditional Chinese medicine technology. The preparation is made from raw Atractylodes macrocephala, banana root, Citrus reticulata, mulberry, Lophatherum gracile, Hovenia dulcis leaf, Ziziphus jujuba leaf, Pogostemon cablin, Citrus reticulata peel, Torreya grandis seed, and licorice. This traditional Chinese medicine preparation significantly increases the number of fecal particles in constipation model rats over 24 hours, increases fecal water content, and improves intestinal propulsion rate, thus improving intestinal peristalsis. In clinical observation, this traditional Chinese medicine preparation effectively relieves the core symptoms of children, shortens the interval between defecation, softens stool, and alleviates straining during defecation. It also improves accompanying symptoms such as abdominal distension and halitosis. After the course of treatment, bowel regularity returns, and there is no significant recurrence during follow-up, providing a new option for the clinical treatment of functional constipation in children.

The invention relates to the technical field of traditional Chinese medicine, in particular to Jianqu and a processing method thereof, and the Jianqu comprises the following raw materials and auxiliary materials: polygonum hydropiper, eupatorium, artemisia apiacea, semen armeniacae amarae, phaseolus calcaratus, fructus aurantii (stir-fried with bran), betel nut powder, rhizoma cyperi powder, magnolia officinalis powder, mint powder, rice sprout powder, malt powder, cinnamon powder, perilla powder, hawthorn (stir-fried), rhizoma atractylodis, radix angelicae, pericarpium citri reticulatae, pogostemon cablin, liquorice, common vladimiria root, wheat bran and flour. According to the Jianqu disclosed by the invention, the herba eupatorii which also has the functions of relieving exterior syndrome and resolving dampness, can promote digestive juice secretion and does not contain toxicity is used for replacing xanthium sibiricum, and the formula does not contain the xanthium sibiricum with toxicity, so that the original effects of improving dyspepsia and relieving gastrointestinal discomfort can be well maintained and even improved; moreover, the injury to the liver can be well avoided, and the safety is better.

The application discloses a preparation method and application of selenium-rich polypeptides with improved cognitive function activity, and belongs to the technical field of functional food. The selenium-rich polypeptides are CSeCGAP, KSeCSeCPK and KHSeCAA. The selenium-rich polypeptides are derived from protease hydrolysis products of selenium-rich Pogostemon iseanus, are safe and nutritious, and have no toxic side effects. The CSeCGAP, KSeCSeCPK and KHSeCAA are combined with BACE-1 through hydrogen bonds to form a relatively stable structure, thereby inhibiting the generation of Aβ and playing the effect of improving the cognitive function activity. The application provides a reference for developing new food-derived bioactive peptide functional peptides with improved cognitive function activity and functional products taking the selenium-rich polypeptides as components for improving the cognitive function activity.

The invention discloses a traditional Chinese medicine compound preparation for treating constipation and a preparation method of the traditional Chinese medicine compound preparation. The traditional Chinese medicine compound preparation is prepared from 20-90 g of radix astragali, 10-60 g of raw rhizoma atractylodis macrocephalae, 10-15 g of peach kernels, 30-60 g of fructus cannabis, 30-45 g of herba leonuri, 6-60 g of raw radix et rhizoma rhei, 30-60 g of fried fructus aurantii immaturus, 15-30 g of ginger processed cortex magnoliae officinalis, 15-20 g of pogostemon cablin, 15-30 g of fried betel nuts, 10-30 g of fried semen raphani, 3-6 g of stevia rebaudiana leaves, 3-10 g of agilawood, 15-30 g of pericarpium citri reticulatae and 10-15 g of radix aucklandiae. The traditional Chinese medicine compound preparation disclosed by the invention has the beneficial effect of comprehensively treating constipation through compatibility of various medicinal materials. Firstly, radix astragali has the effects of enhancing immunity and regulating spleen and stomach functions, and can improve intestinal tract movement and promote digestion and absorption of food; and the raw bighead atractylodes rhizome has the effects of invigorating spleen and replenishing qi, can regulate the transportation and transformation functions of spleen and stomach, and is beneficial to improving the root cause of constipation. The peach kernels and the fructus cannabis have the effect of relaxing bowel, and can promote peristalsis of intestinal tracts.

The present invention discloses a Huoxiang Zhengqi pharmaceutical preparation, its preparation method and application, belonging to the technical field of traditional Chinese medicine. Using the raw materials recorded in the Chinese Pharmacopoeia, after extracting each raw material, the extract is processed, including: the extract of Magnolia officinalis, the extract of Angelica dahurica, Pogostemon oil, Perilla leaf oil are included by beta-cyclodextrin, and the extracts of Atractylodes lancea, Citrus reticulata Blanco, Poria cocos, Areca peel, Pinellia ternata and Glycyrrhiza glabra extract are made into an extract; or the combined extract of Atractylodes lancea, Citrus reticulata Blanco and Angelica dahurica is included by beta-cyclodextrin, and the extracts of Poria cocos, Areca peel, Pinellia ternata and Glycyrrhiza glabra extract are made into an extract; the inclusion compound and the extract are mixed and made into a preparation. The present invention uses beta-cyclodextrin to include the ethanol extract and volatile oil of Magnolia officinalis (or Magnolia officinalis and Angelica dahurica) at the same time. The inclusion compound is insoluble in water and made into an oral solid preparation, which significantly improves the taste, enhances the stability of components such as volatile oil, and avoids the use of co-solvents such as Tween 80 and ethanol.

This invention belongs to the field of pharmaceutical technology and relates to a preparation process of a modified Huoxiang Zhengqi compound. The preparation process is as follows: Pinellia ternata and Angelica dahurica are percolated; Pogostemon cablin, Perilla frutescens, Citrus reticulata peel, Magnolia officinalis, and Atractylodes macrocephala are extracted in groups for 2-5 hours, and the total volatile oil is collected. The residues of each group are decocted with water, and the decoctions of each group are collected; Poria cocos, Platycodon grandiflorus, Glycyrrhiza uralensis, Areca catechu peel, Ziziphus jujuba, and Zingiber officinale are decocted with water to obtain a decoction; the total volatile oil is added to an inclusion material, and inclusion is obtained using an ultrasonic-assisted method; the percolation and decoctions are combined, concentrated, and centrifuged to obtain a supernatant; a preservative is added to the supernatant and the inclusion material to obtain the final product. This invention extracts medicinal materials containing volatile oils in groups and uses a cyclodextrin inclusion complexation process, which not only improves the total extraction rate of volatile oils, but also increases the content of hesperidin, hydrated oxypenicillin, magnolol, honokiol, patchouli flavonol, and baicalein, while improving the taste and flavor of the flavored patchouli flavonoid compound.

The invention discloses a herbal incense moxibustion, a preparation process and a manufacturing device, and relates to the technical field of herbal incense moxibustion. The herbal incense moxibustion comprises a filter tip, tobacco shreds and tobacco paper wrapping the tobacco shreds; the tobacco shreds comprise 5-15 g of radix angelicae, 8-20 g of semen brassicae, 5-15 g of pericarpium citri reticulatae, 10-20 g of clove, 10-20 g of rhizoma acori graminei, 20-30 g of mint, 6-18 g of cape jasmine, 3-12 g of rhizoma cyperi, 5-15 g of hawthorn, 8-12 g of agilawood, 5-15 g of folium artemisiae argyi, 3-9 g of safflower and 10-20 g of pogostemon cablin, after the herbal incense moxibustion is ignited, a user absorbs medicine smoke generated after the traditional Chinese medicinal materials in the herbal incense moxibustion are fully burnt, the medicine efficacy of the medicinal materials can be fully absorbed by the human body, and therefore the effect of the herbal incense moxibustion is achieved. And the device is convenient to carry and can be used for treating the human body without assistance of appliances.

The invention discloses a traditional Chinese medicine compound composition and application thereof in treating chronic kidney disease related pruritus, and belongs to the field of pruritus disease treatment. The traditional Chinese medicine compound composition is prepared from the following raw materials in parts by mass: 45 parts of radix sophorae flavescentis, 45 parts of cortex dictamni, 30 parts of herba schizonepetae, 30 parts of rhizoma alismatis, 30 parts of salted semen plantaginis, 20 parts of oldenlandia diffusa, 20 parts of folium mori, 20 parts of angelica sinensis, 20 parts of ligusticum wallichii, 20 parts of radix polygoni multiflori preparata, 20 parts of astragalus membranaceus, 20 parts of semen coicis and 15 parts of pogostemon cablin. After decoction and rotary evaporation, the traditional Chinese medicine compound composition can be used for lotion / ointment for treating chronic kidney disease related pruritus, and the lotion / ointment is smeared on pruritus parts for treatment; the lotion / ointment is obvious in effect, low in cost, free of toxic and side effects, wide in medicine source and simple and feasible in treatment method.

The invention relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a Yao bath lotion for diminishing inflammation and relieving itching and a preparation method thereof.The Yao bath lotion is composed of a traditional Chinese medicine raw material extracting solution, auxiliary materials and water, and the traditional Chinese medicine raw material extracting solution is prepared from traditional Chinese medicine raw materials; the traditional Chinese medicine raw materials comprise ovateleaf holly bark, pogostemon cablin, lemongrass, cinnamomum camphora, semiliquidambar cathayensis, folium artemisiae argyi, vitex negundo, rhizoma acori graminei, alpinia pumila, poria peel, tuber fleeceflower stem, caulis spatholobi, uncaria rhynchophylla, liquidambar formosana hance, cortex albiziae, rock bean vine and cardamom. The preparation method comprises the following steps: S1, carrying out water extraction on part of the traditional Chinese medicine raw materials, and filtering and concentrating to obtain a water extraction concentrated solution; s2, carrying out ethanol reflux extraction on the residual traditional Chinese medicine raw materials, filtering to recover ethanol, and concentrating to obtain an ethanol extraction concentrated solution; s3, the two concentrated solutions are mixed, auxiliary materials are added for dissolution, the water amount is adjusted, then homogenization and filtration are conducted, and the Yao bath lotion is obtained.The Yao bath lotion has the advantages that active ingredients are enriched through water extraction and alcohol extraction, volatile oil and fat-soluble and water-soluble ingredients are in synergistic effect, itching and inflammation are quickly relieved, and skin inflammation and pruritus symptoms are effectively relieved.

This invention relates to the application of a traditional Chinese medicine composition in a drug for ulcerative colitis, characterized in that the traditional Chinese medicine composition comprises: 1-100 parts of Magnolia officinalis, 1-100 parts of Areca catechu (roasted), 1-100 parts of Amomum villosum (roasted), 1-100 parts of Ephedra sinica, 1-100 parts of Prunus armeniaca (bitter), 1-100 parts of Notopterygium incisum, 1-100 parts of Zingiber officinale (fresh), 1-100 parts of Pogostemon cablin, 1-100 parts of Eupatorium fortunei, 1-100 parts of Atractylodes lancea, 1-160 parts of Poria cocos, 1-120 parts of Atractylodes macrocephala, 1-100 parts of Gypsum fibrosum, 1-100 parts of Crataegus pinnatifida (roasted), 1-100 parts of Massa fermentata (roasted), 1-100 parts of Hordeum vulgare (roasted), 1-100 parts of Pheretima aspergillum, 1-100 parts of Cynanchum paniculatum, 1-100 parts of Dryopteris crassirhizoma, and 1-100 parts of Lepidium apetalum.

The invention discloses a pogostemon cablin ketone acylhydrazone compound, a preparation method and application, an acylhydrazone group is introduced into pogostemon cablin ketone, so that a compound with a novel structure is obtained, the structure of the compound is shown as a formula I: # imgabs0 #, and the preparation method of the compound is relatively simple in operation, easily available in raw materials and low in cost. The compound has broad-spectrum bactericidal activity, especially has a remarkable inhibition effect on valsa mali, sclerotinia sclerotiorum and botrytis cinerea, and can be used as a bactericide for preventing and treating plant fungal diseases.

The invention discloses a sesquiterpenoids compound and a preparation method and application thereof, the sesquiterpenoids compound has a structure as shown in a formula I, and the sesquiterpenoids compound is separated from pogostemon esquirolii of a labiatae thesium plant. The sesquiterpenoids provided by the invention can be used for inhibiting the generation of nitric oxide induced by LPS (Lipopolysaccharide), and also can be used for inhibiting the expression of inflammatory factors IL-6, TNF-alpha, COX-2 and iNOS; the sesquiterpenoids can also inhibit activation of an NF-kappa B pathway and an MAPK pathway induced by LPS, and finally exert an excellent anti-inflammatory effect. The sesquiterpenoids provided by the invention are extracted from a natural plant thesium membranaceum, have small cytotoxicity, can be used for preparing new anti-inflammatory drugs, and provide molecular reserve and scientific basis for research and development of the anti-inflammatory drugs.

The invention discloses a relieving composition containing extracellular vesicles and application, and belongs to the technical field of cosmetics, the relieving composition containing the extracellular vesicles comprises the extracellular vesicles and an olive leaf extract, and the mass ratio of the extracellular vesicles to the olive leaf extract is 1: (0.5-5); the extracellular vesicles are wrinkled gianthyssop herb extracellular vesicles, and the wrinkled gianthyssop herb extracellular vesicles are obtained by centrifuging wrinkled gianthyssop herb juice. According to the soothing composition, the agastache rugosus extracellular vesicles and the olive leaf extract are combined, the mass ratio of the agastache rugosus extracellular vesicles to the olive leaf extract is controlled to be 1: (0.5-5), the soothing effect is remarkably improved under the synergistic effect of the agastache rugosus extracellular vesicles to the olive leaf extract, and the soothing composition can effectively inhibit expression of inflammatory factors, reduce activity of eosinophilic granulocytes and inhibit activity of propionibacterium acnes, and has a good soothing effect. The activity of hyaluronidase is effectively inhibited, meanwhile, the availability of the olive leaf extract is effectively improved through the wrinkled gianthyssop herb extracellular vesicles, and the soothing effect is remarkably improved through combination of the wrinkled gianthyssop herb extracellular vesicles and the olive leaf extract.

The invention provides an external traditional Chinese medicine composition with a bacteriostatic effect and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises 20-40 parts of pepper, 20-40 parts of fructus cnidii, 10-30 parts of ligusticum, 5-15 parts of pogostemon cablin, 20-40 parts of schizonepeta, 10-30 parts of senecio scandens and 20-40 parts of mint. A response surface experiment design is adopted to optimize an extraction process of traditional Chinese medicinal materials and medicine residues, and the content of effective components such as total flavonoids in the extract is increased; the oil-soluble matrix and the water-soluble matrix are selected, so that the water-soluble medicine components and the oil-soluble medicine components can be better mixed, and the stability is high. The traditional Chinese medicine composition disclosed by the invention can inhibit the formation of bacterial cell membranes and destroy the structures of the bacterial cell membranes, and the permeability of the cell membranes is improved, so that macromolecular substances and proteins are leaked; the intracellular ATP content is reduced, and the extracellular alkaline phosphatase is increased, so that the growth of bacteria is finally inhibited or the bacteria are killed. According to the extraction process, effective components of the medicine are extracted to the maximum extent, and efficient utilization of the medicinal materials is guaranteed.

The present application provides a Pogostemon cablin transcription factor PcIDD2 and its application in positively regulating the biosynthesis of pogostone. The amino acid sequence of the Pogostemon cablin transcription factor PcIDD2 is shown in SEQ ID NO.1; it is a potential transcription factor with the function of promoting the biosynthesis of pogostone and is of great significance for promoting the efficient synthesis of pogostone.

This invention relates to the field of traditional Chinese medicine (TCM) technology, providing a TCM preparation for treating diaper dermatitis and its preparation method. The TCM preparation for treating diaper dermatitis comprises the following components by weight: 5-10g of Phellodendron bark, 5-10g of Sophora flavescens root, 5-10g of Kochia scoparia fruit, 5-10g of Sanguisorba officinalis root, 5-10g of Platycladus orientalis leaf, 5-10g of Lycium chinense root bark, 5-10g of Pogostemon cablin, and 5-10g of Polygonatum sibiricum. The optimal weight proportion is: 10g each of Phellodendron bark, Sophora flavescens root, Kochia scoparia fruit, Sanguisorba officinalis root, Platycladus orientalis leaf, Lycium chinense root bark, Pogostemon cablin, and Polygonatum sibiricum. This TCM preparation for treating diaper dermatitis not only selects herbs with heat-clearing, dampness-drying, blood-cooling, and detoxifying effects, but also considers the delicate nature of children's internal organs and insufficient vital energy, selecting herbs such as Polygonatum sibiricum and Pogostemon cablin to achieve the purpose of tonifying deficiency to expel pathogens, addressing both the root cause and the symptoms.