The invention discloses a
traditional Chinese medicine composition for treating
Crohn disease intestinal
fibrosis as well as a preparation method and application of the
traditional Chinese medicine composition. The
traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-18 parts of
codonopsis pilosula, 6-18 parts of bighead atractylodes
rhizome, 1-6 parts of
coptis chinensis, 9-24 parts of Chinese yam, 9-24 parts of dahurian
patrinia herb, 5-15 parts of rhizoma atractylodis, 5-15 parts of
pericarpium citri reticulatae, 5-15 parts of
lotus plumule, 9-24 parts of red paeony root, 9-24 parts of hairyvein agrimony, 5-15 parts of
turtle shell, 5-15 parts of
cassia twig, 9-24 parts of poria cocos, 6-18 parts of peach kernel, 5-15 parts of moutan
bark, 5-15 parts of dendrobe, 5-15 parts of
selaginella tamariscina and 12-30 parts of
coix seed. Aiming at the clinical problem of fibrous
stenosis formed after
inflammation control, the traditional Chinese
medicine composition disclosed by the invention adopts a treatment method of tonifying
spleen and
drying dampness, clearing heat and removing
turbidity, promoting
blood circulation to
remove blood stasis and
softening hardness to dissipate stagnation, and is scientific in formula.
Network pharmacology prediction and experimental
verification show that the compound can regulate and control the
fibrosis process in a multi-target manner, remarkably reverse the formed intestinal
fibrosis and improve the intestinal elasticity, is good in long-term medication safety, and provides an effective traditional Chinese
medicine solution for treating the
Crohn disease intestinal fibrosis.