The present invention discloses a detoxifying and slimming meal replacement powder which is characterized by comprising the following raw materials in parts by weight: 10-40 parts of enzyme powder, 4-16 parts of mussel shell powder, 5-15 parts of pearl powder, 2-10 parts of momordica charantia powder, 2-10 parts of nelumbo nucifera powder, 2-10 parts of peach blossom powder, 2-8 parts of gomphrena globose powder, 2-8 parts of red date powder, 2-8 parts of tremella powder, 2-6 parts of red bean powder and 2-6 parts of coix chinensis powder. The detoxifying and slimming meal replacement powder uses enzyme powder, pearl powder and mussel shell powder as raw materials to produce the replacement powder, is rich in proteins, amino acids, minerals and other nutrients, is easily absorbed by human body, and has efficacies of clearing heat and toxic materials, and improving eyesight and nourishing yin, and at the same time the added momordica charantia powder, nelumbo nucifera powder, peach blossom powder, gomphrena globose powder, red date powder, tremella powder, red bean powder and coix chinensis powder and other accessory ingredients which are rich in vitamins and minerals can not only increase nutrition and dietary fiber, but also have low calories and a strong sense of fullness, and can play roles of replenishing blood, declining swelling, promoting urination, clearing away heat and detoxifying and slimming.