35 results about "Ovulation" patented technology

The application relates to the field of biological medicine, and particularly discloses application of a sophora japonica extract in preparation of a product for improving the reproductive performance of ewes. The sophora japonica extract can effectively inhibit pyroptosis of ovarian granulosa cells by down-regulating expression of cysteine protease B, further reverses follicle atresia and ovulation disorders caused by pyroptosis, and improves the reproductive performance; animal experiments show that the sophora japonica extract can optimize the follicle development structure of ewes, inhibit overdevelopment of large follicles, and significantly improve the ovulation efficiency, thereby providing a new scheme for inhibiting pyroptosis of ovarian granulosa cells and improving the reproductive performance of livestock.

The application discloses a superovulation method based on synergistic effect of composite hormones, which comprises the following steps: injecting PMSG and FSH to induce estrus, and injecting hCG to promote synchronous ovulation. The application adopts synergistic regulation of PMSG (long-acting follicle-stimulating hormone) and FSH (short-acting follicle-stimulating hormone), PMSG completes follicle recruitment, and FSH finely regulates the development stage, thereby avoiding overgrowth of follicles. In the examples, the Burmese cat, the British short cat and the farm cat do not appear OHSS symptoms (such as ovarian enlargement and ascites), and the ovarian state is normal.

The present application relates to the field of traditional Chinese medicine, and specifically relates to a kind of external use traditional Chinese medicine composition for treating thin endometrium, which is composed of the following raw medicinal materials: cinnamon 250-300g, fennel 250-300g, Corydalis 250-480g, Cnidium 250-400g, safflower 250-300g, Evodia 150-200g, mugwort leaf 250-300g, and ginger juice 500-600ml.The external use combined medicine of the present application can obviously improve the symptoms of dysmenorrhea, little menstrual flow, dark red menstrual color, and more menstrual blood clots, thicken the endometrial thickness during ovulation, and improve the clinical pregnancy rate of patients with thin endometrium.The external use traditional Chinese medicine is absorbed through skin, does not burden liver and kidney functions, achieves the purposes of warming meridians, activating blood and resolving stasis through the action of acupoint meridian, has little side effects, and is convenient for promotion.

1. The name of the design product: ovulation detector. 2. The use of the design product: for detecting animal ovulation. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

The invention relates to the field of animal husbandry molecular breeding and precise breeding, in particular to an animal husbandry improved variety breeding twin-fetal cattle system based on gene screening. The system comprises an ovulation potential typing module, a uterine bearing capacity quantification module, a sex compatibility verification module and a decision module. Constructing a combined evaluation model of the double-ovulation basis and the uterus metabolism capability by systematically integrating site specific amplification and gene expression quantification technologies; the core of the method is that a precise reproduction instruction is generated according to full-link data of genotypes and phenotypes; according to the method, a single ovulation rate screening mode is changed, the problem of abortion and weak abortion caused by insufficient intrauterine environment is effectively solved, and the success rate of double-fetal pregnancy is remarkably increased.

The invention provides a breeding method for improving the breeding rate of replacement gilts, and the breeding method comprises the following steps: (1) adding a first functional nutritional composition into feed from 130-150 days old to the early estrus of the replacement gilts; (2) adding a second functional nutrient composition into the feed from the initial estrus period of the replacement gilts to the time before mating; and (3) within 25-35 days after mating of the replacement gilts, adding a second functional nutrient composition into the feed. According to the breeding method, oxidative stress of the replacement gilts can be relieved, development and maturation of follicles can be adjusted, oestrus and ovulation of the gilts can be promoted, the initial estrus period of the replacement gilts can be started in time, embryonic development can be promoted, the conception rate of the replacement gilts can be increased, and the replacement gilts are prevented from being eliminated due to delayed oestrus or non-oestrus or repeated breeding and infertility after oestrus; further, the breeding rate of the replacement gilts is improved.

The invention belongs to the field of medical detection, and particularly relates to a memristor for non-invasive dynamic ovulation monitoring and application. The memristor comprises a substrate, a bottom electrode, a functional layer and a top electrode which are sequentially arranged from top to bottom, wherein the functional layer is a hafnium oxide film. The memristor provided by the invention has the characteristic of ultrahigh sensitivity to electrical property changes of ion concentration and viscosity in biological fluids such as saliva, urine and the like, and a complex physiological state under regulation and control of hormones such as estrogen, LH and the like is converted into a quantifiable electric signal to be output, so that dynamic and accurate capture of a growth window is realized. The low power consumption and stable cycle characteristics of the device lay a solid foundation for developing wearable integrated equipment, and the device is expected to promote the development of reproduction management towards the family, real-time and intelligent directions, and finally the success rate and safety of assisted reproduction treatment are improved.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating polycystic ovarian syndrome as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from Chinese yam, semen cuscutae, pulp of dogwood fruit, radix glehniae, radix scrophulariae, lily, rhizoma polygonati, tortoise shell, cistanche deserticola, lotus seed and raspberry, has the effects of tonifying kidney and replenishing essence, nourishing yin and blood, replenishing qi and tonifying spleen, and benefiting uterus and accommodating fetus, and is mainly used for treating the polycystic ovarian syndrome. Research results show that the traditional Chinese medicine composition can significantly improve the sex hormone level of a patient with the polycystic ovarian syndrome, increase the endometrial thickness, improve the ovarian function and improve the endometrial receptivity, the ovulation rate and the pregnancy rate. Therefore, the traditional Chinese medicine composition has important clinical significance and wide market application prospects.

The invention discloses a composition and method for improving the ovulation concentration ratio of sows in batches and application, and belongs to the technical field of livestock breeding. The method provided by the invention comprises the following steps of: applying a composition containing taurine or a derivative thereof and lactic acid or a derivative thereof to the sow in a period from 7 to 21 days before injecting an ovulation promoting medicine to the end of hybridization, and implementing single-time timed insemination after injecting the ovulation promoting medicine buserelin. The composition can remarkably improve the ovulation concentration ratio of sows in batches, guarantee time synchronism of sperm-egg combination, further reduce the number of oestrus identification times during regular insemination, successfully realize single-time regular insemination, reduce labor, consumables, semen and boar feeding cost, and improve the breeding efficiency of the sows. And synchronous delivery is promoted, and the executability and efficiency of all-in and all-out batch production are improved.

The invention belongs to the technical field of biological medicine, and particularly relates to application of irisin in treatment of polycystic ovarian syndrome, and the specific application of irisin in treatment of polycystic ovarian syndrome is as follows: improving the ovarian morphology and ovarian dysfunction of a patient suffering from PCOS (polycystic ovarian syndrome); the ovarian ferroptosis and iron autophagy of the PCOS patient are improved; ferroptosis of primary ovarian granular cells and KGN cells induced by high androgen is improved; iris is used for regulating and controlling an NCOA4-FTH pathway to reverse iron autophagy of ovarian granulosa cells, and through a PCOS mouse model induced by hyperandrogen, specific targets of irisin for inhibiting ferroptosis of the ovarian granulosa cells are disclosed, abnormal iron metabolism of PCOS patients is reversed, and the normal ovulation function of the PCOS patients is recovered; a safe alternative is provided: irisin can be generated endogenously by movement, avoiding the risk of metabolic disorder caused by exogenous hormone therapy.

The present invention provides an absorbent article with which the day of ovulation can be predicted in a more convenient manner than conventionally, and relates to an absorbent article, comprising a test strip for detecting luteinizing hormone from vaginal discharge using immunochromatography, wherein the test strip detects 0.05 mIU / mL to 2.5 mIU / mL of luteinizing hormone as positive.

A method (400) and system (100) for predicting a fertility cycle of a user is disclosed A processor (302) acquires physiological biomarker data comprising at least one of a heart rate, a heart-rate variability, a skin temperature, and a skin perfusion. A rolling baseline is computed by processing the physiological biomarker data using a rolling-average technique. A stress-rhythm score that decays from a predefined value in response to non-fitness-related heart-rate elevations detected as deviations from the rolling baseline. Lifestyle-biomarker data of the user comprising at least one of a body-mass index (BMI), and an age is received. Historical fertility cycle data of the user is retrieved. A fertility cycle comprising an ovulation day and a fertile window of the user is predicted based on a weighted probabilistic analysis of the physiological biomarker data, the stress-rhythm score, the lifestyle-biomarker data, and the historical fertility cycle data of the user.

The invention discloses an acupoint application for treating polycystic ovarian syndrome and a preparation and use method thereof. The acupoint application comprises a radix salviae miltiorrhizae acupoint application, a semen cuscutae-radix salviae miltiorrhizae acupoint application, a radix morindae officinalis-radix salviae miltiorrhizae acupoint application and a semen cuscutae-radix morindae officinalis acupoint application. The traditional Chinese medicine composition is prepared from salvia miltiorrhiza, semen cuscutae and salvia miltiorrhiza, morinda officinalis and salvia miltiorrhiza, and semen cuscutae and morinda officinalis. The invention further provides a preparation method of the acupoint application and an artificial cycle therapy using method. The acupoint application medicine cake has the advantages that the acupoint application medicine cake is mainly used for treating the polycystic ovarian syndrome, has the effects of tonifying the kidney, activating blood, removing stasis and promoting follicular maturation and ovulation, is convenient and safe to apply externally, can enhance the compliance of a patient, can be absorbed through peritoneal transdermal absorption, can avoid the first-pass effect of oral administration, is closer to a disease site in the administration position, and takes effect faster.

The embodiment of the invention discloses a mammal ovulation prediction method and system based on multi-source clinical information fusion, and the method comprises the steps: obtaining the medical image data of a target animal generated in a conventional clinical examination process, and carrying out the preprocessing of the obtained medical image data; performing analysis according to the follicle image to obtain reference ovulation remaining time and a reference ovulation state in a preset time window; analyzing according to the cervical image to obtain an ovulation stage evaluation result; analyzing according to the uterus image to obtain the corresponding ovulation condition for reflecting the state change of the uterus tissue; and generating a comprehensive ovulation prediction result of the target animal according to the ovulation remaining time, a reference ovulation state in a preset time window, an ovulation stage evaluation result, a result obtained by uterus image analysis and an artificial experience evaluation result. Therefore, an ovulation prediction result which is available in small samples, easy to deploy, high in interpretability, accurate in prediction result and stable can be provided based on conventional clinical data.

This invention belongs to the field of traditional Chinese medicine and provides the application of deer placenta and Salvia miltiorrhiza in the treatment of infertility caused by ovulation disorders. The herbal composition of this invention has good efficacy and can be used as the basis for drugs to treat various types of infertility.

This invention relates to a method and system for detecting ovulation in female's menstrual cycles, which involves collecting menstrual cycle information of a subject to calculate ovulation interval dates. Daily heart rate waveform signals are used to obtain heart rate-related physiological parameters, including the first cumulative power (LF), second cumulative power (HF), standard deviation of interbeat intervals (SDNN), root mean square of successive differences (RMSSD), cumulative power ratio (LF / HF), and heart rate parameter ratio (SDNN / RMSSD). The invention selects the day with the highest cumulative power ratio (LF / HF) and heart rate parameter ratio (SDNN / RMSSD) within the ovulation interval as the day of ovulation.

The invention discloses a virus-mediated gene manipulation method for an embedded in-vitro follicle culture system and application, and belongs to the technical field of biology. According to the virus-mediated gene manipulation method for the embedded in-vitro follicle culture system disclosed by the invention, the optimal virus type is screened and the titer and chemical enhancement conditions are optimized, so that the follicle growth, ovulation, oocyte maturation, fertilization, hormone secretion and other core functions are not influenced; efficient, mild and controllable gene expression regulation is realized; a PCR amplification detection means proves that the vector is not integrated into an oocyte genome under the research condition and is not transferred to a progeny through a reproductive line. The method provides a safe, standardized and reproducible technical route for ovarian biological mechanism research, in-vitro disease model construction and drug / poison evaluation.

The application provides a traditional Chinese medicine composition for adjusting metabolism of polycystic ovary syndrome, a preparation and purposes, which is prepared from the following raw medicinal materials in a proportion by weight: Radix Rehmanniae Preparata 25-35 parts, Radix Paeoniae Alba 25-35 parts, Rhizoma Atractylodis Macrocephalae 25-35 parts, Radix Salviae Miltiorrhizae 25-35 parts, Radix Morindae Officinalis 25-35 parts, Fructus Corni 10-20 parts, Rhizoma Pinelliae Praeparatum 10-20 parts and Pericarpium Citri Reticulatae 10-20 parts. The eight kinds of traditional Chinese medicines are compatible with each other, and the effects of tonifying kidney and essence, invigorating spleen and drying dampness are achieved. The present application can reduce serum androgen, restore the level of estrus cycle, promote ovulation and effectively improve reproductive function. The clinical application practice shows that no intolerable side effect is found.

The utility model belongs to the technical field of medical equipment, and particularly relates to an infertility ovulation collecting and storing device for reproductive medicine, which comprises a liquid nitrogen tank, a lower shell and an upper shell, the liquid nitrogen tank is arranged in the lower shell, one end of the upper shell is rotatably connected with the lower shell through a rotating shaft, the inner bottom of the lower shell is connected with a supporting plate through a plurality of damping shock absorbers, and the supporting plate is connected with the lower shell. The inner wall of the lower shell is slidably connected with two symmetrically-arranged arc-shaped clamping plates through a plurality of sliding rods, the sliding rods are sleeved with first springs, the two ends of the first springs are fixedly connected with the arc-shaped clamping plates and the inner wall of the lower shell correspondingly, the end, away from the rotating shaft, of the upper shell is slidably connected with a clamping mechanism, and the lower shell is provided with clamping grooves corresponding to the clamping mechanism. And the inner top of the upper shell is fixedly connected with a sponge pad. According to the egg cell collecting and storing device, due to the arrangement of a plurality of buffering and damping structures, a damping protection effect can be effectively achieved on the egg cell collecting and storing device, and therefore the use safety of the storing device is effectively improved.

The invention belongs to the technical field of biology, and particularly relates to a Yangtze river cowfish ovulation monitoring method based on ultrasonic examination. According to the ultrasonic examination-based ovulation monitoring method for the Yangtze River globefish, provided by the invention, the imaging change from follicle development to ovulation can be captured in real time without anesthesia or sampling, so that the technical bottleneck of ovulation monitoring of the Yangtze River globefish is broken through, and the accuracy of ovulation judgment and the operation safety are realized.

The invention relates to the technical field of biological medicines, and provides application of GALR1 in preparation of a medicine for treating ovulation disorder of polycystic ovarian syndrome. The important molecular target GALR1 in the PCOS pathogenesis is found according to the important signal channel of the PCOS ovulation disorder, the important molecular target GALR1 can be used as the treatment target of the PCOS ovulation disorder in the future, and a new thought is provided for the research and treatment method of the PCOS pathogenesis molecular mechanism. According to the present invention, the ERK regulation effect and the inhibition effect on the TGFB1-SAMD2 / 3 signal channel mediated by the GALR1 through the target beta-arrestin1 are determined for the first time, such that the pathogenesis of the ovulation disorder of the polycystic ovarian syndrome can be reversed so as to easily explore the potential clinical application value of the GALR1.

The application provides a preparation method of a traditional Chinese medicine composition for treating polycystic ovary syndrome of spleen deficiency and phlegm dampness type. The application is based on Linggui Zhugan Decoction, and through long-term screening of effective substances and active ingredients, each medicinal material is extracted, separated and purified in a modern scientific way, and the extract is screened in combination with pharmacology and efficacy to form a new prescription, so that a new prescription with clear material basis and more accurate and significant curative effect is obtained. Through pharmacodynamic comparative study, it is determined that the effect of the traditional Chinese medicine composition provided by the application is obviously better than that of the control group. The traditional Chinese medicine composition can achieve the purposes of tonifying the kidney and invigorating the spleen, and resolving phlegm and dampness, can obviously regulate the endocrine and metabolic levels of PCOS patients of spleen deficiency and phlegm dampness type, and significantly improve the clinical symptoms. Further, the traditional Chinese medicine composition degrades fat through multiple pathways and multiple targets, promotes the recovery of ovarian function, promotes the growth and development of follicles, induces ovulation and the like, and has a significant effect in treating polycystic ovary syndrome of spleen deficiency and phlegm dampness type.

This invention discloses the application of the compound pimozide in combination with metronidazole in the preparation of a drug for improving oocyte quality and treating endometriosis-related fertility disorders, belonging to the field of biomedical technology. The efficacy of this invention was verified by constructing mouse models of endometriosis driven by pathogenic *Prevotella bisporus* and mouse models of ovarian endometriosis. Experimental results showed that the combined administration significantly eliminated *Prevotella bisporus* colonizing ectopic lesions, reduced succinic acid content in both eutopic and ectopic lesions, decreased the succinylation level of lysine residue 195 of the ACADVL protein, reduced the fluidity of primary endometrial epithelial cell membranes, reduced the volume and weight of endometriotic lesions, and improved oocyte spermatogenesis, ovulation rate, and litter size. This invention solves the problem that existing therapies cannot simultaneously control endometriosis lesions and protect reproductive function, providing a new, safe, and effective combined treatment option for patients with endometriosis and infertility.

The invention provides a pregnancy preparation guidance method and system based on multi-parameter fusion and a storage medium, and the method comprises the steps: obtaining multi-source heterogeneous data of a user through a preset data interface, and carrying out data cleaning, standardization and analysis processing to form a structured data set; then extracting a feature vector set comprising an ovulation index, a pressure index and a nutrition index; sequentially judging whether the pressure index exceeds a pressure threshold value or not and whether the nutrition index is lower than a nutrition threshold value or not by adopting a serial threshold value comparison strategy, and matching an ovulation threshold value according to the ovulation index so as to trigger a corresponding decision path; and finally, based on the decision path identifier, calling a knowledge base to carry out strategy matching and scheme assembly, generating a personalized pregnancy preparation guidance scheme, and outputting the personalized pregnancy preparation guidance scheme to a user side. Meanwhile, according to user feedback data, various thresholds are dynamically adjusted through a threshold comparison model to achieve system optimization; therefore, scientificity, individuation and long-term adaptability of pregnancy preparation guidance are improved.

The invention relates to the technical field of biology, in particular to application of cathepsin L and a product for predicting ovulation. According to the present invention, the first research results show that whether ovulation can be accurately determined according to the CTSL concentration in the female mammal body fluid such as urine and / or blood, the ovulation time can be accurately predicted, the accuracy is significantly higher than the luteinizing hormone (LH) determination method, and the method can be widely used for mammal breeding and human ovulation monitoring, fertility control or contraception.

The invention provides a breeding method for improving the reproductive performance of weaning sows, which comprises the following steps: (1) during the period from weaning to oestrus of the weaning sows, adding a first functional nutritional composition into the feed of the weaning sows; and (2) within 25-35 days after mating of the weaning sows, adding a second functional nutritional composition into the feed for the weaning sows. The breeding method provided by the invention can relieve oxidative stress of the weaned sows, repair nutrient loss of the sows in the lactation period, improve body conditions of the weaned sows, regulate development and maturity of follicles, promote oestrus and ovulation of the sows, promote embryonic development, improve the conception rate of the weaned sows and improve the survival rate of the weaned sows. The weaning sows are prevented from being eliminated due to delayed oestrus or non-oestrus due to the fact that nutrition loss in the lactation period is not repaired in time and repeated mating and infertility after oestrus, so that the reproductive performance of the weaning sows is improved, and the economic benefit of a farm is improved.

The invention belongs to the technical field of biology, and particularly relates to a construction method of an ovulation disorder disease model, and the construction method is realized by injecting BCI-121 and JQ-1 into female mice. The dosage of the injected BCI-121 is 20 mg / kg to 210 mg / kg; the injection dosage of the JQ-1 is 10 mg / kg to 130 mg / kg. The method provided by the invention is simple and efficient to operate, ovulation disorder can be obviously caused only by injecting BCI-121 and JQ-1 into the intraperitoneal cavity of the mouse before ovulation once, and the ovulation number is reduced. The method provided by the invention is safe and stable, long-term permanent ovulation disorder cannot be caused by one-time intraperitoneal injection of BCI-121 and JQ-1 into a mouse before ovulation, and the reproductive function is not influenced. The method provided by the invention provides a new technical approach for constructing an ovulation disorder disease model, and provides important support for revealing pathogenesis of ovulation disorder and establishing a treatment method.

The invention belongs to the technical field of biological medicines, and particularly relates to a medicine for improving ovarian functions. By detecting the influence of the NMDPEF on primordial follicle reserve of an advanced ovary, ovary ovulation rate, oocyte quality and ovary microenvironment, it is found that after NMDPEF treatment, the trend that the number of follicles in the ovary is decreased is obviously relieved, the form and number of oocytes harvested by serum AMH recovery and superovulation are remarkably improved, iron deposition in the ovary is reduced, and the ovary ovulation rate is reduced. The oxidative stress index, the DNA damage index, the aging index and the iron metabolism index are all recovered. Therefore, the NMDPEF can improve the microenvironment of the elderly ovary, delay the depletion of the primordial follicle reservoir, increase the ovulation rate and increase the quality of oocytes.

A method for enhancing artificial insemination (AI) in mammals, particularly bovine livestock, uses a specialized aqueous mastic solution to substantially increase conception success rates from conventional 60-65% to about 95%. The solution comprises ionic minerals including magnesium chloride, calcium chloride, sodium, potassium, and an emulsion of milled mastic gum (Pistacia lentiscus, preferably Chios Mastiha, particulates 15-40 μm) dissolved in water sourced from inland saltwater bodies such as the Great Salt Lake, delivering approximately 72 ionic and trace minerals. The process involves: preparing the uterus by depositing the solution via syringe to maintain pH at 7.35-7.45 and eliminate bacteria; washing donor semen in the solution to isolate healthy, motile sperm and remove debris / reactive elements; and depositing the washed semen directly into the uterus during ovulation, confirmed via luteinizing hormone detection, ultrasound, or chorionic gonadotropin induction.

The invention relates to an application of dihydroartemisinin in preparation of medicines for preventing, delaying and / or treating ovarian senescence and related diseases thereof. It is found for the first time that dihydroartemisinin can effectively prevent, delay and / or treat ovarian senescence, including ovarian fibrosis and age-related fertility decline caused by ovarian fibrosis. Dihydroartemisinin significantly improves the ovary structure and function through the multi-target synergistic effect of regulating reproductive endocrine, inhibiting senescence-related phenotypes, resisting ovarian fibrosis and the like, specifically, the oestrus cycle is recovered, the ovary weight is increased, and the ovulation number and the litter size are increased. Moreover, the invention also proves that dihydroartemisinin has the potential of preventing fertility decline in a middle-aged model, is good in safety, does not cause injury to main visceral organs and reproductive organs, has normal liver and kidney function indexes, and provides a new strategy for clinical intervention of ovarian senescence.