156 results about "Myoma" patented technology

The invention provides a fertility auxiliary judgment method and system for a hysteromyoma patient, and the method comprises the steps: obtaining a sample detection result and a scanning graph of the hysteromyoma of the patient, and recognizing the sample detection data of each detection type of the hysteromyoma based on the sample detection result; identifying three-dimensional structure data and position distribution information of the hysteromyoma on the basis of the scanning graph of the hysteromyoma, and identifying a detection evaluation value of each detection type through a sample evaluation strategy on the basis of the sample detection data of each detection type; based on the three-dimensional structure data and the position distribution information of the hysteromyoma, identifying the fertility influence degree of the hysteromyoma on the fertility influence type of the patient, and based on the detection evaluation value of each detection type and the fertility influence degree of the fertility influence type, identifying the fertility probability value of the patient through a fertility influence evaluation model; and taking the fertility probability value of the patient as a fertility auxiliary judgment result of the patient. By adopting the scheme, the evaluation accuracy of the fertility can be improved.

The invention relates to the field of myoma stripping instruments, and discloses a hysteroscope uterine submucosa myoma stripper which comprises a handle, a controller and a power source, a catheter is arranged at one end of the handle, a smashing head is arranged at one end of the catheter, a movable covering mechanism is arranged on the outer side of the smashing head, and the movable covering mechanism is arranged on the outer side of the handle. The movable covering mechanism is used for clamping and fixing the myoma and then is matched with the crushing head to stably crush the myoma; the movable covering mechanism comprises a plurality of cover plates, one ends of the cover plates are movably connected to the guide pipe, and the cover plates are distributed in the circumferential direction; and the driving assembly is used for driving the plurality of cover plates to realize expansion or contraction actions. According to the myoma crushing device, the movable covering mechanism is arranged, so that the process of covering and wrapping the crushing head and clamping myoma for crushing can be realized according to needs, and compared with adverse consequences caused by overflow of myoma crushing by a direct method, the myoma crushing device is more reasonable in treatment of myoma tissues and higher in safety.

The invention relates to the technical field of focus positioning, in particular to a hysteromyoma focus accurate positioning method combining image analysis and data fusion, which comprises the following steps: acquiring multi-modal uterus image data, and carrying out artifact suppression and spatial registration on an original image; performing three-dimensional reconstruction on the preprocessed multi-modal image data set to generate a three-dimensional uterus model comprising anatomical structure features; lesion feature segmentation is carried out in the three-dimensional uterus model, and morphological parameters and textural features of a myoma lesion are extracted; carrying out hemodynamic analysis to obtain blood perfusion parameters and blood vessel distribution characteristics of the focus area; the blood perfusion parameters and the blood vessel distribution characteristics are fused, the three-dimensional uterus model is combined, and a focus biomechanical characteristic distribution diagram is constructed; and generating a real-time navigation path according to the biomechanical characteristic distribution diagram, and outputting a positioning report. According to the method, personalized ablation energy suggestions are made, the ablation treatment efficiency and success rate are effectively improved, the ablation energy is dynamically adjusted, and the treatment efficiency and safety are ensured.

Systems and methods for enhancing visualization and documentation of fibroid quantity, size, and location with respect to a uterus and endometrium in ultrasound imaging are provided. The method includes receiving, by at least one processor, an ultrasound volume including ultrasound image data of a region of interest that includes a uterus. The method includes automatically segmenting, by the at least one processor, the uterus and an endometrium in the ultrasound volume. The method includes segmenting one or more fibroids in the ultrasound image data. The method includes generating a classification of each of the one or more fibroids based on a location of each of the one or more fibroids with respect to the endometrium and the uterus. The method includes causing, by the at least one processor, a display system to present at least one image identifying the segmented uterus, endometrium, and one or more fibroids.

The invention belongs to the field of biological pharmacy, and provides keratin YK93-4, a coding nucleic acid molecule thereof, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrated with the nucleic acid molecule, and a preparation method and a pharmaceutical composition of the keratin YK93-4. The invention also provides application of the keratin YK93-4 and related products thereof in preparation of medicines for treating lung cancer, lymphoma, breast cancer, melanoma, hysteromyoma, benign prostatic hyperplasia and the like.

Various systems, devices, and methods for tissue penetration are disclosed. The system includes an ablation element that penetrates tissue and a radiofrequency generator that delivers energy to the ablation element. The radiofrequency generator may have two modes: a cutting or insertion mode and an ablation or coagulation mode. The cutting or insertion mode is used to cut or penetrate tissue by providing a voltage or power modulation for cutting or softening tissue contacted by the ablation element. The ablation or coagulation mode is used to ablate or coagulate tissue.

The invention relates to the technical field of traditional Chinese medicines, in particular to application of a traditional Chinese medicine composition in preparation of medicines for preventing and treating hysteromyoma. The traditional Chinese medicine composition comprises spina gleditsiae, polygonum cuspidatum, dandelion, sargentgloryvine stem, codonopsis pilosula, chinaroot greenbrier, radix paeoniae rubra, salvia miltiorrhiza, lindera aggregata and corydalis tuber. The traditional Chinese medicine composition can obviously inhibit the tumor size of a rat with hysteromyoma, reduce the uterine coefficient, reduce the number and size of myoma and improve the pathological state of the uterus; moreover, the content of E2, P and ER in serum can be reduced, and the traditional Chinese medicine composition has a good effect of treating hysteromyoma.

This invention belongs to the field of biopharmaceuticals and provides a keratin YK93-6, its encoding nucleic acid molecule, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or whose genome integrates the nucleic acid molecule, as well as a preparation method and a pharmaceutical composition thereof. It also provides the application of the above-mentioned keratin YK93-6 and other products in the preparation of drugs for treating benign prostatic hyperplasia, lymphoma, melanoma, analgesia, lactation, breast cancer, lung cancer, uterine fibroids, coagulation, etc.

The invention belongs to the field of biological pharmacy, and provides keratin YK93-5, a coding nucleic acid molecule thereof, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrated with the nucleic acid molecule, and a preparation method and a pharmaceutical composition of the keratin YK93-5. The invention also provides application of the keratin YK93-5 and other products in preparation of drugs for treating lung cancer, lymphoma, breast cancer, melanoma, hysteromyoma, prostatic hyperplasia and the like.

The utility model relates to the technical field of medical equipment, and provides a hysteromyoma ultrasonic transducer rotation executing mechanism and a steam ablation device. The utility model provides a rotation actuating mechanism of a hysteromyoma ultrasonic transducer. The rotation actuating mechanism comprises an ultrasonic transducer and a stepless regulation mechanism, the stepless adjusting mechanism is connected with the ultrasonic transducer and used for stepless adjustment of the angle of the ultrasonic transducer. The technical problems that in the prior art, an ultrasonic transducer can only be located at certain fixed angles, and angle adjustment is limited are solved. During specific implementation, through integration of the stepless adjusting mechanism and the ultrasonic transducer, the ultrasonic guiding precision is remarkably improved, and particularly in medical equipment such as a hysteromyoma steam ablation device, the incident angle of ultrasonic waves can be accurately adjusted according to the position and form of an actual focus, so that the ablation process is more accurately guided, and the ablation efficiency is improved. The treatment efficiency and the safety are improved.

The utility model belongs to the technical field of auxiliary medical instruments, and particularly relates to an auxiliary device for a hysteromyoma ablation operation of a sea knife. The device comprises a first fixing plate, a second fixing plate parallel to the first fixing plate is vertically arranged on one side of the first fixing plate, a threaded rod is arranged between the second fixing plate and the first fixing plate, a threaded hole in threaded fit with the threaded rod is formed in the second fixing plate, and a connecting assembly is arranged between the threaded rod and the first fixing plate. The connecting assembly is used for connecting the screw with the second fixing plate and enabling the screw to rotate independently, and a fixing mechanism fixed to a sickbed is arranged at the bottom of the second fixing plate. According to the design, the second fixing plate is fixed to a sickbed, the position of the first fixing plate is adjusted through threaded fit of the screw rod and the second fixing plate, so that the first fixing plate blocks a patient and limits movement of the patient, the patient does not have a constraint feeling, and discomfort caused to the patient is reduced.

Methods for enhancing the visualization of a myoma relative to the uterus and endometrium in ultrasound imaging are provided. The method includes receiving, by at least one processor, an ultrasound volume including ultrasound image data of a region of interest, automatically segmenting the uterus and endometrium in the ultrasound volume, segmenting one or more myomas in the ultrasound image data, and outputting the one or more myomas. A classification of each of the one or more myomas is generated based on a position of each of the one or more myomas relative to the endometrium and the uterus such that the display system presents at least one image identifying the segmented uterus, endometrium, and one or more myomas. The application also provides a system for enhancing the visualization of a myoma relative to the uterus and endometrium during ultrasound imaging.

The invention discloses plant lactobacillus La10 and application thereof in regulating estrogen secretion stability and enhancing ovarian function, and belongs to the technical field of microorganisms. The plant lactobacillus La10 provided by the invention can effectively promote the conversion of free isoflavone (daidzein and genistein), so that the absorption and utilization of intestinal tracts are promoted; the composition has the advantages that the ovarian index and sex hormone estradiol E2 secretion level reduction caused by premature ovarian failure of rats can be obviously improved, and meanwhile, the estrogen secretion level and ovarian index up-regulation caused by mouse hysteromyoma can be improved; the irregular menstruation phenomenon of women is improved, so that the estrogen secretion disorder is regulated. The plant lactobacillus La10 disclosed by the invention has a very wide application range in preparation of functional foods and health-care foods for promoting estrogen balance and protecting female health, and is healthy and safe.

The invention relates to the technical field of medical instruments, and provides a hysteromyoma steam ablation handle device which comprises an ultrasonic handle, a puncture handle and a locking and releasing mechanism, the locking and releasing mechanism comprises a first locking structure, a second locking structure and an unlocking structure, and the ultrasonic handle is movably provided with the first locking structure and the unlocking structure. The puncture handle is fixedly provided with a second locking structure, and the unlocking structure can drive the first locking structure to move so as to be switched between a locking state and an unlocking state; in the locking state, the first locking structure is fixedly connected with the second locking structure, the ultrasonic handle and the puncture handle are attached to each other, and the relative positions of the ultrasonic handle and the puncture handle are locked. In the unlocking state, the first locking structure is separated from the second locking structure so as to release locking of the ultrasonic handle and the puncture handle, it can be guaranteed that the ultrasonic handle and the puncture handle are tightly attached, stability and safety are improved, normal work and the service life are guaranteed, operation is faster and more efficient, and performance and operation experience are improved.

This invention belongs to the field of biopharmaceuticals and provides a keratin YK93-8, its encoding nucleic acid molecule, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or whose genome integrates the nucleic acid molecule, as well as a preparation method and a pharmaceutical composition thereof. It also provides the application of the above-mentioned keratin YK93-8 and other products in the preparation of drugs for treating benign prostatic hyperplasia, lymphoma, melanoma, breast cancer, lung cancer, analgesia, lactation, uterine fibroids, coagulation, etc.

The invention discloses a human-derived hysteromyoma targeting peptide and application thereof, the sequence of the targeting peptide is selected from SEQ ID NO: 1 to SEQ ID NO: 5, and the SEQ ID NO: 1 (VN12) is the most preferable. The fusion protein is obtained by screening through a phage display technology, and has high hysteromyoma targeting specificity and low immunogenicity. The targeting peptide can be coupled with nuclide or fluorescent dye, and is used for accurate PET imaging, fluorescent diagnosis and intraoperative navigation of hysteromyoma. Experiments prove that the molecular marker is specifically enriched in tumor tissues (the tumor / muscle ratio is 60), the biological safety is good, the problems of insufficient diagnosis sensitivity and large treatment wound in the prior art are solved, and the molecular marker has a great application prospect in diagnosis and treatment of hysteromyoma.

The invention relates to the technical field of hysteroscope resectoscopes, and discloses a hysteroscope resectoscope capable of preventing uterine perforation and a using method thereof.The hysteroscope resectoscope comprises a hysteroscope body and a plurality of ultrasonic ranging modules, a camera is arranged at the far end of the hysteroscope body and faces the resection position, the ultrasonic ranging modules are arranged at the far end, and the ultrasonic ranging modules are arranged at the far end of the hysteroscope body and face the resection position. The ultrasonic ranging modules face the electric resection part and are used for measuring the thickness of the uterus wall of the electric resection part. According to the hysteroscope, the ultrasonic ranging modules are arranged at the far end of the hysteroscope body to measure the thickness of the uterus wall of the electric resection part, the situation that when an electric resection operation of uterine submucosal myoma or endometrial polyp is carried out, due to the fact that the thickness of the uterus wall cannot be accurately evaluated, uterus perforation is accidentally caused is avoided, the safety and accuracy of the operation are improved, and the operation efficiency is improved. Complications are reduced, and the fertility of a patient is protected.

The invention discloses a uterine fibroid recognition method based on artificial intelligence. The method comprises the following steps of S1, collecting medical image data of a tested person; s2, preprocessing the medical image data; s3, inputting the preprocessed data into a uterine fibroid deep learning model based on artificial intelligence to extract uterine fibroid features; wherein the deep learning model comprises a feature extraction layer, the feature extraction layer adopts a structure comprising a convolutional layer and jump connection, and the jump connection can select different processing modes according to an obtained input feature map and channel number so as to facilitate information transmission and gradient propagation; and S4, inputting the hysteromyoma features into a classification layer to obtain a hysteromyoma recognition result. According to the invention, aiming at the magnetic resonance medical image, a data processing and deep learning method is improved, and the accuracy and reliability of hysteromyoma identification are further improved.

The invention provides a 3D U-Net-based hysteromyoma intelligent measurement and evaluation system, and the system comprises an intelligent recognition module which is used for constructing a 3D U-Net network model, inputting a real-time image into the 3D U-Net network model for myoma boundary recognition, and judging whether a patient suffers from hysteromyoma or not; the three-dimensional reconstruction module is used for performing three-dimensional reconstruction on the real-time image when the judgment result is that the patient suffers from the hysteromyoma; the growth prediction module is used for performing uterine fibroid growth prediction according to the three-dimensional reconstruction result and outputting a growth prediction result; and the three-dimensional relationship between the myoma and the uterine muscular layer, the blood vessel and other organs can be observed more clearly, so that a more accurate basis is provided for formulating a personalized treatment scheme.

The invention discloses an application of a DHA-RXR-PPAR signal channel in promotion of postoperative recovery of hysteromyoma after HIFU (high intensity focused ultrasound). Clinical sample metabolic spectrum analysis and in-vitro cell function experiments are combined, and research proves that the differential metabolite DHA drives macrophage metabolism reprogramming through an RXR-PPAR signal axis, so that the macrophage is promoted to be transformed into an anti-inflammatory and phagocytosis-promoting repair phenotype, the absorption and repair process of the HIFU postoperative hysteromyoma is accelerated, and the treatment effect of the HIFU postoperative hysteromyoma is improved. A new intervention target spot (RXR-PPAR gamma axis) and a new potential medicine are provided for HIFU (high intensity focused ultrasound) postoperative rehabilitation.

An object of the present invention is to provide a method for preventing or treating myopia, and a composition used in said method. The present invention provides a method and composition for inhibiting, improving, or treating myopia by administering a substance that induces M2 macrophage polarization, a substance that regulates the function of choroid-resident immune cells, such as a mast cell stabilizer or a chemical mediator release inhibitor, or lactic acid bacteria. Regulating the function of choroid-resident immune cells, for example by inducing the polarization of M2 macrophages in the choroid or by administering a mast cell stabilizer, a chemical mediator release inhibitor, or lactic acid bacteria, is effective in myopia prevention and treatment.

The sustained-release formulation of this invention, with its increased initial release, exhibits a rapid release effect within 24 hours after administration, followed by a sustained-release effect, thus simultaneously achieving both prolonged efficacy and rapid initial release. The sustained-release formulation of this invention, containing microspheres of leuprorelin, possesses excellent bioavailability and has been proven safe in humans; therefore, it can be effectively and safely used to treat various luteinizing hormone-releasing hormone-related diseases such as endometriosis, uterine fibroids, prostate cancer, premenopausal breast cancer, and central precocious puberty.

The invention belongs to the field of medical instruments, and particularly discloses a gradient dentition-based hysteromyoma rotary cutter which comprises a rotary cutter bar, the rotary cutter bar is of a hollow tubular structure, a conveying cavity is formed in the rotary cutter bar in a penetrating mode in the axis direction of the rotary cutter bar, a gradient dentition structure is arranged on the inner wall of the front end of the conveying cavity, and the gradient dentition structure is arranged in the axis direction of the conveying cavity; the pull rod is arranged to pull the hysteromyoma slice to promote the hysteromyoma slice to be conveyed to the rear end of the conveying cavity when the rotary cutter bar rotates; the rotary cutter head is fixedly connected to the front end of the rotary cutter bar and is used for cutting hysteromyoma; and a rotary cutting driving device is arranged in the operating handle, is in transmission connection with the rear end of the rotary cutter bar, and is configured to drive the rotary cutter bar to rotate by taking the axis of the rotary cutter bar as a rotating shaft. By means of the structural design, the rotary cutter can pull cut hysteromyoma slices to be conveyed backwards, continuity and high efficiency of an operation are ensured, and meanwhile diffusion of tissue fragments in an operation area is prevented.

The utility model provides a pair of separating forceps for hysteromyoma surgery, which relates to the technical field of medical instruments and comprises two forceps arms, the two forceps arms are rotationally connected through a rotating shaft, one ends of the two forceps arms are respectively provided with a forceps head, the other ends of the two forceps arms are respectively provided with forceps handles, and one ends of the two forceps handles are respectively and fixedly connected with finger rings. The required forceps heads can be replaced according to actual operation requirements through the dismounting and mounting assembly, the preoperative preparation time before an operation is shortened, one set of forceps arms can use various forceps heads, the cost is reduced, and the forceps heads can be independently replaced when a single part is abraded and the like, secondly, the working angles of the forceps handles can be adjusted according to the operation conditions through the bending assembly, and the working efficiency is improved. By means of the technical scheme, the handle can be better attached to an operation area and held in a more comfortable posture, the accuracy of force application and operation is improved, and muscular tension and hand fatigue caused by long-time operation can be reduced.

The utility model relates to the technical field of medical equipment, and provides a uterine fibroid ultrasonic transducer deflection mechanism and a uterine fibroid steam ablation device. The utility model provides a uterine fibroid ultrasonic transducer deflection mechanism. The uterine fibroid ultrasonic transducer deflection mechanism comprises an ultrasonic transducer and a stepless regulation structure, the stepless adjusting structure is connected with the ultrasonic transducer, and in the unlocking state, the stepless adjusting structure is used for adjusting the angle of the ultrasonic transducer in a stepless mode. The utility model provides a hysteromyoma ultrasonic transducer deflection mechanism and a hysteromyoma steam ablation device. The hysteromyoma ultrasonic transducer deflection mechanism and the hysteromyoma steam ablation device are used for solving the technical problems that in the prior art, angle adjustment of an ultrasonic transducer is limited, and an angle adjusting mechanism cannot prevent mistaken touch. In the unlocking state, the stepless adjusting structure can achieve continuous and free adjustment of the angle of the ultrasonic transducer, so that diversified use requirements are met, and particularly, the high requirement for ultrasonic guide angle change is met in precise medical operation such as hysteromyoma ablation.

The invention belongs to the field of biological pharmacy, and provides keratin YK93-2, a coding nucleic acid molecule thereof, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or genome integrated with the nucleic acid molecule, and a preparation method and a pharmaceutical composition of the keratin YK93-2. The invention also provides application of the keratin YK93-2 and other products in preparation of drugs for treating lung cancer, lymphoma, breast cancer, melanoma, hysteromyoma, prostatic hyperplasia and the like.

The invention discloses a method for classifying hysteromyoma and hysterosarcoma by using MRI (Magnetic Resonance Imaging) imageomics, which comprises the following steps of: acquiring MRI original image data of two types of patients with lesions through a three-dimensional image processing workstation, and extracting feature data; inputting the image data into an MRI image perception graph convolutional network, dynamically adjusting and extracting features through a multi-scale convolution kernel, and generating an initial image feature graph; inputting the initial feature map into a generative adversarial feature unwrapping network, and separating calibration features and interference features through adversarial training of a generator and a discriminator; the calibration features are input into a multi-instance learning attention model, lesion area feature representation is enhanced through a weight distribution mechanism, and weighted features are obtained; and constructing a lesion classification feature set in combination with MRI image omics features, and outputting a classification result by a classifier according to the optimized feature set. According to the method, the feature quality is cooperatively improved through a multi-link technology, the classification accuracy and objectivity are guaranteed, subjective interference is reduced, different MRI image characteristics are adapted, and clinical precise classification requirements can be met.

The utility model relates to the technical field of medical equipment, in particular to a disposable multi-specification uterus lifting cup which comprises a uterus lifting frame, a multi-stage uterus lifting cup, a uterus lifting rod, a myoma drill and a guide rod. A first operation screw is arranged on the side portion of the uterus lifting frame, and a first limiting insertion hole is formed in the uterus lifting frame. The multi-stage uterus lifting cup is mounted at one end, far away from the first operation screw, of the uterus lifting frame; the uterus lifting rod is installed in the first limiting penetrating hole, a second limiting penetrating hole is formed in the uterus lifting rod, and a second operation screw is arranged on the side portion of the uterus lifting rod. The myoma drill is installed at the end, away from the second operation screw, of the uterus lifting rod. The guide rod is mounted in the second limiting insertion hole; the multi-stage uterus lifting cup comprises an expansion adjusting seat installed on the uterus lifting frame, the abutting end of the expansion adjusting seat can be expanded and adjusted, an expansion adjusting ring is installed in the expansion adjusting seat, and the operation safety and the overall efficiency can be effectively improved.

The present invention relates to a nitrogen-containing heteropolycyclic derivative modulator, a preparation method therefor and the use thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and the use thereof as a modulator in the preparation of drugs for treating menopausal syndrome, polycystic ovarian syndrome, uterine fibroids, schizophrenia, irritable bowel syndrome, vasomotor symptoms, breast cancer and related disorders thereof, wherein each substituent in general formula (I) is the same as defined in the description.

The invention provides a pair of myoma grasping forceps under a laparoscope, which belongs to the technical field of air compressor equipment and comprises a fixed handle, a clamping assembly, a self-locking assembly and a steering assembly, according to the scheme, an arc-shaped rack is installed on the inner side of the movable handle, the arc-shaped rack is inserted into an installation cavity formed in the fixed handle in a penetrating mode, a ratchet wheel is rotatably installed in the installation cavity, the arc-shaped rack is connected with the ratchet wheel in a meshed mode, and a round rod is rotatably installed at the position, located at the bottom of the ratchet wheel, in the installation cavity; when the movable handle gets close to the fixed handle, the arc-shaped rack moves in the mounting cavity and drives the ratchet wheel to rotate, at the moment, the locking insertion teeth swing in the rotating direction of the ratchet wheel, and the ratchet wheel is locked. And after the ratchet wheel stops rotating, the ratchet wheel is locked by the locking insertion teeth, so that the movable handle is prevented from moving to keep the clamp in a clamping state, and an operator can relax hands temporarily to relieve aching pain.