201 results about "Cervix" patented technology

The utility model relates to a cervical conization knife, and belongs to the field of gynecological operation instruments. Comprising a knife handle and a detachable blade. And the front end 2 of the knife handle tilts and forms an angle with the longitudinal axis of the handheld end 1 of the knife handle. According to different angles between the longitudinal axis of the front end 2 of the scalpel handle and the longitudinal axis of the handheld end 1 of the scalpel handle, the scalpel is divided into three models of A, B and C which are respectively at angles of 27 degrees, 31 degrees and 37 degrees. The cross section of the blade body is arc-shaped, the radian is consistent with that of the cervix uteri, the arc length is 1 / 8 of the circumference of the cervix uteri, namely 1cm, the two sides of the blade are both blade faces 3, the front ends of the blade faces 3 converge to enable the blade tip 4 to be an arc-shaped triangle, the rear end 5 of the blade is a parallel blunt face, and the longitudinal axis of the blade is provided with scales 6. Compared with a traditional cold knife, the novel cervical cold knife can be applied to gynecology cervical cold knife conization, surgical operation is facilitated, a cut cone can be regular, cervical injury is reduced, and the shape and the function of the cervix are reserved to the maximum extent.

Systems, devices, and methods are provided that control, support, and / or elongate a cervix to treat pregnancy complications and / or delay an onset of labor so that a gestational period for a fetus may be extended, thereby preventing preterm labor and delivery of the fetus. The cervical control systems may include a main body configured for placement in a vagina. The main body has in internal passageway configured for acceptance of a cervix therein and an inflatable and / or expandable inner cuff extends from portion of the internal passageway. The inner cuff may be expandable inward toward the cervix, or downward away from the uterus, or both inward and downward so that the inner cuff may engage, or grip, the cervix thereby holding the cervical control system in place while compressing the cervix closed, elongating the cervix, and / or adjusting an angle of orientation of the cervix.

The utility model provides an adjustable cold knife for cervical conization, which belongs to the field of medical instruments and comprises a handle, an adjusting component for adjusting the depth of the knife is slidably mounted in the handle, and an excision component for cervical conization is hinged to the top of the adjusting component. When the control sliding block is pushed slightly, the cutter bar can stably slide along the limiting groove and extend out of the handle, the limiting groove provides stable guidance for sliding of the control sliding block, it is ensured that the control sliding block always keeps linear movement, and then the cutter bar moves accurately without errors; therefore, it is guaranteed that the cutting depth is accurate, the whole operation process is simple, convenient and rapid, the adjusting precision is extremely high, and adjustment can be conducted according to different operation requirements.

The invention provides an HPV16 and HPV18 nucleic acid detection kit based on a one-step two-channel RPA-CRISPR, and belongs to the technical field of cervical cancer detection. The kit for detecting the HPV16 and the HPV18 by the one-step method, provided by the invention, comprises an RPA (recombinase polymerase amplification) reaction reagent, a CRISPR (clustered regularly interspaced short palindromic repeats) / Cas13a detection reagent and a CRISPR / Cas12a detection reagent. The kit disclosed by the invention can be used for simultaneously detecting the HPV16 nucleic acid and the HPV18 nucleic acid on the basis of a one-step two-channel RPA-CRISPR / Cas12a-Cas13a, so that the multi-step transfer operation and the aerosol pollution risk of a two-step CRISPR reaction are effectively avoided, the HPV16 DNA as low as 2.5 copies / L and the HPV18 DNA as low as 5 copies / L can be detected in 30 minutes, and the specificity is good. The sensitivity of the kit for detecting cervix uteri and vagina swab samples is 94.7%, and the specificity is 100%.

The invention provides equipment, a method and a system for evaluating prognosis of cervical cancer, squamous carcinoma and adenocarcinoma and application of the equipment, the method and the system, and belongs to the technical field of medical evaluation. Two biomarkers, namely adenylate kinase 4 and cavernous malformation 2 protein, for evaluating prognosis of cervical squamous cell carcinoma and adenocarcinoma are obtained through multivariate statistical analysis, difference screening, COX regression analysis and other biosignal analysis methods. Based on the biomarker, evaluation equipment, a computer execution method, a computer system and the like for evaluating the prognosis of cervical squamous cell carcinoma and adenocarcinoma are constructed, and the evaluation equipment, the computer execution method, the computer system and the like are used for accurately judging the prognosis condition of a cervical cancer patient.

The utility model discloses a hysteroscope water leakage prevention device, which belongs to the technical field of medical instruments and comprises a circular truncated cone, and the circular truncated cone is provided with an injection port for injecting uterine distention liquid, a discharge port for discharging the uterine distention liquid and an operation hole for accommodating a hysteroscope. The left sides of the discharge port and the injection port are communicated with the pump body through hoses, a buffer plugging assembly is installed in the circular truncated cone, a water leakage prevention assembly is installed on the edge of the left side of the circular truncated cone, and the buffer plugging assembly is communicated with the water leakage prevention assembly. By means of the mode, the discharging opening is blocked by the buffering blocking assembly to prevent the uterine distention liquid from flowing out through the discharging opening, the edge of the circular truncated cone makes close contact with the cervix through the water leakage preventing assembly, the uterine distention liquid is prevented from flowing out of the edge of the circular truncated cone, and therefore the uterine distention liquid is effectively prevented from flowing out during hysteroscope detection or operation; and the buffer plugging assembly is used for elastically plugging the uterine cavity, so that the swelling pain feeling of a patient is reduced and the comfort of the patient is improved during uterine cavity detection or operation.

The invention provides a uterine cavity balloon supporting device and a preparation method, which are used for solving the problem that in the prior art, when a supporting head is used, cervical injury is easily caused. The catheter comprises a first catheter body, a second catheter body and a supporting head made of flexible materials. The supporting head is made of the flexible material, when the expansion medium is conveyed into the supporting head through the conveying channel formed between the inner side wall of the second catheter and the inner side wall of the first catheter, the supporting head can deform and expand to be in the uterine cavity shape, the supporting head can support the uterine cavity, and intrauterine adhesion is prevented. After use, the supporting head can be attached to the first catheter by drawing out the expansion medium in the supporting head, so that the supporting head can be taken out of the human body conveniently. Therefore, the situation that the uterine cavity is scalded due to the fact that liquid with different temperatures is input, and the supporting head is still in an expanded state after use, so that when the supporting head is taken out, the supporting head clamps the cervix uteri, the supporting head is inconvenient to take out and the cervix uteri is injured is avoided.

The invention discloses a cervix uteri and vagina exfoliated cell sampling device for self-sampling HPV (human papillomavirus) detection, which comprises a handle, one end of the handle is fixedly connected with a spherical head body, a sampling brush head is fixedly arranged on the outer side of one end of the spherical head body of the handle, and sampling brushes are uniformly arranged on the surface of the spherical head body. The outer side of the handle is sleeved with a slidable telescopic sleeve shell, and when sampling operation needs to be carried out, the telescopic sleeve shell can slide away from one side of the sampling brush head and one side of the sampling brush brush by sliding the telescopic sleeve shell, so that the sampling brush head and the sampling brush brush are exposed to be used for collecting cervical and vagina exfoliated cells; in a non-sampling state, the sampling brush head and the sampling brush can be sleeved with the telescopic sleeve shell, so that a protection effect is achieved; compared with a traditional sampling brush or cotton swab, the contact area between the sampling brush or cotton swab and the cervix uteri and the vagina wall is greatly increased, the area where pathological cells possibly exist can be covered more comprehensively, the risk of missing sampling is reduced, and the accuracy of a detection result is improved.

The invention relates to the technical field of biological detection, and discloses a reagent composition and a kit for detecting cervical cancer and precancerous lesions of cervical cancer and application of the reagent composition and the kit. The reagent composition provided by the invention is used for detecting the methylation degree of a specific marker gene, and the detection sensitivity and specificity of cervical cancer and high-grade cervical cancer precancerous lesions are at a relatively high level. When the reagent composition is used for screening cervical cancer and precancerous lesions of HPV positive people, compared with conventional cytological detection, the colposcope referral rate is greatly reduced, meanwhile, the detection times for definite diagnosis of high-grade cervical lesions or cervical cancer are reduced, and the waste of medical resources and the examination burden of patients are reduced.

An inflatable speculum device for more comfortably and conveniently expanding the vaginal cavity to facilitate visualization of the cervix includes a tube having an interior space. The tube is made of a resiliently deformable material wherein the tube is configured to inflate. A hose is couplable to the tube and is in environmental communication with the interior space of the tube. A pump is fluidly coupled to the hose wherein activation of the pump moves air into the interior space of the tube through the hose thereby inflating the tube. The tube fits within a body cavity of a user whereby the tube is configured to dilate the body cavity when the tube inflates.

The invention relates to the technical field of medical information, in particular to a placenta position detection system and method based on MRI, and the method comprises the steps: obtaining target MRI image data, carrying out the image segmentation of the target MRI image data, and extracting the three-dimensional models of a placenta, a uterus and a cervix; based on the three-dimensional model, identifying the position relationship between the placenta and the cervix uteri, judging the type of the placenta, and evaluating the placenta implantation risk to generate risk early warning information; and displaying a three-dimensional visual model of the placenta and the uterus, and marking a high-risk area on the three-dimensional visual model based on the risk early warning information. The placenta position detection efficiency, precision and automation are improved, full-process automatic detection can be achieved, and personal errors are reduced.

There is provided a computer system and a computer-implemented method for prediction of parameters indicative of the risk of spontaneous preterm birth (sPTB) for a subject under assessment, the method being executed by at least one hardware processor and comprising the steps of: providing one or more ultrasound images comprising medical image data representative of the anatomical structure and appearance of at least a part of a cervix of the subject; providing a plurality of segmentations of the medical image data each representative of one or more features of the anatomical structure and appearance of the at least a part of the cervix of the subject; and utilizing i) the medical image data, ii) spatial information associated with the medical image data and iii) one or more of the segmentations in a classifier model to determine a prediction metric indicative of the likelihood of sPTB for the subject.

This invention provides a transcervical access system for moving fluids transcervically. [Solution] The transcervical access system 100 is effective in transferring a wide range of fluids into the uterine cavity, including the delivery of a hydrogel precursor, saline solution, and imaging fluid. The transcervical access system 100 is also effective in removing fluids, such as residual bodily fluids, residual fluids from procedures, or tissue from the uterine cavity. The transcervical access system 100 includes a flow limiter, such as an outflow limiter 106 and / or a cervical plug. A method of using the transcervical access system 100 involves using the transcervical access system 100 to transcervically access the uterine cavity and to install the hydrogel. The transcervical access system 100 and related methods are useful in preventing adhesions after intrauterine procedures by providing a biodegradable hydrogel within the uterine cavity, including the cervix.

The utility model belongs to the technical field of medical instruments. The utility model discloses an integrated surgical suture special for cervix uteri. The integrated surgical suture comprises a needle tip and a needle body connected with the needle tip. The needle body is in a concave arc shape, and a needle holding body which is smoothly connected with the needle body and arranged in a convex arc shape so as to stagger the suture needle moving angle, expand the visual field and facilitate suture operation in a narrow space is arranged at the end, away from the needle tip, of the needle body. And an absorbable suture for suturing a cervical wound is arranged at one end, far away from the needle body, of the needle holding body. The cervical suture and knotting device has the advantages that suture and knotting of a cervical wound can be safely, reliably and quickly completed, and the operation time is effectively shortened.

The utility model discloses a kind of hysteroscope liquid leakage prevention structures, including center cylinder base, the both ends of center cylinder base are fixedly connected with end fixed ring, the outer end array of two sides the end fixed ring is fixedly connected with multiple elastic supporting pieces, and the outer end of multiple elastic supporting pieces of same side is equipped with silica gel outer cover, two sides The outer side of elastic supporting piece is fixedly connected with operating slip ring and insertion stop seat respectively, and the outer end of two sides silica gel outer cover is fixedly connected with the outer edge of corresponding side operating slip ring and insertion stop seat.In insertion, small in diameter, it is convenient to set, and will not cause damage to cervix, can effectively solve the problem of clinical surgeon encountered in hysteroscopy surgery in uterine cavity liquid leakage, reduce operation time and surgical complications, improve operation efficiency and safety.

1. The name of the design product: disposable uterine cavity imaging catheter. 2. The use of the design product: through the cervix into the uterine cavity, for the diagnosis and auxiliary operation of uterine cavity diseases. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

The present application relates to in situ model modeling method, especially for a kind of non-invasive cervical cancer in situ model modeling method of mouse, including selecting several 8 weeks old BALB / c-nude mouse, all mice are divided into non-invasive group and operation group, the age, weight of two groups of mice are compared, and there is no statistically significant difference;Non-invasive group is widened with the cotton stick of diameter 3mm and wipes dry vagina, the tumor block with luciferase fluorescence is immersed in modified hydrogel, after heating and making modified hydrogel solidification, the tissue glue mixed with hard gypsum in modified hydrogel is dropped on the surface of modified hydrogel and quickly inserted into vagina, when there is obstruction, stop deepening, pause 30s and wait for tissue glue to be completely dry, when tumor block is fixed in cervix, it is modeling completion;Operation group first opens abdominal cavity, and tumor tissue of same size is sutured on cervix.This kind of non-invasive cervical cancer in situ model modeling method of mouse, using non-invasive method to replace operation method to establish non-invasive cervical cancer in situ model, can reduce the pain of mouse, reduce experimental difficulty.

The utility model discloses examination forceps for gynaecology and obstetrics, and belongs to the technical field of medical instruments. The forceps comprise an upper forceps arm and a lower forceps arm, the upper forceps arm is hinged to the lower forceps arm, the close ends of the upper forceps arm and the lower forceps arm are fixedly connected with a first handle and a second handle respectively, and a limiting rod is fixedly arranged in the middle of the side, close to the second handle, of the first handle. A sliding groove matched with the limiting rod is formed in the middle of the second handle, and a limiting assembly is arranged in the second handle. Under the action of a spring, a clamping rod can be driven to be clamped with a clamping groove in a limiting rod, so that the opening and closing angle of the upper forceps arm and the lower forceps arm is fixed, the situation that the two forceps heads are automatically closed to affect operation is avoided, the opening and closing angle can be adjusted and limited at any time through a pulling plate, doctors can conveniently conduct examination work, and the examination efficiency is improved. The vagina and the cervix uteri of the patient can be illuminated through the illuminating lamp, and examination and operation of a doctor are facilitated.

The invention relates to a handheld gynecological device (10) for cervix handling, comprising a body member (12), a piston member (36), a rod member (26) and a suction head (48). The body member (12) defines a vacuum chamber (16) and having a proximal end (18) and a distal end (20). The piston member (36; 336) is at least partially received in the vacuum chamber (16) and configured such that at least a portion of the piston member (36; 336) is displaceable in the vacuum chamber (16) from a first position to a second position for creating a vacuum in the vacuum chamber (16). The rod member (26) has a proximal end (32) and a distal end (34). The rod member (26) defines a lumen (30) and is configured to be coupled to the body member (12). The suction head (48) is configured to engage at least a portion of a cervix of a patient. The suction head (48) is fluidly connected to the distal end (34) of the rod member (26) and has a cross-section that is larger than a cross-section of the rod member (26).

The invention relates to the technical field of medical instruments, in particular to a cervicitis treatment drug delivery device which comprises a cabinet. A dosing mechanism for dosing is mounted on the inner side wall of the cabinet body, a cleaning mechanism for cleaning the dosing mechanism is mounted on the inner bottom wall of the cabinet body, and a dispensing mechanism for dispensing is mounted on the inner top wall of the cabinet body; in the using process of the device, the drug administration barrel is inserted into the vagina of a patient, then the micro motor is started to drive the sector plate to rotate, and drugs are discharged through the drug administration hole, so that the drugs are directly scattered to the cervix uteri, drug waste caused by the fact that the drugs are scattered into the vagina in the drug administration process is avoided, the drugs are effectively applied to the patient, treatment of the patient is facilitated, and time and labor are saved; and the labor intensity of medical staff is reduced.

The utility model discloses a cervical medicine application auxiliary plug which comprises a main body, one end of the main body is connected with a rope, and the main body is of a structure with the middle protruding and the two ends gradually narrowing in the length direction. The main body is of a multi-layer structure, an inflation balloon is arranged in the main body, and the size of the main body can be changed by inflating the inflation balloon. The device is suitable for the medical field, in the device, the main body is arranged to be of a multi-layer structure with the middle protruding and the two ends gradually narrowing in the length direction, so that when the device is used, a patient feels comfortable, and discomfort of the patient is not likely to be caused; the volume of the main body can be changed by inflating and deflating the inflatable balloon, so that the volume of the device is convenient to adjust, the filler does not need to be increased or decreased, the softness of the whole main body can be higher through the inflatable structure, and a patient can use the device more comfortably.

The invention relates to the technical field of ultrasonic image analysis, and discloses an image detection method and system for prolonging the second birth process of double-fetal vaginal delivery and SPPH risk based on ultrasonic Speckle-tracing, and the method comprises the steps: obtaining an ultrasonic two-dimensional gray-scale image sequence; marking a conjoint analysis area between the cervical wall and the front and rear walls of the vagina; constructing a joint area displacement field; constructing a joint region strain trajectory; extracting parturition process characteristic indexes; and executing risk assessment through a fuzzy rule. The technical problem that in the prior art, risk judgment depends on clinical experience, and especially under the condition that continuous stretching occurs on the cervix uteri and vagina combined wall in the second birth process of double-fetal vaginal delivery, early recognition of the evolution process of the tissue from reversible stretching to irreversible instability is difficult to achieve is solved. Due to the fact that joint area displacement field modeling and logarithmic nonlinear strain analysis are introduced, quantitative characterization and continuous risk description of the mechanical behavior of the tissue in the labor process are achieved.

The invention patent is titled "Dragon and Cypress Gel," belonging to the pharmaceutical category. The main components of Dragon and Cypress Gel are: Phellodendron bark, earthworm, dragon's blood, Oldenlandia diffusa, Sophora flavescens, and Bletilla striata. In recent years, research on cervicitis and cervical lesions has shown good results using external treatments of traditional Chinese medicine. Vaginal cervical medications are characterized by high local drug concentration, low dosage, and safety and effectiveness, receiving high clinical evaluation. The vagina and cervix have abundant capillaries and lymphatic vessels, and lack clearly defined nerve endings, resulting in minimal pain stimulation for patients during administration. This makes it an effective drug release site for specific diseases such as cervicitis and vaginitis. Traditional Chinese medicine gels are a novel type of external preparation of traditional Chinese medicine. They are made by dissolving or uniformly dispersing traditional Chinese medicine in a gel. These gels adhere tightly to the treatment site for a relatively long time, exhibiting good bioadhesion, and are simple to prepare. It is suitable for use on skin, mucous membranes and cavities. It not only avoids the first-pass effect of enzymes and acids in the gastrointestinal tract that exists in oral administration, but also reduces the adverse reactions of drugs. It has the characteristics of good spreadability, non-greasy feeling, easy to wash off, good transdermal absorption, and comfortable use.

The utility model relates to the technical field of cervix uteri treatment, in particular to a special vaginal speculum for a cervix uteri treatment support, which comprises an upper supporting plate and a lower supporting plate, the middle of the upper supporting plate is hinged to the middle of the lower supporting plate, the cross section of the upper supporting plate and the cross section of the lower supporting plate are both V-shaped, the upper supporting plate comprises a first clamping plate positioned at the bottom of the upper supporting plate, and a second clamping plate positioned at the bottom of the lower supporting plate. The lower supporting plate comprises a second clamping plate located at the bottom of the lower supporting plate, a buckling mechanism is arranged between the first clamping plate and the second clamping plate and comprises a clamping groove formed in the first clamping plate in a penetrating mode, an arc-shaped rod is arranged on the second clamping plate, sawteeth are arranged on the arc-shaped rod, and the first clamping plate and the second clamping plate are arranged in the clamping groove. The arc-shaped rod penetrates through the clamping groove, the sawteeth abut against the upper edge of the clamping groove, the sawteeth incline from the direction of the second clamping plate to the direction of the first clamping plate from top to bottom, and an unlocking rod is fixedly connected to the bottom face of the end, away from the second clamping plate, of the arc-shaped rod.

Embodiments of the present application provide a method for determining a region of interest in an ultrasound image and an ultrasound imaging device. The method comprises: acquiring a uterine ultrasound image and displaying the uterine ultrasound image via a display interface; determining first feature points of the endometrium in the uterine ultrasound image, the first feature points comprising a feature point located at the cervix and a feature point located at the fundus; automatically connecting the first feature points comprising the feature points of the cervix and the fundus according to the direction of the endometrium to form an endometrial boundary line of the endometrium; and determining the region in the uterine ultrasound image between at least the endometrial boundary lines as the region of interest. This application can improve the accuracy and efficiency of determining a region of interest that aligns with the endometrial / junctional zone morphology.

The present invention describes a method of treating a high level of squamous intraepithelial lesion (HSIL) associated with human papilloma virus (HPV) type 16 or HPV type 18 of the cervix. The described methods include assessing the presence or absence of miRNA and isomiRs thereof in one or more biological samples.

The present application relates to the medical instrument related technical field, especially the sterile latex vaginal flusher, including holding shell group, water storage tank, multi-section pipe group, linkage assembly, three-leaf plate, locking assembly, the present application is through the step-by-step movement of multi-section pipe group and human structure self-adaptive design, solve the existing rigid flusher fragile mucosa friction causes the problem of pain.In the insertion and flushing process can conform to the physiological structure of vagina, reduce the mechanical friction and stimulation to hyperemic mucosa, effectively reduce the pain of patients, at the same time, through the cooperation of three-leaf plate and locking assembly, the insertion depth is accurately limited, prevent the pipe head from hitting the cervix and causing severe pain, so that the treatment effect is guaranteed, the physiological pain and psychological burden of patients are reduced to the greatest extent.

The utility model provides an improved uterus probe, which belongs to the technical field of uterus probes, and comprises a probe rod, the side surface of the probe rod is provided with length scales, the side surface of the probe rod close to one end is fixedly connected with a handle, the handle does not influence the two end parts of the probe rod, and the inner side of the probe rod is provided with a puncture hole which is linearly communicated with the two end parts of the probe rod. According to the uterine probe, the handle is connected to the side face, close to one end of the probe rod, of the probe rod, so that the handle does not affect the two ends of the probe rod, the puncture hole linearly communicated with the two ends of the probe rod is formed in the inner side of the probe rod, and an injection needle can be inserted into the puncture hole during uterine detection; the improved uterus probe has the advantages that local positioning drug delivery is carried out in the uterine cavity, the cervix uteri or a gestational sac implanted in the cervix uteri or a caesarean section scar part and the like, so that the improved uterus probe has more powerful functions.

The utility model provides a cervix uteri collector, which relates to the technical field of medical sampling tools, and comprises a connecting tube, one side of the connecting tube is fixedly connected with a handle, the inner wall of the connecting tube is connected with a sliding rod in a sliding manner, one end of the sliding rod is fixedly connected with a sampling head, the surface of the sampling head is uniformly provided with hairbrushes, and the hairbrushes are connected with the connecting tube in a sliding manner. The end, away from the sampling head, of the sliding rod is fixedly connected with a connecting plate, a connecting device is arranged at one end of the connecting pipe, and when the connecting device is used, the first semicircular cylinder and the second semicircular cylinder slide out of one end of the connecting pipe at the same time manually; furthermore, a brush arranged on the surface of the sampling head is accommodated in a first semicircular cylinder and a second semicircular cylinder when being accommodated in a connecting pipe, so that the first semicircular cylinder and the second semicircular cylinder slide out of a connecting groove, and a sample adhered to the inner walls of the first semicircular cylinder and the second semicircular cylinder can be taken out; therefore, the sample can be conveniently taken out.

Antibody drug conjugate (ADC) comprising a drug moiety conjugated to antibody or antigen binding fragments thereof that bind to TROP2 disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The ADC of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the ADC disclosed herein can include carcinomas, such as lung cancer, breast cancer, head-and-neck cancer, esophagus cancer, stomach cancer, bladder cancer, pancreatic cancer, colorectal cancer, cervix cancer, endometrial cancer, ovarian cancer, laryngeal cancer, prostate cancer, thyroid cancer and oral cancer.