30 results about "HPV Positive" patented technology

Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E7, E711-19. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.

The inventors now have developed a (molecular) diagnostic assay based on detection of alterations in markers MAL and hsa-mi R124, in particular promoter hypermethylation, to identify human papillomavirus (HPV)-induced high-grade precancerous lesions such as premalignant cervical lesions of invasive cervical cancer, within cell material obtained via self- sampling. In particular, the present invention relates to the use of the MAL gene (including its promoter) and the hsa-mi R124 gene as marker for HPV- induced high-grade premalignant lesions, allowing early detection and a better treatment option for the individual patient.

The invention belongs to the field of bio-medicines, and specifically relates to an HPV (Human Papillomavirus) L1 recombinant annulet DNA immunoglobulin of yolk (IgY) and application thereof in preparing a drug for preventing / treating HPV infection. The HPV L1 recombinant annulet DNA comprises an L1 gene segment of HPV16 and a signal peptide sequence, and is taken as a nucleic acid antigen for directly immunizing a laying hen to obtain the IgY. Bio-activity of the IgY obtained by intramuscular injection of the DNA nucleic acid antigen for immunizing the laying hen is much higher than that of the IgY prepared by a common technology (subcutaneous injection of the protein antigen), valence of an antibody is higher, and specificity is stronger. The IgY can be used for preparing the drug for preventing / treating the HPV infection; a vagina drug inputs the high-activity anti-HPV antibody to a HPV positive patient, and a nano-liposome method is combined, so that the antibody gets across the film to enter into cells to directly neutralize HPV viruses in the cells. The IgY is of great significance for preventing cervical cancer.

The present invention relates to HPV-positive as well as HPV-negative screening platforms that are highly serum-dependent, for use as HNSCC models. These HNSCC models die reproducibly in serum-deprived conditions and the introduction of driver mutations (or increased levels of the WT gene) confers enhanced cell survival and proliferation under serum deprivation. These platforms have the major advantages of allowing functional screening of mutations in relevant HNSCC models (HPV-positive and HPV-negative). In addition to oncogene screening, this model can also be used in drug discovery. Specifically, cells expressing mutations that confer increased survival can then be screened against panels of therapeutic agents to determine if the mutation(s) can predict the optimal treatment for patients whose tumors harbor the mutation(s).

The invention relates to medicine for treating cervical erosion through HPV (human papillomavirus) positive-to-negative change. The medicine comprises the following ingredients in the contents (weight percentage): 30 percent to 40 percent of walnut peel, 10 percent to 15 percent of lithospermum, 5 percent to 10 percent of ramulus mori dust, 5 percent to 10 percent of golden cypress, 7 percent to 10 percent of radix sophorae flavescentis, 7 percent to 10 percent of fructus cnidii, 2 to 5 percent of methylcellulose, 2 to 5 percent of agar and 8 to 12 percent of acacia. The medicine has the advantages that the complete HPV positive-to-negative change can be realized, the cervical erosion is radically treated, simplicity is realized, the implementation is easy, high and low temperature is avoided, and the toxic or side effect on human bodies does not exist.