161 results about "Cervical diseases" patented technology

The invention discloses a thin-sheet-type self-heating element, a preparation method and an application thereof. The thin-sheet-type self-heating element includes the following components, by weight, 20.0-60.0% of iron powder, 4.0-20.0% of activated carbon, 2.0-6.0% of ultrahigh-molecular-weight polyethylene fiber, 0.5-5.5% of xanthan gum, Arabic gum and carboxymethylcellulose (CMC), 1.0-4.0% of industrial salt, 0.3-1.5% of an anionic surfactant NP-4 and 12.0-28.0% of water. The self-heating element is greatly improved in heating temperature stability, can be prepared into a thin-sheet-type heating element, is free of leakage and is safe, can be widely applied in a body warming patch, a medical operation warming cushion, a medical and health-caring patch, a female menstrual-period dysmenorrhea-alleviating patch, breast caring, medical health caring of lumbar and cervical disease, instruments and meters, and digital product portable heating and the like fields.

The invention provides a monoclonal rabbit antibody for identifying HPV16 positive cervical tissues. The antibody can be used for specifically detecting a biomarker HPV16E7 protein in tissues including cervical cancer and cervical lesions, so that HPV persistent infection related cervical cancer tissues from abnormal or noncancerous cervical epithelial tissues, cervical cancer caused by high-risk HPV infection can be accurately diagnosed, and risk early-warning can be especially performed for whether early cervical lesions cancerate or not, so that the misdiagnosed rate of cervical lesions can be effectively reduced, and injuries and resource waste caused by over treatment for patients can be improved.

The present invention relates to a digital system for cervical disease screening and detection, with clinical application as adjunct to Pap smear. The device of the present invention is designed for insertion into a woman's genital cavity, and is composed of a digital camera and light source at one end to take pictures of the cervix and its environment, of a flexible tubing connecting said end to a distal end, and of a distal end comprising a digital mean with capacity to store images, display, transfer and share them as required, on-site or at a remote location. This instrument can either be used by a health professional, or self-operated.The present invention provides a system making cervical disease screening routinely accessible to every woman, by improving frequency and cost-effectiveness of cervical disease surveillance in general, and facilitating access to health care professionals even to women in rural or underserved areas.

Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical smear or monolayer of cervical cells. The biomarkers of the invention include genes and proteins that are involved in cell cycle regulation, signal transduction, and DNA replication and transcription. In particular claims, the biomarker is an S-phase gene. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.

The invention provides a flexible and foldable biomembrane and a preparation method thereof. The flexible and foldable biomembrane is composed of an inner layer and an outer layer, wherein the outer layer is a medical polyurethane membrane which can be fragmented after absorbing liquid, the inner layer is a wounded surface covering layer and is composed of, for example, chitosan and derivatives thereof or alginate or the mixture dressings of both the chitosan and the alginate, the inner layer can be separately applied to wounded surface repairing and can be used for bonding treatment medicinesto a medicine carrier absorbing layer before the inner layer is used to achieve a treating effect, wounded surfaces comprises skin, mucous membranes or in vivo tissues, and the biomembrane is particularly suitable for cervical repairing. The flexible and foldable biomembrane is produced to be a mushroom-shaped, a protrusion is arranged in the middle, before the flexible and foldable biomembrane is used, the treating medicines are bonded to the chitosan and the derivatives thereof or the alginate dressings, when the biomembrane is used, a special vaginal clamp or a special pushing tool is usedfor pushing the biomembrane and covering the surface of os uteri, the protrusion is fixed to orificium vaginae, sustained local application of a cervical part is achieved, and the treating effect onchronic cervical diseases of cervical erosion and HPV is improved.

The invention discloses a novel pasteurization method and an abnormal cervical cell automatic identification method. The novel pasteurization method comprises two modules, the module 1 is used for training a cervical cell classification model based on a mass cervical cell data set, and the module 2 is used for identifying abnormal cervical cells by using the trained classification model. The invention provides the novel pasteurization method, so that the problems existing in the traditional pasteurization method are well solved, and the possibility is provided for realizing automatic and high-precision positioning of cervical cell nuclei by a computer. The invention also provides the abnormal cervical cell automatic identification method, and experiments show that the method realizes the ultrahigh-precision automatic identification of abnormal cervical cells, so that the diagnosis burden of pathologists is greatly reduced, the diagnosis efficiency and the precision of the cervical diseases are improved, and the method has very high practical value and huge social benefits.

The invention discloses a traditional Chinese medicine composition for treating neck shoulder pain or lumbocrural pains. The traditional Chinese medicine composition is prepared from the following raw medicinal materials by weight: 5-10g of Szechuan lovage rhizome, 5-10g of cassia twig, 5-10g of kudzuvine root, 5-10g of Chinese angelica, 5-10g of lesser galangal rhizome, 5-10g of incised notopterygium rhizome, 5-10g of dried ginger, 5-10g of common clubmoss herb, 5-10g of tuberculate speranskia herb, 5-10g of safflower, 5-10g of dahurian angelica root, 5-10g of Chinese ligusticum rhizome, 5-10g of galanga resurrectionlily rhizome, 5-10g of stem of Chinese starjasmine, 5-10g of suberect spatholobus stem, 5-10g of argy wormwood leaf and 1.5kg of large-particle sea salt. The traditional Chinese medicine composition has a very strong curative effect of improving symptoms of lumbar and cervical diseases including wind-cold-dampness arthralgia, limb numbness, arthralgia and the like.

The invention discloses a digital colposcope taking a single chip microcomputer as a core, wherein the digital colposcope is suitable for auxiliary diagnosis and image management of gynaecological vulva, vagina and cervical diseases. The digital colposcope comprises a computer system, professional digital colposcope software, a camera, a rotary bracket, a control handle, a pedal switch, a control mainboard and a shell. The single chip microcomputer is controlled by programs; DSP (Digital Signal Processor) dynamic electron-focusing freeze control is adopted; 3.5 inch high-definition color display is internally arranged in the digital colposcope, so that double screens of the digital colposcope and a computer are synchronously displayed in real time; and a doctor only needs to observe focus images on the screens. An LED (light emitting diode) annular multipoint group cold light source is adopted, the outer ring of the light source emits white light, and the inner ring of the light source emits green light, so that the color difference between blood and other human tissues as well as organs is increased, therefore the vision of the doctor in an operation is clearer; and images have no light loss, so that the images are convenient to print and output in color. Extremely tiny image details can be identified through high-quality light source and high magnification of the images. The camera can be freely telescopic and rotary according to the focus position of a patient, so that accurate positioning is realized. The pedal switch is connected with the computer, so that required images are frozen at any time.

The invention relates to an intelligent pillow which comprises an electric control device and a mechanical structure portion (a pillow support). The electric control device can adjust the height of the pillow automatically according to sleeping positions of a human body. The electric control device is composed of a forward sampling amplitude comparison circuit, a reverse sampling amplitude comparison circuit, a forward execution control circuit, a reverse execution control circuit, a motor driving circuit, a forward shut-down integrated switch, a reverse shut-down integrated switch, a vibration sensor circuit, a motor, and a position display and control circuit. A lifting plate is arranged at the middle position inside a casing of a pillow support structure, a pillow supporting plate is arranged on the lower portion of the casing, the motor is arranged on the lateral side inside the casing, and the motor is connected with a rotating rod through a coupler and a gearbox. A bevel gear is fixedly arranged at a terminal of the rotating rod and matched with a bevel gear wheel arranged at the bottom of the casing. The intelligent pillow can adjust the height of the pillow automatically along with the sleeping positions of the human body, can nurse the necks of people in sleep, and enables the necks to keep a normal physiological curvature. Therefore, comfortableness and quality of sleeping are improved, and a cervical disease and a spinal disease are prevented.

The invention provides a gynecological cervical disease examination and diagnosis and treatment device. The gynecological cervical disease examination and diagnosis and treatment device comprises an inner pipe and a casing pipe. The inner pipe is arranged in the casing pipe in a sleeved mode, an ultrasonic probe is arranged at the upper end of the inner pipe, a plurality of limiting holes are formed in the two sides of the upper portion of the inner pipe, and bristles are arranged in the limiting holes in a penetrating mode and connected with a push handle outside the casing pipe through a connecting rod, a fixing plate and a push rod. A liquid bag is arranged outside the side wall of the upper portion of the casing pipe in a sleeving mode, at least two liquid passing pipes communicated with the liquid bag are arranged in the casing pipe, and the other ends of the liquid passing pipes extend to the outside of the casing pipe. By arranging the liquid bag, uterus dilation can be carried out in detection, and the pain of a patient is relieved; the liquid bag is communicated with the liquid passing pipes, liquid injection and liquid discharge can be rapidly carried out, and efficiency is higher; the ultrasonic probe is arranged at the top end and has higher detection performance in cooperation with the water bag, and diagnosis accuracy is improved; meanwhile, a sampling brush is arranged, and sampling detection can be carried out.

This invention describes new protocols for screening for cervical carcinomas or high-grade premalignant cervical lesions based on combinations of testing for the presence of high-risk HPV, HPV genotyping, marker analysis, and / or cytology. With these protocols the number of women that have to undergo follow-updiagnostic testing and / or clinical examinations will decrease. Further, the number of false positives and false negatives will decrease.

The invention discloses a primer and probe composition for detecting HPV (Human Papillomavirus) high-risk type 16 by applying an RPA (Recombinase Polymerase Amplification) technology. A forward primersequence is shown as SEQ ID No. 1, a backward primer sequence is shown as SEQ ID No. 2 and a probe sequence is shown as SEQ ID No. 3. According to the method provided by the invention, a lot of RPA primers and probes are designed according to an HPV high-risk type 16 genome sequence, and one pair of the primer and probe composition capable of rapidly and effectively detecting HPV high-risk type 16 nucleic acid is screened. By applying a primer pair, a probe and a corresponding kit, provided by the invention, rapid constant-temperature fluorescence detection can be carried out on an HPV high-risk type 16 DNA (Deoxyribonucleic Acid) segment in unknown samples including woman cervical epithelial cells, genitalsecretion and the like. A detection result can be used for auxiliary diagnosis of HPV high-risk type 16 infection and early screening of cervical carcinoma, follow-up of cervical lesions and guidance of development of vaccines.

The invention relates to an automatic cupping physiotherapy massage device for orthopedic cervical spondylosis, which includes a supporting top plate, a downward pressure suction device, two massage devices and a rotating manipulator device. The downward pressure suction device is installed on the top lower end surface of the support top plate, Two massage devices are symmetrically installed on the pressing suction device, and the rotating manipulator device is located on the left side of the massage device, and the rotating manipulator device is installed on the supporting top plate. The present invention can solve the problem that the existing orthopedic cervical spondylosis cannot be automatically grasped and pushed when manual cupping is used for physiotherapy, the cupping jar is easily dropped when manually taken, and the spraying position of safflower oil needs to be manually adjusted, and the spraying of safflower oil is required. Unevenness, the need to manually massage the back of the human body, and the inability to perform infusion during cupping; it can realize the function of automatically performing massage and cupping on the human body during the treatment of orthopedic cervical spondylosis.

The invention relates to the technical field of medicines, in particular relating to a composition of 5-aminolevulinic acid and a derivative thereof as well as application thereof. The composition of the 5-aminolevulinic acid and the derivative thereof disclosed in the invention comprises an effective dose of active constituent of the 5- aminolevulinic acid and the derivative thereof, and is characterized in that the composition also comprises proteolytic enzyme which is 0.035-277U per gram of the composition. The invention simultaneously discloses the application of the composition in the preparation of medicines for treating gynecological diseases. The composition can effectively improve the influence of cervical mucus on an active constituent ALA and a derivative thereof, enhances the permeability of the active constituent ALA and the derivative thereof in the cervical part, and improves the bioavailability of the ALA and the derivative thereof. The composition not only greatly improves the effect of the ALA and the derivative thereof on treating the gynecological diseases and in particular the cervical diseases, but also ameliorates the disamenity of the patients in the traditional treating process.

The invention discloses a full-automatic ultra-silence ecological pillow and relates to sleeping articles for use. The full-automatic ultra-silence ecological pillow comprises a sleeping posture signal detecting and transmitting system, a control and power system, an executing system and a noise-reduction vibration-proof system. The control and power system is isolated from the pillow part, and measures of sound insulation and vibration resistance are taken to achieve ultra-silence effect of the pillow body. With changing of modern life and working habit, ratio of patients with cervical vertebra increases gradually, if a user sleeps on their back by a high pillow, that is, the user works in the daytime with the head low and sleeps at night still with the head low, and natural radian of the cervical vertebra of the user straightens to cause cervical diseases, however, existing pillows cannot well solve this problem. The headrest part and the neck rest part of the pillow are independently controlled, and the problem that heights of the headrest part and the neck rest part of the common pillow cannot be automatically adjusted along with sleeping posture of the user is solved. The full-automatic ultra-silence ecological pillow has the auxiliary treatment and healthcare rehabilitation function for patients with cervical spondylosis.

A photoelectric integration three-dimensional colposcope is suitable for auxiliary diagnosis and image management of vulva, vagina and cervical diseases in the gynecology. An LED cold light source diaphragm, a stereoscopic microscope and a digital camera constitute a stereo-micrography optical system together, an objective lens of the stereoscopic microscope is aligned to a focus of a patient under irradiation of the LED cold light source diaphragm, changes of epitheliums and blood vessels, which cannot be seen by naked eyes, can be observed three-dimensionally through the objective lens, the digital camera is used for converting optical signals under the lens of the stereoscopic microscope into digital signals through a high-resolution color CCD picture pick-up system, pictures are displayed on a display through communication with a host, and the pictures are synchronously displayed on the stereoscopic microscope and the display in real time. The photoelectric integration three-dimensional colposcope has the advantages that the perfect stereo-micrography optical system is provided, stereoimaging is achieved, color resolution is high, true color fidelity is high, stereoscopic impression is strong, and the depth of field is ultra large; moreover, a colposcope image processing system with strong functions is provided.

The invention discloses a nano iodine-chitosan cervical disease treating membrane agent and a preparation method of the membrane. The treating membrane is prepared by adding plasticizer and adsorbent to chitosan, povidone iodine, dialkyl quaternary ammonium salt and chlorhexidine acetate used as main effective ingredients. The treating membrane disclosed by the invention has killing activity to multiple pathogenic microorganisms, has no irrigation to mucosa, can relieve itching, arrest bleeding and promote the growth of epidermic tissues, can be used for treating colpitis, trichomonas vaginalis, cervicitis, cervical erosion and other gynecological diseases, has better repair action on vaginal and cervical injury, and can effectively prevent the propagation of venereal diseases such as gonorrhoea, syphilis, AIDS (acquired immunodeficiency syndrome) and the like.

The invention discloses a leaning type safe light and convenient vehicle for people to pick and husk Chinese chestnuts. The leaning type safe light and convenient vehicle for people to pick and husk the Chinese chestnuts comprises a leaning type movable mechanism, a husking mechanism, a flexible telescopic gliding module, a wrapping type telescopic grabbing and picking mechanism and a detachable loading vehicle, wherein the husking mechanism is arranged on the leaning type movable mechanism; the wrapping type telescopic grabbing and picking mechanism is arranged on the leaning type movable mechanism; one end of the flexible telescopic gliding module is arranged on the wrapping type telescopic grabbing and picking mechanism; the other end of the flexible telescopic gliding module is arranged on the husking mechanism; and the detachable loading vehicle is detachably arranged at the rear end of the leaning type movable mechanism. The invention belongs to the field of farm tools, particularly, by the leaning type safe light and convenient vehicle for people to pick and husk the Chinese chestnut, the practicality is high, people pick the Chinese chestnuts comfortably, the working efficiency is improved, the labor intensity is reduced, the problems that people who pick the Chinese chestnuts easily suffer from cervical diseases when looking up to observe the Chinese chestnuts, and theChinese chestnuts are difficult to pick due to over-high Chinese chestnut trees are solved, and husks of the Chinese chestnuts are automatically and nondestructively removed.

The invention discloses a 3D (Three-Dimensional) pillow interior for a cervical pillow and a production method of the 3D pillow interior. The 3D pillow interior for the cervical pillow adopts the technical scheme as follows: the pillow interior comprises a body core and a layer of sandwich mesh which is attached to the surface of the body core, wherein the main core is processed by 3D upright cotton blended by 35-45% of ELK fibers by weight, 25-35% of hollow polyester fibers by weight and 25-35% of anion fibers by weight. The production method of the 3D pillow interior comprises four steps. The body core is processed by adopting the 3D upright cotton blended by the ELK fibers, the hollow polyester fibers and the anion fibers, so that the special functions of purifying air, sterilizing, playing the effects of sleep and asthma improvement as well as sub-health care on a human body, and improving and repairing cervical diseases of the pillow interior are achieved, meanwhile, the pillow interior has the characteristics of no toxicity, no smell, fire prevention, environmental protection, good softness, good rebound resilience, good air permeability, light weight and washable property.

The invention relates to the field of health care technology, in particular to a health pillow for treating cervical spondylosis, which specifically includes a pillow case and a pillow core, the pillow core is covered with a dust cover, a groove is arranged in the middle of the pillow core, a medicine pillow is arranged under the groove, and a pillow is arranged inside the pillow core. An air bag is arranged, and an inflatable device is arranged outside the pillow core; the air bag is connected with the inflatable device. The present invention is designed according to ergonomics, and a groove is set in the middle of the pillow core, which can fix the head and reduce the possibility of stiff neck; a medicine pillow is set under the groove, which can prevent bacteria and mites, inhibit the growth of mold, and drive away the irritating odor produced by the growth of mold, and can Regulate cervical spondylosis, high blood pressure, and have health care effects. Grind the filling of the medicated pillow into powder without affecting sleep.

Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM2 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.

The invention discloses a notebook radiator, comprising a radiator body, a fan arranged in the radiator body and a support frame installed on the radiator body in a hinged manner, wherein the upper surface of the radiator body is a slant plane of which the tilt angle is 6 degrees to 13 degrees. The notebook radiator of the invention has simple structure and small volume, and the tilt angle of theupper surface of the radiator body matches the principle of ergonomics, thereby being capable of increasing working comfort level, preventing cervical disease, effectively assisting radiation of the notebook, and being convenient for carrying.

An adjustable program automatically controlled displayer comprises a programmable logic controller (PLC) and a signal collector. A support of the adjustable program automatically controlled displayer is composed of an upper support and a lower support, wherein the upper support and the lower support are connected through a rotating shaft, and an intelligent electric executing mechanism is installed on the lower support. The signal collector collects status signals of a human body and outputs a switch signal to the PLC, the PLC outputs a digital signal to the intelligent electric executing mechanism, the electric executing mechanism can rotate in positive and negative directions according to a control signal, and the intelligent electric executing mechanism drives the rotating shaft to rotate by a certain angle through a reducer. Due to the fact that a program control displayer rotates by a certain angle regularly, when people works, the head and the neck are 'forced' to change the position, and functions of rest, adjustment and relaxation can be achieved. The adjustable program automatically controlled displayer has the advantages of being simple in structure, full-automatic in control, convenient to use, and capable of playing a significant role in prevention of cervical disease and promotion of human health.

The invention belongs to the technical field of clinical medicine, provides application of Notch1, p16<INK4a> and hTERC genes as screening markers for cervical cancer, and relates to molecular markersfor detecting double or triple genes of cervical precancerous lesion and early diagnosis of the cervical cancer. Patients with cervical disease have no significant symptoms in the early stages of onset, and are easily overlooked and fail to be treated in time, so that the risk of the disease and the difficulty of treatment are increased. It is controversial to use p16<INK4a> protein as a diagnostic screening index for the cervical cancer, and the credibility is not high. The invention provides a set of markers, namely, the application of the Notch1, p16<INK4a> and hTERC genes as the screeningmarkers for the cervical cancer, positive correlation exists between p16<INK4a>, Notch1 and hTERC genes and carcinogenesis of HPV16, and significant positive correlation exists between p16<INK4a> andhTERC genes and the carcinogenesis of the HPV16, and the markers can be used for application of molecular marker reagents for detecting double or triple genes of cervical precancerous lesion and early diagnosis or screening of the cervical cancer.

The invention relates to a gear transmission-based display double-layer lifting support. It consists of a base, a vertical column, a lifting platform, a lifting device, a positioning device, and lighting fixtures; the vertical column includes a left and a right column, which are fixed on a horizontal base by screws, and the left and right columns are all cube-shaped and hollow structure, its front and rear surfaces are designed with concave grooves; the lifting platform includes a display platform, a cube keyboard platform, a mouse pad, and double U-shaped support arms; the lifting device includes a pair of racks, wheels, rotating shafts, A pair of handwheels and a pair of rollers; the positioning device includes a box body, a spring, a tooth block, a handle, and a concave protrusion; the beneficial effect of the present invention is that the height of the display and the keyboard can be raised by adjusting the handwheel; It solves the problem that desktop computer users are tired from sitting, have pain in the buttocks, can use the monitor and use the keyboard and mouse synchronously while standing, and can also reduce the probability of suffering from cervical spondylosis.

The invention belongs to the technical field of medicines and provides a pharmaceutical composition. The pharmaceutical composition comprises germacrone, furanodiene, curdione, beta-elemene, curcumol, curzerene and borneol. The components of the pharmaceutical composition are definite, and the quality can be controlled. The pharmaceutical composition can be used for preparing vaginal or rectal preparations and has a good effect of treating HR-HPV (high risk human papillomavirus) and / or LR-HPV (low risk human papillomavirus) infection and cervical diseases and can be used widely clinically.

The invention is in the field of medicine and is concerned with a molecular diagnostic marker for progression to invasiveness of HPV-induced premalignant lesions and future metastatic potential of HPV-induced premalignant lesions and carcinomas. In particular the present invention relates to the use of the TSLC1 gene as marker for progression to invasive cervical cancer and metastatic potential of cervical lesions. The invention provides methods for detecting HPV-induced invasive cancers and their precursor lesions associated with tumor suppressor lung cancer 1 (TSLC1), comprising contacting a target cellular component of a test cell with a reagent that detects TSLC1 and detecting a reduction in the TSLC1 as compared to that of a comparable normal cell. The invention also provides molecular diagnostic markers for premalignant cervical lesions with invasive potential associated with tumor suppressor lung cancer 1 (TSLC1) in cytologically abnormal cervical smears and / or biopsies.

The invention relates to an acupoint fitness rod by utilizing an eight-diagram-shaped appetizer. The acupoint fitness rod comprises a main rod body. At least one massage structure is distributed along the radial direction of the main rod body. Each massage structure is embedded into the interior of the main rod body and located in cylinder space with one enclosed and one opened. Each massage structure comprises a spring. The stretching direction of each spring is in the same as the radial direction of the main rod body. One end of each spring is fixed into the main rod body and the other end of each spring is connected with a massage ball. When the elasticity of each spring is controlled in the state of maximal elongation, each massage ball is not completely exposed outside of the main rod body. When each spring is in the state of maximal contraction, each massage ball is not completely concealed in the interior of the main rod body. The acupoint fitness rod by utilizing the eight-diagram-shaped appetizer has following beneficial effects: complete functions including massage, acupoint pressure and tapping are obtained by the fitness rod so that massage and health care can be carried out in multiple manners; the main rod body can be utilized as the fitness body and can help to treat cervical diseases; and the acupoint fitness rod is not electric and low in cost and is not limited by a power supply and is portably used and conveniently carried anytime and anywhere.

The invention discloses a medicament for treating cervical vertebra diseases and method for preparation, wherein the medicament is prepared from kudzu vine root, epimeddium, astragalus root, root of herbaceous peony, Chinese angelica root, Ligusticum wallichii, corydalis tuber, notoginseng, Chinese flowering quince, batryticated silkworm, licorice root, peach kernels, bark of peony root, pubescent angelica root and notopterygium root.