77 results about "Astilbin" patented technology

The present invention discloses a method for extracting and separating dihydroquercetin from wolfberry leaf, in which dihydroquercetin is prepared from wolfberry leaf through extracting, concentrating, column chromatography, crystallizing and hydrolyzing to generate an acicular crystal white dihydroquercetin, wherein the content of dihydroquercetin more than 95%(HPLC test). The present invention can extract astilbin, quercetin and dihydroquercetin from wolfberry leaf simultaneously, which has advantages of high yield and ripe technology, and it is suitable for industrialization and continuous production.

The invention belongs to the field of traditional Chinese medicines and relates to a use of rhizoma smilacis glabrae extract in preparation of lipid-lowering and fat-reducing medicines and health-care foods. The rhizoma smilacis glabrae extract comprises 5-O-caffeoylshikimic acid, astilbin, isoastilbin, neoastilbin, neoisoastilbin, taxifolin, engeletin, isoengelitin and resveratrol. An animal experiment shows that the rhizoma smilacis glabrae extract can obviously reduce mice abdominal cavity fat weight, reduce mice body weight, and reduce triglyceride and total cholesterol concentrations of mice serum. Effects of the rhizoma smilacis glabrae extract are stronger than effects of a single astilbin component. The rhizoma smilacis glabrae extract is extracted from traditional Chinese medicines, has synergism of components, has good fat-reducing effects and broadens a rhizoma smilacis glabrae application range.

The invention relates to a Chinese herbal medicine compound preparation for treating skin and mucous membrane disease. The Chinese herbal medicine compound preparation is prepared from the following raw materials: cortex moutan, polygonum chinense, radix salviae miltiorrhizae, herba lycopi, common dayflower herb, rhizoma smilacis glabrae, ramulus cinnamomi, caulis dendrobii officinalis, gorgon fruit and cortex cinnamomi; the ingredient of the Chinese herbal medicine compound preparation comprises a cortex moutan extract, a polygonum chinense extract, a radix salviae miltiorrhizae extract, a herba lycopi extract, a common dayflower herb extract, a rhizoma smilacis glabrae extract, a ramulus cinnamomi extract, a caulis dendrobii officinalis extract, a gorgon fruit extract and a cortex cinnamomi extract; and the effective ingredient of the cortex moutan extract is paeonol, the effective ingredient of the polygonum chinense extract is quercitrin, the effective ingredient of the radix salviae miltiorrhizae extract is tanshinone IIA, the effective ingredient of herba lycopi is ursolic acid, the effective ingredient of common dayflower herb is commelinin, the effective ingredient of rhizoma smilacis glabrae is astilbin, the effective ingredient of ramulus cinnamomi is cinnamaldehyde, the effective ingredient of caulis dendrobii officinalis is erianin, the effective ingredient of gorgon fruit is cyclo(profilum), and the effective ingredient of cortex cinnamomi is cinnamaldehyde.

A cosmetic, pharmaceutical or dermatological preparation containing extract of the plant Eperua falcata, active principles of the plant Eperua falcata, astilbin or engeletin. The preparation is useful to inhibit release of pro-imflammatory mediators and neuropeptides, including CGRP and SP, for skin and hair treatment, including, sensitive skin, acne, scalp itch and neurogenous inflammation.

The invention relates to a method for extracting astilbin and dihydroquercetin from engelhardia roxburghiana wall leaves and application of extractives thereof. The method for extracting the astilbin from the engelhardia roxburghiana wall leaves comprises the steps of: extracting by refluxing ethanol, degreasing by using ligarine, extracting by using ethyl acetate, blending two organic solvents with different polarities in proportion, and performing recrystallization so as to obtain the astilbin; and the method for extracting the dihydroquercetin from the engelhardia roxburghiana wall leaves mainly comprises the steps of: firstly, obtaining the astilbin by using the provided method, and then hydrolyzing the astilbin to obtain the dihydroquercetin. The methods provided by the invention are beneficial to simplification of the traditional operation processes such as resin absorption, polyamide column or silicagel column chromatography and the like, and have the characteristics of simple, convenient and feasible process, simplicity for operation, lower cost and higher extraction efficiency and content; and after being measured with the HPLC (High Performance Liquid Chromatography) method, the contents of the astilbin and the dihydroquercetin are both more than 90%, therefore the method is suitable for industrialized production.

The invention provides a process for extracting astilbin from leaves of Engelhardtia roxburghiana wall, which consists of extracting with dissolvent, concentrating, disintegrating and purifying, crystallizing and drying, wherein the dissolvent can employ water or low carbon alcohols such as methanol, ethanol, propanol, isopropyl alcohol, butanol and amylic alcohol.

The invention relates to a method for extracting an astilbin from a china root. The method comprises the following steps: taking the china root as a raw material; extracting in a manner of water backflow; adding salt and acid, and depositing flavonoid glycoside; after degreasing deposition, dissolving in alcohol and adding a macro-porous resin column; utilizing water to remove impurities; utilizing the alcohol to elute in a gradient form; collecting the astilbin stream; and concentrating and re-crystallizing, thereby obtaining a product. The method for producing the astilbin has the advantages of convenience in operation, low cost, environmental friendliness, strong technical specificity, high yield and high purity.

The invention relates to a preparation method of astilbin with simple and convenient operation, little pollution and less energy consumption. The process comprises the following steps of: taking trester, adding ethanol to a microwave extraction device and carrying out microwave extraction, collecting extraction liquid, filtering, decompressing, recycling and concentrating ethanol to obtain an extract; carrying out counter-current extraction on a mixed solution of ethyl acetate and water in a ratio of 8 to 1, mixing the extraction liquid, decompressing and recycling the solvent; adding macroporous adsorptive resin for adsorption, eluting with the ethanol, collecting 3-8 times by measuring pin volume of eluent, decompressing, recycling and concentrating the solvent; and adding ethanol for crystallization, cleanly separating, washing and drying. The method of the invention is adopted for preparing astilbin with high product purity and is easy to realize industrial amplification.

The invention relates to a quality control method of a medicine preparation, and especially relates to thin layer chromatogram authentication and content determination of smilax glabra in a xiaojiean preparation. The method is a thin layer chromatogram authentication and / or content determination method formulated by using a special component in the smilax glabra of the xiaojiean preparation as an index component, wherein the special component is astilbin, and the xiaojiean preparation is a traditional Chinese medicine compound preparation prepared from 1100 parts of leatherleaf mahonia, 750 parts of thin evodia, 750 parts of motherwort, 750 parts of spatholobus stem, 900 parts of smilax glabra and 750 parts of fructus forsythiae. The thin layer chromatogram authentication method with a strong specialization can authenticate smilax glabra accurately and reliably, and a generally employed HPLC can determine the astilbin content in the xiaojiean preparation, so as to produce valuable significance for monitoring and controlling medicinal material purchase, preparation production process and preparation quality in market, and ensuring product safety, effectiveness and quality stabilization. According to the method, problem of confused smilax glabra basic material provided in the market can be solved effectively to ensure that xiaojiean preparation meets the national medicine standards strictly.

The invention relates to a phenolic hydroxyl derivative, a benzene ring substituted derivative and a carbonyl derivative of astilbin, and also provides a preparation method for the derivatives.

The invention discloses aspergillus fumigates SQH4, and applications thereof in preparation of taxifolin through biotransformation. According to the applications, astilbin is taken as a substrate, a fermentation broth prepared via aspergillus fumigates SQH4 fermentation is taken as a catalyst, and the taxifolin conversion rate is 92.3% when the substrate feed concentration is controlled to be 3g/L. The technical advantages are that: the shortage problem of taxifolin extracted from plants is solved; the conversion specificity is better and product yield is higher than that of astilbin acid hydrolysis method. A production of taxifolin disclosed in the invention is low in production cost and environment pollution, and high in conversion rate.

The invention discloses a traditional Chinese medicine active part for preventing chronic pelvic inflammation, and a preparation method and applications thereof. The content of the traditional Chinese medicine active part is 50-90%, and the traditional Chinese medicine active part comprises the following components in percentage by weight: 8.37-16.11% of astilbin, 4.52-12.55% of neoastilbin, 6.97-15.90% of isoastilbin, 15.47-22.65% of neoisoastilbin, 15.66-24.97% of engeletin and 3.75-7.15% of gracillin. The traditional Chinese medicine active part preparation for preventing chronic pelvic inflammation is prepared by combining smilax china flavonoid compound and saponin according to certain proportions, the curative effect is definite, the active ingredients are clear, and the traditional Chinese medicine active part has the efficacies of clearing away heat and toxic materials and invigorating blood circulation to remove blood stasis, is effectively used for preventing chronic pelvic inflammation, and is safe to use, convenient to take, small in dose and good in compliance of patients.

The invention discloses a medicinal composition containing active ingredients extracted from glabrous sarcandra herb, including flavones, and/or saponin, and/or polysaccharides, or one or more of the following flavone active ingredients: isofraxidin-7-O-glucopyranoside, 5,7-dihydroxyl flavanone, 2',6'-dihydroxy-4'-methoxyl chalcone, pinostrobin, dihydromyricetin, Astilbin, naringenin 4',7-dimethyl ether.

The invention discloses an astilbin derivative and a preparation method thereof. The derivative is AB-N-X or AB-H-X; the general formula of the AB-N-X is shown in the description, wherein R1 represents glycine, leucine, proline, serine or alanine; the general formula of the AB-H-X is shown in the description, wherein the representation of R2 is shown in the description. The preparation method comprises the steps: 1, dissolving astilbin organic solvent, and carrying out the replacement reaction with Bian chlorine or Bian bromine under catalyst, obtaining AB-N-1 after extraction and purification; 2, dissolving the AB-N-1 by adding organic solvent, adding natural amino acid or acid anhydride for reaction, and obtaining AB-N-2 or AB-H-1 after purification; 3, injecting hydrogen into the AB-N-2 or AB-H-1 under the catalysis of the catalyst, taking off protection to obtain the final product AB-N-X or AB-H-X. The astilbin derivative has high bioavailability; the preparation method is reliable in process, simple to operate, and high in yield.

The invention relates to application of flavonone compounds in the preparation of a farnesol X receptor stimulant. The flavonone compounds including dihydromyricetin, astilbin, isoastilbin, engeletin, isoengeletin, dihydroquercetin and dihydrokaempferol have a relatively strong FXR stimulation effect and can be used as a potential farnesol X receptor stimulant. The flavonone compounds including dihydromyricetin, astilbin, isoastilbin, engeletin, isoengeletin, dihydroquercetin and dihydrokaempferol have a remarkable inhibition effect to the active increase of Tbil, ALT, APL and gamma-GT caused due to ANIT-induced cholestasis, are capable of obviously improving the inhibition to ANIT-induced hepatic cell injury, inflammatory cell infiltration and bile excretion, have a relatively good treatment effect to cholestasis type hepatitis and can be used as potential drugs for treating the cholestasis type hepatitis.

The invention discloses a method for determining active ingredients of a rhizoma smilacis glabrae medicinal material, relating to the filed of medicament analysis. In the invention, a fingerprint taking an astilbin chromatographic peak as an internal reference peak is established. The method comprises the following steps of: (a) preparing a test article solution; (b) taking astilbin as a reference substance and taking 0.10mg/mL astilbin solution prepared from methanol as a reference substance solution; (c) chromatographic conditions: taking a chromatographic column made of octadecylsilane chemically bonded silica as filler; adopting gradient elution, detecting the wavelength of 325+/-2 nm and the column temperature of 30+/-5DEG C; calculating the theoretical column plate number not less than 3,000 according to astilbin peak; and (d) determining. The fingerprint established by rhizoma smilacis glabrae ethanol-soluble extractives contains active ingredients with main activity of rhizoma smilacis glabrae. The fingerprint is used for judging the quality of rhizoma smilacis glabrae and the one sidedness for judging the quality of rhizoma smilacis glabrae by determining one or two chemical components can be avoided. The method has the advantages of simpleness, convenience, stability, high precision, favorable reproduction, easy grasp and capability of rapidly and accurately identifying the authenticity and merits of products.

The invention discloses an application of an astilbin organic acid composition in treatment of psoriasis. The astilbin organic acid composition comprises astilbin or a structural analogue thereof andan organic acid in any ratio. The composition has the beneficial effects that astilbin and organic acid are combined, so that the effect of preventing or treating psoriasis is good, and the pharmaceutical composition is safe and non-toxic and does not have side effects caused by hormones.

The invention discloses a process for extracting astilbin from Engelhardia roxburghiana Wall leaves, and belongs to the technical field of extraction of active ingredients from Engelhardia roxburghiana Wall leaves. The astilbin is prepared by the following steps: pulverizing, first decolorizing, coarse crystallization, second decolorizing, separation and purification by macroreticular resin, concentration and crystallization, drying and the like. The extraction yield of the prepared astilbin is 65.48% or above, the purity is 98.16% or above, and the extraction yield and the purity are higher than the extraction yield and the purity of the astilbin prepared in the prior art.

A quality detection method for a traditional Chinese medicine formula which is named compound detoxication decoction. In the quality detection method, ultra performance liquid chromatography (UPLC) is employed for simultaneously detecting the contents of astilbin, forsythiaside A and forsythin in the compound detoxication decoction at 275 nm. According to the method, the various active components in the compound detoxication decoction are detected through the UPLC. The method is ultrahigh in separation rate, speed and sensitivity on the astilbin, the forsythiaside A and the forsythin. The method can achieve excellent chromatographic peak separation rate just through one injection without complex pre-treatment processes to a sample, so that the method is greatly increased in chromatographic separation rate and analysis speed, effectively saves analysis time, achieves quick and high-resolution quality detection for the compound detoxication decoction, and has excellent effects on clinical quality control.

The invention provides an emulsion containing astilbin and a preparation method thereof. The emulsion comprises the components of an isotonic agent and a surfactant such as astilbin, water, oil as well as a stabilizing agent. The emulsion does not contain an organic solvent and a solubiliser with toxic and side effects, and has the advantages of no allergy and little side-effect.