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34 results about "Central composite design" patented technology

In statistics, a central composite design is an experimental design, useful in response surface methodology, for building a second order (quadratic) model for the response variable without needing to use a complete three-level factorial experiment.

Method for optimizing process parameters of angelica sinensis total flavonoid extraction with response surface methodology

The invention discloses a method for optimizing process parameters of angelica sinensis total flavonoid extraction with response surface methodology. According to the method, extraction duration, a solid-liquid ratio and ethanol content with greater influence on the total flavonoid extraction rate are selected on the basis of a single-factor experiment with an ultrasonic assisted extraction method and are investigated, a quadratic polynomial equation model about a relationship between the total flavonoid extraction content and three factors is established with the response surface methodology, a three-dimensional surface diagram is drawn and comprehensively analyzed, and following optimal technological conditions are obtained: the extraction time is 60 min, the solid-liquid ratio is 1:30g / ml, and the ethanol content is 80%. The optimization experiment and the data analysis are performed simply and reliably with central composite design and the response surface methodology by the aid of statistical software Design Expert 7.0.0, the process parameters of the total flavonoid extraction of Mingui No.3 are optimized, and a better effect is realized; with the adoption of the method, reference is provided for evaluation of inherent quality of the Mingui No.3, and a foundation is laid for popularization and application of a new variety of angelica sinensis.
Owner:GANSU UNIV OF CHINESE MEDICINE

R language-based optimal extraction technology for extracting saponin and total flavonoids in liquorice

The invention discloses an R language-based optimal extraction technology for extracting saponin and total flavonoids in liquorice. A central composite design experiment in a response surface method is adopted, the saponin content and flavone content in liquorice are used as detection indexes, and an entropy weight method in an R language environment is adopted for weight assignment of the two indexes, a BP neural network and genetic algorithm mathematical model is established, and target optimizing is performed for the extraction technology to obtain an optimal extraction technology. The optimal extraction conditions are as follows: the ammonia concentration is 0.62%, the ethanol concentration is 64%, the reflux time is 1.8h, and the liquid-solid ratio is 12:1. Relative error between the comprehensive evaluation predicted value of the model and the average comprehensive evaluation value of a verification experiment is 1.43%, proving relatively good predictability of the neutral network and genetic algorithm. In the invention, the established mathematical model searching for the optimal extraction conditions for extracting saponin and total flavonoids in liquorice is scientific and feasible, and new reference and idea are provided for optimizing multiple targets of the chemical components and even effective substance basis of traditional Chinese medicine.
Owner:ZHEJIANG CHINESE MEDICAL UNIVERSITY

Parameter analysis method of paigeite ground by adopting microwave assisted method

ActiveCN104353534AExpand and change mechanical propertiesChange the mechanical propertiesGrain treatmentsDesign–ExpertMicrowave oven
The invention relates to a parameter analysis method of paigeite ground by adopting a microwave assisted method and belongs to the technical field of mineral processing. The parameter analysis method comprises the following steps: (1) carrying out microwave roasting on paigeite in a microwave oven, ensuring that the microwave power is 1500-2500 W, heating to be 450-650 DEG C and ensuring that the feeding quantity is 50-250 g; (2) grinding the paigeite treated by microwaves for 5-6 minutes and screening parts of which the grain sizes are less than or equal to 75 [mu]m; (3) optimizing the ball-milling process of the paigeite by adopting the central composite design of a response surface method, wherein the selected influence factors are microwave power X1 of which the unit is W, microwave roasting temperature X2 of which the unit is DEG C and feeding quantity X3 of which the unit is g, and a response value Y which is set to be the yield percentage of grains with the grain size of less than or equal to 75 [mu]m; (4) analyzing the influence of the selected experimental factors on the grinding efficiency of the paigeite through Design-Expert experimental design optimization software so as to obtain significant factors and optimal technological conditions capable of influencing the paigeite grinding efficiency.
Owner:NORTHEASTERN UNIV

Method for optimizing parameters of contact line and pantograph based on sensitivity analysis

The invention discloses a method for optimizing parameters of a contact line and a pantograph based on sensitivity analysis. According to bow-net contact pressure during running of a high speed train, the existing problem is analyzed, level value design of the parameters is carried out through central composite design, and multi-factor and five-level parameters are obtained; an Spearman rank correlation coefficient method is adopted to compute correlation coefficients between the parameters of the contact line and the pantograph and the contact pressure to judge the correlation; and an Sobol method is adopted to compute sensitivity coefficients of the parameters of the contact line and the pantograph about the contact pressure, judge the impact of the parameters on the contact pressure and determine an optimization order of the parameters when the bow-net parameter optimization is carried out, after each index meets relevant standard requirements, optimization is ended and all bow-net parameter values are output. The method has reasonable optimization, and the parameters of the contact line and the pantograph can be adjusted quickly and reasonably, so that the contact pressure of the parameters of the contact line and the pantograph can be controlled reasonably.
Owner:BEIJING JIAOTONG UNIV

Cladding layer cross section contour curve under broadband laser effect and modeling method

The invention relates to a cladding layer cross section contour curve under broadband laser effect and a modeling method, and a cladding layer cross section contour curvilinear equation is that y=hc-0.5*wc/sin theta+ the square root of [0.5*wc/sin theta)<2>-x<2>], x belongs to [-wc/2,wc/2],wherein, y is an ordinate of a coordinate system XOY; X is an abscissa; hc is the height of the cladding layer; wc is the width of the cladding layer; theta is a deposition angle; and the XOY coordinate system takes the bottom center of the cladding layer as a round O, the width direction of the cladding layer as shaft X, the height direction of the cladding layer as the shaft Y; hc, wc and theta are described as the functions of a technological parameter laser power P, a powder layer thickness T and a scan speed V. <{EN2}>The curvilinear equation modeling method comprises the steps of conducting a broadband laser cladding selectivity all factor test to obtain a technological parameter preferable scope; performing central composite design test; intercepting a cladding layer cross section for sampling; plotting the geometric dimension of the cladding layer cross section; establishing a quantification description relation formula of the geometric dimension of the cladding layer cross section and the technological parameter; deriving a contour curvilinear equation of the cladding layer cross section, and verifying the contour curvilinear equation of the cladding layer cross section. <{EN3}>The curve provide data support for the layered slice of a laser cladding application and a locus program; the modeling method is simple; the operability is strong; and the accuracy is high.
Owner:WUHAN UNIV OF TECH

Multi-index-based evaluating-optimizing glabrous sarcandra herb preparation technology

The invention discloses a multi-index-based evaluating-optimizing glabrous sarcandra herb preparation technology. The multi-index-based evaluating-optimizing glabrous sarcandra herb preparation technology comprises the following steps of HPLC determination of specified components, process optimization of glabrous sarcandra herb leaves, single factor experimental investigation of glabrous sarcandraherb stems, cutting-preparing design scheme of the glabrous sarcandra herb stems, establishment of an AHP model, a comprehensive scoring method and CCD-RSM optimized glabrous sarcandra herb stem cutting-preparing process and verification test. Through a single-factor test, the comprehensive scores of the content of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, caffeic acid, isofraxidin, astilbin and rosmarinic acid are taken as the evaluation indicators, a central composite design-response surface methodology is used to screen glabrous sarcandra herb softening and cutting-preparing processes, the glabrous sarcandra herb stems and leaves subjected to process optimization by choosing different treatment methods, a multi-index analytic hierarchy process (AHP) is combined with the central composite design-response surface methodology to optimize the glabrous sarcandra herb preparation technology, the study is beneficial to the further development of glabrous sarcandra herb, and an experimental basis is expected to be provided for the establishment of related preparation specifications and quality standards of glabrous sarcandra herb.
Owner:JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Design method of cement stabilized iron tailing sand base course material

ActiveCN109020338ASolve the problem of low intensityImprove the accumulation statusRoad engineeringFineness modulus
The invention provides a design method of a cement stabilized iron tailing sand base course material and relates to a design method of a base course material, aiming at solving the problem that a traditional design method of the cement stabilized iron tailing sand base course material cannot meet the design of the cement stabilized iron tailing sand base course material. The design method comprises the following steps: 1: determining an utilization range of deign parameters; 2: measuring 7-day unconfined compressive strength of each group of test in a central composite design test table; 3: obtaining a ternary quadratic fitting equation; 4: obtaining optimal ranges of fineness modulus of iron tailing sand, utilization amount of the iron tailing sand and utilization amount of a cement binding material; 5: selecting three stone material gradations through single-gear gradation adjustment; 6: selecting a maximal stone material gradation with the 7-day unconfined compressive strength as anoptimal gradation; 7: measuring the optimal moisture content and the maximum dry density of a standard compaction test part under different cement utilization amounts; 8: determining an optimal cement utilization amount; 9: preparing a test part and carrying out freezing resistance identification on the test part. The design method provided by the invention is used for the technical field of roadengineering materials.
Owner:HARBIN INST OF TECH +1

Method for optimizing parameters of angelica sinensis essential oil extracting process based on response surface methodology

The invention discloses a method for optimizing parameters of an angelica sinensis essential oil extracting process based on a response surface methodology. By virtue of a steam distillation method, soaking time, a liquid-solid mass ratio and extracting time, which have relatively great influence on the oil extracting amount, are selected on the basis of a single-factor test for investigation; a quadratic polynomial equation model, which shows a relation between the oil extracting amount and three factors, is established by virtue of the response surface methodology; and a three-dimensional surface figure is drawn and is analyzed comprehensively, so as to obtain optimal technological conditions: the soaking time is 5h, the liquid-solid mass ratio is 12: 1 and the extracting time is 9h. The method provided by the invention, on the basis of central composite design and response surface analysis, can conduct an optimal experiment and data analysis conveniently and reliably by virtue of statistical software Design Expert7.0.0, and the technological parameters of extracting essential oil from 'Mingui No.3' are optimized so as to achieve a relatively good effect. The method provided by the invention provides a reference for evaluating inherent quality of the 'Mingui No.3' and lays a foundation for the popularization and the application of a novel angelica sinensis variety.
Owner:GANSU UNIV OF CHINESE MEDICINE

Structure topology optimization design method based on response surface method

PendingCN113190980ARealize multi-dimensional optimal designImprove securityGeometric CADDesign optimisation/simulationFeature DimensionAlgorithm
The invention discloses a structural topology optimization design method based on a response surface method. The method comprises the following steps: selecting feature sizes which have relatively large influence on total weight as design variables; determining a test center point required for performing response surface test design by adopting the center combination design; generating a sample point data table for response surface optimization, and performing topological optimization; performing response surface fitting on test results obtained by each group of tests; setting a design variable value combination corresponding to a minimum value point in the fitting results as a new sample point, performing topological optimization on a structure corresponding to the new sample point, and substituting the test results into the test results of the original sample point data table to perform response surface fitting again; and obtaining the plane configuration of the optimal structure until the value of the design variable corresponding to the minimum value point in the response surface fitting result does not change any more or is stabilized in the determined small range, thereby realizing the multi-dimensional optimization design of the structure.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS

An Optimization Method of Catenary and Pantograph Parameters Based on Sensitivity Analysis

The invention discloses a method for optimizing parameters of a contact line and a pantograph based on sensitivity analysis. According to bow-net contact pressure during running of a high speed train, the existing problem is analyzed, level value design of the parameters is carried out through central composite design, and multi-factor and five-level parameters are obtained; an Spearman rank correlation coefficient method is adopted to compute correlation coefficients between the parameters of the contact line and the pantograph and the contact pressure to judge the correlation; and an Sobol method is adopted to compute sensitivity coefficients of the parameters of the contact line and the pantograph about the contact pressure, judge the impact of the parameters on the contact pressure and determine an optimization order of the parameters when the bow-net parameter optimization is carried out, after each index meets relevant standard requirements, optimization is ended and all bow-net parameter values are output. The method has reasonable optimization, and the parameters of the contact line and the pantograph can be adjusted quickly and reasonably, so that the contact pressure of the parameters of the contact line and the pantograph can be controlled reasonably.
Owner:BEIJING JIAOTONG UNIV

A design method of cement-stabilized iron-like tailings sand base material

ActiveCN109020338BSolve the problem of low intensityImprove the accumulation statusFineness modulusEngineering
The invention provides a design method of a cement stabilized iron tailing sand base course material and relates to a design method of a base course material, aiming at solving the problem that a traditional design method of the cement stabilized iron tailing sand base course material cannot meet the design of the cement stabilized iron tailing sand base course material. The design method comprises the following steps: 1: determining an utilization range of deign parameters; 2: measuring 7-day unconfined compressive strength of each group of test in a central composite design test table; 3: obtaining a ternary quadratic fitting equation; 4: obtaining optimal ranges of fineness modulus of iron tailing sand, utilization amount of the iron tailing sand and utilization amount of a cement binding material; 5: selecting three stone material gradations through single-gear gradation adjustment; 6: selecting a maximal stone material gradation with the 7-day unconfined compressive strength as anoptimal gradation; 7: measuring the optimal moisture content and the maximum dry density of a standard compaction test part under different cement utilization amounts; 8: determining an optimal cement utilization amount; 9: preparing a test part and carrying out freezing resistance identification on the test part. The design method provided by the invention is used for the technical field of roadengineering materials.
Owner:HARBIN INST OF TECH +1
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