The invention discloses a multi-index-based evaluating-optimizing glabrous sarcandra herb preparation technology. The multi-index-based evaluating-optimizing glabrous sarcandra herb preparation technology comprises the following steps of HPLC determination of specified components, process optimization of glabrous sarcandra herb leaves, single factor experimental investigation of glabrous sarcandraherb stems, cutting-preparing design scheme of the glabrous sarcandra herb stems, establishment of an AHP model, a comprehensive scoring method and CCD-RSM optimized glabrous sarcandra herb stem cutting-preparing process and verification test. Through a single-factor test, the comprehensive scores of the content of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, caffeic acid, isofraxidin, astilbin and rosmarinic acid are taken as the evaluation indicators, a central composite design-response surface methodology is used to screen glabrous sarcandra herb softening and cutting-preparing processes, the glabrous sarcandra herb stems and leaves subjected to process optimization by choosing different treatment methods, a multi-index analytic hierarchy process (AHP) is combined with the central composite design-response surface methodology to optimize the glabrous sarcandra herb preparation technology, the study is beneficial to the further development of glabrous sarcandra herb, and an experimental basis is expected to be provided for the establishment of related preparation specifications and quality standards of glabrous sarcandra herb.