8 results about "Tropane" patented technology

The present invention relates to a method for the preparation of an N-monofluoroalkyl tropane, a method for the preparation of a trialkyltin tropane, a method for the preparation of an iodinated and / or radioiodinated tropane and the use of the N-monofluoroalkyl tropane as a precursor in the method for the preparation of the trialkyltin tropane and / or the iodinated and / or radioiodinated tropane.

Provided herein are gels, ointments, lotions, or cream formulations comprising an active pharmaceutical ingredient comprising a tropane moiety. The gel, lotion, or cream formulation may comprise at least one low molecular weight (LMW) compound, or a pharmaceutically acceptable salt thereof. Also provided herein are gel, ointment, lotion, or cream formulations comprising an active agent, such as atropine, pilocarpine, hyacinth bean alkali, or travoprost.

One aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, (I) wherein: ring A is a 5- or 6-membered aromatic or heteroaromatic ring, wherein said aromatic or heteroaromatic ring is optionally substituted with one or more substituents selected from F, Cl, Br, I, CN, alkoxy, NR11R11',OH, alkyl, haloalkyl, aralkyl, aryl and heteroaryl, and wherein said aryl and heteroaryl substituents are in turn optionally substituted with one or more substituents, each independently selected from F, Cl, Br, I, CN, alkoxy, NR11R11' OH, alkyl, haloalkyl and aralkyl; And is selected from C=N-OH and CR10R10' wherein R10 and R10' are selected independently from H, F, alkyl and haloalkyl; R1, R4 and R5 are selected independently from H, F, Cl, Br and I; R2 and R3 are selected independently from H, F, Cl, Br, I, CN, methoxy and haloalkyl;and R11 and R11' are independently selected from H, alkyl, haloalkyl, COR12 and SO2R13, wherein R12 and R13 are both alkyl; for use as a medicament. Other aspects of the invention relate to compounds of formula (I) for use in the field of immuno-oncology, immunology and related applications, and to compounds of formula (I) per se.

A chemical sensor includes a sensor element; a first electrode electrically connected to the sensor element; a second electrode electrically connected to the sensor element; an aptamer located on a surface of the sensor element; a solution covering the surface of the sensor element and the aptamer; and a tropane derivative having a tropane skeleton and contained in the solution.

One aspect of the invention relates to the use of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof as a medicament, wherein: ring A is a 5- or 6-membered aromatic ring or heteroaromatic ring, wherein the aromatic ring or heteroaromatic ring is optionally selected from F, Cl, Br, I, CN, alkoxy, NR 11 R 11 One or more substituents of ', OH, alkyl, haloalkyl, aralkyl, aryl, and heteroaryl, wherein said aryl and heteroaryl substituents are optionally each independently selected from F, Cl, Br, I, CN, alkoxy, NR 11 R 11 One or more substituents selected from ', OH, alkyl, haloalkyl, and aralkyl; Y is selected from C=N-OH and CR 10 R 10' , where R 10 and R 10' Each is independently selected from H, F, alkyl, and haloalkyl; R1, R4, and R5 are each independently selected from H, F, Cl, Br, and I; R2 and R3 are each independently selected from H, F, Cl, Br, I, CN, methoxy, and haloalkyl; and R 11 and R 11 Each is independently selected from H, alkyl, haloalkyl, COR 12 and SO2R 13 , where R 12 and R 13 All are alkyl groups. The invention also relates to the use of compounds of formula (I) in immuno-oncology, immunology, and related applications, as well as to compounds of formula (I) themselves.

The invention relates to the technical field of heterocyclic compound drugs and preparation and application thereof, in particular to a novel hyoscyamine quaternary ammonium salt derivative and application thereof. According to the invention, 6beta, 7beta-epoxy tropane is taken as a parent nucleus, and a nitrogen-containing heterocyclic group is introduced to a C3 site of the tropane parent nucleus to form a biquaternary ammonium cation structure, so that the membrane penetrability and stability of the medicine are improved; the N1 site of a parent nucleus is connected with a targeting ligand through a pH-sensitive hydrazone bond, so that multiple effects are realized; the multi-target compound disclosed by the invention has remarkable advantages in the aspects of long effectiveness, synergistic interaction and safety.

The invention discloses a preparation method and application of a supramolecular fluorescence sensing array. The supramolecular fluorescence sensing array is a cucurbituril-based supramolecular fluorescence sensing array constructed by taking a TPE-P (at) Q [7] supramolecular fluorescence probe and a C7 (at) Q [8] supramolecular fluorescence probe as sensing units. The supramolecular fluorescence sensing array constructed by the invention not only can be used for qualitatively detecting four anticholine drugs, namely AS, RA, SH and IB, but also can be used for distinguishing different concentration gradients of the same drug. In addition, interference experiments prove that the sensing array has good anti-interference performance, and artificial urine, milk, pork and herbal tea samples prove that the constructed array also has the potential of simultaneously analyzing four anti-choline drugs in a complex system. The invention provides a novel method for detecting hyoscyamine anticholine drugs, and the method is more visual and convenient compared with a traditional detection technology.