143 results about "Cucurbituril" patented technology

The invention relates to a cucurbituril compound and medical application thereof. Specifically, the invention relates to a compound as shown in a formula (I) and a pharmaceutically acceptable salt thereof, a preparation method thereof, a pharmaceutical composition containing the compound and application thereof as a therapeutic agent, especially application in treatment or prevention of proliferative diseases, cardiovascular related diseases or hematologic cancers, use in reversing drug-induced neuromuscular block and / or anesthesia. I) # imgabs0 #

The invention discloses a self-classification driven supramolecular dimer as well as a preparation method and application thereof. According to the supermolecule composite material, cucurbit [8] uril serves as a subject, a phenylpyridinium derivative G serves as an object, and a small-size supermolecule dimer with red / near-infrared delayed emission is formed through subject-object inclusion interaction and a self-classification strategy. The supramolecular dimer structure inhibits distorted intramolecular charge transfer (TICT) and promotes space charge transfer (TSCT), enabling red thermally activated delayed fluorescence (in some embodiments, 620 nm) and near infrared phosphorescence (in some embodiments, 740 nm) of simple organic small molecules. The proposed synergistic supramolecular strategy provides a new way for realizing simple red / near-infrared delayed emission of small organic molecules in a water phase, and has potential application value in the fields of biological materials and the like.

The invention relates to the technical field of nuclear waste treatment, in particular to a cucurbituril-based supramolecular organic framework material as well as a preparation method and application thereof. A construction unit of the supramolecular organic framework material is constructed by taking cucurbit [8] uril (CB8) as a subject and terephthalyl viologen ligand 1, 1 ''-(1, 4-phenylene) bis ([4, 4 '-bipyridyl]-1-onium) salt (PBV. 2X) as an object through the bonding effect of the subject and the object; in the molecular structure of the supramolecular organic framework material, the construction units are staggered and stacked in parallel in the space, and NO3 <-> is located at the gap of the adjacent CB8. The supramolecular organic framework material disclosed by the invention has high structural stability and cationic framework characteristics, and a rigid framework and a pyridine conjugated system of CB8 endow the material with excellent chemical / irradiation stability, so that the material shows ultrahigh removal rate on ReO4 <-> / TcO4 <-> in extreme environments (strong acid, strong alkali and high irradiation).

The invention discloses a fluorescent probe for targeting mitochondrial ferric ions as well as preparation and application of the fluorescent probe. The fluorescent probe is prepared by reacting cucurbit [7] uril with (E)-4-(4-(dimethylamino) styryl)-1-(3-(triphenylphosphonium) propyl) pyridine-1-onium bromide according to a molar ratio of 1: 1. The fluorescent probe can be used for detecting Fe < 3 + > ions, and has the characteristics of simple preparation method, convenience in operation, high sensitivity, high selectivity, low cost and rapidness in detection.

The invention provides a synthesis method of a boron cluster-cucurbituril-triazine unit three-component supramolecular reversible photochromic material, which is characterized in that an electron donor boron cluster is directly introduced into a cucurbituril cavity encapsulated with an electron acceptor 2, 4, 6-tri (4-pyridine)-1, 3, 5-triazine in a subject-object self-assembly manner. According to the material, the characteristics that a boron cluster is rich in electrons and negative charges are distributed in a delocalization mode are used as electron donors, convenience is provided for charge transfer between the boron cluster and 2, 4, 6-tri (4-pyridine)-1, 3, 5-triazine by means of a cucurbituril cavity, and photochromism is achieved. Under the irradiation of ultraviolet light, the material is subjected to electron transfer and evolves from creamy white to green, the color can be recovered after the ultraviolet light is removed, and good photochromic performance and fatigue resistance are shown. The supramolecular light-induced reversible color-changing material prepared by the invention is a powdery solid, and the preparation method is simple to operate, reliable in process, good in repeatability and easy for large-scale preparation.

The application discloses a misaligned ten-membered cucurbituril-based assembly and application thereof in detecting and removing trinitrophenol. The assembly is assembled by using misaligned ten-membered cucurbituril and 8-hydroxyquinoline as raw materials. The misaligned ten-membered cucurbituril-based assembly is a novel supramolecular assembly, can be used for fluorescent identification of trinitrophenol in an aqueous solution, and has the characteristics of simple detection instrument, high selectivity, good sensitivity, wide detection range, fast response time, and the like. In addition, the misaligned ten-membered cucurbituril-based assembly has the characteristic of being capable of removing trinitrophenol in the aqueous solution.

The invention discloses tea aroma congealed fat balsam which is prepared from the following components in percentage by mass: 15 to 25 percent of wax substance, 60 to 70 percent of oil and grease, 8 to 10.5 percent of essence, 4 to 8 percent of pigment, 0.1 to 2 percent of cyclodextrin sustained-release material, 0.05 to 0.5 percent of preservative and 0.05 to 0.5 percent of antioxidant. According to the balsam, the cucurbituril modified cyclodextrin compound is added as a slow-release material, so that the fragrance retention time of the balsam is longer, and meanwhile, the color is bright and lasting due to the addition of the modified pigment.

The application provides a cucurbituril fluorescent probe and a preparation method and application thereof, and a qualitative and quantitative detection method of melamine, and belongs to the field of substance detection. The application provides a cucurbituril fluorescent probe, which comprises cucurbit[8]uril (CB[8]) and rhodamine, and the rhodamine is included in the cavity of the cucurbit[8]uril. The application contains the rhodamine in the cavity of CB[8] through host-guest non-covalent interaction, and aims at detecting melamine; the probe has high sensitivity, simple operation and the characteristics of rapid detection.

The present invention provides a ternary complex of a cucurbituril subject, such as CB [8], with a first aryl guest and a second aryl guest, where the first aryl guest is a group within a biomolecule, such as insulin, and the first and second aryl guests are different. Also provided is a method of de-compositing a complex, the method comprising the steps of treating the complex with a competing guest, and allowing the competing guest to replace at least a first aryl guest from the complex.

The invention discloses a method for improving sensitivity and selectivity of an SERS (Surface Enhanced Raman Scattering) substrate and the SERS substrate. According to the method, supramolecules or modified supramolecules with a host-guest effect are combined with noble metal nano sol to be used as the SERS substrate; the supramolecules comprise cucurbituril, pillararene and cyclodextrin; according to the method, after supramolecules are utilized or supramolecular branched chain functional groups are changed into functional groups with amino groups or sulfydryl groups, gaps of noble metal particles are adjusted to nanoscale through branched chain functional groups or modified functional groups on a supramolecular main body, and the purpose of effectively enhancing the SERS electromagnetic enhancement effect is achieved, so that the sensitivity of an SERS method is improved. The supramolecules with unique subject-object recognition capability are applied to Raman detection, and the purpose of capturing and limiting analytes and hot spots can be achieved, so that the selectivity of the method is improved.

The invention provides a preparation method and application of a cucurbit [6] uril-based supramolecular fluorescent probe material. The fluorescent probe material is experimented in a reaction kettle by adopting a solvothermal synthesis method, and a novel supramolecular assembly fluorescent probe is successfully prepared by taking cucurbit [6] uril (CB [6]) as a main body and 3-amino isonicotinic acid as a structure inducer. The invention has the advantages of simple synthesis method, cheap raw materials, high detection sensitivity, strong anti-interference capability, fast response speed and the like. The supramolecular assembly is of great significance for monitoring water pollution.

The invention discloses an application of fat-soluble ring-opened cucurbituril in specific recognition of organic compounds in organic solvents, the fat-soluble ring-opened cucurbituril is composed of glycoluril tetramer and terminal aromatic ring, the terminal aromatic ring is modified by phosphate side chain, and the terminal aromatic ring has good solubility in various organic solvents; according to the invention, the C-shaped adjustable cavity of the fat-soluble ring-opened cucurbituril is matched with the size of a guest molecule, and is matched with hydrogen bonds, pi-pi interaction and the like, so that efficient molecular recognition of organic matters in an organic solvent is realized; the application of the supramolecular macrocyclic main body in organic solvents is expanded by utilizing fat-soluble ring-opening cucurbituril, and the supramolecular macrocyclic main body is expected to be applied to the fields of medicine, chemical industry, environment and the like.

The invention discloses a preparation method of a metal-supported aluminum-based catalyst and application of the metal-supported aluminum-based catalyst in nitrification wastewater treatment.The catalyst takes an aluminum source as a carrier, zinc-niobium-iron metal as an active component and cucurbituril as a modifier and has the advantages of being good in adsorption effect and high in reaction efficiency. By combining with the nitrification wastewater treatment method provided by the invention, the recycling rate of dinitrotoluene can be effectively increased, the total nitrophenol content and COD content in the nitrification wastewater can be remarkably reduced, the blockage problem caused by separation of ammonium bicarbonate from equipment pipelines is solved, and the method has the advantages of high recycling rate, good treatment effect and long operation period.

The invention relates to a solvent free method for producing chimeric hemicucurbit[n]urils. The method of the invention comprises a first step of contacting, under mechanical agitation, at least two different cyclic urea derivatives and a compound that can form methylene bridges in the presence of an acid and templating anions and a second step of aging the products for at least about 30 minutes. The method has a very low process mass intensity (PMI) of 4, making it very attractive from a green chemistry perspective. New chimeric hemicucurbit[n]urils incorporating D-biotin are also described.

The invention belongs to the technical field of pharmaceutical chemistry, radiopharmaceutical chemistry and clinical nuclear medicine, and particularly relates to a rotaxane protection-based radioactive halogen labeled compound as well as a preparation method and application thereof. A rotaxane protection-based radioactive halogen labeled compound comprises: a macrocyclic compound having a cavity, the macrocyclic compound comprising one of cyclodextrin, cucurbituril, calixarene and pillararene; a radioactive halogen-labeled compound: the radioactive halogen-labeled position is located in the cavity of the macrocyclic compound; and the end-capping group is positioned at the opening end of the cavity, is connected to two ends of the radioactive halogen-labeled compound and is used for preventing the radioactive halogen-labeled compound from sliding out of the cavity. The rotaxane protection-based radioactive halogen labeled compound provided by the invention has good in-vivo stability, and solves the problem of poor in-vivo stability caused by dissociation of radioactive halogen and a tracer agent in the existing radioactive halogen labeled compound.

A capture complex comprising: a cucurbituril compound having formula (I), wherein n is 5, 6, 7, 8, or 10; and for each cucurbituril unit, R 1 is selected from hydrogen, halogen, optionally substituted -(C1-C6)alkyl, optionally substituted -(C1-C6)haloalkyl, or -OH; and at least one guest molecule, wherein the complex is configured to selectively and reversibly adsorb CO2.

The invention provides a specific probe for detecting perfluorinated compounds in a water body and a detection method thereof, and belongs to the technical field of detection. The probe provided by the invention is a compound formed by cucurbituril and fluorescein; the detection method provided by the invention comprises the following steps: adding a cucurbituril and fluorescein conjugate into a to-be-detected water sample containing the perfluorinated compounds, carrying out equilibrium reaction for a period of time, and then detecting the fluorescence response intensity in the water body so as to quantitatively evaluate the concentration of the specific perfluorinated compounds in the water sample. Compared with the prior art, the probe equipment provided by the invention is small in size, convenient to carry, capable of simultaneously detecting multiple samples and short in reaction time; the whole material of the probe is green and harmless, and chemical agents such as sulfate which easily cause secondary pollution are not used; other impurity removal and enrichment small columns and complex masking agents do not need to be used. In addition, the detection method provided by the invention has a lower detection limit, the sensitivity and convenience of novel perfluorinated compound detection are remarkably improved, and the application range is wider.

The invention belongs to the field of preparation of organic-inorganic hybrid materials, and relates to a preparation method and application of cucurbit [n] uril-gold nanoparticles. Through a simple one-pot synthesis method, chloroauric acid, silver nitrate, a reducing agent and cucurbit [n] uril are added for co-reduction to prepare hollow gold nanoflowers; the gold nanospheres with different sizes are prepared by regulating and controlling the input amount of cucurbit [n] uril. The gold nanoparticle hybrid material shows excellent hydrogen evolution side reaction inhibition capability in the application of electro-catalysis CO2 reduction, and the CO selectivity is obviously improved.

The invention relates to a carbon dioxide separation membrane as well as a preparation method and application thereof. The carbon dioxide separation membrane is prepared from cucurbit [7] uril CB [7] and a dual-network hydrogel polymer matrix, the dual-network hydrogel polymer matrix is formed by carrying out ultraviolet polymerization on a first network monomer and a second network monomer; the first network monomer is 2-acrylamide-2-methyl propane sulfonic acid (AMPS); and the second network monomer is N, N-dimethylacrylamide DMAAm (N, N-dimethylacrylamide). The CB [7] inherent nanopore channel and an additional channel formed by the CB [7] and a polymer chain interface cooperatively construct an efficient CO2 transmission path, and meanwhile, the CO2 permeability and CO2 / CH4 selectivity of the membrane are improved; the separation membrane is simple in preparation method and stable in performance, and has a wide application prospect in the field of carbon dioxide separation such as biogas upgrading.

The invention relates to a supramolecular polypeptide coupled drug as well as a preparation method and application thereof. The supramolecular polypeptide coupled drug comprises a conjugate and an anti-tumor functional unit, wherein the conjugate is formed by sequentially connecting tumor targeting peptide, an enzyme response connexon and cucurbit [7] uril, and the anti-tumor functional unit is loaded onto the cucurbit [7] uril through non-covalent host-guest interaction. In the supramolecular polypeptide coupled drug, an anti-tumor functional unit is loaded on cucurbit [7] uril through non-covalent host-guest interaction, chemical modification of small-molecular drugs in a traditional method is avoided, and cucurbit [7] uril as a carrier can be compatible with various small-molecular hydrophobic drugs; due to the introduction of the tumor targeting peptide, the efficient enrichment of the medicine in tumor tissues can be realized; the unique design of the enzyme response connexon can realize rapid and efficient release of the anti-tumor functional unit in tumor cells.

The invention discloses a biomolecular sensor based on a cucurbit [7] uril functionalized nanopore. The sensor comprises a conical nanopore formed in a quartz glass tube, and an assembly of mercaptopropyltrimethoxysilane, gold nanoparticles and cucurbit [7] uril, wherein the mercaptopropyltrimethoxysilane, the gold nanoparticles and the cucurbit [7] uril are sequentially modified in the nanopore. The biomolecular sensor has a good application effect in recognition of amino acids, biogenic amines, polypeptides and proteins. The sensor has the advantages of high efficiency, high sensitivity, simplicity and convenience in operation and the like, and is suitable for popularization and application.

The invention discloses a cucurbit [5] uril-based framework material as well as a preparation method and application thereof, and belongs to the crossing field of supramolecular chemistry and functional materials. The preparation method comprises the following steps: dissolving potassium salt and cucurbit [5] uril in distilled water; then adding a 3, 3 '-disulfo-[1, 1'-biphenyl]-4, 4 '-dicarboxylic acid ligand, and stirring to obtain a mixed solution; the mixed solution is subjected to a heating reaction, then cooling, filtering and drying are conducted, and the cucurbit [5] uril-based framework material is obtained, and the chemical formula is C396H360K18N180O198S18. Through coordination of an organic ligand containing a sulfonic acid group and metal ions, in combination with non-covalent interaction of hydrogen bonds, Van der Waals force and the like, and through optimal regulation and control of a material ratio, pH and temperature, a honeycomb three-dimensional porous framework structure with high stability is successfully constructed. By utilizing the fluorescence characteristic and the structural characteristic, the efficient recognition of Fe < 3 + > and Pb < 2 + > heavy metal ions and norfloxacin antibiotics in a water body can be realized. The problems that in the prior art, when heavy metal ions and antibiotics in water are detected, operation is tedious, and cost is high are solved.

The application discloses a ternary supramolecular nanoparticle based on a cyclodextrin-opened cucurbituril double host, which is prepared by adding an organic solvent containing a guest hydrophobic pyridine-pyrrole boron derivative and a hydrophobic adamantyl disulfide modified antitumor drug into an aqueous solution of water-soluble cyclodextrin-opened cucurbituril, and then performing ultrasonic treatment, standing, self-assembly through host-guest interaction between molecules, dialysis in the dark, filtration and drying, so as to obtain the ternary supramolecular nanoparticle. The ternary supramolecular nanoparticle has the advantages of mild preparation conditions, simple operation, uniform size and good stability, and can significantly improve the water solubility of the hydrophobic drugs BP and AD-SS-D. The application realizes a significant synergistic effect of photodynamic therapy and chemotherapy, can effectively induce cancer cell apoptosis and inhibit the migration of the cancer cells, and has low toxicity to normal cells, and provides a safe and efficient novel nanoparticle drug delivery platform for multifunctional synergistic antitumor treatment.

The invention provides a phase-change composite material for an oil-based drilling fluid as well as a preparation method and application of the phase-change composite material. The phase-change composite material for the oil-based drilling fluid comprises a phase-change basic substance, an amination modified porous material, modified asphalt and macrocyclic compound molecule cucurbituril [n]. The preparation method comprises the following steps: mixing NaNO3, KNO3 and LiNO3, heating, cooling and crushing to obtain a phase change basic substance; carrying out modification treatment on expanded graphite and / or montmorillonite to obtain an amination modified porous material; the preparation method comprises the following steps: adding macrocyclic compound molecule cucurbituril [n] into an aqueous solution of an amination modified porous material to obtain a first suspension, preparing a phase change basic substance into a solution, adding the solution into the first suspension to obtain a second suspension, and calcining the second suspension to obtain a first phase change composite material; and dissolving the modified asphalt in petroleum ether to obtain a third suspension, dispersing the first phase-change composite material in the third suspension, freezing, performing vacuum filtration, and drying to obtain the phase-change composite material for the oil-based drilling fluid.

The disclosures herein relate to cucurbituril compounds and methods and compositions for reducing the amount of a toxin in a patient by administering to the patient an effective amount of the cucurbituril compound. Also provided are methods and compositions for preventing or treating an overdose from a toxin that has been ingested by a patient.

The application discloses a phenylpyridine salt derivative G, a room-temperature phosphorescent supramolecular gel and a preparation method and application thereof. The preparation method of the room-temperature phosphorescent supramolecular gel comprises the following steps: taking Cucurbit[8]uril (CB[8]) as a host, a phenylpyridine salt derivative containing a urea-based pyrimidone (UPy) quadruple hydrogen bond site as a guest, self-assembling a supramolecular assembly phosphorescent material in a 1:2 molar ratio in an aqueous solution; and introducing the assembly into a polyvinyl alcohol (PVA) matrix to obtain a humidity-responsive room-temperature phosphorescent supramolecular gel. The assembly and the supramolecular gel both present phosphorescent emission at room temperature. Under the dual constraints of macrocycle limitation and multiple hydrogen bonds on the phosphorescent molecules, the phosphorescent intensity and lifetime of the supramolecular gel are greatly enhanced compared with the assembly. Meanwhile, the phosphorescent intensity and the light-emitting color of the supramolecular gel change with the water content of the gel or the environmental humidity, realizing a visual response from green to blue, and the supramolecular gel can be applied to humidity sensing, anti-counterfeiting and information encryption.

The invention provides a well wall stabilizer for drilling fluid as well as a preparation method and application thereof. The invention provides a well wall stabilizer for drilling fluid. The raw materials of the stabilizer comprise cucurbituril and cyclodextrin, the cucurbituril is an annular cage compound formed by connecting 2n methylene bridges with n glycolurils, and n is selected from 5-20. Wherein cucurbituril is called Q [n] for short. The invention provides a preparation method of a stabilizer. The preparation method of the stabilizer comprises the step of mixing water, cucurbituril, an alkali supply agent, cyclodextrin, a surfactant, organic silanol and a salt bridging agent to obtain the stabilizer. The invention provides the drilling fluid well wall stabilizer prepared from cucurbituril and cyclodextrin, the prepared drilling fluid well wall stabilizer is used in drilling fluid, the rolling dispersion recovery rate of the drilling fluid can reach 65% or above, and the membrane efficiency of the drilling fluid can reach 17% or above.

The application belongs to the technical field of biological medical materials and radiation medicine, and particularly relates to a bismuth-chloride cluster-cucurbit[6]uril-based supramolecular framework material and a preparation method and application thereof. 10 ] 4‑ Anion clusters) as a building unit and cucurbit[6]uril (CB[6]) are fused and co-constructed through host-guest interaction to prepare a supramolecular framework material. The structure and physicochemical properties of the compound are determined through single crystal structure testing and various spectroscopic characterizations, and the application of the compound as a radiotherapy sensitizer is studied. The results of in-vitro and in-vivo biological experiments prove that the material can be used for inhibiting the growth of various cancer cells by significantly sensitizing radiotherapy.

The present invention discloses a highly water-soluble taste-masking agent, the chemical structural formula of which is shown below. The taste-masking agent of the present invention is a cationic open-ring cucurbituril prepared using urea, 1,3-butanedione, paraformaldehyde, and N-methylpiperazine as raw materials. The taste-masking agent of the present invention has a good taste-masking effect on the bitter drug quinine. The taste-masking agent is easy to prepare and has outstanding advantages such as good taste-masking effect and high water solubility. The agent can be developed into a highly effective taste-masking agent for bitter drugs.

The disclosure herein relates, inter alia, to inventive cucurbituril compounds and glycoluril compounds having formula (II), glycoluril compounds having formula (II'), glycoluril bisethers of formula (III), glycoluril dimers of formula (IV), glycoluril tetramer compounds of formula (V), and novel methods for their preparation using sodium 4,4'-(1,4-phenylenebis(oxy))bis(butane-1-sulfonate), which result in significantly improved purity and yields of intermediates and final products.