309 results about "Trimer" patented technology

The invention belongs to the field of veterinary drugs, and relates to an avian infectious bronchitis virus antigen recombinant protein S-Trimer and a subunit vaccine thereof. The invention provides an avian infectious bronchitis virus antigen recombinant protein S-Trimer. The amino acid sequence of the antigen recombinant protein S-Trimer is as shown in SEQ ID No. 4. The invention provides an infectious bronchitis virus antigen. The infectious bronchitis virus antigen is of a trimer structure of the recombinant protein S-Trimer. The invention provides a chicken infectious bronchitis virus subunit vaccine. The subunit vaccine comprises a pharmaceutically acceptable carrier and an immune dose of the chicken infectious bronchitis virus antigen. The vaccine is high in safety, good in immunogenicity and stable in batches, and can provide complete protection for attacking the infectious bronchitis virus.

The present invention relates to combination therapies employing tumor targeted anti-CEA / CD3 bispecific antibodies and / or agents blocking PD-L1 / PD-1 interaction in combination with 4-1BB (CD137) agonists, in particular 4-1BBL trimer containing antigen binding molecules that also target FAP, the use of these combination therapies for the treatment of cancer and methods of using the combination therapies.

The invention discloses a polyurethane repairing material for underground engineering concrete, and relates to the technical field of engineering leakage treatment. A component A is a polyether polyol system containing a silane coupling agent and active inorganic powder, a component B is an emulsion of a modified MDI prepolymer-aliphatic isocyanurate tripolymer and an alkaline activator, the two components are instantaneously converged in a three-cavity grouting gun and a constant-temperature air three-runner according to the mass ratio of 0.8-1.2: 1, gel is formed in the environment of-10 DEG C to 50 DEG C for 90 s, and water is stopped in 10 min. The micro-foaming expansion rate is 2-4 times, geopolymers are synchronously generated, organic-inorganic dual-curing interlocking is achieved, the closed porosity is larger than or equal to 95%, and the compression strength is gt; the permeability coefficient is less than or equal to 10-m / s. Silane chemical bridging enables the bonding strength to be higher than the splitting strength of the base material.

The invention discloses an RSV pre-F tripolymer protein combination and application thereof in preparation of bivalent RSV vaccines, and relates to the technical field of human vaccines. The vaccine is prepared by mixing an RSV-A subtype pre-F tripolymer protein and an RSV-B subtype pre-F tripolymer protein in equal mass, and matching with an aluminum hydroxide adjuvant with the concentration of 0.35 mg / 0.5 mL. A p27 fragment and a C-terminal esterification region of each of the two F proteins are deleted, the two F proteins are connected with F2 / F1 through GSGSGS, inter-chain disulfide bonds are introduced to S146C / N460C and A149C / Y458C sites respectively, intra-chain disulfide bonds are introduced to S155C / S290C sites respectively, and stable pre-F trimers are spontaneously assembled after secretion expression of CHO cells; the vaccine does not need to be freeze-dried, still keeps high purity and neutralizing epitope integrity after being stored at 37 DEG C for 28 days, can obviously induce neutralizing antibody and T cell immunity, and can be used for preventing various RSV-A / B infections.

The invention relates to germline-targeting designs, stabilization designs, and / or combinations thereof, of proteins designed with modified surfaces helpful for immunization regimens, other protein modifications and / or development of nanoparticles, methods of making and using the same, and to (a) germline-targeting priming or boosting / shepherding immunogens to initiate or guide maturation of VRC01-class responses (b) PCT64 / PG9-germline-targeting designs (c) BG18-germline-targeting designs or boosting / shepherding immunogens to initiate or guide maturation of BG18-like responses, and / or (d) trimer stabilization and presentation in a membrane-bound format.

The invention discloses a flame-retardant corrosion-resistant coating and a preparation method thereof, and relates to the technical field of fluorocarbon resin powder coatings. The flame-retardant corrosion-resistant coating comprises the following raw materials in parts by weight: 15-25 parts of fluorocarbon resin, 40-50 parts of epoxy resin, 3-5 parts of a curing agent, 5-7 parts of a reinforcing agent, 4-6 parts of a corrosion inhibitor, 6-8 parts of filler, 1-2 parts of a flatting agent and 0.5-1 part of benzoin. The preparation method comprises the following steps: reacting phosphonitrilic chloride trimer with p-hydroxybenzaldehyde to generate an intermediate 1, reacting the intermediate 1 with p-aminobenzoic acid to generate an intermediate 2, and reacting the intermediate 2 with 2-heptyl ethylene oxide to generate the reinforcing agent. The flame-retardant corrosion-resistant coating prepared by the invention has excellent mechanical properties, corrosion resistance, aging resistance and flame retardance.

The present application belongs to the field of veterinary drugs, and provides a recombinant protein S-Trimer of an infectious bronchitis virus antigen and a subunit vaccine therefor. Provided in the present application is a recombinant protein S-Trimer of an infectious bronchitis virus antigen, wherein the recombinant protein S-Trimer of the antigen has an amino acid sequence as set forth in SEQ ID No. 4. Also provided in the present application is an infectious bronchitis virus antigen. The infectious bronchitis virus antigen is of a trimer structure of the recombinant protein S-Trimer described above. The present application provides a subunit vaccine for an infectious bronchitis virus, wherein the subunit vaccine comprises a pharmaceutically acceptable carrier and an immunogenic amount of the infectious bronchitis virus antigen.

The application discloses an isocyanate polymerization catalyst and a preparation method thereof, and a preparation method of polyisocyanate, and a structural expression of the catalyst is as follows: the preparation method of the polyisocyanate is that, under an inert gas atmosphere, a polyisocyanate is used as a raw material to perform a self-polymerization reaction under the catalysis of the catalyst. The catalyst has a good catalysis effect, and the reaction temperature is stable, so that the catalyst is used for preparing an isocyanate trimer product with low viscosity and good storage stability.

The invention relates to a radionuclide labeled trimer probe 68Ga-TRAP-(FAPI) 3 targeting FAP and a preparation method thereof, Trap is used as a trivalent chelating platform, and three FAPI targeting units are covalently connected by clicking a chemical linking arm to form a trimer structure; the invention further relates to application of the 68Ga-TRAP-(FAPI) 3 probe in preparation of imaging agents or therapeutic drugs for diagnosing FAP positive diseases, experiments prove that the trimer probe is good in affinity and high in stability, and in cell experiments and animal experiments, the uptake rate of FAP positive cells is kept at a high level within 240 minutes; preclinical and preliminary clinical applications show that the tumor detection rate of the < 68 > Ga-TRAP-FAPI 3 in various cancer models is superior to that of < 18 > F-FDG, and compared with < 68 > Ga-FAPI-04, the < 68 > Ga-TRAP-FAPI 3 is clearer to display focuses (particularly tiny metastases), higher in uptake intensity and particularly outstanding in delayed imaging, and the < 68 > Ga-TRAP-FAPI 3 can be used for preparing a medicine for treating cancer. And a novel drug candidate with better performance is provided for precise diagnosis and staging of tumors and subsequent radionuclide targeted therapy.

The invention provides an FAPI trimer compound, a preparation method of the FAPI trimer compound, a PET developer based on the FAPI trimer compound and a preparation method of the developer. Amphipathic polyethylene glycol chains and trimeric structures in molecules of the FAPI trimer compound can improve in-vivo dynamic characteristics of the compound, and the in-vivo dynamic characteristics of the compound can be improved. The residence time in the tumor is prolonged; the PET imaging agent based on the FAPI trimer compound can improve the uptake and imaging effects of the PET imaging agent in tumors, and has good application prospects in PET imaging, preparation of drugs for diagnosing FAP-q expressed tumors and drugs for marking therapeutic nuclide (177Lu or 90Y) to treat the FAP-q expressed tumors in the future.

The invention relates to a base material of a self-lubricating sliding bearing as well as a preparation method and application of the base material. The base material comprises a component A, a component B and a component C, and the mass ratio of the component A to the component B to the component C is (0.4-0.8): (0.1-0.3): (0.1-0.3); wherein the component A is prepared from the following raw materials: vinyl cyclic siloxane, 1-thioglycerol and methacryloyl isocyanate; the component B is prepared from the following raw materials: a hexamethylene diisocyanate tripolymer and 2-hydroxy propyl methacrylate; and the component C is prepared from the following raw materials: a diphenylmethane diisocyanate tripolymer and 2-hydroxy propyl methacrylate. The compression strength and the compression modulus of the base material are both higher than those of commercially available resin, the bearing performance of the self-lubricating sliding bearing is greatly improved, meanwhile, the wear rate of the bearing is reduced through the high-crosslinking-degree resin, the gasket is more wear-resistant, and the service life of the bearing is prolonged.

Herpesviridae glycoprotein B (gB) polypeptides comprising a modified ectodomain is stabilized in the prefusion state, enabling development of inhibitors and vaccines directed against these viral pathogens. Modifications to DI, DII, and DV subdomains are important to stabilization of gB in the prefusion state, and additional modifications result in a further improved stabilization of gB in the prefusion state. The gB can be derived from an Epstein Barr Virus (EBV), a Human Cytomegalovirus (CMV), a Human Herpesvirus 6 (HHV6), a Herpes Simplex Virus 1 (HSV1), or a Varicella Zoster Virus (VZV). Polypeptides, nucleic acid constructs, compositions, and methods of using same to elicit an immune response are described.

The invention relates to a near-infrared two-region small organic molecule fluorescent probe with a photoacoustic effect and a preparation method and application thereof.The NIR-II small fluorescent molecule is of a tripolymer structure, is obtained by polymerizing three benzothiadiazole near-infrared two-region small organic molecules through the Schiff base generation reaction of amino and ketone, has good biocompatibility, and can be used for preparing a near-infrared two-region small organic molecule fluorescent probe with the photoacoustic effect. The fluorescence-photoacoustic dual-mode imaging material has the advantages of good optical property, photoacoustic property and photothermal property, no toxicity, good biocompatibility, easy absorption and metabolism by organisms, and realization of fluorescence-photoacoustic dual-mode imaging of osteosarcoma mice.

This invention discloses transcription factors As NF-YB3 Its application in regulating drought resistance in oats falls under the field of biotechnology. (Transcription factors) As NF-YB3 The amino acid sequence is shown in SEQ ID NO.1. As NF-YB3 The CDS sequence of the gene is shown in SEQ ID NO.2, and the gDNA sequence is shown in SEQ ID NO.3. Overexpression As NF-YB3 The gene significantly enhances the drought resistance of oats, while also increasing the activity of CAT and SOD enzymes in oats, slowing down the water loss rate of detached leaves, and improving seedling survival rate under drought stress. AsNF-YB3 forms a heterotrimeric complex with AsNF-YA1 and AsNF-YC5, and its 4bp insertion / deletion mutation in the promoter region regulates oat drought resistance by affecting AsARF1 binding and gene expression. This provides a new gene resource and technical pathway for agricultural stress-resistance breeding.

The invention discloses a procyanidine trimer compound, which has a chemical structure as shown in the specification. The hypoglycemic potential of the compound is evaluated through an in-vitro enzyme inhibition experiment, and the result shows that the compound has a remarkable inhibition effect on alpha-amylase, has good water solubility, is derived from natural plant resources, is clear in structure and good in safety, and has a huge application prospect in development of novel natural-source hypoglycemic drugs.

The invention relates to the technical field of vaccines, and particularly discloses a recombinant extracellular domain mutant trimer of a respiratory syncytial virus pre-fusion F protein, application of the recombinant extracellular domain mutant trimer and a vaccine. The mutant trimer comprises three recombinant F2-F1 extracellular domain protomers, and the recombinant F2-F1 extracellular domain protomers comprise three recombinant F2-F1 extracellular domain In some embodiments, the recombinant F2-F1 extracellular domain protomers each comprise a deletion of positions 104-144 and a peptide linker between positions 103 and 145, and comprise a L373R substitution and an engineered disulfide bond consisting of 55C and 188C, 149C and 458C substitutions, relative to a reference sequence. The recombinant extracellular domain mutant trimer of the F protein before fusion of the respiratory syncytial virus, provided by the invention, has higher yield, and the immunogenicity and stability of the antigen are further improved.

The invention discloses a hand brushing and spraying dual-purpose odorless anti-yellowing transparent polyurethane primer suitable for various base materials and a preparation method thereof. The primer mainly comprises a component A, a component B and a component C, the component A is mainly prepared from odorless coconut oil alkyd resin, zinc stearate, a defoaming agent, a flatting agent, an anti-settling agent, functional resin and an organic solvent; the component B is mainly prepared from an HDI (hexamethylene diisocyanate) tripolymer, a TDI (toluene diisocynate) tripolymer, a dehydrating solvent and a dehydrating agent; the component C is mainly prepared from dimethyl carbonate, n-butyl acetate and propylene glycol methyl ether acetate; the anti-settling agent is a mixed solution of polyamide wax slurry 6900-20X and n-butyl acetate, and the mass concentration of the polyamide wax slurry 6900-20X in the mixed solution is 40%; the functional resin is a mixed solution of cellulose acetate butyrate CAB-381-0.5 and n-butyl acetate, and the mass concentration of the cellulose acetate butyrate CAB-381-0.5 in the mixed solution is 20%. The odorless yellowing-resistant transparent polyurethane primer has the advantages of no blistering, no prickly heat, suitability for various base materials, dual purposes of hand brushing and spraying, and the like.

The invention discloses a damp-heat-resistant flame-retardant polyether-ether-ketone modified material and a preparation method thereof, and relates to the technical field of high polymer material modification. The modified material is prepared from the following raw materials in parts by mass: 70 to 90 parts of polyether-ether-ketone, 5 to 15 parts of polyphenylene sulfide, 10 to 25 parts of self-crosslinking modified phosphorus-nitrogen flame retardant, 0.5 to 2.0 parts of hydrolysis-resistant stabilizer, 0.1 to 0.8 part of antioxidant and 0.2 to 1.0 part of lubricating dispersant, the self-crosslinking modified phosphorus-nitrogen flame retardant is prepared by introducing hydroxyl-containing polyhedral oligomeric silsesquioxane (POSS) and phosphonitrilic chloride trimer into the self-crosslinking modified phosphorus-nitrogen flame retardant and carrying out graft condensation on the hydroxyl-containing POSS and phosphonitrilic chloride trimer. According to the material, through cross-linking hybrid modification and interface synergistic regulation and control, hydrolysis and acid production of the flame retardant are inhibited by utilizing the large steric hindrance hydrophobic effect of POSS, matrix degradation is blocked, the compactness of a flame-retardant layer is enhanced by virtue of the ceramic-carbonization synergistic effect, and the problems that a traditional flame retardant is easy to decompose and is not resistant to damp and heat can be effectively solved; the mechanical strength retention rate and the flame-retardant reliability of the material after high-temperature and high-humidity aging are remarkably improved.

The application belongs to the field of seawater desalination materials, and particularly relates to a polymer containing aniline trimer, which is obtained by polymerization of aniline trimer, polyethylene glycol and aliphatic diisocyanate, has a porous foam form, has water wettability and good photo-thermal conversion performance, and can be used as a seawater desalination material. The application also relates to a preparation method and application of the polymer, and the preparation method comprises polymerization of aniline trimer and polyethylene glycol in an organic solvent. The preparation method is simple, and process parameters are easy to control.

The present application relates to a kind of polyaspartic ester explosion-proof paint and its preparation method and application.The paint is composed of component A and component B, component A includes by weight parts: polyaspartic ester resin 100 parts, fluorosilicon block copolymer 1-5 parts, isocyanate modified graphene 0.8-1.2 parts, surface treated sodium bicarbonate powder 5-20 parts, melamine polyphosphate 10-30 parts, dispersing agent 0.5-1.0 parts, defoaming agent 0.2-0.5 parts and leveling agent 0.2-0.4 parts;Component B is hexamethylene diisocyanate trimer 60-120 parts by weight parts.The paint has low VOC, high solid content, fast drying, corrosion resistance and other properties, through fluorosilicon block copolymer realizes anti-sticking, surface treated sodium bicarbonate high temperature release gas forms air curtain, modified graphene rapid heat conduction, melamine polyphosphate flame retardant, forms "prevention-separation-dispersion-inhibition" multi-level synergistic protection mechanism.

To provide an etching method using hexafluoropropene.SOLUTION: Etching gas contains at least one kind of component selected from the group consisting of hexafluoropropene and hexafluorocyclopropane, and a dimer and / or a trimer derived from hexafluoropropene and hexafluorocyclopropane. With respect to the total amount of the etching gas, (1) 95 vol.% to 99.99999 vol.% of the hexafluoropropene is contained, and (2) 1 vol.ppm to 1,000 vol.ppm of at least one kind of component selected from the group consisting of hexafluoropropene and hexafluorocyclopropane, and a dimer and / or a trimer derived from hexafluoropropene and hexafluorocyclopropane is contained.SELECTED DRAWING: None

The application discloses a novel trimeric recombinant protein vaccine. Specifically disclosed are a mutant protein RBD8M with an amino acid sequence of SEQ ID No. 1 and a fusion protein of positions 26-277, positions 1-277 and SEQ ID No. 4. The application also discloses a vaccine containing the fusion protein, and further develops a trimeric recombinant protein vaccine containing the fusion protein and a double adjuvant. Experiments show that the vaccine prepared in the application can effectively induce cellular immunity and humoral immunity of the body in animals, a trace amount of the protein can stimulate a very high immune response of mice, has a good protection effect, can simultaneously produce high-titer neutralizing antibodies against various epidemic strains of the novel coronavirus, is a broad-spectrum effective new coronavirus vaccine, and has important significance for preventing novel coronavirus infection and a wide clinical application prospect.

The present invention provides a composition for a heat transfer fluid, which contains hexafluoropropylene trimers represented by formulae (I) to (III), and which contains 10 mass% or more and less than 85 mass% of the compound represented by formula (I) with respect to the total amount of the compounds represented by formulae (I) to (III).

The present invention relates to glycosylate HIV timer nanoparticles fused to self-assembling ferritin proteins which may be utilized as immunogens to enhance trafficking to lymph nodes and germinal centers and to heighten immune responses.

The present invention concerns a recombinant SARS-CoV-2 S glycoprotein trimer stabilized in a conformation that is anterior to the post-fusion conformation, as well as a proteoliposome comprising such a recombinant trimer and a vaccine based on such a proteoliposome. The invention also relates to a method of treating or preventing a SARS-CoV-2 infection in a subject using such a vaccine.

The invention belongs to the technical field of polyurethane elastomers and application thereof, and particularly relates to acrylic modified TPU (thermoplastic polyurethane) resin, a preparation method thereof and application of the acrylic modified TPU resin in low-temperature curing ink. The acrylic modified TPU resin is prepared from the following raw materials: polyol, hydroxyl and carboxyl acrylic resin, diisocyanate, a chain extender and a catalyst. The acrylic modified TPU resin is used for preparing the low-temperature curing ink, and the method mainly comprises the following steps: dissolving the acrylic modified TPU resin in a solvent, sequentially adding aliphatic blocked polyisocyanate, an oxazoline polymer and the like, stirring and curing to obtain the low-temperature curing ink; the aliphatic blocked polyisocyanate is an HDI (Hexamethylene Diisocyanate) tripolymer. According to the TPU resin chemically modified by the acrylic resin and the preparation method of the TPU resin, the compatibility of the TPU resin and the acrylic resin is remarkably improved, and the TPU resin has low-temperature curing performance, adhesive force, flexibility and tolerance and is suitable for the field of high-performance low-temperature curing ink.

The application discloses a kind of avian influenza and avian infectious bronchitis two-union recombinant subunit vaccine and its preparation method and application.The recombinant protein is by replacing the head domain of AIV HA protein with the RBD domain of IBV S protein, while adding GCN4, Trimer-tag trimer tag in sequence, the recombinant protein obtained, the recombinant protein is expressed in vitro using insect cells and prepared into subunit vaccine.The vaccine prepared by the application can produce high-level neutralizing antibodies against homologous and heterologous H9N2 subtype avian influenza virus after immunizing chicken population, while significantly reducing the virus discharge level and the histopathological changes caused, and can also induce high-level specific antibodies and neutralizing antibodies against QX subtype avian infectious bronchitis virus, effectively inhibit discharge, viral load, and reduce tissue lesions.The application does not depend on chicken embryo, and has low production cost and short cycle, and can simultaneously prevent avian influenza and avian infectious bronchitis.

Provided is a composition capable of suppressing generation of a trimer even when an aliphatic aldehyde at a high concentration of 90 mass% or more is stored at a low temperature. The composition contains 90 mass% or more of an aliphatic aldehyde having 8-16 carbon atoms and 100 ppm or more and 1 mass% or less of an additive with respect to the mass of the aliphatic aldehyde, wherein the additive is one or more selected from the group consisting of polyalkylene glycol derivatives represented by formula (I), sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitol fatty acid esters, amino acids represented by formula (II), anthranilic acid esters represented by formula (III), and pyrazine derivatives represented by formula (IV).

The invention belongs to the technical field of coatings, and provides a self-repairing, self-cleaning and weather-resistant iron base plate primer-topcoat integrated coating and a preparation method thereof, and the self-repairing, self-cleaning and weather-resistant iron base plate primer-topcoat integrated coating is prepared by mixing a component A and a component B according to an isocyanate index of 1-1.1, wherein the component A is prepared from the following components in parts by mass: 26 to 31 parts of polyaspartic acid ester PAE-1, 26 to 29 parts of polyaspartic acid ester PAE-2, 4 to 8 parts of polyaspartic acid ester PAE-3, 3 to 5 parts of mica powder, 1 to 3 parts of wetting dispersant, 0.5 to 1 part of defoaming agent, 0.3 to 0.6 part of flatting agent, 0 to 3 parts of color paste, 2 to 4 parts of anti-precipitation aid, 5 to 8 parts of ultraviolet light absorber, 13.2 to 24.9 parts of zinc phosphate and 1 to 4 parts of barium sulfate; the component B is prepared from 7 to 12 parts of isocyanate prepolymer A, 16 to 22 parts of isocyanate prepolymer B, 65 to 75 parts of hexamethylene diisocyanate tripolymer and 2 to 4 parts of butyl acetate. According to the technical scheme, the problem that in the prior art, a polyaspartic acid ester polyurea coating is insufficient in salt mist resistance and weather resistance is solved.