660 results about "Trimer" patented technology

The object of the present invention is to provide a carbon nanotube composition that does not impair the characteristics of the carbon nanotubes itself, allows the carbon nanotubes to be dispersed or solubilized in a solvent, does not cause separation or aggregation of the carbon nanotubes even during long-term storage, has superior electrical conductivity, film formability and moldability, can be easily coated or covered onto a base material, and the resulting coated film has superior moisture resistance, weather resistance and hardness; a composite having a coated film composed thereof; and, their production methods. In order to achieve this object, the present invention provides a carbon nanotube composition that contains a conducting polymer (a) or heterocyclic compound trimer (i), a solvent (b) and carbon nanotubes (c), and may additionally contain a high molecular weight compound (d), a basic compound (e), a surfactant (f), a silane coupling agent (g) and colloidal silica (h) as necessary; a composite having a coated film composed of the composition; and, their production methods.

The invention discloses a dynamic bond-containing polyurethane material for 3D printing and its preparation method and use. The preparation method utilizes, by mole, 100 parts of diisocyanate, 50-75 parts of polyester polyol or polyether polyol, 50-125 parts of a Diels-Alder bond-containing dihydric alcohol chain extender, 0-50 parts of a diisocyanate trimer cross-linking agent, 50-100 parts of a ligand-containing dihydric alcohol chain extender and 0-50 parts of a metal salt cross-linking agent. The Diels-Alder bond-containing dihydric alcohol chain extender and the diisocyanate trimer cross-linking agent are matched and are used for preparation of a Diels-Alder bond-containing polyurethane material. The ligand-containing dihydric alcohol chain extender and the metal salt cross-linking agent are matched and are used for preparation of a metal ligand-containing polyurethane material. Molecular structures of the prepared polyurethane materials contain a dynamic medical bond Diels-Alder bond and a metal ligand bond. The Diels-Alder bond-containing or metal ligand-containing polyurethane material has functions of self-restoration and self-bonding.

The invention provides small molecule mimics of the Smac peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.

The present invention refers to fusion proteins comprising a TNF superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a trimerization domain and a nucleic acid molecule encoding the fusion protein. The fusion protein is present as a trimeric complex or as an oligomer thereof and is suitable for therapeutic, diagnostic and/or research applications.

The invention discloses a 2-(2-(diphenyl phosphine) phenyl) oxazoline nickel halogenide series complex. Said invention provides the structure formula of said complex and its preparation method. Said invention also provides catalyst composition containing said complex and its application in ethylene oligopolymerization. Said catalyst composition has higher ethylene oligopolymerization activity, and the obtained oligomer takes ethylene dimmer and trimer as main components.

The invention relates to a preparation method of a photo-moisture dual cured hot melt polyurethane sealant. The preparation method comprises following steps: firstly, an HDI (hexamethylene diisocyanate) trimer reacts with a hydroxyl acrylate monomer, after the reaction, polyether polyol is added for continuous reaction, and a prepolymer A is obtained; bifunctional isocyanate reacts with crystalline polyester polyol and non-crystalline polyester polyol, and a prepolymer B is obtained; the prepolymer A and the prepolymer B are mixed in a certain ratio, then a photoinitiator, a catalyst, a coupling agent and the like are added, and the photo-moisture dual cured hot melt polyurethane sealant is obtained. The preparation method improves the defects of failure in rapid positioning of UV glue, low initial strength of the hot melt polyurethane sealant and the like, rapid positioning can be realized, the hot melt polyurethane sealant can achieve higher strength in a short time, and the hot melt polyurethane sealant can be used for bonding of appliances, furniture, electronic components and the like.

Single chain trimer (SCT) molecules are disclosed, comprising an MHC antigen peptide sequence, a β₂-microglobulin sequence and a full-length MHC class I heavy chain sequence, joined by linker sequences. Further described are nucleic acids encoding single chain trimers. Methods for expansion of antigen-specific T cell populations using single chain trimer molecules are also disclosed. In some configurations, these methods comprise co-culturing, in a first stage, CD8+ T cells from a donor with antigen presenting cells comprising an MHC antigen peptide, and co-culturing, in a second stage, the CD8+ T cells with cells comprising an SCT which has an MHC antigen peptide sequence identical to the sequence of the antigen peptide in the first stage. The methods can provide 10,000-100,000 fold expansion of antigen-specific CD8+ T cells within about 28 days after establishing culture, and can yield over 1 billion antigen-specific CD8+ T cells expanded from an individual donor.

This invention provides a first composition comprising a pharmaceutically acceptable particle and a stable HIV-1 pre-fusion envelope glycoprotein trimeric complex operably affixed thereto. This invention further provides a second composition comprising (a) a pharmaceutically acceptable particle, (b) an antigen, and (c) an agent which is operably affixed to the particle and is specifically bound to the antigen, whereby the antigen is operably bound to the particle. Finally, this invention provides related nucleic acids, vectors, cells, compositions, production methods, and prophylactic and therapeutic methods.

A low-free radical TDI polyurethane curing agent, its production and product are disclosed. The process is carried out by putting tolylene-diisoester cyanate, solvent S and catalyst A into reactor, adding into antioxidant and long-chain alcohol, agitating in reactor, heating, keeping temperature, inspecting NCO value, adding into phase-transferring solvent X while reaching NCO value to 20-40%, adding into catalyst B till reaching NCO value to 10-15, adding into inhibitor to stop reaction, adding into solvent S, decreasing pressure, distilling and removing phase-transferring solvent X. It's cheap and convenient.

The invention discloses macrocyclic and cage-like molecules based on biphenylarene and derivatives of the macrocyclic and cage-like molecules as well as synthetic methods and applications of the macrocyclic and cage-like molecules and the derivatives. A series of novel macrocycles are obtained mainly by performing a reaction on bis(2,4-dialkoxyphenyl)arenes (naphthalene, anthracene, pyrene, porphyrin and the like) or tris(2,4-dialkoxyphenyl)arenes (benzene, sym-tribenzobenzene) and paraformaldehyde under the catalysis of a Lewis acid in high yield. In addition, perhydroxybiphenylarenes (quaterphenyl trimer, naphthalene dimer and the like) can be obtained by performing demethylation, a plurality of water-soluble derivatives can be obtained by performing further modification, and the derivatives show good bonding ability to guest molecules (viologen and the like); and moreover, functional groups introduced into the framework make the biphenylarene have excellent adsorption and separationability and photophysical properties. The compounds, derivatives and methods provided by the invention have the following advantages: raw materials of the biphenylarene are commercially available, the synthesis is simple and convenient, the yield is high, and the modification is convenient, so that the compounds and the derivatives have broad application prospects in gas adsorption and separation, performance improvement of light-emitting materials, and adsorption of water-soluble toxic substances.

The invention discloses a phosphazene flame retardant and a preparation method thereof. The phosphazene flame retardant is obtained through the reaction of fluorocarbon alcohol and phosphonitrilic chloride trimer, wherein, as the phosphazene flame retardant contains the elements of P and N, the flame-retardant effect is more obvious; as at least one of Rf1, Rf2, Rf3, Rf4, Rf5 and Rf6 is a fluorocarbon group which provides convenience for enhancing the flashing points of the electrolyte and reducing the viscosity of the electrolyte, the viscosity of the phosphazene flame retardant is proper, and the phosphazene flame retardant has favorable systematic consistence; moreover, the O bond and the P bond on the side chain of the phosphazene flame retardant are connected to a P group of a loop chain at the same time, so as to form a V-shaped hole, which provides convenience for absorbing metal positive ions to get far away from corresponding negative ions as well as for the migration of the positive ions, and further improves the electric conductivity of the electrolyte. The invention further provides a lithium ion battery electrolyte comprising electrolyte salt, a solvent and the phosphazene flame retardant. Experimental results show that the lithium ion battery electrolyte provided by the invention has favorable conductibility.

The invention discloses a water-dispersible HDI-TDI mixed tripolymer curing agent and a preparation method thereof. The method comprises steps as follows: (1) diisocyanate monomers and a nonionic hydrophilic modifying agent are put into a round-bottom flask under the protection of nitrogen and heated to reach 50-70 DEG C for a thermal reaction; (2) after the mixture reacts for 2-4 h, a trimerization catalyst is added, the mixture is subjected to a thermal reaction continuously, a polymerization inhibitor is added after the percentage composition of -NCO of the system reaches the target, and the mixture is subjected to the thermal reaction for 0.5-1.5 h; (3) an anion hydrophilic modifying agent is added to a tripolymer obtained in the step (2), the mixture is continuously stirred and subjected to the thermal reaction at the temperature of 60-80 DEG C, a neutralizing agent is added after the mixture reacts for 5-7 h, and the mixture is stirred uniformly, subjected to the thermal reaction for 0.5-1.5 h and discharged after being cooled. The preparation method is simple, and the prepared curing agent has the advantages of good water dispersibility, good storage stability and good film water resistance and can be applied to a water-based bi-component polyurethane coating well.

The invention belongs to the technical field of curing agents and discloses a high-solid and averaged-molecular weight non-toxic polyurethane curing agent for a sub-gloss varnish and a preparation method thereof. The method comprises the steps of (1) in the nitrogen protection environment, adding a catalyst drop by drop in a reaction vessel filled with a solvent and toluene diisocynate during the stirring process, reacting at the temperature of 40-55 DEG C, cooling on the condition that the content of NCO is lowered to be 13%-23%, and adding an acidic polymerization inhibitor to obtain a toluene diisocyanate trimer; (2) mixing a polyhydroxy compound with a dehydrating agent, adding the obtained mixture in the toluene diisocyanate drop by drop, reacting and cooling to obtain a polyurethane addition product; (3) stirring and mixing the toluene diisocyanate trimer with the polyurethane addition product, separating in a film evaporator, adding a dilution solvent and stirring evenly to obtain the high-solid and averaged-molecular weight non-toxic polyurethane curing agent. The curing agent is centralized in the distribution of molecular weight, low in viscosity, and high in content of effective isocyanate groups. After a varnish is prepared by the curing agent, a paint film is fast in drying speed, good in levelability and high in fullness.

The invention belongs to the field of flame-retardant auxiliaries of epoxy resin, and discloses a flame-retardant curing agent containing a phosphazene/aromatic imine composite structure and a preparation method thereof. The flame-retardant curing agent is composed of cyclotriphosphazene, aromatic imine and active amino groups, and the structural formula of the flame-retardant curing agent is shown in a formula I which is described in the specification. According to the invention, phosphonitrilic chloride trimer is subjected to substitution and condensation reactions with hydroxyl-containing aldehydes and aromatic diamines in sequence respectively so as to successfully prepare the phosphonitrile/aromatic imine composite structure-containing flame-retardant curing agent containing the polyfunctional active amino groups at the tail end. The whole preparation process has the characteristics of mild reaction conditions, controllable and adjustable reaction process, higher yield and the like, so the method is suitable for expanded production. According to the flame-retardant curing agent prepared by the invention, the contained active amino groups undergoes chemical reactions such as curing cross-linking with matrix epoxy resin and directly participates in forming of a polymer network three-dimensional structure to introduce a flame-retardant structure, so the prepared polymer material has excellent flame-retardant performance.

The invention provides a water-based woodware seal primer which comprises a component A and a component B. The component A is composed of the following ingredients in parts by weight: 70-90 parts of water-based hydroxy acrylic resin, 4-6 parts of film forming aid, 0.2-0.5 part of defoaming agent, 0.2-0.5 part of wetting agent, 1-3 parts of sanding aid, 0.5-1 part of thickener, 1-2 parts of tannic acid polymerization inhibitor and the balance of water. The component B is a water-based HDI (hexamethylene diisocyanate) tripolymer. The water-based woodware seal primer provided by the invention is a water-based woodware anti-bleeding seal primer, can reduce the leaching of tannic acid, and has better binding force for the substrate, thereby enhancing the sealing effect. When being especially used for wood substrates with higher tannic acid content, the seal primer can implement favorable seal effect on the tannic acid in the water-based system, thereby avoiding the resulting common application defects.

Conjugates between a minor groove binding molecule, such as the trimer of 1,2-dihydro-(3H)-pyrrolo[3,2-e]indole-7-carboxylate (CDPI₃), and an oligonucleotide form unusually stable hybrids with complementary target sequences, in which the tethered CDPI₃ group resides in the minor groove of the duplex. These conjugates can be used as probes and primers. Due to their unusually high binding affinity, conjugates as short as 8-mers can be used as amplification primers with high specificity and efficiency. MGB conjugation also increases the discriminatory power of short oligonucleotides, providing enhanced detection of nucleotide sequence mismatches by short oligonucleotides. The MGB-conjugated probes and primers described herein facilitate various analytic and diagnostic procedures, such as amplification reactions, PCR, detection of single-nucleotide polymorphisms, gene hunting, differential display, fluorescence energy transfer, hydrolyzable probe assays and others; by allowing the use of shorter oligonucleotides, which have higher specificity and better discriminatory power.

Two component (2K) waterborne polyurethane coating compositions which when cured achieve excellent anti-graffiti properties at low VOC level (below 100 g/L) are disclosed. The composition comprises (A) a fluorinated polyol and optionally a non-fluorinated polyol; and (B), a blend of polyisocyanates comprising a hydrophilically modified trimer of hexamethylene diisocyanate (HDT) and a hydrophilic ally modified trimer of isophorone diisocyanate (IPDT). The glass transition temperature of the ambient cured coatings, crosslinked network structure, and fluorine content at the surface enable excellent anti-graffiti properties. The waterborn coatings of the invention have excellent recoatability and exceptional chemical resistance.

The invention discloses a polyaspartate polyurea adhesive and a preparation method thereof. The polyaspartate polyurea adhesive comprises a component A and a component B spaced from each other before being used, wherein the component A and the component B are mixed at a weight ratio of 4 to (1-1.05) when being used; the component A comprises the following components in parts by weight: 4.0-5.0 parts of polyaspartate polyurea, 4.0-4.50 parts of fillers, 0.005-0.01 parts of a defoamer and 0.005-0.01 parts of a leveling agent; the component B is hexamethylene diisocyanate trimer. According to the polyaspartate polyurea adhesive, the component A and the component B are mixed, so that the bonding strength in a bonding process is high and especially the bonding strength between the adhesive and a cement matrix is high; moreover, the adhesive has excellent performances of chemical corrosion resistance, water resistance, weather resistance, temperature resistance, low VOC (volatile organic compounds), environmental protection and the like.