89results about How to "Inhibition of growth rate" patented technology

This invention provides a first composition comprising a pharmaceutically acceptable particle and a stable HIV-1 pre-fusion envelope glycoprotein trimeric complex operably affixed thereto. This invention further provides a second composition comprising (a) a pharmaceutically acceptable particle, (b) an antigen, and (c) an agent which is operably affixed to the particle and is specifically bound to the antigen, whereby the antigen is operably bound to the particle. Finally, this invention provides related nucleic acids, vectors, cells, compositions, production methods, and prophylactic and therapeutic methods.

The invention relates to a synthesis method of a low-silicon nano SAPO-34 molecular sieve, which comprises the following steps: sequentially mixing a silicon source, an aluminum source, a template agent R, deionized water and a phosphorus source to obtain a gel mixture; placing the gel mixture in a stainless steel high-pressure reaction kettle of which the liner is made of polytetrafluoroethylene, sealing, putting into a drying oven, and performing primary traditional hydrothermal crystallization; adding a dispersant agent S into the primary traditional hydrothermal crystallization solution, stirring for 0.5-4 hours, transferring into the reaction kettle of which the liner is made of polytetrafluoroethylene, sealing, putting into a microwave reactor, and performing secondary microwave hydrothermal crystallization; and washing, drying, and roasting to obtain the nano SAPO-34 molecular sieve. Compared with the prior art, the invention greatly lowers the crystallization temperature and shortens the time of the whole synthesis process. The nano molecular sieve can be widely used for conversion, separation and absorption of hydrocarbons, and especially has the advantages of high conversion rate, high low-carbon alkene selectivity, low carbon deposition rate, long reaction life and the like in the process of preparing alkene from methanol.

The invention belongs to the technical field of biological pharmacy, and relates to a tumor targeting polypeptide-medicine coupling derivative, and a preparation method and application thereof. The tumor targeting polypeptide-medicine coupling derivative comprises targeting polypeptides, long effect polypeptides and medicine molecules, wherein the targeting polypeptides are connected onto the endC of the long effect polypeptides through flexible connecting peptides; fusion peptides are used as carriers of the medicine molecules; the medicine carriers and the long effect polypeptides in the fusion peptides are connected through chemical bonds; and the long effect polypeptides are polypeptide or protein structural domains having the affine mutual effects with human serum albumin. The tumortargeting polypeptide-medicine coupling derivative can be combined with the human serum albumin; the remaining half-life period in the blood circulation system can be obviously prolonged; the long-term effectiveness in the body is realized; the targeting and seepage into the tumor tissues or cells can be realized; then, free effect molecules are released in tumor tissue micro acid environments orin cells in through an acid hydrolysis mechanism; and a better anti-tumor efficiency is achieved.

Contortrostatin, a homodimeric disintegrin, modulates the adhesion, motility, and invasiveness of integrin expressing tumor cells. When formulated as a pharmaceutically acceptable composition, the proteins can be used to treat patients by inhibiting or disrupting disease processes associated with an integrin binding to an αvβ3 or αvβ5 integrin.

The invention provides a preparing technology of a Ni-Fe-P alloy-based compound coating. The matrix material of the compound coating is amorphous/ nanocrystalline Ni-Fe-P alloy, the Ni content is 80-90wt% of the compound coating, the Fe content is 5-20wt% of the compound coating, and the P content is 5-15wt% of the compound coating. A second phase in the compound coating is a grain growth inhibitor, such as VC<1-x> and TiC, and the content of the second phase is 0-5wt% of the compound coating. The preparing technology of the compound coating comprises: 1, pretreating a metal plated surface; 2, activating second phase particles; 3, carrying out electric brushing plating on a Ni-Fe-P amorphous compound coating; and 4, carrying out partial crystallization transformation on the compound coating.

The invention discloses a quasicrystal-strengthened Mg-6Zn-3Y alloy with an ultrafine solidification texture and a preparation method thereof. The quasicrystal-strengthened Mg-6Zn-3Y alloy consists of the following chemical components in percentage by weight: 87.0 to 93.0 percent of Mg, 3.0 to 10.0 percent of Zn and 0.5 to 3.0 percent of Y. The Mg-6Zn-3Y alloy with the ultrafine solidification texture, which contains nanoscale granular quasicrystals, is prepared from normal-pressure as-cast Mg-Zn-Y alloy material under GPa-level ultrahigh pressure as solidification pressure, temperature and solidification cooling rate are controlled. The as-cast texture is characterized in that: the granular quasicrystals are evenly and dispersely distributed on the ultrafine Alpha-Mg matrix, wherein the secondary dendrite arm spacing between Alpha-Mg dendrites is 7Mu m to 10Mu m, the diameter of the granular quasicrystal is 50nm to 100nm, and the volume of the granular quasicrystals accounts for 25 to 35 percent of the total volume of the alloy. The invention adopts a cubic press, solidification process parameters are controlled, i.e., the solidification pressure is 6GPa, the solidification temperature is 1300DEG C, and the solidification rate is 300K/S. Theultrafin quasicrystal-strengthened Mg-6Zn-3Y alloy has high mechanical properties and good thermal stability.

The invention discloses a surface treatment method regulating and controlling a transition interface structure of a thermal barrier coating through laser shock. A single circular light spot is adopted, a pit is formed in the surface of a bonding material through laser shock treatment, a special geometrical morphology of the surface layer of a bonding layer is formed, thus, the bonding strength between a plasma-spray ceramic layer and the bonding layer is improved, prefabrication residual stress is formed on the surface, in the high-temperature cyclic oxidation process, thermal stress of the thermal barrier coating can be adjusted, the TGO growth speed and formation of contiguous TGO are effectively restrained, and damage of thermal stress to bonding force of the bonding layer and the ceramic layer is reduced. Through thermal shock property tests, the service life of the thermal barrier coating after bonding layer shock is greatly prolonged. The thermal barrier coating interface structure regulating method is simple in process, easy to operate and convenient to implement.

The present invention discloses a treating agent for microbe environmental-protective garbage, which comprises anaerobic bacteria and facultative aerobe. The weight ratio for the anaerobic bacteria and facultative aerobe is 1: .65-1.1; because the composite fostered active bacteria preparation can decompose ammonia gas, nitrogen gas and sulfureted hydrogen and so on, the active preparation can restrict the growth speed of spoilage organisms, block the growth of the myiasis and destroy the hatch of mosquito and fly. So the present invention has the great effects to kill the mosquito and fly, deodorization, and to cure corruption. The duration is much longer; the decreasing ratio for the mosquito and fly in the refuse dump reaches up to 95 percent and the decreasing ratio for the bad smelly reaches up to 80 percent. The present invention can decrease the pollution in the refuse dump, decrease the output of the firedamp and decrease the storage volume for the garbage. Besides, the product has not any side effect and special smelly. The present invention is not dangerous to the health, without producing the garbage and bringing the second pollution. After being used with the present invention, the neighboring environment around the refuse dump can be enhanced greatly.

The invention discloses a tin plating or tin-lead alloy plating solution applied to leadless electronic components as well as a preparation method and an electroplating method of the tin plating or tin-lead alloy plating solution. The plating solution is prepared from the following components: a multi-component complexing agent, tin methanesulfonate, lead methanesulfonate, a surfactant, a semi-bright additive and an antioxidant; the pH value of the plating solution is 4-7; the contents of the multi-component complexing agent, the tin methanesulfonate, the lead methanesulfonate, the surfactant,the semi-bright additive, the antioxidant and water in the plating solution are respectively 200-300g/L, 10-25g/L, 1.0-2.5g/L, 1-8g/L, 0.05-0.3g/L, 0.4-2g/L and margin. Compared with the prior art, the plating solution provided by the invention has the main advantages that the multi-component complex is adopted, so that tin and lead are effectively complexed, and overplating is better avoided; furthermore, the plating solution is stable, is not easily turbid after being used for a long time, and is harmless to a human body and the environment.

The invention belongs to the technical field of preparation of monocrystal diamonds, and particularly relates to a method for inhibiting polycrystallizing of ridges of a monocrystal diamond. The method for inhibiting the polycrystallizing of the ridges of the monocrystal diamond comprises the following steps of (1) preparation and selection of a substrate: slicing the monocrystal to obtain a plurality of substrates, wherein each substrate is oriented as shown in (100), and the thickness is 300 to 350mum; (2) pretreatment of the substrate: sequentially performing acid treatment, acetone and alkaline ultrasonic cleaning on the substrates in step (1), and selecting one surface with higher quality and no impurity defect as the growth surface; (3) growth of crystals. The method has the advantages that by strictly controlling the ratio of flow rate of gas in each step and the power/pressure ratio in the preparation process, the corresponding parameter ratio is designed according to each growth stage; by matching with the strict temperature control, the deposition quality of the monocrystal diamond is finally improved.

The invention relates to the preparation of an oil pipeline drag reducer. The method followed by the following steps : first adding main catalyst and promoter under the protection of nitrogen into respond containers, using ultrasonic vibration generator for 18 -26 minutes; In nitrogen, oscillations and -60 degreeC to 10 degree C ambient temperature conditions, adding polymerization monomer for reaction; Monitoring reaction temperature, when the reaction temperature rises above 3 DEG C than the initial reaction temperature, adding nitrobenzene retarder; cease oscillation when the system viscosity rise to 3500 -6000MPa .s; ultrasonic vibration generator to 25 KHz frequency, power adjustable. After the cessation of oscillation system, continued reaction to 5 ~ 14 days, finally obtain purple polymer. This method is easy to operate, easy to control, easy to ensure the quality.

The invention provides a production process of ultrafine calcium carbonate powder, and relates to the technical field of calcium carbonate powder. The production process of the ultrafine calcium carbonate powder comprises the following steps: firstly, carrying out a digestion reaction on water and quick lime according to a mass ratio of (7-8):1, ageing for 24-36 h, and sieving to obtain a refinedslurry; adding water into the refined slurry to prepare a calcium hydroxide slurry with the concentration of 1-1.5 mol/L; adding a crystal form control agent into 10 L of the calcium hydroxide slurry,introducing gas, and carrying out a carbonization reaction; finally, performing a reaction for 2-2.5 h at 70-80 DEG C; and centrifuging, drying and crushing the slurry obtained by the reaction to obtain the ultrafine calcium carbonate powder. The ultrafine sodium carbonate prepared by reasonable blending has small size, good solubility, good controllability and good dispersity, can be controlledto be prepared into calcium carbonate with different crystal forms and morphologies, and has different use effects.

The invention relates to the field of environmental technology utilization and discloses a treatment method for improving the repair effect on cadmium-contaminated soil. According to the method, the combined effect of a chemical repair agent, sisal and bamboo reeds is adopted; after the repair agent is applied to the to-be-repaired cadmium-contaminated soil, the sisal and the bamboo reeds are interplanted; heavy metal cadmium is absorbed and accumulated by utilizing the flocculation effect of the chemical repair agent and the enrichment effect of the sisal and the bamboo reeds; and after outplanting in autumn every year, ashing processing is performed, so as to extract the heavy metal cadmium and achieve the purpose of repairing the soil. According to the treatment method, the combined effect of the chemical repair agent, the sisal and the bamboo reeds is adopted, because the biomass of the sisal and the bamboo reeds is large, the patience and the transfer volume to cadmium in the soil environment are large, the bamboo reeds are perennial plants and can be simply planted and managed, and processing is separated from food chains, the repair effect on the cadmium-contaminated soil and the safety of a subsequent process are greatly improved, secondary pollution is avoided, and the cadmium-contaminated soil can be preferably repaired.

The invention discloses a brown planthopper survival and growth development-associated NlPIK3R1 gene, and a coded protein and an application thereof. The gene NlPIK3R1 for coding a brown planthopper phosphatidyl inositol 3 kinase p85 alpha subunit comprises a nucleotide sequence as shown in SEQ ID NO:1 and a homologous mutant sequence thereof. The gene has an important function in a survival and growth development process of the brown planthopper, and is restrained in function to cause brown planthopper survival rate drop, slow growth and delayed adult eclosion. The protein coded by the brown planthopper NlPIK3R1 gene comprises an amino acid sequence as shown in SEQ ID NO:2 and a homologous mutant sequence thereof. The gene is restrained in function to cause brown planthopper survival rate drop, slow growth and delayed adult eclosion. RNA interference of the brown planthopper NlPIK3R1 gene is applied to control brown planthopper. RNA interference is successfully performed on the gene, the survival rate of pests is decreased according to the results, the survival and the growth development are obviously restrained, the weight is reduced, and the adult eclosion is delayed.

The invention discloses an alpha-tubulin inhibitor and application thereof. The active ingredients of the alpha-tubulin inhibitor consist of effective quantities of at least one lactone compound of alantolactone, isoalantolactone, dihydro-alantolactone, dehydrocostunolide lactone, costunolide and dihydro-costunolide. The alpha-tubulin inhibitor disclosed by the invention can obviously inhibit alpha-tubulin and the mRNA (Messenger Ribonucleic Acid) level thereof, can inhibit the forming of spindles, block the cell cycle in the G2/M period, induce cell apoptosis and the like, can effectively inhibit the tumor growth speed, can obviously inhibit growth of various tumor cells, particularly has an obvious effect on melanoma, can be expected to be used for preparing medicament preparations for resisting tumors and has wide application prospect, wherein the tumors comprise lung cancer, pancreatic cancer, prostatic cancer, neuroblastoma, melanoma and breast cancer.

The invention discloses an anti-shrinkage antibacterial woolen sweater treatment liquid containing capric triglyceride, which comprises the following components in parts by weight: 4-7 parts of capric triglyceride, 2-5 parts of propylene glycol, 2-6 parts of potassium citrate, 5-7 parts of hydroxyethyl cellulose, 3-6 parts of liquorice extract, 3-5 parts of cortex magnoliae officinalis extract and 80-100 parts of water. After being treated by the prepared woolen sweater treatment liquid, the woolen sweater has the functions of reducing the shrinkage rate of the woolen sweater and inhibiting the growth of escherichia coli and aspergillus flavus.

The invention discloses an overall treatment method of starch and starch derivatives, which is performed by carrying out sterilization and bacteriostatic treatment on critical points in a pipeline, a receiver tank, a washer, a separation plant, a drying plant and farinaceous size; specifically the method comprises the following steps: using acid-base sterilization method in combination with disinfectant and employing soaking or slug flow method to sterilize the pipeline, the receiver tank and the washer the farinaceous size flows through; adopting an ultraviolet sterilization lamp to carry out farinaceous size surface sterilization on the receiver tank and a head tank; adopting disinfectant to carry out sterilization on the internal surface of a centrifugal machine; adopting chemical modification self sterilization method and adding disinfectant to carry out sterilization and bacteriostatic treatment on the farinaceous size; adopting the method for cleaning residual powder in combination with air-heater high temperature sterilization for blowing clean the residual dust and then drying the powder. Through a series of overall control methods, the finished product of starch meets the requirements for starch microorganism applied to food and medicine, thus providing an effective microorganism control method for starch production enterprises and enhancing product competitiveness of such enterprises.

The invention provides a preparation method of a sheet ZSM-5 molecular sieve. The method includes: in a gel preparation process, mixing a silicon source, an aluminum source, a template agent and an additive, and performing stirring at 10-50DEG C for 1-20h; conducting standing aging for 10-30h at 10-90DEG C; putting the prepared gel reaction mixture into a reaction kettle, then putting the reactionkettle into an oven, conducting crystallization at 100-220DEG C for 4-30h, then taking the product out, and carrying out filtering, washing and drying to obtain the ZSM-5 molecular sieve product. Themethod provided by the invention synthesizes the ZSM-5 molecular sieve under a solid like phase condition, and the obtained ZSM-5 molecular sieve product is sheet shaped, and has a relative crystallinity of 90-110%, and an SiO2/Al2O3 molar ratio of less than or equal to 100.

The invention relates to a preparation method of Chinese sauerkraut. The preparation method specifically comprises the steps that raw materials are selected after being checked to be qualified; the raw materials are washed with clean water, drained and aired; salt, lactic acid bacteria and water are added, and the materials are sealed and fermented; after being taken out of a pond, the raw materials are sorted, roots are removed, and cutting is conducted; secondary fermentation is carried out after a lactic acid bacteria solution is added; finally, the fermented Chinese sauerkraut is sequentially subjected to weighing, bagging, vacuum sealing, metal detection, boxing, inspection and storage, and the Chinese sauerkraut is obtained. According to the preparation method of the Chinese sauerkraut, the operation of each link is strictly controlled, and the biological bacteriostatic technology is adopted, so that the Chinese sauerkraut is rich in lactic acid bacteria, dietary fiber and othernutrients, the prepared Chinese sauerkraut has mellow taste and is crisp and tasty, the high quality and high nutrition of products are ensured, and the eating safety of consumers is ensured.

The invention discloses a rice planting method. The method comprises the step of fertilization. Fertilizer applied to soil is prepared from, by weight of parts, dried poultry dung, earthworms, compressed yeast, calcium superphosphate, ferrous sulfate, zinc sulfate, sodium borate, cottonseed oil, medical stone, manganese sulfate, fulvic acid, bagasse, naphthylacetic acid, bentonite, sargent gloryvine, willow branches, Jerusalem artichoke and dragon's tongue leaves. Fertilizer applied to water is prepared from, by weight of parts, tea seed meal, soybean meal, rapeseed meal, bran, embryo meal, brown sugar, phospholipid oil, lysine, soya bean lecithin, 2-8 parts of walnut skin, peanut oil, astragalus membranaceus, garden burnet, phtheirospermum tenuisectum branches, manioc residues, Chinese cypress, honeysuckle, rehmannia, poria cocos, bighead atractylodes rhizome, common leafflower herb with roots, sage, dried tangerine or orange peel, rose root powder, spiral seaweed powder, fish meal, lucerne meal and shrimp shell meal.

An apparatus for farming oysters and, in particular, intertidal oysters. The apparatus includes a float, at least one oyster container configured to hold oysters and be carryable on the float, and a driver operable to periodically move each of the at least one oyster container between an underwater position and an above water position.

The invention discloses a black goat breeding method which includes the steps: S1 selecting healthy Boer bill goats and Wushan local nanny black goats and performing hybridization to obtain F1-generation crossbred Boer goats; S2 cross-breeding nanny goats in the F1-generation crossbred Boer goats with Wushan local black bill goats to obtain F2-generation crossbred Boer goats; S3 back-crossing bill goats in the F2-generation crossbred Boer goats with Wushan local nanny goats to obtain F3-generation crossbred Boer goats; S4 breeding the F3-generation crossbred Boer goats in a grouped manner according to the breeding standard of selecting goats with hair colors the most approximate to black in the current generation to obtain Fn-generation crossbred Boer goats with completely black hair colors; S5 crossly fixing the Fn-generation crossbred Boer goats to obtain black goat new species. The selection standard of the nanny goats in the F1-generation crossbred Boer goats is a flower hair color. The selection standard of the nanny goats in the F2-generation crossbred Boer goats is a brown hair color. The bred new black goat species have excellent reproductive performances and meat performances, and the disease resistance of the bred new black goat species is stronger than that of the Wushan local black goats.

The invention discloses a method for culturing tea seedlings and relates to the technical field of tea planting. The method comprises the following steps that A, a seedling land is ridged and arranged into multiple seedling beds after deep plough, disinfection and insect killing treatment, and soil on the surface of the seedling beds is smashed and raked; B, the seedling beds are wetted, and cuttage is conducted on the seedling bed with tea branches, wherein the line space of cuttage of the tea branches ranges from 1 cm to 1.5 cm, and the tea branch space ranges from 0.3 cm to 0.4 cm; C, after the tea seedlings grow for 40 to 50 days, the tea seedlings are watered every two to three days; D, when the tea seedlings grow to be about to reach horizontal closure, trimming is conducted to make the heights of all the tea seedlings on the seedling beds identical; E, after the tea seedlings grow for 200 to 250 days, the tea seedlings are acclimatized for 90 days; F, after the acclimatized tea seedlings continue growing for 40 to 50 days, the tea seedlings can transplanted out of the seedling beds. Compared with the prior art, the method for culturing the tea seedlings can solve the problems that existing tea seedlings are low in qualified seedling percentage and high in culturing cost.