The invention relates to the field of
sugar chemistry, in particular to
thioester modified
sugar amino acid and a method for synthesizing
glycopeptide by using the
thioester modified
sugar amino acid. The
thioester modified glycoamino acid is selectively activated by a silver
reagent and can be coupled with amino at the
tail end of
solid-phase loaded polypeptide resin to synthesize first
glycopeptide under the action of an additive and organic alkali, and quantitative (100%) reaction can be realized within 10 minutes by only needing 1 equivalent dosage of each reaction
reagent under the
microwave reaction condition. Fmoc protection in thioester-modified glycoamino acid in the first
glycopeptide can be removed subsequently,
amino acid or polypeptide fragments are used as raw materials, second glycopeptide is synthesized through a
solid-phase polypeptide synthesis method, the second glycopeptide can be subjected to structural modification, and the second glycopeptide can be obtained. The structural modification method comprises the following steps: connecting polypeptide fragments through natural chemical connection and
serine /
threonine chemical connection reaction, or extending sugar chains through an enzymic method; and finally, performing deprotection and
cracking to obtain a target product.