414 results about "Calcium biphosphate" patented technology

The invention discloses ultra-high performance concrete and a preparation method thereof. The ultra-high performance concrete comprises the following components in percentage by mass: 15%-25% of cement, 3%-6% of nano SiO2, 30%-35% of fly ash or steel slag powder, 35%-40% of recycled aggregate, 1%-4% of fiber, 0.5% of a microbial remediation agent and 1%-3% of nano TiO2. The preparation method comprises the following steps: S1, pretreating the recycled aggregate; and S2, packaging the microbial remediation agent: mixing the bacillus pasteurii spores with calcium lactate, and wrapping the mixture in calcium phosphate microspheres. S3, step-by-step stirring; S3.1, dry mixing: uniformly stirring the cement, the fly ash, the nano SiO2, the nano TiO2 and the recycled aggregate; s3.2, wet mixing is carried out, water solution fibers containing the polycarboxylic acid water reducing agent are added, uniform stirring is carried out, and the water-binder ratio of the water solution containing the polycarboxylic acid water reducing agent is 0.18; s3.3, final mixing: adding the packaged microbial remediation agent, and uniformly stirring; and S4, directional curing: performing steam curing at 80 DEG C for 48 hours, performing ultraviolet irradiation, and performing constant-temperature and constant-humidity curing for 7 days. The ultra-high performance concrete has the effects of low cost, low carbon emission, multi-function integration and repeatable crack self-repairing.

The invention relates to the technical field of sludge reduction and resource utilization, in particular to a method for resource utilization of sludge gasification slag. According to the method, municipal sludge gasification slag is smashed and then subjected to acid leaching, acid leaching liquid and acid leaching slag are obtained, iron in the acid leaching liquid is recycled, meanwhile, the acid leaching slag is subjected to alkaline leaching, under the strong alkaline condition, a calcium source is added into alkaline leaching liquid, then calcium phosphate sediment can be obtained, and iron in alkaline leaching separation liquid is recycled; a calcium ion solution can be generated in the processes of recovering iron in the pickle liquor and refining calcium phosphate, and the obtained calcium ion solution can be used as a calcium source for comprehensive utilization. The method disclosed by the invention can be used for realizing extraction and resource utilization of phosphorus, iron, aluminum and calcium in the sludge gasification slag, and has important significance on environmental protection and resource saving.

The invention discloses a compound feed for raising plateau live pigs and a preparation method thereof, and relates to the technical field of feed processing. The compound feed for raising the plateau live pigs is prepared from manganese-selenium compound modified charcoal, soybean polysaccharide polylysine-based supported nanoparticles, aspergillus oryzae, soybean meal powder, corn flour, wheat bran, mountain flour, calcium hydrophosphate, table salt and multivitamins. Manganese-selenium composite modified charcoal, soybean polysaccharide polylysine-based supported nanoparticles and aspergillus oryzae are subjected to co-fermentation culture to form a uniform, stable, loose and porous three-dimensional network fermentation substrate composite system, so that the damage of gastric acid to components is reduced, the targeted release of intestinal tracts is realized, and the bioavailability is improved. The composite functional additive which is high in nutrition, easy to absorb, anti-oxidation, anti-anemia, anti-ultraviolet radiation and the like is obtained, and the adverse effects of low temperature, oxygen deficit and ultraviolet factors on animal growth and feed oxidative rancidity are effectively reduced.

The invention relates to a curcumin-loaded MMP response type melittin nano-pellicle vesicle as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: firstly, preparing curcumin entrapped lipidosome; then carrying out culture amplification on engineering bacteria carrying melittin recombinant plasmids, extracting cell membranes after removing cell walls, and carrying out ultrasonic treatment and membrane extrusion to obtain melittin cell membrane nano-vesicles; fusing the curcumin lipidosome and the cell membrane nano-vesicles in an ultrasonic extrusion mode to obtain fused vesicles; and finally, carrying out surface calcium phosphate mineralization treatment on the fused vesicles to obtain the curcumin-loaded MMP response type melittin nano pellicle vesicles. The nano mycofilm vesicle prepared by the invention can be used for preparing antitumor drugs, and the biocompatibility and in-vivo stability of nanoparticles are improved by introducing a calcium phosphate coating; through combined delivery of melittin and curcumin, the anti-tumor effect is enhanced, so that the growth and proliferation of tumor cells are inhibited.

The invention belongs to the field of feeds, and discloses a biological feed containing a microbial microcapsule preparation and a preparation method of the biological feed. The biological feed is prepared from the following components in parts by weight: 90 to 93 parts of wall-broken rhodopseudomonas palustris powder, 2 to 3 parts of lysine hydrochloride, 0.1 to 0.5 part of methionine, 0.1 to 0.5 part of threonine, 0.3 to 1 part of arginine, 2 to 3 parts of calcium hydrophosphate, 1 to 2 parts of calcium carbonate, 0.5 to 1.2 parts of an antioxidant additive, 0.3 to 0.8 part of modified nano montmorillonite and 1 to 5 parts of a microbial microcapsule preparation. According to the biological feed, the wall-broken rhodopseudomonas palustris serves as basic nutrition and a main microorganism source of the feed and is matched with the compound probiotics of the microorganism micro-capsule preparation, the intestinal nutrition utilization rate is effectively increased, meanwhile, the antioxidant additive is added, and the problems that a single additive is narrow in function and prone to oxidation are solved; the modified nano montmorillonite is added to solve the problem of antagonism of toxin adsorption and mineral absorption.

The invention discloses a preparation method for simultaneously and efficiently extracting crocodile polypeptide and crocodile oil, and relates to the technical field of biological extraction, crocodile meat is used as a raw material, and heating micro-pressure treatment is sequentially performed to promote component dissolution; a multi-stage enzymolysis process is adopted, alkaline protease, neutral protease and lipase are sequentially used, and a calcium phosphate system is used for assisting filtration and a natural antioxidant is added in a gradient manner in the enzymolysis process; performing plate frame filtration and standing layering subsequently to realize crude separation of the oil peptide; finally, the crocodile polypeptide liquid is subjected to multi-stage membrane filtration and spray drying, the crocodile crude oil is subjected to ultrasonic-assisted fishy smell removal, ceramic membrane fine filtration and gradient cooling phase change refining, and after enzymolysis treatment and before filtration, a composite additive is added into enzymatic hydrolysate and stirred. No organic solvent exists in the whole process, and the product yield, purity and oxidation stability are remarkably improved.

The invention discloses a grading reaction crystallization recovery process and system for semiconductor fluorine-containing and phosphorus-containing waste liquid, the fluorine-containing and phosphorus-containing waste liquid and a lime solution react in a fluorine recovery crystallization reactor under the condition that the pH is 3-4 to form calcium fluoride crystals, and the calcium fluoride crystals are dehydrated to obtain calcium fluoride particle crystal products; the effluent of the fluorine recovery crystallization reactor, the calcium fluoride crystal dehydration filtrate, the lime solution and the calcium chloride solution react in a secondary reaction tank under the condition that the pH is 5-6, and calcium fluoride, fluorapatite, silicon dioxide and silicon-aluminum precipitates are removed through coagulation, flocculation and precipitation; effluent of the second-stage reaction tank, the lime solution and the calcium chloride solution react in the phosphorus recovery crystallization reactor under the condition that the pH is 7-8 to generate hydroxyapatite crystals, and the hydroxyapatite crystals are dehydrated to obtain hydroxyl calcium phosphate particle crystal products. Meanwhile, a high-purity calcium fluoride crystal product and a hydroxyl calcium phosphate crystal product are produced, and fluorine and phosphorus are recycled.

The invention discloses a method for preparing lithium phosphate with high efficiency and low cost, which comprises the following steps: roasting spodumene concentrate and phosphoric acid, and carrying out slurrying leaching and solid-liquid separation to obtain a lithium dihydrogen phosphate solution; the method comprises the following steps: evaporating and concentrating a lithium dihydrogen phosphate solution, regulating the pH value of the lithium dihydrogen phosphate solution to 7-8 by adopting ammonia water, adding calcium phosphate seed crystals, inducing to remove residual calcium ions and magnesium ions in the solution, and carrying out solid-liquid separation to obtain a phosphate solution containing lithium ions; and then adjusting the pH value back to 11-13 by adopting alkali for lithium precipitation to obtain a lithium phosphate solid, and washing and drying to obtain a battery-grade lithium phosphate product. According to the preparation process of the lithium phosphate, the spodumene is acidized and roasted by adopting phosphoric acid, and pulpified and leached, and calcium ions and magnesium ions in a solution are directly induced by adopting calcium phosphate seed crystals to form crystals to be separated out on the basis of a weakly alkaline condition, so that the process steps are simple and convenient, the subsequent purification procedure is omitted, and the preparation process is more suitable for industrialization; meanwhile, the lithium phosphate product with high purity and high yield can be obtained through the simple and convenient process, the purity can reach 99.5% or above, and the yield can reach 92% or above.

The invention discloses microcapsule powder for covering the oil smell of euphausia superba oil and a preparation method of the microcapsule powder, and belongs to the field of euphausia superba oil processing. The microcapsule powder is composed of 50-75% of OSA starch, 10-30% of euphausia superba oil, 3-20% of sodium alginate, 1-10% of succinic acid and 0.5-5% of calcium hydrophosphate, during preparation, the OSA starch is gelatinized and then sheared and homogenized with the euphausia superba oil to obtain a miniemulsion, the succinic acid, the sodium alginate and the calcium hydrophosphate are prepared into a mixed solution, the mixed solution is mixed with the miniemulsion in proportion, and spray drying is performed to obtain a finished product. An OSA starch-sodium alginate double-wall material system is adopted, a compact cross-linked layer is formed through pH response, peculiar smell substances such as trimethylamine can be completely masked, the astaxanthin retention rate is up to 95.14%, the embedding rate reaches 89.48%, krill oil oxidation is effectively inhibited, krill oil is converted into powder, the stability and the sensory property are improved, application of krill oil in the food field is widened, the technology is simple, and the method is suitable for industrial production. The method is suitable for industrial production.

The invention relates to the technical field of biomedical materials, in particular to multi-material 3D printing bionic gradient soft-hard integrated hydrogel as well as a preparation method and application thereof. Based on a copolymerization system of high-strength supramolecular N-acryloylglycinamide and vinyl phosphoric acid, an NAGA aqueous solution and an NAGA-VPA aqueous solution are printed into hydrogel of a gradient structure by adopting a DLP multi-material printing technology, then the hydrogel is sequentially soaked in a calcium-phosphorus mixed aqueous solution (Ca / P = 1.67), ammonia water, a calcium chloride aqueous solution and deionized water, and the hydrogel is prepared through a hydrothermal method. Therefore, in-situ gradient deposition and curing of hydroxyapatite (HAP) are realized. The multi-material 3D printing bionic gradient soft-hard integrated hydrogel prepared by the method has a continuous biochemical-mechanical gradient, a surface layer low-modulus area is matched with cartilage performance, a deep layer high-mineralization area is integrated with bone tissue, the HAP crystallinity of a transition area is in spatial dependence distribution, and the hydrogel is suitable for osteochondral defect repair and manufacturing of bionic joint prostheses.

The invention relates to the technical field of building glazed tiles, in particular to an antibacterial glazed tile and a preparation method thereof.The antibacterial glazed tile comprises a green body layer and an antibacterial glaze layer which are sequentially arranged from bottom to top; wherein the antibacterial glaze layer is obtained by calcining antibacterial glaze; the antibacterial glaze is prepared from the following raw materials: high-temperature antibacterial frit, calcined kaolin, corundum, quartz, dolomite, calcined talc, strontium carbonate, wollastonite, potassium feldspar and albite; the high-temperature antibacterial frit is prepared from the following raw materials: zirconium silicate, a silver antibacterial agent, calcined aluminum oxide, calcined talc, quartz, wollastonite, kaolin, calcium phosphate, potassium feldspar, albite, boric acid and lithium carbonate. According to the antibacterial glazed tile and the preparation method thereof provided by the invention, the formula of the antibacterial glaze is optimized, so that the antistatic property and the corrosion resistance can be improved on the premise of ensuring the antibacterial property of the antibacterial glazed tile.

The invention relates to the technical field of seed coating materials, and discloses a wheat and rice seed coating material and a coating process. The wheat and rice seed coating material comprises micron iron powder, nano calcium phosphate, nano magnesium hydroxide and a binder, the addition amounts of the micron iron powder, the nano calcium phosphate and the nano magnesium hydroxide respectively account for 10%-20%, 2%-10% and 3%-10% of the total weight of the seeds; the binder is at least one of a polyvinyl alcohol colloidal solution, a carboxymethyl cellulose colloidal solution and a hydroxypropyl methyl cellulose colloidal solution. The invention also provides a coating process of the wheat and rice seed coating material. The coating material disclosed by the invention not only can protect seeds, but also can efficiently adsorb and fix heavy metal ions of lead, cadmium and arsenic after the micron iron powder, the nano calcium phosphate and the nano magnesium hydroxide are slowly released in soil, so that integrated prevention and control from'seeds' to'rhizosphere 'is realized.

The application provides a radionuclide nanohydrogel microneedle and a preparation method and application thereof, and belongs to the field of nanobiomedicine. 32 P-labeled calcium phosphate, which is formed by a biomimetic reaction of Ag2S@Ca 32 P nanoparticles, and a base layer which is a base matrix and comprises hyaluronic acid 32 P nanohydrogel microneedle can release Ag2S nanoparticles in response to a weakly acidic tumor environment, and under the irradiation of near-infrared light, the photothermal conversion efficiency can effectively kill bacteria, effectively improve the tumor hypoxic environment, enhance the treatment effect of radionuclides, play an antibacterial and wound healing promoting role in melanoma defect repair, and maximize the inhibition of tumor growth and tumor recurrence.

The invention discloses a preparation method of a pesticide pollution remediation agent for groundwater of karst landforms, and relates to the technical field of groundwater pollution remediation. The method has the effect of enhancing pesticide degradation, pesticide pollutants can be efficiently degraded in a complex environment of karst underground water by compounding hard water-resistant fungi, dehalogenation bacteria and denitrifying bacteria, and a better remediation effect is achieved; the medicament can improve the stability and the adsorption capacity of the carrier, the bionic calcium phosphate nano carrier is adopted, the specific surface area is high, the adsorption capacity is excellent, the adsorption capacity on pollutants can be effectively enhanced, and the remediation effect is improved; the agent has an efficient repairing mechanism, the load capacity of the flora is enhanced through biological induction mineralization and physical adsorption enhancement of a bacterium-carrier complex, the release rate of the flora is controlled through an intelligent coating technology, and precise repairing is achieved.

The invention discloses a method for extracting lithium from lithium precipitation mother liquor to obtain lithium phosphate, which specifically comprises the following steps of: performing preliminary extraction on the lithium precipitation mother liquor, performing reverse extraction by adopting a composite reverse extraction agent consisting of phosphoric acid and acetylacetone in a molar ratio of (5-15): 1, controlling the pH value of a reverse extraction system to be 5-7, and performing phase splitting to obtain a lithium phosphate wet product; and finally, adding the lithium phosphate wet product into lithium hydroxide for reaction, and filtering to obtain lithium phosphate. According to the method, efficient enrichment of lithium ions in the lithium precipitation mother liquor is achieved through the extraction and reverse extraction processes, meanwhile, through optimization of a reverse extraction system in the reverse extraction process, formation of calcium phosphate impurities is reduced, the extraction purity of lithium is improved, the morphology of lithium phosphate can be regulated and controlled in the reverse extraction process, batch stability is achieved, and the product quality is improved.

The invention discloses white dry granules with a multi-layer three-dimensional effect and a preparation method thereof, and relates to the technical field of building ceramic materials. The white dry granules with the multi-layer three-dimensional effect are prepared from a frit base material and a rare earth calcium phosphate additive, rare earth and calcium phosphate are added into a frit base material to serve as an additive, the high refractive index of oxides of La < 3 + > and Ce < 3 + > is utilized, refractive index difference is formed between the oxides of La < 3 + > and Ce < 3 + > and the frit base material, and light rays are subjected to multiple scattering and refraction at an interface; and meanwhile, the refractive index gradient is formed through particle size grading synergism, the reflection and refraction paths of light rays among particles with different particle sizes are different, and the visual'depth sense 'is generated. The additive is uniformly dispersed to ensure the consistent optical effect and avoid local over-brightness or over-darkness; due to the high refractive index of rare earth ions, light scattering is enhanced, and whiteness is improved; grain size distribution and light scattering are cooperated to form a multi-layer stereoscopic visual effect of bottom-layer framework support, middle-layer transition connection and top-layer fineness and brightness, and the decoration is enhanced.

The invention discloses a method and system for treating neutral high-calcium wastewater through combination of an MICP technology and chemical precipitation, and relates to the technical field of wastewater treatment. The method comprises the following steps: S1, inoculating a bacterial liquid containing synechocystis into neutral high-calcium wastewater; s2, under the daytime illumination condition, calcium ions in the wastewater are induced to form calcium carbonate precipitates through photosynthesis of synechocystis, and primary calcium removal is carried out; s3, under the dark condition at night, phosphate is added in batches by means of extracellular polymeric substances secreted by synechocystis, residual calcium ions in the wastewater are induced to form calcium phosphate or hydroxyapatite precipitates, and deep calcium removal is carried out. The day and night alternate metabolism characteristic of synechocystis is applied to neutral high-calcium wastewater treatment, so that efficient decalcification under a neutral condition can be realized, and stable water quality and controllable precipitation are considered. The open pond type reactor is adopted, so that water can stand and settle, mechanical stirring or temperature control equipment is not needed, and the operation cost is reduced.

The present disclosure provides a method for producing calcium nitrate from calcium lactate. The method comprises: a) providing an aqueous calcium lactate solution; b) adding phosphoric acid to the aqueous calcium lactate solution, thereby producing a first composition comprising lactic acid and calcium phosphate; c) separating the calcium phosphate from the first composition, thereby obtaining an aqueous lactic acid solution and a second solid composition comprising calcium phosphate; d) reacting the second solid composition with nitric acid, thereby obtaining a third composition comprising phosphoric acid and calcium nitrate; and e) separating the calcium nitrate from the third composition, thereby obtaining an aqueous phosphoric acid solution and a solid calcium nitrate composition.

The present disclosure provides a novel method for producing a calcium salt. The preparation method of the calcium salt provided by the technical scheme of the invention comprises the following steps. And step S20, carrying out acid treatment on the raw material containing calcium phosphate to obtain an acid extracting solution. And S30, mixing the obtained acid extracting solution with alkali to obtain calcium phosphate precipitate. And S40, mixing the obtained calcium phosphate precipitate with acid and / or salt thereof to form calcium salt.

This invention provides a DNAzyme-based nanoregulator, its preparation method, and its application, belonging to the field of breast cancer treatment technology. The preparation method of this invention comprises the following steps: using GOx as a template, manganese-doped calcium phosphate is synthesized via a one-step biomimetic mineralization method; a DNAzyme nucleic acid sequence is loaded onto the surface of the manganese-doped calcium phosphate to obtain an empty calcium nanoregulator; and DOX is loaded into the DNAzyme nucleic acid sequence to obtain the calcium nanoregulator. The DNAzyme-based calcium nanoregulator of this invention can perform multiple combined therapies: in the acidic microenvironment of the tumor, GOx can effectively convert glucose into H2O2 for subsequent Mn2 production. 2+ The Fenton-like catalytic reaction mediated by the calcium nano-modulator effectively consumes glucose and generates ·OH; in vivo experiments showed that the combination of calcium nano-modulators with DOX chemotherapy achieved a high tumor-suppressing effect.

The invention provides a bifunctional polymer stabilized calcium phosphate precursor nano-material, a preparation method thereof and application of the bifunctional polymer stabilized calcium phosphate precursor nano-material in surface modification of a PPESK coating. The bifunctional polymer stabilized calcium phosphate precursor nano-material comprises the following components according to concentration: a bifunctional polymer with the concentration of 0.05-0.2 g / mL; the concentration of PO4 < 3-> is 0.05 to 0.5 mol / L; the concentration of Ca < 2 + > is 0.05-0.5 mol / L, and the solvent is deionized water; the diameter of the calcium phosphate precursor nano material is 20 to 100 nm. The preparation method comprises the following steps: preparing a polyacrylamide block polymer by adopting free radical polymerization, and then grafting a calcium chelating agent to obtain a bifunctional polymer; combining the difunctional polymer with a calcium-phosphorus solution to prepare a difunctional polymer stabilized calcium phosphate precursor nano material; according to the invention, the polymer is endowed with calcium chelating ability and collagenous fiber binding ability, so that the material can enter the collagenous fiber to be fully mineralized, the surface of the PPESK coating is mineralized, the biocompatibility of the material is improved, the material has osteogenesis promoting ability, and the material has a wide application prospect in the aspect of bone implant materials.

The application discloses a bone cement for orthopedic repair and a preparation method thereof, and relates to the technical field of bone cement.The bone cement for orthopedic repair comprises solid-phase powder and liquid-phase components; the solid-phase powder comprises the following components in parts by weight: 55-65 parts of composite calcium phosphate salt, 10-15 parts of bioactive glass, 2-3 parts of developing agent, 1-2 parts of hydroxyapatite, 8-12 parts of modified toughening agent and 2-3 parts of nanocellulose fiber; and the liquid-phase components comprise the following components in parts by weight: 40-50 parts of sodium alginate solution, 10-20 parts of methacrylated gelatin, 0.5-1 part of transglutaminase, 30-60 parts of citric acid buffer and 1-2 parts of antibacterial agent. The intermediate 1 is obtained by the reaction of pentaerythritol and 12-oxododecanoic acid, and the modified toughening agent is prepared by the reaction of the intermediate 1 and dopamine. The bone cement for orthopedic repair prepared by the application has good mechanical properties, self-repairing performance and antibacterial performance.

The application relates to an in-situ composite preparation method of a calcium phosphate / boron nitride high-temperature wave-absorbing material and application thereof, and belongs to the technical field of wave-absorbing materials. The method solves the problem that traditional insulator materials boron nitride have no electromagnetic wave absorption capacity. The method comprises the following steps: preparing Ca3(PO4)2 ion oligomers; preparing Ca3(PO4)2 ion oligomer gel; preparing a transparent hot solution of melamine diboric acid, then mixing the transparent hot solution of melamine diboric acid with the Ca3(PO4)2 ion oligomer gel, and then cooling, centrifuging, drying and sintering, so that the preparation is completed. The calcium phosphate / boron nitride high-temperature wave-absorbing material is prepared by adopting the in-situ composite mode, the process is simple, the cost is low, the process is green and pollution-free; the wave-transparent boron nitride material is converted into a wave-absorbing material through the simple composite of inorganic non-metallic substances, the balanced magnetic property and polarization effect of the material are matched with each other, high-strength and wide-band electromagnetic wave absorption performance is finally realized, and meanwhile, the lightweight and high-temperature-resistant characteristics of boron nitride are maintained.

The application discloses fluorescent molecules, calcium phosphate nanoparticles thereof, and a preparation method and application thereof. Specifically, the application discloses a compound as shown in formula I, or a salt thereof. The calcium phosphate nanoparticles formed by the fluorescent molecules provided by the application have both improved fluorescence quantum yield and metabolic rate.

The invention discloses a bio-based composite activating aid for producing active calcium phosphate by utilizing renewable resources as well as a preparation method and application of the bio-based composite activating aid, and belongs to the technical field of active calcium phosphate preparation. The bio-based composite active auxiliary agent is prepared from the following raw material components in parts by mass: 20 to 40 parts of bio-based organic acid or bio-based organic acid salt, 15 to 30 parts of polysaccharide or a derivative thereof, 25 to 45 parts of alkali metal silicate and 5 to 15 parts of alkali metal carbonate. According to the invention, the bio-based composite activating auxiliary agent is prepared through synergism of multiple components, and the bio-based composite activating auxiliary agent is matched with the phosphorus-containing solid waste to prepare the active calcium phosphate, so that integration of high-valued renewable resources, high performance of the active calcium phosphate and performance upgrading of electronic ceramics is realized, meanwhile, the auxiliary agent is ensured to be green and non-toxic, and is adaptive to various scenes, and the production cost and the environmental risk are reduced.

The purpose of the present invention is to provide a dialysis membrane capable of removing CPPs while suppressing a reduction in minerals and capable of being suitably used for blood processing including the adsorption of CPPs. The present invention pertains to a dialysis membrane comprising a hollow fiber membrane or a semipermeable membrane which is a flat membrane, wherein said dialysis membrane is used for blood processing including the adsorption of calciprotein particles which are complexes of calcium phosphate and proteins, and has a compound (A) in which a film-forming polymer constituting the semipermeable membrane has, in a portion other than terminals of a main chain, at least one electron-donating group selected from the group consisting of an amino group, a carboxy group, a phosphoric acid group, a phosphono group, a phosphino group, and a thiol group, and / or has, separately from the semipermeable membrane, at least one electron-donating group selected from the group consisting of an amino group, a carboxy group, a phosphoric acid group, a phosphono group, a phosphino group, and a thiol group.

The present invention is situated in the field of mineral micro-particles selected from the list consisting of aluminum hydroxide, aluminum phosphate, amorphous aluminium hydroxyphosphate and calcium phosphate micro-particles. More particularly, the invention provides organically-derivatized mineral micro-particles, uses thereof, and methods of preparing the same.

The application discloses a kind of composite materials for 3D printing wild animal skeleton, which is composed of composite nanoparticles of calcium phosphate and hydroxyapatite, and is prepared by a combined method of biomimetic in-situ synthesis-solvent thermal phase inversion-spray drying method.The composite material has high specific surface area and excellent fluidity, and can be used for 3D printing wild animal skeleton, with broad market application prospect.

The invention discloses a cation-doped biphase calcium phosphate material and a preparation method and application thereof.The preparation method comprises the steps that a chemical precipitation method is adopted, the reaction process is precisely regulated and controlled, firstly, a reaction is carried out in an acidic microenvironment with the pH being 2-6, then aging is carried out under the alkaline condition with the pH being 9-12, and a two-step pH precise control strategy that acidity is carried out first and then alkalinity is carried out is adopted, so that the cation-doped biphase calcium phosphate material is obtained. According to the strategy, thermodynamic interference of cation doping on the HA / beta-TCP phase proportion can be effectively counteracted, and stable control over product phase composition is achieved. The preparation method has the core advantages that the proportion of hydroxyapatite (HA) to beta-tricalcium phosphate (beta-TCP) in the prepared biphase calcium phosphate material is highly stable, and the proportion does not obviously fluctuate in a specific range of the cation doping amount due to the change of the doping amount or cation types; the problem that the phase proportion is uncontrollable due to doping in the prior art is solved.

One embodiment of the present specification provides a method for preparing a low-crystallinity calcium phosphate-based antibacterial bone graft material, comprising the steps of: (a) adding a calcium precursor and a phosphate precursor at one time to synthesize calcium phosphate; (b) putting the calcium phosphate into an antibacterial substance precursor solution to react; (c) a step of freeze-drying the product of step (b); (d) a step of mixing the product of step (c) with a shape control agent and performing press molding to prepare a molded body; and (e) a step in which the shape control agent of the molded body is removed in a solvent having a temperature equal to or higher than the boiling point and then dried.