235 results about "Calcium biphosphate" patented technology

The invention relates to a curcumin-loaded MMP response type melittin nano-pellicle vesicle as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: firstly, preparing curcumin entrapped lipidosome; then carrying out culture amplification on engineering bacteria carrying melittin recombinant plasmids, extracting cell membranes after removing cell walls, and carrying out ultrasonic treatment and membrane extrusion to obtain melittin cell membrane nano-vesicles; fusing the curcumin lipidosome and the cell membrane nano-vesicles in an ultrasonic extrusion mode to obtain fused vesicles; and finally, carrying out surface calcium phosphate mineralization treatment on the fused vesicles to obtain the curcumin-loaded MMP response type melittin nano pellicle vesicles. The nano mycofilm vesicle prepared by the invention can be used for preparing antitumor drugs, and the biocompatibility and in-vivo stability of nanoparticles are improved by introducing a calcium phosphate coating; through combined delivery of melittin and curcumin, the anti-tumor effect is enhanced, so that the growth and proliferation of tumor cells are inhibited.

The invention discloses a grading reaction crystallization recovery process and system for semiconductor fluorine-containing and phosphorus-containing waste liquid, the fluorine-containing and phosphorus-containing waste liquid and a lime solution react in a fluorine recovery crystallization reactor under the condition that the pH is 3-4 to form calcium fluoride crystals, and the calcium fluoride crystals are dehydrated to obtain calcium fluoride particle crystal products; the effluent of the fluorine recovery crystallization reactor, the calcium fluoride crystal dehydration filtrate, the lime solution and the calcium chloride solution react in a secondary reaction tank under the condition that the pH is 5-6, and calcium fluoride, fluorapatite, silicon dioxide and silicon-aluminum precipitates are removed through coagulation, flocculation and precipitation; effluent of the second-stage reaction tank, the lime solution and the calcium chloride solution react in the phosphorus recovery crystallization reactor under the condition that the pH is 7-8 to generate hydroxyapatite crystals, and the hydroxyapatite crystals are dehydrated to obtain hydroxyl calcium phosphate particle crystal products. Meanwhile, a high-purity calcium fluoride crystal product and a hydroxyl calcium phosphate crystal product are produced, and fluorine and phosphorus are recycled.

The invention discloses microcapsule powder for covering the oil smell of euphausia superba oil and a preparation method of the microcapsule powder, and belongs to the field of euphausia superba oil processing. The microcapsule powder is composed of 50-75% of OSA starch, 10-30% of euphausia superba oil, 3-20% of sodium alginate, 1-10% of succinic acid and 0.5-5% of calcium hydrophosphate, during preparation, the OSA starch is gelatinized and then sheared and homogenized with the euphausia superba oil to obtain a miniemulsion, the succinic acid, the sodium alginate and the calcium hydrophosphate are prepared into a mixed solution, the mixed solution is mixed with the miniemulsion in proportion, and spray drying is performed to obtain a finished product. An OSA starch-sodium alginate double-wall material system is adopted, a compact cross-linked layer is formed through pH response, peculiar smell substances such as trimethylamine can be completely masked, the astaxanthin retention rate is up to 95.14%, the embedding rate reaches 89.48%, krill oil oxidation is effectively inhibited, krill oil is converted into powder, the stability and the sensory property are improved, application of krill oil in the food field is widened, the technology is simple, and the method is suitable for industrial production. The method is suitable for industrial production.

The invention relates to the technical field of biomedical materials, in particular to multi-material 3D printing bionic gradient soft-hard integrated hydrogel as well as a preparation method and application thereof. Based on a copolymerization system of high-strength supramolecular N-acryloylglycinamide and vinyl phosphoric acid, an NAGA aqueous solution and an NAGA-VPA aqueous solution are printed into hydrogel of a gradient structure by adopting a DLP multi-material printing technology, then the hydrogel is sequentially soaked in a calcium-phosphorus mixed aqueous solution (Ca / P = 1.67), ammonia water, a calcium chloride aqueous solution and deionized water, and the hydrogel is prepared through a hydrothermal method. Therefore, in-situ gradient deposition and curing of hydroxyapatite (HAP) are realized. The multi-material 3D printing bionic gradient soft-hard integrated hydrogel prepared by the method has a continuous biochemical-mechanical gradient, a surface layer low-modulus area is matched with cartilage performance, a deep layer high-mineralization area is integrated with bone tissue, the HAP crystallinity of a transition area is in spatial dependence distribution, and the hydrogel is suitable for osteochondral defect repair and manufacturing of bionic joint prostheses.

The invention relates to the technical field of seed coating materials, and discloses a wheat and rice seed coating material and a coating process. The wheat and rice seed coating material comprises micron iron powder, nano calcium phosphate, nano magnesium hydroxide and a binder, the addition amounts of the micron iron powder, the nano calcium phosphate and the nano magnesium hydroxide respectively account for 10%-20%, 2%-10% and 3%-10% of the total weight of the seeds; the binder is at least one of a polyvinyl alcohol colloidal solution, a carboxymethyl cellulose colloidal solution and a hydroxypropyl methyl cellulose colloidal solution. The invention also provides a coating process of the wheat and rice seed coating material. The coating material disclosed by the invention not only can protect seeds, but also can efficiently adsorb and fix heavy metal ions of lead, cadmium and arsenic after the micron iron powder, the nano calcium phosphate and the nano magnesium hydroxide are slowly released in soil, so that integrated prevention and control from'seeds' to'rhizosphere 'is realized.

The application provides a radionuclide nanohydrogel microneedle and a preparation method and application thereof, and belongs to the field of nanobiomedicine. 32 P-labeled calcium phosphate, which is formed by a biomimetic reaction of Ag2S@Ca 32 P nanoparticles, and a base layer which is a base matrix and comprises hyaluronic acid 32 P nanohydrogel microneedle can release Ag2S nanoparticles in response to a weakly acidic tumor environment, and under the irradiation of near-infrared light, the photothermal conversion efficiency can effectively kill bacteria, effectively improve the tumor hypoxic environment, enhance the treatment effect of radionuclides, play an antibacterial and wound healing promoting role in melanoma defect repair, and maximize the inhibition of tumor growth and tumor recurrence.

The invention discloses a method for extracting lithium from lithium precipitation mother liquor to obtain lithium phosphate, which specifically comprises the following steps of: performing preliminary extraction on the lithium precipitation mother liquor, performing reverse extraction by adopting a composite reverse extraction agent consisting of phosphoric acid and acetylacetone in a molar ratio of (5-15): 1, controlling the pH value of a reverse extraction system to be 5-7, and performing phase splitting to obtain a lithium phosphate wet product; and finally, adding the lithium phosphate wet product into lithium hydroxide for reaction, and filtering to obtain lithium phosphate. According to the method, efficient enrichment of lithium ions in the lithium precipitation mother liquor is achieved through the extraction and reverse extraction processes, meanwhile, through optimization of a reverse extraction system in the reverse extraction process, formation of calcium phosphate impurities is reduced, the extraction purity of lithium is improved, the morphology of lithium phosphate can be regulated and controlled in the reverse extraction process, batch stability is achieved, and the product quality is improved.

The invention discloses a method and system for treating neutral high-calcium wastewater through combination of an MICP technology and chemical precipitation, and relates to the technical field of wastewater treatment. The method comprises the following steps: S1, inoculating a bacterial liquid containing synechocystis into neutral high-calcium wastewater; s2, under the daytime illumination condition, calcium ions in the wastewater are induced to form calcium carbonate precipitates through photosynthesis of synechocystis, and primary calcium removal is carried out; s3, under the dark condition at night, phosphate is added in batches by means of extracellular polymeric substances secreted by synechocystis, residual calcium ions in the wastewater are induced to form calcium phosphate or hydroxyapatite precipitates, and deep calcium removal is carried out. The day and night alternate metabolism characteristic of synechocystis is applied to neutral high-calcium wastewater treatment, so that efficient decalcification under a neutral condition can be realized, and stable water quality and controllable precipitation are considered. The open pond type reactor is adopted, so that water can stand and settle, mechanical stirring or temperature control equipment is not needed, and the operation cost is reduced.

The present disclosure provides a novel method for producing a calcium salt. The preparation method of the calcium salt provided by the technical scheme of the invention comprises the following steps. And step S20, carrying out acid treatment on the raw material containing calcium phosphate to obtain an acid extracting solution. And S30, mixing the obtained acid extracting solution with alkali to obtain calcium phosphate precipitate. And S40, mixing the obtained calcium phosphate precipitate with acid and / or salt thereof to form calcium salt.

The application discloses fluorescent molecules, calcium phosphate nanoparticles thereof, and a preparation method and application thereof. Specifically, the application discloses a compound as shown in formula I, or a salt thereof. The calcium phosphate nanoparticles formed by the fluorescent molecules provided by the application have both improved fluorescence quantum yield and metabolic rate.

The invention discloses a bio-based composite activating aid for producing active calcium phosphate by utilizing renewable resources as well as a preparation method and application of the bio-based composite activating aid, and belongs to the technical field of active calcium phosphate preparation. The bio-based composite active auxiliary agent is prepared from the following raw material components in parts by mass: 20 to 40 parts of bio-based organic acid or bio-based organic acid salt, 15 to 30 parts of polysaccharide or a derivative thereof, 25 to 45 parts of alkali metal silicate and 5 to 15 parts of alkali metal carbonate. According to the invention, the bio-based composite activating auxiliary agent is prepared through synergism of multiple components, and the bio-based composite activating auxiliary agent is matched with the phosphorus-containing solid waste to prepare the active calcium phosphate, so that integration of high-valued renewable resources, high performance of the active calcium phosphate and performance upgrading of electronic ceramics is realized, meanwhile, the auxiliary agent is ensured to be green and non-toxic, and is adaptive to various scenes, and the production cost and the environmental risk are reduced.

The present invention is situated in the field of mineral micro-particles selected from the list consisting of aluminum hydroxide, aluminum phosphate, amorphous aluminium hydroxyphosphate and calcium phosphate micro-particles. More particularly, the invention provides organically-derivatized mineral micro-particles, uses thereof, and methods of preparing the same.

The application discloses a kind of composite materials for 3D printing wild animal skeleton, which is composed of composite nanoparticles of calcium phosphate and hydroxyapatite, and is prepared by a combined method of biomimetic in-situ synthesis-solvent thermal phase inversion-spray drying method.The composite material has high specific surface area and excellent fluidity, and can be used for 3D printing wild animal skeleton, with broad market application prospect.

One embodiment of the present specification provides a method for preparing a low-crystallinity calcium phosphate-based antibacterial bone graft material, comprising the steps of: (a) adding a calcium precursor and a phosphate precursor at one time to synthesize calcium phosphate; (b) putting the calcium phosphate into an antibacterial substance precursor solution to react; (c) a step of freeze-drying the product of step (b); (d) a step of mixing the product of step (c) with a shape control agent and performing press molding to prepare a molded body; and (e) a step in which the shape control agent of the molded body is removed in a solvent having a temperature equal to or higher than the boiling point and then dried.

A bone substitute composition includes a bone substitute matrix and a conditioning solution. The bone substitute matrix includes 85% to 98% by weight of alkaline calcium phosphate powder, 1% to 10% by weight of a polymer, and 1% to 5% by weight of a crosslinker. The conditioning solution includes 90% to 97% by weight of water, 1% to 5% by weight of a phosphate, and 1% to 5% by weight of a water-soluble acidic compound.

The invention discloses a laboratory mouse feed and a preparation method thereof. The feed consists of the following raw materials in percentage by weight: 32-38% of corn flour, 22-28% of fermented soybean meal, 8-12% of fish meal, 4-6% of silkworm chrysalis meal, 10-15% of low-gluten wheat flour, 2-3% of purple perilla seed oil, 1.5-2.5% of calcium carbonate, 0.8-1.2% of calcium hydrophosphate, 0.3-0.5% of table salt, 0.8-1.2% of microencapsulated compound vitamins, 0.2-0.4% of an enzyme preparation compound, 3-5% of dietary fibers and the balance of mineral premix. The preparation method has the beneficial effects that the vitamin retention rate of the technical scheme is increased by 30-40% compared with a contrast, and the problem of nutrient loss caused by a traditional high-temperature process is solved; the water uniformity is improved by 68% through gradient cooling, the quality guarantee period is prolonged from 50 days to 85-95 days in combination with a microencapsulation technology, and the storage loss is reduced.

The invention relates to the technical field of conveying equipment, in particular to a bagged calcium hydrophosphate conveying and position adjusting device which comprises a rack. An incoming material conveying belt and a discharging conveying belt are arranged on the rack and form an included angle, and the discharging end of the incoming material conveying belt is higher than the feeding end of the discharging conveying belt; a pushing-over mechanism is arranged on the rack and comprises an L-shaped bearing frame, a pushing frame and a driving air cylinder. The two ends of the L-shaped bearing frame are hinged to the rack and the back face of the push frame respectively. The end, away from the L-shaped bearing frame, of the push frame is vertically hinged to the rack in a sliding mode. The mounting end of the driving air cylinder is hinged to the rack, and the telescopic end is hinged to the back face of the L-shaped bearing frame; the end, facing the L-shaped bearing frame, of the push frame extends to be provided with a push arm. The rack is provided with a sliding way communicated with the discharging conveying belt. The bagged calcium hydrophosphate conveying and position adjusting device can stably convert bagged materials from a vertical state to a lodging state, the conversion process is stable, and the posture is accurate.

The invention discloses a hydraulic antibacterial paste material as well as a preparation method and application thereof. The hydrogel antibacterial paste material is obtained by mixing a powder raw material and a liquid raw material which accounts for 30-35 wt% of the mass of the powder raw material, the hydrogel antibacterial paste material comprises the following components in percentage by mass of the powder raw material: 20-40 wt% of a calcium silicate compound, 5-40 wt% of a calcium phosphate compound, 10-40 wt% of a radiation-resistant material and 0.2-0.4 wt% of a macromolecular antibacterial agent, and the macromolecular antibacterial agent is polyhexamethylene biguanide salt. The injectable hydrogel antibacterial paste material can be used for preparing orthopedic or dental filling materials. Compared with the prior art, the antibacterial paste material not only can be self-cured, but also has excellent antibacterial performance, the preparation method is simple and quick, and the antibacterial paste material can be applied to the field of dental or orthopedic repair.

The invention relates to a sliding material based on PTFE polymer with a filler to improve the friction properties, wherein the filler comprises at least one phosphate, in particular calcium phosphate, calcium pyrophosphate, magnesium phosphate, magnesium pyrophosphate, lithium phosphate, hydroxyapatite or combinations thereof, and at least one metal sulfide, wherein the proportion of metal sulfide is > 2%. The invention also relates to the use of the sliding material.

The application discloses a degradable organic-inorganic composite film and a preparation method and application thereof, and belongs to the technical field of composite materials. The method comprises the following steps: (1) preparing a calcium phosphate nanocluster precursor by using an organic amine stabilizer, a calcium source, a phosphorus source and an organic solvent, and further separating the calcium phosphate nanocluster; (2) mixing the calcium phosphate nanocluster and a natural polymer material to prepare a uniformly dispersed emulsion, wherein the natural polymer material comprises carboxymethyl chitosan and an alginate, and film is prepared by using the emulsion; in the film preparation process, an evaporation-induced self-assembly process occurs, the calcium phosphate nanocluster is phase changed into crystalline rod-shaped hydroxyapatite nanocrystals, and the natural polymer material is combined, so that the degradable organic-inorganic composite film is obtained. The mechanical property of the organic-inorganic composite film is adjustable, the organic-inorganic composite film can be directly degraded in soil, and has a wide application prospect in the fields of packaging, agriculture, medical treatment and the like.

The utility model discloses grinding equipment for superfine calcium hydrophosphate production, which belongs to the field of calcium hydrophosphate production, and comprises a box body, one side of the box body is fixedly connected with a mounting frame, two sides of the box body are respectively and rotatably connected with a first bidirectional screw rod and a second bidirectional screw rod, and the outer wall of the first bidirectional screw rod is in threaded connection with a moving block. A limiting rod is fixedly connected to one side of the box body, the limiting rod is located above the first two-way screw rod, and a fixing block is in threaded connection with the outer wall of the second two-way screw rod, and in the scheme, when the first two-way screw rod and the second two-way screw rod rotate at the same time, the distance between the two grinding rollers is close to each other; by means of the design, the distance between the two grinding rollers can be adjusted, superfine calcium hydrophosphate can be obtained through grinding according to the fineness requirement, the requirements of workers under different conditions are met, and the use convenience of the device is improved.

The invention provides a bone adhesion solid-phase composition, a bone adhesive as well as a preparation method and application of the bone adhesive, and belongs to the technical field of bone repair materials. The invention provides a bone bonding solid-phase composition which comprises the following components in percentage by mass: 5-60% of phosphoserine, 10-80% of calcium phosphate and 5-50% of polyglutamic acid. According to the invention, by adding the polyglutamic acid and utilizing the chelation of the polyglutamic acid and calcium ions, the polyglutamic acid is adsorbed on the surface of the powder to form steric hindrance, the viscosity is improved, the ion diffusion is delayed, the reaction rate of calcium phosphate and phosphoserine is reduced, and the curing time is prolonged; meanwhile, due to the viscosity, the early-stage viscosity and the overall compressive strength of the material are enhanced. The result of the embodiment shows that the putty time of the bone adhesive prepared from the bone adhesive solid-phase composition provided by the invention can reach 20-70 minutes, and the adhesive strength and compressive strength are remarkably enhanced.

The application relates to the technical field of integrated circuit manufacturing, and discloses wafer thinning equipment and a thinning method. The wafer thinning equipment comprises a grinding device and an adsorption platform. The adsorption platform is used for supporting a wafer and driving the wafer to rotate. The grinding device is arranged above the adsorption platform in a lifting mode. The lower part of the grinding device is provided with a grinding wheel used for grinding the wafer. The grinding wheel comprises a base material and a plurality of grinding blocks. The grinding blocks are fixed to the base material through an adhesive layer. The grinding blocks comprise a gel ceramic combination body which has a staggered spiral stacking structure and is used for dispersing stress during grinding. The raw material of the gel ceramic combination body is a ceramic gel bonding agent which comprises calcium carbonate / calcium phosphate composite gel and chitin nanocrystals. The above technical scheme solves the problems of large total thickness deviation of the thinned wafer and easy formation of a subsurface damage layer in the related art.

This invention discloses a fermented feed for improving the natural antibacterial and antioxidant properties of duck eggs. The fermented feed is prepared through a two-stage fermentation process using a fermentation substrate comprising the following components in parts by weight: 35-60 parts corn, 15-30 parts soybean meal, 5-15 parts wheat bran, 4-10 parts rice bran, 5-9 parts extruded flaxseed, 2-6 parts grape seed meal, 1-4 parts moringa flavonoid powder, 0.5-2.5 parts dicalcium phosphate, 0.5-3 parts limestone powder, 0.1-0.5 parts salt, and 0.1-0.8 parts compound premix. The two-stage fermentation involves first inoculating with Bacillus for aerobic fermentation, followed by inoculation with lactic acid bacteria and the addition of chitosan oligosaccharides for anaerobic fermentation. This invention significantly increases the content of active proteins such as lysozyme and ovotransferrin in duck egg white, enhancing its antibacterial properties and antioxidant capacity, and providing an efficient and economical technical path for the development of highly active duck egg white raw materials.

This invention discloses a method for preparing biomimetic calcium phosphate particles carrying type III recombinant human collagen, relating to the field of new biomedical materials. The particle formulation, by mass percentage, contains 50%-90% hydroxyapatite and 10%-50% type III recombinant human collagen. The preparation process involves artificially synthesizing hydroxyapatite precipitate, then compounding it with type III recombinant human collagen. The compounded material is then spread, naturally dried, crushed, and sieved to form particles. The resulting particles have a uniform and controllable particle size. When mixed with blood or water, they can quickly form a high-viscosity, malleable, and stable filling material, directly adapting to the site preservation requirements of alveolar sockets after tooth extraction. The advantages are: the degradation rate of these particles precisely matches the bone regeneration rate after site preservation surgery, efficiently guiding bone tissue regeneration while significantly shortening the waiting period for implantation after tooth extraction. This solves the clinical promotion difficulties caused by the long waiting period and complex operation of site preservation surgery, contributing to the widespread application of this technology in oral clinical practice.

The application discloses a kind of biphasic bioactive tissue repair scaffolds and preparation method, comprising the following steps: step 1: calcium phosphate ceramic powder is modified on surface, and the modified calcium phosphate ceramic powder is obtained;Step 2: the modified calcium phosphate ceramic powder, potassium sodium niobate piezoelectric ceramic powder, dispersing agent, photoinitiator, photosensitive resin are mixed evenly, and the light-cured resin slurry is obtained after ball milling;Step 3: according to the design, 3D printing model is constructed, and the light-cured resin slurry is printed according to 3D printing model, and the scaffold body can be obtained;Step 4: scaffold body is cleaned, and the required scaffold can be obtained after defatting sintering;The application can prepare biphasic bioactive tissue repair scaffold with good mechanical properties, efficient antitumor ability and better bone regeneration capacity, and provide technical support for the repair of bone tumor postoperative bone defect in clinic.

To provide a bone regeneration material having both antibacterial properties and high aesthetic properties, and to provide a method for producing the bone regeneration material.SOLUTION: A bone regeneration material in a cotton form comprising a biodegradable fiber, wherein the biodegradable fiber contains calcium phosphate, silver ion-solid solution calcium phosphate, and a biodegradable polymer, and a content ratio of the silver ion-solid solution calcium phosphate to a total amount of the calcium phosphate and the silver ion-solid solution calcium phosphate is 60 mass% or more. The silver ion solid solution calcium phosphate is preferably silver ion solid solution β - tricalcium phosphate.SELECTED DRAWING: None

A method for applying a corrosion inhibitor composition to a water stream in a water system includes determining a calcium phosphate saturation index of the water stream, determining at least one other parameter of the water stream, determining a dosage of the corrosion inhibitor composition based on a relationship between the dosage and the calcium phosphate saturation index including the at least one other parameter, and controlling administration of the corrosion inhibitor composition to the water stream based on the determined dosage.

The application discloses a kind of high-stability doped sodium sulfate positive electrode materials and preparation method thereof, belong to sodium ion battery electrode material technical field.For the current sodium sulfate in high rate under the problem of sodium storage capacity, cycle performance and poor water resistance, the high-stability doped sodium sulfate positive electrode material of the application includes sodium iron sulfate zinc calcium phosphate particles and carbon nanotube, mass ratio is 85~95:5~15.By ball milling anhydrous ferrous sulfate, anhydrous sodium sulfate, anhydrous calcium phosphate, anhydrous zinc phosphate and carbon nanotube in inert atmosphere ball mill jar to obtain calcined precursor;Then the calcined precursor is placed in inert atmosphere tube furnace at 360~400 DEG C for 16~24h, to obtain sodium iron sulfate zinc calcium phosphate composite electrode material.The electrode material provided by the application has the advantages of simple and convenient preparation method, low cost, good air stability and rate performance, good cycle stability (>6000 times) and other advantages, and has strong market competitiveness in large-scale energy storage application field.

The invention discloses a three-enzyme-inorganic hybrid nanoflower as well as a preparation method and an application method thereof, and belongs to the technical field of enzyme immobilization. The three enzymes in the material are creatininase, creatinase and sarcosine oxidase, and the carrier is calcium phosphate. According to the three-enzyme-inorganic hybrid nanoflower, creatininase, creatinase and sarcosine oxidase are loaded on the same carrier, and the three-enzyme-inorganic hybrid nanoflower can be generated on the surface of a working electrode in situ and can also be directly dropwise added to the surface of the working electrode for electrochemical precise detection of creatinine. The method has the advantages of being simple in operation, green, environmentally friendly and the like, and the prepared three-enzyme-inorganic nanoflower material is high in stability and rapid in detection and has a good application prospect in the field of biosensing.