36 results about "Trimethylene carbonate" patented technology

The present invention provides a cyclic carbonate synthesis method, and belongs to the technical field of organic ester compound synthesis, and the cyclic carbonate synthesis method comprises the following steps: S1, 1, 3-propylene glycol, a dehydrating agent and a catalyst are added into a high pressure reaction kettle, and CO2 is introduced into the high pressure reaction kettle for a reaction; s2, after the reaction is finished, after the high-pressure reaction kettle is cooled to the room temperature, redundant gas in the high-pressure reaction kettle is discharged, after the gas in the high-pressure reaction kettle is completely discharged, the high-pressure reaction kettle is opened, the catalyst is filtered out, and the solution is subjected to vacuum-pumping separation to obtain a target product; the catalyst is a heterogeneous catalyst MxOy (at) Zn-dpot. Carbon dioxide conversion is carried out in a chemical utilization mode, a chemical product trimethylene carbonate can be produced, the synthesis route is easy to operate, and after the MxOy at Zn-dpot catalyst is added, the yield is high, the high additional value is achieved, and the green chemistry concept is met.

The present invention discloses a coated controlled-release fertilizer containing a thermosensitive block copolymer switch and a preparation method thereof. The thermosensitive block copolymer is copolymerized by modified three blocks A, B, and C, block A is synthesized by chitosan and trimethylene carbonate, block B is dimethylaminoethyl methacrylate, and block C is synthesized by the reaction of epoxybutene and diethanolamine. The prepared thermosensitive block copolymer is combined with a basic membrane material to obtain a coated controlled-release fertilizer that is sensitive to ambient temperature, thereby realizing intelligent controlled release of fertilizer. The present invention provides a coated controlled-release fertilizer containing a thermosensitive block copolymer switch and a preparation method thereof, so that the controlled-release fertilizer can respond to ambient temperature, thereby controlling the release of nutrients.

The present invention provides a cyclic carbonate synthesis method, and belongs to the technical field of organic ester compound synthesis, and the cyclic carbonate synthesis method comprises the following steps: S1, 1, 3-propylene glycol, a dehydrating agent and a catalyst are added into a high pressure reaction kettle, and CO2 is introduced into the high pressure reaction kettle for a reaction; s2, after the reaction is finished, after the high-pressure reaction kettle is cooled to the room temperature, redundant gas in the high-pressure reaction kettle is discharged, after the gas in the high-pressure reaction kettle is completely discharged, the high-pressure reaction kettle is opened, the catalyst is filtered out, and the solution is subjected to vacuum-pumping separation to obtain a target product; the catalyst is a heterogeneous catalyst M < 1 > < x > M < 2 > < y > O < z > (at) Bi-TDPAT. According to the invention, carbon dioxide conversion is carried out in a chemical utilization manner, a chemical product trimethylene carbonate can be produced, the synthesis route is easy to operate, and after the M1xM2yOz-Bi-TDPAT catalyst is added, the yield is high, the added value is high, and the green chemistry concept is met.

The application relates to the technical field of batteries, in particular to an electrolyte suitable for primary lithium-manganese batteries and a preparation method thereof. The electrolyte comprises propylene carbonate, ethylene carbonate, lithium bisfluorosulfonylimide, lithium perchlorate, lithium bisoxalate borate, terminal bisdifluorophosphorylated oligomeric trimethylene carbonate, ethylene glycol dimethyl ether, lithium difluorooxalate borate and 1,3-propane sultone. The electrolyte is prepared through a pre-coordination and segmented dilution process with specific timing. The electrolyte system can synergistically optimize the electrode interface film forming process, has high discharge capacity retention rate and low direct current resistance at low temperature (-20 DEG C), and has high capacity retention rate after high-temperature storage (60 DEG C), thereby significantly improving the comprehensive performance of the primary lithium-manganese battery in a wide temperature range.

An absorbable copolymer, and a preparation method and use thereof are disclosed. Firstly lactide and trimethylene carbonate are polymerized to form a prepolymer, and then the prepolymer is copolymerized with glycolide to form a PGLT copolymer. The PGLT copolymer contains three chain segments of polymerized glycolide, polymerized lactide and polymerized trimethylene carbonate. The PGLT copolymer obtained by stepwise polymerization has high strength and good toughness. It is suitable for the preparation of medical instruments such as absorbable tissue closure clips, suture clips, suture anchors, anastomosis nails, etc.

The present invention refers to an electro-spun multilayer tube or wrap to protect or bridge damaged nerve comprising an electro-spun isolating outer layer comprising at least one polymer selected from poly(caprolactone), polylactide, polyglycolide, poly(trimethylene carbonate), poly(dioxanone), polyethylene glycol, polyurethane, their copolymers or mixtures thereof and at least one electro-spun inner layer comprising a reagent which is able to undergo covalent bonds with proteins and peptides, which comprises at least one group selected from N-hydroxy succinimide, maleimide, sulfur-NHS and biotin-NHS, carboxylic acid or aldehydes. Furthermore, the present invention refers to methods of manufacturing such tubes or wraps as well as their use in protecting or bridging nerves or to stimulate nerve growth and cell proliferation.

The invention relates to the technical field of batteries, in particular to a dry binder as well as a preparation method and application thereof. The dry binder comprises a base material and an elastic polymer layer arranged on the surface of the base material, the base material comprises a fibrillated binding material; the elastic polymer layer is formed by polymerizing polymeric monomers, and the polymeric monomers comprise at least one of tetrahydro-2H-2-pyrone, trimesoyl chloride, trimethylene carbonate and trifluoropropene. According to the dry-method binder, the elastic polymer layer is stable at low potential, cannot react with components in a battery and can isolate a base material from being in contact with active lithium and a conductive agent, the elastic polymer layer can still form wrapping in the fibration process of the fibration binder, and therefore the structure of a dry-method electrode is more stable, and the service life of the dry-method electrode is prolonged. And the cycling stability and coulombic efficiency of the battery can be improved.

The invention discloses a synthesis method of trimethylene carbonate, which comprises the following steps: sequentially adding a MO-Ce-CMNDI catalyst, 2-cyano furan, potassium carbonate and 1, 3-propylene glycol into a reaction kettle in a water-free and oxygen-free environment, introducing CO2 for reaction, and obtaining a target product after the reaction is finished. When the MO-Ce-CMNDI catalyst is used for the trimethylene carbonate synthesis reaction, the catalytic activity is high, the reusability is good, and the yield of the product is improved.

The present invention discloses a free-radical in-situ polymerization semi-solid-state battery. The free-radical in-situ polymerization semi-solid-state battery comprises a positive electrode, a negative electrode and a semi-solid electrolyte. The semi-solid electrolyte is formed through in-situ polymerization by adding a polymerizable monomer, a plasticizer and an initiator into a liquid electrolyte. The polymerizable monomer is a combination of vinylene carbonate (VC) and trimethylene carbonate (TMC) with a mass ratio of 20 to 35:0.1 to 1.5. By optimizing the components of the gel electrolyte, the impedance of the battery is reduced, the performance of the battery is improved, the hardness of the gel electrolyte is enhanced, the solid-solid interface in the battery is benefited, and the safety of the battery is improved.

The invention discloses a collagen composite artificial bone which is characterized in that raw materials comprise type I collagen and hydroxyapatite, and further comprise one or more of polylactic acid, polyglycolic acid, a polylactic acid-glycolic acid copolymer, polycaprolactone, poly (trimethylene carbonate), polymethyl methacrylate, hyaluronic acid and alginic acid. According to the collagen composite artificial bone, one or more specific high polymer materials are added in the preparation process of the artificial bone, so that the collagen composite artificial bone has excellent mechanical properties and stability, and the preparation method is simple, easy in expanded production, high in yield and low in cost. The artificial bone is suitable for various application fields such as various bone fractures with bone defects, nonunion or deformity healing, orthopedic bone grafting, other bone defect repair without bone grafting taboo in the orthopedics department and the like.

Compounds and compositions are provided which are useful in additive printing, particularly additive printing techniques such as stereolithography (SLA) wherein a macromer is photopolymerized to form a manufactured article. Representative compounds comprise a polyaxial central core (CC) and 2-4 arms of the formula (A)-(B) or (B)-(A) extending from the central core, where at least one of the arms comprise a light-reactive functional group (Q) and (A) is the free-radical polymerization product from monomers selected from trimethylene carbonate (T) and ε-caprolactone (C), while (B) is the free-radical polymerization product from monomers selected from glycolide, lactide and p-dioxanone.

The application discloses a 4D printing shape memory composite stent for delivering exosomes and magnesium ions and a preparation method and application thereof. The preparation method comprises the following steps: (1) mixing hydroxyapatite and silicon dioxide nanoparticles with poly(D, L-lactic acid-co-trimethylene carbonate) in dichloromethane to obtain an oil phase; adding exosomes into a magnesium oxide nanoparticle water dispersion to obtain an aqueous phase; and mixing to obtain a water-in-oil Pickering emulsion; and (2) using a 4D printing technology to prepare the composite porous shape memory stent (PHS / MgO-EXO) loaded with exosomes by using the Pickering emulsion ink. The stent has a multi-stage interconnected pore structure, and can promote cell osteogenic differentiation and bone tissue regeneration by synergistically releasing exosomes and magnesium ions. The stent also has a temperature-sensitive shape memory function, can restore the original shape under a slightly higher body temperature stimulus, can accurately match irregular bone defects, and is suitable for minimally invasive repair treatment of clinical irregular bone defects.

The invention discloses a preparation process of trimethylene carbonate, which comprises the following steps: reacting PDO with DMC under the catalysis of lipase to generate 3-hydroxypropyl methyl carbonate and C, C '-1, 3-propanediyl, C, C'-dicarboxylic acid carbonate; or reacting PDO with DMC under the catalysis of a molecular sieve to generate C, C '-1, 3-propanediyl and C, C'-dicarboxylic acid carbonate; then, the C, C '-1, 3-propanediyl and C, C'-dicarboxylic acid carbonate is converted into 3-hydroxypropyl methyl carbonate under enzyme catalysis or non-enzyme catalysis, and trimethylene carbonate is prepared through thermal cyclization of the 3-hydroxypropyl methyl carbonate. The method has the obvious advantages of wide raw material source, low price and the like. Compared with a technology for preparing trimethylene carbonate by catalyzing reaction of PDO and DMC by using lanthanum 2-ethylhexanoate as a catalyst, the method disclosed by the invention has higher safety and economical efficiency and has very important industrial application prospects.

The present invention provides a cyclic carbonate synthesis method, and belongs to the technical field of organic ester compound synthesis, and the cyclic carbonate synthesis method comprises the following steps: S1, 1, 3-propylene glycol, a dehydrating agent and a catalyst are added into a high pressure reaction kettle, and CO2 is introduced into the high pressure reaction kettle for a reaction; s2, after the reaction is finished, after the high-pressure reaction kettle is cooled to the room temperature, redundant gas in the high-pressure reaction kettle is discharged, after the gas in the high-pressure reaction kettle is completely discharged, the high-pressure reaction kettle is opened, the catalyst is filtered out, and the solution is subjected to vacuum-pumping separation to obtain a target product; the catalyst is a heterogeneous catalyst M < x > O < y >-Mn-MOF. Carbon dioxide conversion is carried out in a chemical utilization mode, a chemical product trimethylene carbonate can be produced, the synthesis route is easy to operate, and after the MxOy-Mn-MOF catalyst is added, the yield is high, the high additional value is achieved, and the green chemistry concept is met.

The invention discloses a poly (trimethylene carbonate-co-lactide) copolymer capable of accurately regulating and controlling the monomer proportion and a preparation method and application thereof.The copolymer is formed by polymerizing trimethylene carbonate and L-lactide, trimethylene carbonate, lactide and stannous octoate are subjected to high-strength purification and impurity removal, a reaction system is pretreated, and the poly (trimethylene carbonate-co-lactide) copolymer is obtained. A high-molecular-weight PTLA series material with the molecular weight of about 550 kDa is synthesized by adopting a ring-opening copolymerization method, and random copolymers with different block lengths and distribution are constructed by accurately controlling the molar ratio of TMC to LA. According to the invention, the high-molecular-weight material is degraded in 28 days to keep the stable form, and the problem that the traditional low-molecular-weight material is easy to deform is solved; a degradation product is free of accumulation of acidic substances and excellent in biocompatibility; a wide-range degradation period of 30-685 days can be obtained through composition regulation and control, and the different requirements of orthopedic fixation (rapid degradation), cardiovascular stent (long-term maintenance) and the like are met.

The invention provides a degradable oral repair film and a preparation method thereof. The degradable oral cavity restoration film is formed by interweaving and stacking cellosilk and is of a porous structure; the preparation raw materials of the degradable oral cavity repairing film comprise a non-elastomer material, an elastomer material and a natural high polymer material, and, the non-elastomeric material comprises a glycolide-trimethylene carbonate copolymer. The degradable oral cavity restoration film has good biodegradability and biocompatibility, good mechanical properties and a proper degradation period, is low in swelling degree in the use process, does not have the conditions of displacement and the like, also has relatively good softness and adhesiveness, and can effectively promote soft tissue healing and reduce the exposure infection rate.

The invention belongs to the field of medical materials, and particularly relates to a novel application of a PLLA-TMC-GA polymer, a PHA-loaded PLLA-TMC-GA microsphere, a microsphere support and a preparation method of the PHA-loaded PLLA-TMC-GA microsphere. The technical problem to be solved by the invention is to provide a bone defect repair material with osteogenic property and mechanical property and a preparation method thereof. The preparation method comprises the following steps: firstly, based on new application of a polylactic acid-trimethylene carbonate-polyglycolic acid ternary polymer (PLLA-TMC-GA) material, preparing a microsphere, a microsphere bracket, a hydrogel composite bracket and a drug-loaded hydrogel composite bracket on the basis of the ternary polymer and polydopamine modified nano-hydroxyapatite; the products have different degrees of conversion effects from artificial bones to biological bones, and a brand-new effective technical scheme is provided for irregular bone defect repair.

The invention relates to an electrospun hybrid scaffold for medical applications comprising at least one synthetic polymer selected from poly(caprolactone), polylactide, poly(trimethylene carbonate), poly(lactide-co-caprolactone), poly(lactide-co-trimethylene carbonate), polylactide-b-polyethylene glycol, their copolymers or mixtures thereof and collagen-like protein. The invention also relates to methods of dispersing collagen-like protein into synthetic resorbable polymers and forming compositions suitable for electrospinning.

A block copolymer includes a block A and a block B. The A block provides mechanical strength and the B block provides elasticity to the polymeric material. The block copolymer may be an ABA triblock copolymer. The A block may include one or more of polyglycolide (PGA), polylactic acid (PLA), or a copolymer thereof. The B block may include a random copolymer of (i) glycolide (GA) and / or lactide (LA), (ii) trimethylene carbonate (TMC), and (iii) epsilon-caprolactone (CL). The block copolymer can cover an implantable device, and the implantable device can be used for achieving immediate hemostasis at a punctured part of a blood vessel wall.

The present invention relates to the technical field of medical instruments. Particularly disclosed are an absorbable segmented copolymer and a preparation method therefor and the use thereof, and an absorbable binding strap. The absorbable segmented copolymer comprises a chain segment A, which is a first segment and is a crystalline prepolymer formed by the polymerization of L-lactide, the weight percentage content thereof in the segmented copolymer being 50-75%; and a chain segment B, which is a second segment, the weight percentage content thereof in the segmented copolymer being 25-50%, wherein the monomer of the chain segment B comprises ε-caprolactone or a mixture of ε-caprolactone and other monomers, the other monomers comprising glycolide, trimethylene carbonate, p-dioxanone, DL lactide or L-lactide. In the present invention, the absorbable segmented copolymer is obtained by first polymerizing L-lactide that serves as a hard segment and then polymerizing a soft segment (containing ε-caprolactone); and the absorbable segmented copolymer can provide high strength, high toughness and appropriate degradation time which are required by an absorbable binding strap, and is more suitable for use in the preparation of an absorbable binding strap for orthopedic internal fixation.

The invention discloses a catalyst for synthesizing cyclic carbonate and a preparation method of the catalyst. The catalyst is MO (at) Ag-HOF; wherein Ag-HOF represents a hydrogen bond organic framework material [Ag (HMCTA) (H2MCTA)] synthesized from AgNO3 and 5-methyl-1-(4-carboxyl phenyl)-1H-1, 2, 3-triazole-4-formic acid (H2MCTCA), and the chemical formula of the Ag-HOF is shown in the description. When the MO-Ag-HOF catalyst is used for cyclization synthesis of trimethylene carbonate from CO2 and 3-chloro-1-propanol, the catalytic activity is high, the reusability is good, and the yield of the product is greatly improved.

The invention relates to the technical field of medical materials, in particular to a medical closing clip composite material which comprises the following components in parts by weight: 65-75 parts of polyhydroxyalkanoate, 10-15 parts of a degradable copolymer, 4-8 parts of a compound and 2-4 parts of a nano compound, the preparation method of the compound comprises the following steps: premixing barium sulfate modified by an organic surface modifier with polylactic acid particles, and carrying out melt blending and hot press molding to obtain the compound. The organic surface modifier is N, N '-ethylene bis (phthalimide); the degradable copolymer is prepared by carrying out copolymerization reaction on glycolide, lactide and trimethylene carbonate according to the weight ratio of (3 to 4): (2 to 3): 1. Through the synergistic effect of the polyhydroxyalkanoate, the degradable copolymer, the compound and the nano-compound, a good biological dissolving effect is achieved, and meanwhile, due to the fact that the modified barium sulfate is fused into the product and the outer surface of the product is coated with the hafnium element, a good developing effect is achieved.

The invention discloses a self-repairing photo-thermal shape memory material based on aliphatic polycarbonate and a preparation method thereof, and the preparation method is characterized by comprising the following steps: (1) weighing 2 g of MPEG113, a certain amount of 5-methyl-5-benzyloxycarbonyl trimethylene carbonate (MBC) and 1, 4-dioxane ketone (DO); putting the components into a polymerization tube, and adding a certain amount of Prussian blue nanoparticles; (2) mixing all the components, sealing a polymerization tube, and putting the polymerization tube into a heating device; the polymerization temperature is set to be 140 DEG C, and polymerization is performed for 24 hours under the temperature condition. The self-repairing photo-thermal shape memory material based on aliphatic polycarbonate and the preparation method thereof have the characteristics and beneficial effects that efficient self-repairing, intelligent shape memory and excellent photo-thermal conversion capability are realized, and the self-repairing photo-thermal shape memory material based on aliphatic polycarbonate is suitable for multiple fields of biomedicine, intelligent materials, conductive materials and the like.

The present invention refers to an electro-spun multilayer tube or wrap to protect or bridge damaged nerve comprising an electro-spun isolating outer layer comprising at least one polymer selected from poly(caprolactone), polylactide, polyglycolide, poly(trimethylene carbonate), poly(dioxanone), polyethylene glycol, polyurethane, their copolymers or mixtures thereof; and an active inner layer comprising at least one electrical conducting compound and / or at least one ionic conducting compound and / or at least one peptide or protein to stimulate nerve growth. Furthermore, the present invention refers to methods of manufacturing such tubes or wraps as well as their use in protecting or bridging nerves or to stimulate nerve growth and cell proliferation.

The present invention discloses a preparation method of a lacrimal canaliculus plug for sustained release of tafluprost, which comprises the following steps: (1) dispersing tafluprost, poly(trimethylene carbonate), chitosan, and tri-lysine in a solvent and mixing evenly, wherein the mass ratio of tafluprost: poly(trimethylene carbonate): chitosan: tri-lysine is 0.001-0.5: 15-35: 10-35: 0.5-2; (2) carrying out a cross-linking reaction at 40-50 °C for 8-20 h, cooling, and drying to obtain a mixture; (3) subjecting the mixture obtained in step (2) to plasma treatment at less than 6 Pa for 30 s-5 min, and then curing and molding to obtain a lacrimal canaliculus plug for sustained release of tafluprost. The present invention uses tafluprost, poly(trimethylene carbonate), chitosan, and tri-lysine as raw materials for cross-linking reaction, and then the lacrimal canaliculus plug for sustained release of tafluprost prepared by plasma treatment can reduce the frequency of using antibiotic drugs or eliminate the need to use antibiotic drugs, with good patient compliance, good comfort, good biocompatibility, short-term degradation, small side effects, good water-swellable performance, not easy to fall off, reducing intraocular pressure while treating dry eye, and low corneal toxicity.

The invention provides a preparation method of trimethylene carbonate, which comprises the following steps: carrying out transesterification by taking dimethyl carbonate and 1, 3-propylene glycol as raw materials and sylvite as a catalyst; wherein the catalyst is selected from one or more of potassium carbonate, potassium hydroxide, potassium bicarbonate, potassium chloride, potassium nitrate and potassium sulfate; the reaction conditions are normal pressure and the reaction temperature is 90-140 DEG C. According to the preparation method provided by the invention, the potassium salt is innovatively used as the catalyst, the one-pot method is adopted for preparation under milder reaction conditions, the excellent trimethylene carbonate yield can be obtained, the catalyst is low in cost and easy to obtain, the preparation process is simple and convenient, and industrial popularization is facilitated.

The invention discloses an absorbable ligature clip with excellent mechanical properties and a preparation method of the absorbable ligature clip, and belongs to the technical field of absorbable materials and application. The absorbable ligature clip is of a double-layer structure made of different materials and comprises an inner-layer clip body and an outer-layer clip body, the inner-layer clip body is made of a mixture of a glycolide trimethylene carbonate block copolymer (PGA-TMC) and polyglycolide (PGA), and the outer-layer clip body is made of poly (p-dioxo-cyclohexanone) (PPDO); and the outer-layer clamp completely wraps the inner-layer clamp. And the glycolide trimethylene carbonate block copolymer (PGA-TMC) in the inner layer clamp accounts for 10 to 30 percent of the weight of the inner layer clamp. According to the invention, the mixed material of PGA-TMC and PGA is adopted in the inner layer clip, so that the overall rigidity of the ligature clip is reduced to a certain extent, and the mechanical maintenance time is prolonged.

The invention discloses a coaxial electrostatic spinning fiber scaffold preparation method which comprises the following steps: firstly, selecting powdery polylactic acid resin as a shell raw material, then putting the shell raw material into a dichloromethane solution, heating and stirring to enable the polylactic acid resin to be dissolved in the dichloromethane solution to prepare a polylactic acid solution; according to the method, the polylactic acid solution and the poly (trimethylene carbonate) solution are input into the same coated electrified spray head through two ejectors, and the poly (trimethylene carbonate) solution is linearly sprayed out through the coated spray head; meanwhile, a polylactic acid solution is injected into a coating type electrified spray head, then the sprayed mixed solution is emitted to a receiving plate to form fibers, and the sprayed poly (trimethylene carbonate) solution drives the polylactic acid solution to flow, so that the polylactic acid solution stably coats the surface of the poly (trimethylene carbonate) solution; and the quality of the electrostatic spinning fiber bracket is kept stable.

The invention relates to an absorbable surgical suture and a preparation method thereof, the surgical suture takes a bioabsorbable polymer as a main body material, and the bioabsorbable polymer comprises the following raw materials: a polyglycolide copolymer, a function enhancer and an optional coloring agent, polymeric monomers of the polyglycolide copolymer comprise glycolide and comonomers selected from one or more of lactide, caprolactone, trimethylene carbonate and p-dioxanone, and the function enhancer is selected from at least one of a carbodiimide compound, an oxazoline compound, an isocyanate compound and an epoxy compound. By adding a small amount of function enhancer into the polyglycolide copolymer, the mechanical retentivity of the polymer is enhanced, the degradation time of the polymer is not affected, and compared with the prior art, the surgical suture has better fracture strength retentivity and stability.

The application discloses a kind of free radical in-situ polymerization semi-solid batteries;Including positive electrode, negative electrode and semi-solid electrolyte, the semi-solid electrolyte is the semi-solid electrolyte formed by adding polymerization monomer, plasticizer and initiator in-situ polymerization in liquid electrolyte;The polymerization monomer is the combination of vinylene carbonate VC and trimethylene carbonate TMC with mass ratio 20-35:0.1-1.5.The application improves gel electrolyte component, reduces battery impedance, improves battery performance, improves the hardness of gel electrolyte, is conducive to solid-solid interface in battery, improves the safety of battery.