35results about How to "Does not cause inflammation" patented technology

The invention belongs to the field of medical implant materials and particularly relates to a novel biodegradable zinc-based metal material and a ureteral expandable stent obtained through the material. The zinc-based metal material is composed of zinc and/or zinc alloy. The zinc alloy is composed of Zn and one or more elements of Mg, Al, Ti, Cu, Ag, Si, Ca, Sr, Y, Zr, Sc, Gd, Nd, Dy, Er, Li, Mn, La, Ce, Pr, Sm, Tb, Ho, Tm, Yb and Lu. The biodegradable zinc-based metal material has good biocompatibility, degradability and mechanical properties, and has wide market application prospects.

The invention discloses a biodegradable stent composite. The biodegradable stent composite is prepared from biodegradable medical polyurethane and a biodegradable metal material. The weight ratio between the biodegradable medical polyurethane and the biodegradable metal material is 0.1-99%:1-99.9%, preferably 5-90%:10-95%. To regulate the hardness of the material, other high molecular materials, such as polylactic acid, polycaprolactone, poly-p-dioxanone and copolymers thereof (PPDO and P(LA-PDA)), poly trimethylene carbonate, polylactic acid-trimethylene carbonate copolymer, polycaprolactone-trimethylene carbonate copolymer, polyglycolic acid and polylactic acid-glycolic acid copolymer, can be added, so that clinical usage is facilitated.

The invention discloses a preparing method of artificial intervertebral disc nucleus pulposus prosthesis in the macromolecular technical domain, which comprises the following steps: preparing polyurethane bag material; blending the polymer dihydroxy alcohol and diisocyanate; stirring the composition protected by nitrogen to make the prepolymer; heating to add chain-expanding cross linker; stirring to react; maturing; moulding the polyurethane bag; preparing the silicon rubber filler through blending base gel, cross linker, filler and catalyst to stir evenly; injecting the silicon rubber filler into the polyurethane bag through injector. The invention doesn't harm human body with good biological compatibility and dynamic property, which has chemical inert to possess long-term mechanic strength.

The invention discloses a long-acting subcutaneous implant that contains degradable polyurethane coated collagen and is used for subcutaneous soft tissue filling and a preparation method thereof. The implant has the advantages of good elasticity, excellent degradation resistance, and long duration after injection, is very suitable for subcutaneous filling, wrinkle removing, breast prosthesis filling and use as a drug carrier, etc.

The invention relates to a preparation method of developing polyurethane, which pertains to the technical field of high polymer material. The preparation method comprises the steps that: firstly, polymers, diatomic alcohol and diisocyanate are mixed; the mixture of the diatomic alcohol and the diisocyanate is stirred and reacts under the protection of nitrogen gas to obtain a prepolymer; after the temperature thereof is raised, the prepolymer is added with a chain extender and stirred for reaction; and the polymers are cured. As the chain extender contains developing atoms and developing groups are connected with the polyurethane by the effect of chemical bonds, the developing polyurethane prepared by the preparation method has long lasting development effect, good stability, biocompatibility and anticoagulant performance, arouses no inflammation in human bodies, is biological aging resistant and animalcule resistant, has good physical properties, can be sterilized by usual methods, is easy to be processed and takes advantages over non-developing polyurethane when being applied to heart valves, conduits and vascular stents. The preparation method is flexible, effective, simple and easy to be realized.

The invention discloses biosoluble antibacterial ultrafine glass wool and a preparation method thereof. The biosoluble antibacterial ultrafine glass wool comprises the following chemical components bymass: 60-68 parts of SiO2, 0 to 3 parts of Al2O3, 6 to 12 parts of CaO and MgO, 15 to 20 parts of Na2O and K2O, 0 to 3 parts of ZnO, 0 to 6 parts of Ag2O, 4 to 8 parts of B2O3, and no more than 3 parts of Fe2O3, SO3, ZrO2 and CeO2, wherein the content of CeO2 is not less than 0.5 part. The biosoluble antibacterial ultrafine glass wool has good biosolubility, bacteriostatic effect and thermal insulation properties.

The invention provides a method for constructing engineering arterial blood vessel in vivo by taking melt-spinning fiber as a skeleton. The method comprises the following steps: firstly preparing a melt spinning and medical silica gel tube composite mandrel, and then preparing the in-vivo engineering arterial blood vessel taking melt-spinning fiber as a skeleton by taking subcutaneous part of an animal as a bioreactor; the specific steps are as follows: 1) preparing the melt spinning and medical silica gel tube composite mandrel; 2) preparing the in-vivo engineering arterial blood vessel taking melt-spinning fiber as a skeleton by taking subcutaneous part of an animal as a bioreactor; and 3) performing in-situ transplanting of the in-vivo engineering arterial blood vessel so as to replace lesion blood vessels. The method has the advantages that the in-vivo engineering arterial blood vessel has good biocompatibility, all the components are originated from autologous tissues, and therefore, the artificial blood vessel is non-toxic, free from immunogenicity, and incapable of causing inflammation; due to the existence of melt spinning fiber, the prepared in-vivo engineering blood vessel has good mechanical strength, tenacity and compliance, and is suitable for surgical sewing operation.

The invention relates to a multivesicular liposome for ocular vitreous injection. The multivesicular liposome is prepared from the following components in parts by weight: 1 part of bevacizumab, 0.2-150 parts of lipid, 5-500 parts of an osmotic pressure regulator and 6-200 parts of a co-emulsifier. A preparation method of the multivesicular liposome for ocular vitreous injection comprises the steps of dispersing an inner water phase into a lipid phase according to the volume ratio of the inner water phase to the lipid phase of (1:1) to (1:10) to form a W/O primary emulsion; dispersing the W/O primary emulsion into an outer water phase according to the volume ratio of the W/O primary emulsion to the outer water phase of (1:1) to (1:5) to form a W/O/W compound emulsion; transferring the W/O/W compound emulsion to the outer water phase and removing an organic solvent in the compound emulsion; and centrifuging the obtained solution at 500-3,000rpm, taking lower sediments and adding normal saline for dispersion again to obtain the multivesicular liposome. According to the method provided by the invention, the prepared multivesicular liposome is high in encapsulation efficiency and has a good slow release effect, the particle sizes are 10-50 microns, the administration times are reduced and the compliance of a patient is improved.

The invention relates to a saccule electrode duct for cavity tissue ablation. The saccule electrode duct comprises a duct a and a duct b arranged in the duct a, wherein an electrode sleeve ring a, a saccule b, an electrode sleeve ring b, a potential electrode a, a potential electrode b, an electrode sleeve ring c, a saccule a, and an electrode sleeve ring d are sequentially arranged on the outer surface of the duct a from left to right; a metal claw cage b is arranged between the electrode sleeve ring a and the electrode sleeve ring b; a metal claw cage a is arranged between the electrode sleeve ring c and the electrode sleeve ring d; the electrode sleeve ring b, the electrode sleeve ring c and the duct a are fixedly connected; the electrode sleeve ring a and the electrode sleeve ring d can freely slide in the duct a; the duct b is a flexible hollow columnar pipe body, and 4 conducting wires in spacing spiral wounding are arranged on the outer surface; and the conducting wires are respectively connected with the electrode sleeve ring b, the electrode sleeve ring c, the potential electrode a and the potential electrode b. The invention provides the saccule electrode duct which can perform safe and effective ablation radical cure treatment on malignant tumors.

The invention discloses a skin firming and anti-oxidation compound essential oil, which comprises the following raw materials of mass percentage: 50-80% of wheat germ oil, 5-15% of strawberry seed oil, 1.5-2.5% of a Selaginella tamariscina extract, 6-12% of oil ethylhexyl palmitate, and 0.5-1% of bisabolol; preferably comprises, 5-15% aloe oil and 3 to 5% of melaleuca alternifolia oil. The compound essential oil of the invention has smooth and non-sticky feel, good storage stability, and has the functions of antibacterial sterilization, anti-inflammatory and analgesic, is suitable for sensitive skin and skin with wounds, and can quickly wrinkle and remove scars and improve skin elasticity.

The invention provides Maotai-flavor snuff and a preparation method thereof. The Maotai-flavor snuff is prepared from tobacco leaves, Maotai-flavor liquor and a traditional Chinese medicine composition. The Maotai-flavor snuff plays a role mainly through the nasal cavity and the airway mucosa, lung injury and inflammation cannot be caused, and therefore the Maotai-flavor snuff is safe and reliable to the health of a user; according to the Maotai-flavor snuff, the pressure of nervous tension can be relieved in the smoking experience, the tired body can have a temporary rest and relax, the refreshing effect can be achieved, the symptoms of dizziness, weakness, illusion, xerophthalmia and nasal obstruction can be obviously improved, the smoking amount of a smoker for a traditional burning cigarette is effectively reduced, and the smoking experience of the smoker is improved. Certain health-care and body immunity improving effects are achieved; according to the Maotai-flavor snuff, the Maotai flavor and the medicine flavor supplement each other, and the Maotai-flavor snuff is mellow, lingering, mild, relaxed and natural in taste and gives physiological enjoyment to smokers.

The invention belongs to the technical field of adhesive materials and relates to a preparation method of a high-adhesiveness degradable fiber protein adhesive. The high-adhesiveness degradable fiberprotein adhesive is prepared by adopting glutaraldehyde as a cross-linking agent for cross linking with glucan molecules, adopting fibrin glue as a raw material and adopting glucose modified polyurethane as an adhesive. The hydroxyl-containing glucan molecules are available for direct reaction with glutaraldehyde under violent reaction conditions, and by cross linking of hydroxyl and formyl, the prepared high-adhesiveness degradable fiber protein adhesive can be quickly polymerized to realize form adhesion while degradability is realized; by adoption of glucose for modification of polyurethanewith unique advantages of high bonding strength, resistance to water, solvents and low temperature, availability for low-temperature curing and the like, polyurethane is endowed with high degradability. Therefore, high bonding strength and a soft-hard transition layer with great physical properties can be formed between substrates by the prepared high-adhesiveness degradable fiber protein adhesive.

The invention provides basil type snuff and a preparation method thereof. The basil type snuff is prepared from tobacco leaves, basil and a traditional Chinese medicine composition. The basil type snuff provided by the invention plays a role mainly through a nasal cavity and an airway mucosa, and does not cause lung injury and inflammation, so that the basil type snuff is safe and reliable to the health of a user; the basil snuff provided by the invention can relieve the pressure of nervous tension in the smoking experience, so that a tired body can temporarily rest and relax, and the basil snuff can also refresh and restore consciousness, obviously improve the symptoms such as dizziness, weakness, nasal obstruction, restlessness and the like, effectively reduce the smoking amount of a smoker on a traditional burning cigarette, and improve the smoking experience of the smoker. Certain health-care and body immunity improving effects are achieved; the sweet basil type snuff provided by the invention is cool in smell, sweet in aftertaste, mellow and lingering in fragrance, relaxed and natural, and gives taste enjoyment to a smoker.

The invention provides a preparation method of a transdermal drug delivery system (TDDS). The preparation method comprises the following steps that 1. adding midchain PHA (polyhydroxyalkanoate) to chloroform solution to be mixed to obtain solution A; 2. adding drugs to dimethyl sulfoxide solution to be mixed to obtain solution B; and 3. mixing the solution A with the solution B uniformly, then coating the mixture on glass paper and drying the glass paper, thus obtaining the final product, namely the TDDS. The preparation method has the beneficial effects that the biodegradable material PHA obtained by synthesizing microorganisms is utilized as one of the raw materials and can replace adhesives and micromolecular accelerants in the existing TDDSs; PHA is combined with ionic and insoluble drugs respectively by utilizing the physiochemical properties of PHA, thus forming the TDDS; with slow release property, PHA can control drug release; and the TDDS has high transmittance, obvious effects, simple steps and better application prospect and is easy to operate.