Method of producing artificial prosthesis of disci intervertebrales nucleus pulposus

A technology of intervertebral disc and nucleus pulposus, applied in the field of artificial intervertebral disc nucleus pulposus prosthesis, can solve the problems of prolonged operation time, long coagulation time, human toxicity, etc., and achieve excellent mechanical properties and biocompatibility, elongation at break Good rate and hardness, good biocompatibility

Inactive Publication Date: 2008-02-27
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason is that most material monomers that can be polymerized in situ have certain toxicity to the human body, and most monomers will generate heat when polymerized, which may cause damage to the cartilage endplate, and postoperative manifestations similar to intervertebral discitis
In addition, the polymerization and coagulation time of some monomers is longer, in addition to prolonging the operation time, there is also the risk of liquid monomers leaking from the intervertebral space before coagulation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] The preparation method of artificial intervertebral disc nucleus pulposus prosthesis that the present invention proposes, following steps:

[0022] (1) Synthesis of polyurethane capsule material:

[0023] Mix the polymer diol and diisocyanate, the molar ratio of mixing is: polymer diol:diisocyanate=0.25~0.70:1, under the protection of nitrogen, stir and mix at 60~85°C for 1~4 hours to obtain the pre- Polymer; increase the temperature to 80-120°C, add chain-extending cross-linking agent, the molar ratio of adding is: chain-extending cross-linking agent: diisocyanate = 0.30:1-0.75:1, and stir for about 2-12 minutes to produce material; aging the obtained polymer at a temperature of 90-100° C. for 3-12 hours;

[0024] (2) Molding and processing of polyurethane capsule:

[0025] Process the polyurethane material into a hollow capsule by blow molding or molding;

[0026] (3) Preparation of silicone rubber filler:

[0027] The rubber base, the crosslinking agent, the fill...

Embodiment 1

[0047] (1) Preparation of polyurethane capsule:

[0048] Mix the pre-vacuum dehydrated polytetrahydrofuran ether diol with a molecular weight of 650 and 4,4'-diphenylmethane diisocyanate in a molar ratio of 0.60:1, stir and mix at 80°C for 2 hours under the protection of nitrogen to obtain the pre- Polymer; raise the temperature to 90°C, add pre-dehydrated 1,4-butanediol, and its molar ratio to 4,4'-diphenylmethane diisocyanate is 0.40:1, stir and react for about 6 minutes to discharge; The obtained polymer was aged at 100° C. for 12 h.

[0049] (2) Molding and processing of polyurethane capsule:

[0050] The polyurethane material is processed into hollow capsules by blow molding or compression molding. The formed capsule has the following characteristics: the shape is a flat ellipsoid, and the length and width are obviously greater than the height. At the same time, the outer edge of the capsule (that is, the part in contact with the annulus fibrosus after being implanted ...

Embodiment 2

[0056] (1) Preparation of polyurethane capsule:

[0057] Mix the pre-vacuum dehydrated polytetrahydrofuran ether diol with a molecular weight of 1000 and 2,4- or 2,6-toluene diisocyanate (TDI) at a molar ratio of 0.65:1, and stir and mix at 80°C under nitrogen protection 2h to obtain a prepolymer; raise the temperature to 90°C, add pre-dehydrated 1,4-butanediol, and its molar ratio to 2,4- or 2,6-toluene diisocyanate (TDI) is 0.35:1 , stirring and reacting for about 5 minutes and discharging; the obtained polymer was matured at a temperature of 100° C. for 12 hours.

[0058] (2) Molding and processing of polyurethane capsule:

[0059] The polyurethane material is processed into hollow capsules by blow molding or compression molding. The formed capsule has the following characteristics: the shape is a flat ellipsoid, and the length and width are obviously greater than the height. At the same time, the outer edge of the capsule (that is, the part in contact with the annulus f...

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PUM

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Abstract

The invention discloses a preparing method of artificial intervertebral disc nucleus pulposus prosthesis in the macromolecular technical domain, which comprises the following steps: preparing polyurethane bag material; blending the polymer dihydroxy alcohol and diisocyanate; stirring the composition protected by nitrogen to make the prepolymer; heating to add chain-expanding cross linker; stirring to react; maturing; moulding the polyurethane bag; preparing the silicon rubber filler through blending base gel, cross linker, filler and catalyst to stir evenly; injecting the silicon rubber filler into the polyurethane bag through injector. The invention doesn't harm human body with good biological compatibility and dynamic property, which has chemical inert to possess long-term mechanic strength.

Description

technical field [0001] The invention relates to a preparation method of an artificial intervertebral disc nucleus pulposus, and belongs to the technical field of polymer materials. Background technique [0002] Lumbar degenerative disease is a common disease in spinal surgery. Patients not only have to endure pain, but in severe cases, they may even lose their ability to work and take care of themselves. The current common method of treatment for this disease is lumbar fusion. However, after lumbar fusion, the motion function of the corresponding segment will be lost, resulting in accelerated degeneration of the intervertebral disc in the adjacent upper and lower segments, resulting in discogenic low back pain and even spondylolisthesis, spinal stenosis and other changes. In recent years, a new method for the treatment of lumbar degenerative diseases has come out, that is, lumbar artificial nucleus pulposus replacement. The biggest advantage of this operation is that it c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61F2/44
Inventor 庹新林夏维娟王婧王晓工吴继功邹德威
Owner TSINGHUA UNIV
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