148 results about "Butanediol" patented technology

This invention discloses a visible-light-responsive dynamically covalently cross-linked self-healing polyurethane and its preparation method, belonging to the field of self-healing materials technology. The material is prepared by reacting diisocyanate, long-chain diol, butanediol, trimethylolpropane, and a monool containing an azophenylboronic acid structure in a certain proportion at 60°C. This invention achieves visible-light-responsive self-healing of the polyurethane material by introducing a visible-light-responsive azophenylboronic acid structure into the polyurethane and utilizing the photoresponsive cis-trans isomerization of the azo structure to regulate the reversible breakage and recombination of the boron-oxygen hexacyclic ring. The visible-light-responsive dynamically covalently cross-linked self-healing polyurethane material prepared by this invention maintains high mechanical strength (16.47 MPa) while exhibiting a strength self-healing efficiency of 95.8% after 8 hours of visible light irradiation, showing broad application prospects in smart materials, anti-corrosion coatings, and other fields.

Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.

This application discloses an acetaldehyde recovery device and method in the production of 1,3-butanediol, belonging to the field of fine chemicals. The device includes: a feed pump, a preheater, a distillation column, a falling film reboiler, a bottom circulating pump, a bottom cooler, a top primary condenser, a reflux ratio distributor, a top secondary condenser, a top product tank, a top transfer tank, a bottom product tank, a bottom transfer tank, a vacuum condenser, a vacuum pump inlet separator, a high vacuum unit, and a vacuum pump outlet separator. The horizontal condenser is directly installed at the top of the distillation column, giving it advantages such as simple structure, convenient operation, low pipeline loss, and high vacuum. A method for acetaldehyde recovery in the production of 1,3-butanediol using this device is also disclosed. Compared to existing technologies, this invention uses falling film evaporation combined with vacuum deep cooling, which avoids the thermal decomposition of 3-hydroxybutyraldehyde and achieves low-temperature, high-efficiency acetaldehyde recovery. It is suitable for continuous production.

The utility model discloses a 1,4-butynediol rectification tower system, the crude butynediol storage tank's discharge gate is linked with crude butynediol delivery pump feed port, and crude butynediol delivery pump discharge gate is connected with the feed port of 1,4-butynediol stripping tower in proper order through bag filter no.

The present invention relates to a method for producing 1,4-butanediol using a 1,4-butanediol-producing microorganism. The method for producing 1,4-butanediol can efficiently produce 1,4-butanediol by culturing a microorganism that produces 1,4-butanediol from glutamic acid under optimal medium conditions.

The present application belongs to the technical field of daily chemical preparation, and particularly relates to a gynecological gel for inhibiting bacteria, regulating microecological balance and tightening vagina and a preparation method thereof. The gynecological gel comprises the following raw materials in mass fractions: 0.5-1 parts of carbomer, 0.04-0.09 parts of sodium hydroxide, 1-3 parts of collagen, 0.01-0.06 parts of sodium hyaluronate, 0.5-1.5 parts of isomaltooligosaccharide, 2-5 parts of propylene glycol, 0.05-0.3 parts of hydroxybenzoic acid methyl ester, 0.02-0.15 parts of hydroxyphenyl ethyl ester, 0.1-1.5 parts of hydrogenated lecithin, 1-6 parts of 1,3-butanediol, 3-5 parts of glycerol, 0.5-1 part of xanthan gum and 70-90 parts of water. The present application uses buckwheat filtrate to prepare collagen, and the active ingredients in the buckwheat filtrate can penetrate the cell membrane of pathogenic bacteria to play an antibacterial role; the collagen can repair the vaginal mucosa barrier and reduce the adhesion and invasion of pathogenic bacteria; therefore, after being compounded with the raw materials such as carbomer, sodium hydroxide, sodium hyaluronate, isomaltooligosaccharide and propylene glycol, the multiple components can synergistically promote the synthesis and repair of collagen fibers and improve the elasticity of tissues.

This invention discloses an essence for repairing hormone-induced facial dermatitis and its application, belonging to the field of cosmetics and skin repair technology. The essence uses deionized water as the main solvent, with butylene glycol and glycerin as the core moisturizing base. It is compounded with five major active ingredients: niacinamide, Bacillus ferment precipitate, mussel extract, sodium hyaluronate, and allantoin, supplemented with auxiliary components such as 1,3-propylene glycol, capryloyl hydroxamic acid, 1,2-hexanediol, ethylhexylglycerin, disodium EDTA, and ethanol. Through scientific compounding, a synergistic repair system is formed, achieving integrated effects of skin barrier repair, anti-inflammatory soothing, microecological balance regulation, deep moisturizing and water locking, and redness reduction and stabilization. The formula of this invention is gentle and non-irritating, free of hormones, fragrances, pigments, and strong allergens, suitable for use on hormone-induced facial dermatitis, dermatitis-prone skin, and severely sensitive skin. The product has good stability, high safety, and is suitable for industrial production, possessing significant skin repair value and promising market application prospects.

The application discloses a flame-retardant epoxy resin electrolyte prepolymer and a solid electrolyte membrane containing the same, the flame-retardant epoxy resin electrolyte prepolymer is an oligomer obtained through ring-opening addition reaction of phosphonate diol, diglycidyl ether and polyether amine; the terminal of the 1,4-butanediol oligomer contains unreacted epoxy groups and / or amine groups; the chemical formula of the 1,4-butanediol phosphonate diol is shown as formula (I): formula (I); wherein, R1 and R2 are alkyl or aryl; the flame-retardant epoxy resin electrolyte prepolymer of the application improves the flame retardance of the epoxy resin electrolyte prepolymer by introducing the phosphonate diol, improves the compatibility with lithium salt by providing lithium ion coordination sites through ether bonds P-O-C bonds and P=O, guarantees the smooth progress of subsequent curing reaction by retaining unreacted active groups (epoxy groups and / or amine groups), and finally improves the flame retardance and ionic conductivity of the epoxy resin solid electrolyte membrane formed after the epoxy resin electrolyte prepolymer and lithium salt are cured.

The application discloses a kind of carbonic anhydrase catalysis CO2 Mineralization enhanced bamboo fiber composite material and preparation method thereof, belong to environmental protection material field.The composite material formula includes by weight parts 15-20 parts of terephthalic acid, 1,4-butanediol 16-25 parts, catalyst 0.2-1 part, bamboo fiber 50-55 parts, calcium chloride 5-8 parts, carbonic anhydrase 0.01-0.03 parts, pH regulator 1-2 parts, antioxidant 0.3-1 part.The preparation process is first used carbonic anhydrase mineralization bamboo fiber, and obtains mineralization bamboo fiber, and PBT is synthesized under the catalysis of catalyst to obtain mineralization bamboo fiber-PBT copolyester composite material.The composite material prepared by the scheme has the characteristics of degradability, low cost, good interfacial compatibility and excellent mechanical properties.

This invention belongs to the field of microbial metabolic engineering and synthetic biology, specifically relating to a strain for high-yield... R,R -2,3-Butanediol ( R,R Salt-tolerant Jeju Bacillus DT01 IM3 DLB6 (-2,3-BDO), production strain constructed from this strain and its application in fermentation production. R,R Applications of -2,3-BDO. This invention screens a high-yielding strain through heavy ion beam irradiation mutagenesis. R,R Jeju Bacillus DT01 IM3 DL B6 with -2,3-BDO, preservation number CGMCC No. 37311. This strain exhibits excellent salt tolerance and low endotoxin properties. The production strain constructed from it has extremely high product synthesis capabilities, enabling high-concentration, high-intensity industrial fermentation production.

The application discloses a dimethyl maleate hydrogenation catalyst and a preparation method and application thereof. The catalyst comprises CuO, Al2O3 and Mn oxide; the specific surface area of the catalyst is 40-70 m 2 / g; the catalyst is subjected to H2-N2O titration test, and the dispersion degree of metal Cu is 42-70%. The catalyst is used for hydrogenation of dimethyl maleate to prepare 1,4-butanediol, gamma-butyrolactone and tetrahydrofuran in combination, and has high conversion rate and target product selectivity.

The application discloses a high-elongation-strength anti-fatigue TPU blended material and a preparation method thereof, and relates to the field of polymer materials. In the preparation of the high-elongation-strength anti-fatigue TPU blended material, phosphorus chloride is reacted with 4'-vinyl-[1,1'-biphenyl]-4-alcohol and p-phenylphenol to obtain a phosphite antioxidant; nano-silicon dioxide is sequentially reacted with trimethoxysilane and the phosphite antioxidant to obtain modified silicon dioxide; a modified polyurethane elastomer is prepared by reacting hydroxyl-terminated polysiloxane, 1,4-butanediol, isophorone diisocyanate and adipic dihydrazide; polyether amide elastomer and the modified polyurethane elastomer are mixed, mixed with a compatilizer, modified silicon dioxide and antioxidant 1010, dried, mechanically mixed, and melt-blended to obtain the high-elongation-strength anti-fatigue TPU blended material. The high-elongation-strength anti-fatigue TPU blended material prepared by the application has the abilities of self-repairing, durability and flame resistance.

The application discloses a dehydrogenation catalyst and a synthesis method and application thereof. The synthesis method of the catalyst comprises the following steps: (1) mixing soluble copper salt, soluble zinc salt and soluble aluminum salt with dichloromethane and ethanol to obtain a mixed solution containing copper, zinc and aluminum, and then adding polylactic acid and stirring to obtain a spinning solution; (2) using a coaxial electrostatic spinning nozzle to electrostatically spin the spinning solution obtained in the step (1) and collecting a solid; (3) placing the solid obtained in the step (2) in an ethanol solution of trimesic acid to perform a reaction, and then washing and drying the catalyst precursor after the reaction is completed; and (4) calcining and post-treating the catalyst precursor obtained in the step (3) to obtain the catalyst. The catalyst obtained by the method has high conversion rate and selectivity in the reaction of dehydrogenating 1,4-butanediol to prepare gamma-butyrolactone.

The patent discloses a low-smoke oil residue heating cigarette sheet and an aerosol generating system. The heating cigarette sheet comprises a tobacco base material, an atomizing agent, water, an additional fiber, an adhesive and a gas generating agent. The gas generating agent comprises one or more combinations of inorganic bicarbonate, basic carbonate, organic acid salt and small molecule sugar alcohol. The atomizing agent is selected from one or more combinations of glycerol, propylene glycol and 1,3-butanediol. The addition ratio of the atomizing agent to the gas generating agent is 1:(0.10-0.15), 1:(0.15-0.20), 1:(0.20-0.25) or 1:(0.25-0.30) by weight. The gas generating rate of the heating cigarette sheet is greater than 10 mL / min, the single puff gas generating amount is greater than 5 mL / puff, the gas generating agent makes the proportion of carbon dioxide in the decomposition gas of the heating cigarette sheet not less than 80%, and the condensation residue amount of the heating cigarette sheet in the heating smoking set is less than 1.3 mg / branch. The patent achieves the purpose of accelerating smoke exhaust.

The application relates to the technical field of cosmetics, in particular to a water-in-oil system makeup primer and a preparation method thereof. The water-in-oil system makeup primer comprises the following components in parts by weight: cosmetic-grade purified water, cetyl PEG / PPG-10 / 1 dimethicone, dimethicone, isononyl isononanoate, synthetic wax, microcrystalline wax, glycerol, 1,3-propanediol / octyldodecanol / ethylhexylglycerin, butylene glycol, sodium chloride and a polyoxyethylene (20) sorbitan monolaurate-polyoxypropylene (4) sorbitan monolaurate compound. The water-in-oil system makeup primer provided by the application can realize 80% high-aqueous-phase stable bearing, provide sufficient moisturizing reserves for dry skin, realize instant film forming and water locking during smearing, improve the water retention rate to more than 85%, solve the problem of water supplement efficacy attenuation, thereby realize the dual effects of instant water locking and long-acting moisturizing, and resolve the contradiction between water locking and skin feeling.

Extract of Halopteris scoparia comprising, for 100% of its mass, 80% by mass to 95% by mass of water, 4.5% by mass to 15% by mass of an organic solvent selected from the elements of the group consisting of 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 1,2-butanediol, 1,2-pentanediol, 2-methyl-2,4-pentanediol, 1,6-hexanediol, 1,8-octanediol and a mixture of these compounds, and 0.5% by mass to 5% by mass of dry matter, and its use as cosmetic and pharmaceutical active ingredients.

The present application relates to a kind of tetrahydrofuran and its preparation method, belong to synthetic technical field.The purity of tetrahydrofuran is ≥99.990%, does not contain succinic anhydride and methyl tetrahydrofuran, and the rest is impurity;Impurity includes γ-butyrolactone, content ≤0.009%, 1,4-butanediol, content ≤0.004%.Its preparation includes the following steps: maleic anhydride solution and hydrogen are introduced into the reactor loaded with supported catalyst to carry out reaction, then after separation and purification, tetrahydrofuran is obtained;Wherein the preparation of catalyst includes the following steps: S1, to pitch and molybdenum disulfide are heat treated, and porous carbon / molybdenum disulfide carrier is obtained;S2, nickel precursor and hydrophobic compound are dispersed in water, and mixed solution is obtained;The structural formula of hydrophobic compound is n ≥6;S3, porous carbon / molybdenum disulfide carrier is immersed in mixed solution, after aging, drying and heat reduction treatment, supported catalyst is obtained, and the final goal that product purity can reach 99.99% or more is achieved.

The application provides a metal-doped niobium oxide material, which is used as a catalyst to catalyze 1,4-butanediol to prepare tetrahydrofuran. The catalyst preparation method is simple, and the catalyst can be recycled and reused, and is safer and more environmentally friendly compared with a traditional strong acid homogeneous catalyst. In addition, the catalyst has a lower required temperature in a reaction process, a greatly prolonged catalyst service life compared with a traditional strong acid heterogeneous catalyst, and good hydrothermal stability. Therefore, the metal-doped niobium oxide material M@NbO x prepared by the application has certain industrial application prospects.

The present application relates to a kind of biological gamma-butyrolactone and its production method, the production method of biological gamma-butyrolactone of the present application includes the following steps: preparation biological succinic acid solution;The obtained biological succinic acid solution and hydrogen continuously enter the fixed bed containing nickel copper catalyst and carry out hydrogenation reaction, obtain crude product;The obtained crude product enters separation column and is separated and purified, obtain biological gamma-butyrolactone;Nickel loading in the nickel copper catalyst is 30wt%~60wt%, copper loading is 1wt%~5wt%, the content of hydrophobic compound is 0.01wt%~0.2wt%.The present application is prepared by 5wt%~30wt% biological 1,4-butanedioic acid dilute solution continuously into fixed bed hydrogenation reactor, and biological gamma-butyrolactone liquid is prepared, continuously enters rectification separation column and is separated, and biological gamma-butyrolactone product with purity ≥99.99% can be prepared, and the rest is impurity;The impurity includes tetrahydrofuran and 1,4-butanediol;The content of tetrahydrofuran is ≤0.004%;The content of 1,4-butanediol is ≤0.005%.

The present disclosure provides a self-healing polyurethane resin and a preparation method thereof. The preparation method of the self-healing polyurethane resin coating comprises the following steps: polytetrahydrofuran is placed in a three-necked flask, heated to remove water and kept in an oxygen-free environment; a certain amount of isophorone diisocyanate and a catalyst dibutyltin dilaurate, anhydrous tetrahydrofuran are added into the system and reacted at this temperature; the system is cooled and 1,4-butanediol or bis(2-hydroxyethyl)disulfide, anhydrous tetrahydrofuran are added into the system for reaction; after the reaction is completed, the system is immediately cooled, more than solvent is spun off by rotary evaporation, the product is coated on the surface of a substrate and solidified to form a coating. The obtained coating has high self-healing ability, long healing life, low curing temperature, and excellent mechanical properties and corrosion and stain resistance.

This invention provides a nanomaterial for tumor immunotherapy and its preparation method. The nanomaterial is prepared by a nanoprecipitation method using a phenylalanine-based polymer and a stabilizer. The phenylalanine polymer is obtained from triethylamine, p-nitrophenol, L-phenylalanine, and butanediol. The nanomaterial provided by this invention can induce the body to produce effective CD8+. + T-cell immune response, increased CD8 + The proportion of T cells, promoting CD8 + T-cell immune function, ultimately aiming to prevent and treat tumors, is a treatment approach that effectively treats tumors by influencing the function of the immune system.

This invention discloses a method for the catalytic hydrogenation of bio-based small molecule diols to prepare monohydric alcohols. The method includes the following steps: placing an aqueous solution of a bio-based small molecule diol in a high-pressure reactor, adding an activated carbon-supported metal catalyst and a solid or liquid acid, then introducing hydrogen gas at a certain pressure, and stirring the reaction at a certain temperature for a period of time to obtain the monohydric alcohol; the small molecule diol is one of ethylene glycol, 1,2-propanediol, 1,4-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol; the activated carbon raw material is widely available, easy to prepare, and recyclable. The catalyst preparation process is simple, reusable, inexpensive, has high catalytic activity, and the reaction conditions are relatively mild, making it easy to promote.

This invention relates to the field of skin tissue repair material manufacturing, and particularly to a porous polyurethane dermal scaffold and its preparation method. The preparation method of the porous polyurethane dermal scaffold includes the following steps: adding dibutyltin dilaurate, triethylenediamine, butanediol, and silicone oil sequentially to polyethylene glycol and mixing thoroughly to obtain a mixed solution; adding lysine diisocyanate and ultrapure water to the mixed solution and mixing thoroughly to obtain a mixture; placing the mixture in a mold and allowing it to foam and solidify, then curing, demolding, washing, and drying to obtain the porous polyurethane dermal scaffold. The preparation method of this invention is simple, the material has a pore size of 30-200 μm, a porosity > 95%, a tensile strength of 10-12 N / cm, an elongation at break > 50%, is non-toxic and non-immunogenic, and meets the biocompatibility requirements of standards such as GB / T 16886, showing great application potential in wound dressings and skin tissue engineering.

This invention discloses a copper-chromium catalyst, its preparation method, and its application. The preparation method of the catalyst includes: (1) mixing polylactic acid with dichloromethane and ethanol to obtain a polymer solution, adding a soluble copper salt to it, stirring, and obtaining a spinning solution; (2) using a coaxial electrospinning nozzle to perform electrospinning with the obtained spinning solution, and collecting the obtained solid; (3) placing the obtained solid in an ethanol solution of trimesic acid to react, washing and drying after the reaction, and collecting the obtained solid; (4) dissolving a soluble chromium salt in ethanol and reacting it with the obtained solid, then washing and drying, and collecting the obtained catalyst precursor; (5) calcining the obtained catalyst precursor to obtain an unformed catalyst, then pressing it into tablets to obtain the copper-chromium catalyst. This catalyst can improve the conversion rate and selectivity of the catalyst in the hydrogenation of dimethyl maleate to prepare 1,4-butanediol and co-production of γ-butyrolactone and tetrahydrofuran.

The present invention relates to a novel carboxylic acid reductase variant and a method for producing 1,4-butanediol using same, wherein the carboxylic acid reductase variant has altered protein activity resulting from substitution of one or more amino acids in the amino acid sequence constituting carboxylic acid reductase, so that a transformant or recombinant microorganism comprising same can efficiently produce the carboxylic acid reductase.

This invention discloses a eutectic solvent and its ultrasonic method for extracting polysaccharides from evening primrose seeds, belonging to the field of polysaccharide extraction technology. The eutectic solvent comprises a hydrogen bond acceptor and a hydrogen bond donor in a molar ratio of 1:(1~2); the hydrogen bond acceptor is choline chloride, and the hydrogen bond donor is a single component or a two-component. The single component includes any one of glycerol, malonic acid, lactic acid, 1,3-butanediol, butylene glycol, D-sorbitol, citric acid, and ethanol; the two-component is 1,3-butanediol and butylene glycol in a molar ratio of 2:(0.5~1). This invention uses an ultrasonic method with a eutectic solvent to extract polysaccharides from evening primrose seeds. The eutectic solvent and evening primrose seed powder are mixed in a certain proportion, and the polysaccharide extract is obtained after ultrasonic extraction. This significantly improves the extraction rate of evening primrose seed polysaccharides and greatly enhances the resource utilization rate of evening primrose. Compared with water extraction, it has a lower extraction temperature, shorter extraction time, and higher extraction rate.

The application discloses a kind of PBAT composite film and preparation method thereof, the PBAT composite film includes following raw materials, PBAT resin, calcium carbonate, optional PLA and optional other auxiliary agent, wherein, the preparation method of the PBAT resin includes following steps: (1) short straight chain aliphatic dibasic acid is esterified with short branched-chain aliphatic dihydric alcohol, and polyester oligomer A is obtained;(2) adipic acid, terephthalic acid and 1,4-butanediol are esterified and polycondensed, and polyester oligomer B is obtained;(3) polyester oligomer B is added to polyester oligomer A to carry out ester exchange reaction, and PBAT resin is obtained.The application can significantly improve the molecular chain movement ability by reacting with aliphatic polyester oligomer during PBAT polymerization, so that the glass transition temperature and crystallinity of PBAT are significantly reduced, so as to improve the heat sealing effect of composite film.

This invention belongs to the field of bioengineering technology, specifically relating to a method for... R,R BmoR protein mutants with a wider detection range (0-200 mM) for 2,3-butanediol, and their applications in... R,R Applications in the detection or biosensor of 2,3-butanediol. The BmoR protein mutant was obtained by mutating the wild-type BmoR protein shown in SEQ ID NO.1 with the N89D mutation, and has the amino acid sequence shown in SEQ ID NO.3. The N89D mutant... R,R -2,3-Butanediol has a wider detection range (0-200 mM), solving the problem of the inability to screen wild-type BmoR proteins. R,R The problem of high-yield strains of 2,3-butanediol can be addressed by screening and applying strains with even higher yields.

The present invention provides an EG copolymer PBT composition that exhibits excellent molding cycle characteristics, interlocking properties and hinge characteristics of the resulting molded articles, and is easily converted to high molecular weight by solid-phase polycondensation. [Solution] A method for producing an ethylene glycol copolymerized polybutylene terephthalate composition, comprising the step of reacting ethylene glycol with dimethyl terephthalate and / or terephthalic acid and 1,4-butanediol, and then reacting the resulting reaction product with ethylene glycol. A method for producing an ethylene glycol copolymerized polybutylene terephthalate composition, comprising the step of reacting dimethyl terephthalate and / or terephthalic acid and 1,4-butanediol, and then reacting the resulting reaction product with ethylene glycol, dimethyl terephthalate and / or terephthalic acid and 1,4-butanediol.

The invention relates to a barrier layer laminate (10) with a three-layer structure, wherein a barrier material layer (30) consisting of a mixture of ethylene vinyl alcohol copolymer (EVOH) and butanediol vinyl alcohol copolymer (BVOH) is embedded between two, preferably material-identical, polyolefin layers (20), and furthermore a method for producing the barrier layer laminate (10) and its use for producing a packaging laminate with a barrier layer and / or for producing packaging.