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Polyurethane-polypeptide graft copolymer and preparation method thereof

A graft copolymer and graft polymer technology are applied in the field of biopolymer material preparation to achieve the effects of precise control of relative content and simple preparation method

Inactive Publication Date: 2011-09-14
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, this graft copolymer has not been reported in the literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Step 1) molecular chain has the synthesis of the polyurethane of side carboxyl group

[0021] Add 5.7 grams of toluene diisocyanate, 22 grams of polypropylene glycol (molecular weight: 2000), and 3 grams of polyethylene glycol (molecular weight: 1000) into the dry reaction bottle, add 200 grams of dimethylformamide to dissolve, and add the above reactants Dibutyltin dilaurate with a total weight of 5‰, under an inert atmosphere, stirred and reacted at 55°C for 40 minutes; then added 1.63 grams of dimethylolpropionic acid dissolved in dimethylformamide and reacted for 10 minutes; then added 0.5 1,4-gram of 1,4-butanediol was reacted for 10 minutes; then 0.5 gram of butanol was added and reacted for 5 minutes to terminate the reaction and obtain the target product.

[0022] Step 2) synthesis of polyurethane-polypeptide graft copolymer

[0023] 18 grams of polyurethane with side carboxyl groups in the molecular chain and 13.71 grams of PBLG (molecular weight: 5000) were c...

Embodiment 2

[0025] Step 1) molecular chain has the synthesis of the polyurethane of side carboxyl group

[0026] Add 295.96 grams of hexamethylene diisocyanate, 430 grams of polypropylene glycol (molecular weight is 2000), 56 grams of polyethylene glycol (molecular weight is 1000) in the dry reaction bottle, add 900 grams of dimethylformamide to dissolve, and add the above reactant total Dibutyltin dilaurate with a weight of 5‰, under an inert atmosphere, stirred and reacted at 60°C for 40 minutes; then added 173.84 grams of dimethylolpropionic acid dissolved in dimethylformamide and reacted for 15 minutes; then added 10 grams 1,4-butanediol was reacted for 10 minutes; then 10 g of butanol was added and reacted for 5 minutes to terminate the reaction and obtain the target product.

[0027] Step 2) synthesis of polyurethane-polypeptide graft copolymer

[0028] 60 grams of polyurethane with side carboxyl groups in the molecular chain and 32.3 grams of PBLG (molecular weight is 500) were co...

Embodiment 3

[0030] Step 1) molecular chain has the synthesis of the polyurethane of side carboxyl group

[0031] Add 115 grams of diphenylmethane diisocyanate, 220 grams of polypropylene glycol (molecular weight is 2000), 30 grams of polyethylene glycol (molecular weight is 1000) in the dry reaction flask, add 300 grams of dimethylformamide to dissolve, and add Dibutyltin dilaurate with a total weight of 5‰ of the above-mentioned reactants was stirred and reacted at 65° C. for 45 minutes under an inert atmosphere; then 32 grams of dimethylolpropionic acid dissolved in dimethylformamide was added and reacted for 15 minutes; Then add 5 grams of 1,4-butanediol and react for 10 minutes; then add 5 grams of butanol and react for 5 minutes to terminate the reaction and obtain the target product.

[0032] Step 2) synthesis of polyurethane-polypeptide graft copolymer

[0033] Dissolve 8 grams of polyurethane with side carboxyl groups in its molecular chain and 20 grams of PBLG (molecular weight:...

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Abstract

The invention relates to a polyurethane-polypeptide graft copolymer and a preparation method thereof. The graft copolymer is a comb-shaped polymer, wherein the molecular weight of polyurethane is 10,000 to 100,000; and the molecular weight of the polypeptide chain segment is 500 to 5,000. The preparation method comprises the following steps of: 1) synthesis of polyurethane provided with lateral carboxyl on the molecular chain: adding diisocyanate, polypropylene glycol, polyethylene glycol, dibutyltin dilaurate catalyst and dimethyl formamide solvent into a dry reaction bottle, performing stirring reaction under inert atmosphere, adding dimethylolpropionic acid dissolved in dimethyl formamide to react, adding butanediol to react, finally adding butanol to react, and obtaining a target product; and 2) synthesis of the polyurethane-polypeptide graft copolymer: putting the polyurethane provided with lateral carboxyl on the molecular chain, a solvent and a condensation agent into a dry reactor, adding polypeptide homopolymer into the reactor, and performing stirring reaction under the inert atmosphere to obtain a target product with pH response.

Description

technical field [0001] The invention relates to a polyurethane-polypeptide graft copolymer and a preparation method thereof, belonging to the technical field of biopolymer material preparation. Background technique [0002] Polyurethane is usually a multi-block copolymer composed of soft segments and hard segments alternately. The urethane group (-NHCOO) contained in the molecular chain can cause strong hydrogen bond interaction between the molecule and the molecule. By selecting appropriate soft and hard segment structures and their proportions, polymer materials with good physical and mechanical properties, such as good flexibility and elasticity, can be obtained. At the same time, polyurethane also has excellent anticoagulant properties, biocompatibility, and no allergic reactions, so it has been widely used in the field of biomedicine and is the first choice for making artificial hearts, artificial blood vessels, and artificial catheters. Materials [Feng Zengguo et al.,...

Claims

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Application Information

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IPC IPC(8): C08G81/00C08G18/83C08G18/66C08G18/48C08G69/48
Inventor 朱国全王发刚李国昌柳玉英高巧春王萍巩丽
Owner SHANDONG UNIV OF TECH
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