8494 results about "Anti bacterial" patented technology

The invention discloses bone cement for orthopedic repair and a preparation method thereof, and relates to the technical field of bone cement. The bone cement for orthopedic repair comprises solid-phase powder and a liquid-phase component, the solid-phase powder comprises the following components in parts by weight: 55-65 parts of composite calcium phosphate, 10-15 parts of bioactive glass, 2-3 parts of a developing agent, 1-2 parts of hydroxyapatite, 8-12 parts of a modified toughening agent and 2-3 parts of nano cellulose fibers; the liquid phase component is prepared from the following components in parts by weight: 40 to 50 parts of a sodium alginate solution, 10 to 20 parts of methacrylated gelatin, 0.5 to 1 part of transglutaminase, 30 to 60 parts of a citric acid buffer solution and 1 to 2 parts of an antibacterial agent. The preparation method comprises the following steps: reacting pentaerythritol with 12-oxododecanoic acid to obtain an intermediate 1, and reacting the intermediate 1 with dopamine to prepare the modified toughening agent. The bone cement for orthopedic repair prepared by the invention has good mechanical, self-repairing and antibacterial properties.

The invention belongs to antibacterial materials, and particularly relates to antibacterial modified waterborne polyurethane and a preparation method and application thereof.The preparation method of the antibacterial modified waterborne polyurethane comprises the following steps that polyol and diisocyanate are mixed and subjected to a prepolymerization reaction, and a polyurethane prepolymer is obtained; mixing the polyurethane prepolymer and a chain extender, and carrying out chain extension reaction; in the chain extension reaction, adding the graft and carrying out esterification reaction to obtain a first intermediate; mixing the first intermediate with triethylamine and carrying out neutralization reaction to obtain a second intermediate; and emulsifying the second intermediate in deionized water to obtain the antibacterial modified waterborne polyurethane. Compared with the prior art, the antibacterial waterborne polyurethane has the advantages that the problems of poor intermiscibility, low durability and the like in physical addition and the problems of limited binding objects and weak antibacterial effect in covalent binding in the antibacterial waterborne polyurethane in the prior art are solved. According to the scheme, arginine and chitosan are grafted to a molecular chain of waterborne polyurethane, so that the waterborne polyurethane is endowed with a synergistic antibacterial property.

The invention provides an intelligent evaluation method and system for the antibacterial effect of a water matrix standard substance, and relates to the technical field of intelligent evaluation, and the method comprises the following steps: preparing a bacterial suspension in a logarithmic phase and checking turbidity; preparing a water matrix standard substance and a control solvent, and obtaining a baseline parameter set; setting inoculum size and incubation conditions, determining the antibacterial efficiency in parallel, and performing image segmentation correction on sticky colonies to obtain an original observation set; establishing a deviation transfer relationship, correcting the original data, and forming an endpoint quantization set; and the bacteriostatic validity is output through evidence fusion, and a supplementary experiment is carried out on a critical condition. According to the method, the accuracy and reliability of bacteriostatic effect evaluation of the water matrix standard substance are improved.

The invention discloses a Janus wound dressing with antibacterial and tissue repair promoting functions and a preparation method of the Janus wound dressing, belongs to the technical field of wound dressings, and aims to realize antibacterial, tissue repair promoting and moist wound healing microenvironment through freeze drying and electrostatic spinning technologies. Polycaprolactone (PCL), bioactive glass (BG) and curcumin Cur are used for preparing a hydrophobic inner layer capable of promoting tissue repair, methacrylated gelatin GelMA is used for preparing a hydrophilic outer layer with moisturizing performance, and the PCL-BG-Cur / GelMA composite wound dressing with antibacterial, moisturizing and repair promoting functions is constructed. Animal experiment results show that the dressing loaded with curcumin Cur and bioactive glass BG has multiple functions of synergistic antibiosis, moisturizing and the like, the result shows that the prepared dressing has the performance of promoting epithelization, collagen deposition, new hair follicle formation and the like, and the dressing has a considerable application prospect in the aspect of rapid wound repair.

The invention discloses hydrogel loaded with antibacterial polypeptide as well as a preparation method and application of the hydrogel. The preparation method of the hydrogel comprises the steps that antibacterial polypeptide and polyethylene glycol dimethacrylate are subjected to a cross-linking reaction, the hydrogel can be obtained, and the antibacterial polypeptide is obtained through polymerization synthesis of a cationic CBL monomer compound and an HBL monomer compound; the hydrogel has remarkable sterilization and anti-biofilm effects, and in-vitro cytotoxicity shows that the antibacterial polypeptide hydrogel product has no inhibition effect on normal cell growth; when the hydrogel dressing is used as a hydrogel dressing and is combined with novobiocin for use, more than 99% of antibacterial effect is achieved in a diabetes wound infection model and a fungal psoriasis infection model; and when being used as a hydrogel preparation to be combined with fluconazole, the compound has the effect of inhibiting growth of more than 99% of fungi in an animal vaginitis model.

The invention discloses a metal-doped carbon quantum dot as well as preparation and application of the metal-doped carbon quantum dot in a nano antibacterial agent, citric acid, urea and tea polyphenol are taken as precursors, metal salt is added, carbon dot synthesis and metal ion doping are synchronously completed in one step through a hydrothermal method, and the metal-doped carbon quantum dot is prepared; the surfaces of the metal-doped carbon quantum dots are negatively charged, and the metal-doped carbon quantum dots have peroxidase-like activity and catalase-like activity at the same time; the metal ions adopt any one of Fe < 3 + >, Cu < 2 + > and Ce < 3 + >; the metal-doped carbon quantum dots are in a sphere-like shape. The metal-doped carbon quantum dots prepared by the preparation method disclosed by the invention have peroxidase-like activity and catalase-like activity at the same time through precise doping of metal ions, and the two activities have a synergistic effect in an oral periodontitis microenvironment, so that a good antibacterial effect is achieved.

The invention relates to the technical field of antibacterial and antifouling fabrics, provides a preparation method of an antibacterial and antifouling fabric, and solves the problem of poor fabric durability caused by single functional component and lack of physical protection in the prior art. The preparation method comprises the following steps: S1, preparing MOFs loaded antibacterial fibers: blending a metal organic framework antibacterial composite nanomaterial and a polymer matrix material, and carrying out melt spinning to prepare the MOFs loaded antibacterial fibers; s2, constructing a self-cleaning functional coating: dispersing the fluorinated nanoparticles and a polymer adhesive in a solvent to prepare a self-cleaning coating solution; s2, performing surface activation treatment on the MOFs-loaded antibacterial fiber obtained in the step S1, soaking the MOFs-loaded antibacterial fiber in the self-cleaning coating liquid, and performing pulling and curing to form a bionic micro-nano structure coating on the surface of the MOFs-loaded antibacterial fiber so as to obtain a functional composite fiber; s3, spinning forming: taking the functional composite fibers obtained in the step S2 as warp yarns and / or weft yarns, and weaving to obtain the antibacterial and antifouling fabric.

The invention discloses an MOF-CQD enzyme-sensitive FRET hydrogel diagnosis and treatment probe as well as a preparation method and application thereof, and belongs to the technical field of biomedical detection and treatment. The probe takes a carboxyl carbon quantum dot (CQD) as a donor and a metal organic framework (MOF) as an acceptor, and the donor and the acceptor are connected through a replaceable enzyme response polypeptide bridge; when the fluorescence is complete, FRET is generated to quench the CQD fluorescence, the FRET is interrupted after the target enzyme cuts off the peptide bridge, and the blue / red fluorescence ratio is changed to realize nanomole-level quantitative detection and has self-correction capability. The probe is packaged in a four-arm PEG transparent hydrogel which does not need a photoinitiator and can be quickly self-crosslinked, and can be prepared into a film, a tooth socket and the like for POCT (point-of-care testing) of parts such as an oral cavity / skin and the like. After detection, the MOF is activated by illumination of 630-660 nm to generate active singlet oxygen, so that local antibacterial or anti-tumor treatment is realized, and a diagnosis and treatment integrated scheme is constructed.

A male cap can include a male tapered outer surface that can be configured to mate with a female luer to create a fluid tight fit. The male cap can also include a water-soluble antimicrobial composition disposed on the male extension. The male cap can include a fluid-soluble, slower-dissolving material covering the water-soluble antimicrobial composition or incorporated within the water-soluble antimicrobial composition. The slower-dissolving material can be configured to slow a dissolution of the water-soluble antimicrobial composition during installation of the male cap into the female luer.

Provided is an antibacterial peptide having an amino acid sequence X1KRFKKFFX2KLKKWV-NH2, wherein X1 is selected from any one or of amino acids A, C, D, E, F, G, H, K, L, N, M, P, Q, R, S, I, V, W, Y, and T or is absent; and X2 is an amino acid having an aromatic side chain or an amino acid having an alkaline side chain. In view of defects such as poor gastrointestinal fluid stability of antibacterial peptides in the prior art, a brand-new sequence design scheme and preparation method for an antibacterial peptide are provided. By means of a complete or partial D-amino acid substitution or structural derivatization of a peptide sequence, a series of antimicrobial peptides having stronger antibacterial activity and gastrointestinal stability as compared with the prior art are obtained, such that the antibacterial peptides have a wider application range and higher development potential value.

The invention relates to a novel application of animal bifidobacterium subsp. Lactis BGI-N3, in particular to an application of the animal bifidobacterium subsp. Lactis BGI-N3 in preparation of a preparation for relieving skin allergy. The invention finds that the bifidobacterium animalis subsp. Lactis BGI-N3 has a very remarkable effect in the aspect of relieving skin allergy, and the effect is specifically shown as follows: in an atopic dermatitis animal model, the dermatitis score, scratching times and percutaneous water loss are remarkably reduced, and the atopic dermatitis skin tissue damage condition is relieved; the immune organ edema condition is improved, the levels of Th2 type cell factors and inflammatory factors IL-6, TNF-alpha and IFN-gamma related to dermatitis are reduced, and the immune balance of the body is recovered; expression of fibroin and endothelial protein in skin tissue is improved, and the skin barrier is repaired; the level of antibacterial peptide in skin tissues is recovered, and the antibacterial activity of the skin is enhanced. Meanwhile, compared with a traditional chemical medicine for treating atopic dermatitis, the animal bifidobacterium subsp. Lactis BGI-N3 has no side effects such as weight loss, immune organ atrophy, immune imbalance and the like.

The invention discloses an amphiphilic chitosan and plant nanocellulose composite coating fresh-keeping material, which is prepared from the following ingredients in percentage by mass: 0.5 to 20 percent of amphiphilic chitosan, 0.1 to 5.0 percent of plant nanocellulose, 0.5 to 10.0 percent of coalescing agents, 0.1 to 3.0 percent of antioxidants and the balance deionized water. Wherein the amphiphilic chitosan is prepared from chitosan, quaternary phosphonium salt and sorbic acid. Amphipathic chitosan of the material has hydrophilic groups such as amino and carboxyl and a sorbate hydrophobic group, has hydrophilicity and hydrophobicity at the same time, and is extremely easy to combine with substances such as a coalescing agent, plant nanocellulose and an antioxidant to form a stable polymeric membrane layer, so that the mechanical property after membrane formation is remarkably improved, and the material has a good application prospect. Meanwhile, the plant nanocellulose particles can be stably coated in the polymeric membrane material layer, so that the mechanical property of the material is enhanced, and lasting and efficient antibacterial and antioxidant effects are realized. The invention further discloses a preparation method and application of the amphiphilic chitosan and plant nanocellulose composite coating fresh-keeping material.

The invention relates to a preparation method of antibacterial gamma-polyglutamic acid superabsorbent hydrogel. The preparation method comprises the following steps: (1) preparing a gamma-polyglutamic acid solution; (2) dissolving an antibacterial agent in the gamma-polyglutamic acid solution, and fully stirring and uniformly mixing to obtain a mixed solution 1; adjusting the pH value of the mixed solution 1, heating the mixed solution 1 to 60 DEG C, and continuously reacting for 1-2 hours to obtain a mixed solution 2; cooling the mixed solution 2 to room temperature, adding a cross-linking agent, and uniformly mixing to obtain a mixed solution 3; standing the mixed solution 3 at room temperature for 1-3 hours and then carrying out gradient heating reaction to obtain an antibacterial gelatinous product; and (3) dehydrating the antibacterial gelatinous product, and carrying out vacuum negative pressure drying to obtain a dried hydrogel product, namely the antibacterial gamma-polyglutamic acid super absorbent hydrogel. The antibacterial gamma-polyglutamic acid superabsorbent hydrogel prepared by the invention has good biocompatibility, is safe and non-toxic, also has excellent water absorption performance and antibacterial performance, and has a good application prospect.

The invention relates to the technical field of medical dressings, in particular to a perianal drug dressing of a multi-layer flow guide composite fabric and a preparation method and application of the perianal drug dressing of the multi-layer flow guide composite fabric. The perianal drug dressing is of a four-layer structure, a wet tissue adhesion layer is made of polydopamine modified chitosan / oxidized hyaluronic acid hydrogel, and wet-state adhesion is achieved; the drug sustained-release layer is used for dispersing mesoporous silica loaded with ciprofloxacin hydrochloride / defensin and chitosan microspheres loaded with epidermal growth factors / lonicera japonica into a polycaprolactone fiber membrane to achieve synergistic antibacterial and healing promotion; the directional flow guide layer is of a gradient wettability sandwich structure with a bionic micro-channel, and one-way rapid drainage can be achieved; the high-absorption outer layer is carboxymethyl cellulose / sodium polyacrylate composite sponge, liquid is locked efficiently, the wound surface is kept dry and comfortable, the clinical problem in perianal infection wound treatment can be effectively solved, and the treatment effect and the patient comfort are remarkably improved.

The invention belongs to the technical field of textile materials, and particularly relates to an antibacterial regenerated wool blended yarn and a production process thereof.The antibacterial regenerated wool blended yarn is prepared from, by weight, 35 parts of regenerated wool fibers, 25-33 parts of LF tencel, 15-27 parts of cellulosic fibers, 8-12 parts of antibacterial chinlon 6 and 5 parts of an antibacterial complexing agent; according to the regenerated wool fiber prepared from the waste wool product through a synergistic improvement process of biological enzyme targeted cleaning and plasma etching, the natural properties of the wool fiber are reserved, and meanwhile, a surface pore structure capable of being combined with an antibacterial complexing agent is also formed; through a Z / S double-twist asynchronous spinning process, dynamic balance of a multilayer structure and hygroscopicity and strength of the blended yarn is achieved, and environment friendliness and commercial feasibility are both achieved.

The invention discloses a macrocyclic covalent organic polymer material for inhibiting a pi-pi stacking effect and application of the macrocyclic covalent organic polymer material, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: adding 5, 10, 15, 20-tetra (4-ethynylphenyl) copper porphyrin and a macrocyclic monomer into an organic solvent in a protective atmosphere, and carrying out solvothermal reaction in the presence of a catalyst and alkali to obtain the macrocyclic covalent organic polymer material. According to the invention, 5, 10, 15, 20-tetra (4-ethynylphenyl) copper porphyrin and a macrocyclic monomer form a porous polymer MCP-CU-POP, the material utilizes the photo-thermal capability to combine the effects of simulated photo-thermal (PTT), photodynamic (PDT), peroxidase (PODs) and glutathione peroxidase (GSH-Px) to perform synergistic antibiosis, and the inherent characteristics of an infected microenvironment can also be utilized to induce death of bacteria, so that the antibacterial property of the material is greatly improved, and the antibacterial property of the material is greatly improved. And the microenvironment of the bacterial infection part can be adjusted, so that the recovery of the bacterial infection wound can be obviously accelerated.

The invention discloses a photo-thermal composite hydrogel patch and a preparation method and application thereof.The hydrogel patch is of a three-dimensional latticed porous structure formed by taking methylacryloyl gelatin (GelMA) and methylacryloyl hyaluronic acid (HAMA) as matrixes, loading niobium carbide nano-particles (Nb2CNPs) and vinipofen (VP) and conducting 3D printing or casting molding, the hydrogel patch is named as VP-Nb2C-coated GelMA / HAMA (VNGH) hydrogel patch for short. The VNGH has good photo-thermal antibacterial property, oxidation resistance and reepithelization promoting function, can significantly improve the quality of mouse diabetic wound healing, and provides a new thought and strategy for realizing scar-free healing of diabetic wounds.

The invention discloses an antibacterial peptide based on D-type amino acid and application of the antibacterial peptide, and the antibacterial peptide is characterized in that the amino acid sequence is w-r-r-w-r-r-w-w-r-k-r (dTrp-dArg-dArg-dTrp-dArg-dArg-dTrp-dTrp-dArg-dLys-dArg). The antibacterial peptide can be synthesized through an Fmoc solid-phase chemical method, the synthesis difficulty is low, and the in-vivo antibacterial activity is good. The antibacterial peptide especially has broad-spectrum killing activity on carbapenem-resistant pseudomonas aeruginosa, pseudomonas aeruginosa, klebsiella pneumoniae, escherichia coli, methicillin-resistant staphylococcus aureus and staphylococcus aureus, is low in hemolytic toxicity, can reach half or more of cell survival rate under medium and low concentration, almost has no toxic effect on cells, and can be used for preparing the antibacterial peptide with a broad-spectrum killing activity on carbapenem-resistant pseudomonas aeruginosa, klebsiella pneumoniae, escherichia coli, methicillin-resistant staphylococcus aureus and staphylococcus aureus. The stability is good, the operability is high, and the cost is low.

The invention relates to the technical field of biomedical materials, in particular to a metal-loaded antibacterial agent and a preparation method thereof.The preparation method comprises the following steps that a metal precursor is loaded to the surface of a carrier, and then washing and drying are conducted; and carrying out mechanical ball milling on the dried sample by using a planetary ball mill, carrying out in-situ roasting in the mechanical ball milling process, cooling to room temperature, washing with water, and drying to obtain the metal-loaded antibacterial agent. According to the preparation method, the regulation and control on the interaction between the metal and the carrier can be realized by utilizing mechanical ball milling, the interaction between the metal and the carrier in the prepared antibacterial agent is stronger than that of a sample prepared by an impregnation method, and the regulation and control on the interaction between the metal and the carrier can be realized by changing parameters of a ball milling process; and meanwhile, by regulating and controlling the interaction strength of the'metal-carrier ', the controllable slow release of metal ions can be realized, the antibacterial effect is ensured, and the action duration of the medicine is prolonged.

The invention discloses a dual-mechanism antibacterial photosensitizer as well as a preparation method and application thereof, and relates to the technical field of biomedical photoelectric functional materials. The invention relates to a triphenylamine derivative, which can realize fluorescence imaging of bacterial or fungal infection by utilizing fluorescence characteristics, can generate active oxygen under illumination to play a photodynamic therapy role, is suitable for preparing photodynamic therapy preparations and developing antibacterial materials, and can also be applied to the fields of environment and public health and tumor treatment. The problems that an existing photosensitizer is insufficient in broad spectrum, different in fungus drug resistance mechanism, limited in single treatment effect and the like can be effectively solved, and the photosensitizer has wide application prospects.

The invention provides a hydroxytyrosol supramolecular compound and a preparation method and application thereof, and belongs to the technical field of cosmetics and biological medicine, the supramolecular compound comprises the following chemical components by mass: 0.01-10% of hydroxytyrosol, 2-45% of an amino acid compound, 2-20% of alpha hydroxy acid, 2-30% of urea, and 15-92% of water. The supramolecular compound can promote transdermal delivery of hydroxytyrosol and maintain the biological activity of hydroxytyrosol, shows high biocompatibility, and can be applied to product development in the antibacterial field, the regeneration field and the anti-aging field.

The invention discloses an antibacterial non-woven fabric and a preparation process thereof, and belongs to the technical field of non-woven fabrics. Comprising the following raw materials in parts by weight: 60-70 parts of polypropylene resin, 10-20 parts of modified bamboo fibers, 5-8 parts of chitosan and 0.5-1.5 parts of an antioxidant. The chitosan and the bamboo fiber have certain antibacterial property, so that the antibacterial property of the non-woven fabric is improved; by modifying the bamboo fibers, the antibacterial performance of the non-woven fabric is remarkably improved, the compatibility of the bamboo fibers and a matrix is improved, meanwhile, micromolecular organic chains are grafted to the bamboo fibers, the migration resistance and seepage resistance of antibacterial components are remarkably improved, and the problems that according to a traditional coating method, falling is prone to occurring, and washing is not durable are solved; the bamboo fiber and the chitosan in the raw materials are natural and renewable materials and are environmentally friendly; in conclusion, the prepared non-woven fabric has stable and efficient antibacterial property, is environmentally friendly and has important application value in the technical field of non-woven fabrics.

A material for producing macromolecule air fibers, a preparation method, and an application thereof are provided. The material for producing macromolecule air fiber is prepared by preparation of doped antibacterial TiO2 / ZnO / ZrO2 ceramic powder, deposition of magnetic iron oxide, surface modification with tannic acid, addition of water-soluble chitosan solution, immersion in a spined TPEE air fiber membrane, uniform addition of Genipin solution, heating and reacting, membrane removal, washing, and drying. The TPEE air fiber membrane produced by the present disclosure has good mechanical properties, and modified ceramic powder is uniformly dispersed in the TPEE air fiber membrane, which plays a good role in antibacterial, environmental protection, immune regulation, magnetic therapy, far-infrared heating and other effects, rendering the material for producing macromolecule air fibers have better comprehensive performance and a good mattress support material with broad application prospects.

The invention relates to the technical field of food packaging materials, in particular to a cerium dioxide nano-enzyme modified antibacterial coating and application of the cerium dioxide nano-enzyme modified antibacterial coating in food packaging. The biomimetic mineralization layer comprises the following components in percentage by weight: 35-45% of a green base material, 8-12% of dopamine modified yttrium-doped cerium dioxide nano-enzyme, 4-6% of a composite antibacterial agent, 3-4% of a natural cross-linking agent, 2-3% of a degradable plasticizer, 1-2% of a biomimetic mineralization layer precursor and the balance of deionized water, the green base material is a blend of a chitosan-polyethylene glycol graft and polylactic acid; the doping amount of Y3 in the nano enzyme is 3-4at%. The antibacterial agent is excellent and lasting in antibacterial effect, has no migration risk of the antibacterial agent, and can guarantee food safety; a green base material and a degradable plasticizer are adopted, so that natural degradation is realized, and environmental pollution is avoided; the mechanical property is good, the aging resistance is realized, and the oxygen barrier property is strong; the food packaging box is suitable for various foods, effectively prolongs the shelf life, and meets the requirement of green packaging.

The invention discloses an eel antibacterial polypeptide Ajaspkidin and application thereof in preparation of an anti-vibrio composition. The amino acid sequence of the eel antibacterial polypeptide Ajaspkidin is shown as SEQ ID NO.01. The invention further discloses an application of the eel antibacterial polypeptide The zebra fish antibacterial peptide has the characteristics of excellent molecular characteristics, broad-spectrum antibacterial activity, efficient bactericidal ability, high thermal stability, high biological safety, anti-infection effect on zebra fish infected by vibrio vulnificus, capability of remarkably improving the survival rate of bred animals and the like, and has a wide application prospect.

The invention belongs to the technical field of textile, and relates to an efficient antibacterial fabric for preparing underwear and a dyeing and finishing method and application thereof.The provided antibacterial fabric is weft-knitted bird eye double-faced knitted fabric and is composed of polyester, cotton and modal fibers, the surface density is 180 g / m, surface yarn of the antibacterial fabric is hollow polyester fibers with special-shaped sections, and the surface yarn of the antibacterial fabric is hollow polyester fibers with special-shaped sections. The lining yarn is formed by weaving dacron and blended yarn according to the proportion of 2: 1. According to the method, dyeing and finishing of the antibacterial fabric, fabric weaving and ergonomic sewing are combined, the fabric which has efficient antibacterial performance, good moisture permeability and ultraviolet-proof performance and high color fastness is obtained, and the prepared antibacterial clothes are high in quick-drying performance, comfortable to wear and high in environmental adaptability.

The invention discloses injectable hydrogel for photo-thermal adjuvant therapy of periodontitis and a preparation method, and belongs to the technical field of high polymer material preparation, the preparation method comprises the following steps: reacting MXene dispersion liquid with epigallocatechin gallate and MgSO4; then sequentially carrying out ultrasonic treatment, centrifugation, washing and freeze-drying to obtain a multifunctional nanosheet MP-Mg; adding the multifunctional nanosheet MP-Mg into an oxidized gellan gum aqueous solution, and carrying out a mixed reaction to obtain a solution A; mixing the quaternary ammonium salt chitosan aqueous solution and the carboxymethyl chitosan aqueous solution in equal volume, and reacting to obtain a solution B; and mixing the solution A and the solution B in equal volume for reaction. The hydrogel prepared by the preparation method disclosed by the invention has injectability, photo-thermal responsiveness, biological membrane penetrability, synergistic antibacterial property and long-acting anti-inflammatory property, and an innovative and practical photo-thermal adjuvant therapy platform is provided for clinical treatment of periodontitis.

The invention discloses an antibacterial peptide fragment intercepted from chitinase IDGF4 protein and application of the antibacterial peptide fragment in preparation of antibacterial drugs. According to the invention, short peptide fragments in chitinase IDGF4 protein are screened, three candidate peptides are obtained through chemical synthesis, the antibacterial performance of the candidate peptides is systematically evaluated, and the evaluation result shows that the peptide fragment with the amino acid sequence as shown in SEQ ID No.2 can effectively inhibit the growth of salmonella and staphylococcus aureus under the concentration of 1mg / mL; the antibacterial effect of the compound is confirmed in inhibition zone experiments, enzyme-labeled turbidimetry and growth curve monitoring, and the compound shows stable and remarkable antibacterial activity and can be used as a novel antibacterial molecule; the invention provides a new candidate sequence for developing the antibacterial peptide with high efficiency and low drug resistance risk, and has application potential in the aspect of preparing clinical antibacterial drugs.

The invention relates to the technical field of antibacterial drugs, in particular to an antibacterial peptide which has an amino acid sequence X1KRFKKFFX2KLKKWV-NH2, in which X1 is selected from any one or deletion of amino acids A, C, D, E, F, G, H, K, L, N, M, P, Q, R, S, I, V, W, Y and T; and X2 represents an amino acid having an aromatic side chain or an amino acid having a basic side chain. Aiming at the defects of poor gastrointestinal fluid stability and the like of the antibacterial peptide in the prior art, the invention provides a brand new antibacterial peptide sequence design scheme and a preparation method thereof, and the peptide sequence is subjected to full D-type amino acid or partial D-type amino acid replacement or structure derivation; compared with the prior art, a series of antibacterial peptides with higher antibacterial activity and gastrointestinal fluid stability are obtained, so that the antibacterial peptides have wider application range and higher potential development value.