1606 results about "Antibacterial peptide" patented technology

The invention discloses an identification method and system of a short antibacterial peptide sequence, a terminal and a storage medium. Relates to the technical field of bioinformatics. A short antibacterial peptide data set is obtained in advance, a training set is obtained through division according to the short antibacterial peptide data set, and a pre-trained protein language model is finely adjusted according to the training set; obtaining sequence features of a to-be-classified sequence through the fine-tuned protein language model; obtaining physicochemical characteristics of the to-be-classified sequences through an analysis method based on pseudo amino acid components; inputting the sequence features and the physicochemical features into an attention model for feature fusion to obtain fusion features of the to-be-classified sequence; and inputting the fusion features into a classifier to obtain a prediction category of the to-be-classified sequence. According to the method, the pre-training model is finely adjusted by establishing a more perfect short antibacterial peptide data set, the sequence features and the physicochemical features of the to-be-classified sequences are fused, and the sequences are classified through the fused features, so that the recognition accuracy of the short antibacterial peptides can be effectively improved.

Provided are a small-molecule antibacterial polypeptide, and a preparation method therefor and a use thereof. The antibacterial peptide provided has stronger antibacterial activity than most other derivative polypeptides and antibacterial polypeptides disclosed in existing reports. Multiple strains known for drug resistance are used to carry out bactericidal activity evaluation. The result shows that the antibacterial peptide provided has broad-spectrum antibacterial activity against drug-resistant strains, achieves more comprehensive antibacterial effects, and has a wider range of indications.

The invention discloses an antibacterial peptide and antibacterial application thereof. The amino acid sequence of the antibacterial peptide is as shown in SEQ ID No.1, and the C end of the antibacterial peptide is amidated. The antibacterial peptide provided by the invention has the activity of resisting staphylococcus aureus and escherichia coli, and plays a role in inhibiting bacteria by destroying cell membranes. The antibacterial peptide is excellent in antibacterial activity, good in stability and not prone to generating drug resistance, can be used for synthesizing and preparing antibacterial compositions, and has great potential in application in the fields of food and medicine.

The invention discloses a broad-spectrum antibacterial peptide SS-7 and application thereof, and belongs to the field of biological medicine. The amino acid sequence of the broad-spectrum antibacterial peptide SS-7 disclosed by the invention is VRRVRFVVLRRIKKWRRI, and the broad-spectrum antibacterial peptide SS-7 has a remarkable inhibition effect on various gram-positive bacteria and gram-negative bacteria such as drug-resistant strains such as methicillin-resistant staphylococcus aureus (ATCC43300) and shows low toxicity and no hemolytic toxicity on eukaryotic cells and red blood cells of mammals; lPS and lipoteichoic acid on the surfaces of bacteria can be combined to achieve the effect of neutralizing the bacteria, and a very good treatment and protection effect is achieved on animals infected by the bacteria. The antibacterial peptide SS-7 can be used for preparing an antibacterial agent and preparing a medicine for preventing or treating bacterial infection, has the advantages of being wide in antibacterial spectrum, low in drug-resistant mutation frequency, low in toxicity and low in production cost, can effectively solve the current bacterial drug resistance problem, and has wide application prospects and important clinical value.

The invention provides a broad-spectrum antibacterial peptide, an antibacterial agent and application, and belongs to the technical field of biological medicine. The invention provides a broad-spectrum antibacterial peptide. The broad-spectrum antibacterial peptide comprises an amino acid sequence as shown in SEQ ID No. 1. The minimum inhibitory concentration of the antibacterial peptide to gram-positive bacteria, gram-negative bacteria and fungi proves that the antibacterial peptide has obvious antibacterial activity to the gram-positive bacteria, the gram-negative bacteria and the fungi. The invention also verifies the minimum inhibitory concentration of the antibacterial peptide to clinical drug-resistant bacteria. The cytotoxicity of the SL-12 disclosed by the invention is relatively weak, the SL-12 only shows obvious cytotoxicity at 200 [mu] g / ml, and the minimum inhibitory concentration of the SL-12 is 6.25-12.5 [mu] g / ml; the SL-12 has no obvious hemolytic activity when the concentration is 100 [mu] g / ml or lower, and is high in safety.

The invention relates to the technical field of antibacterial peptide application, in particular to an antibacterial peptide for inhibiting drug-resistant acinetobacter baumannii as well as a preparation method and application of the antibacterial peptide. The antibacterial peptide is cd77AHP-2, and the amino acid sequence of the antibacterial peptide is shown as SEQ ID NO.1. The antibacterial peptide cd77 obtained through artificial chemical synthesis is modified, distribution of cationic amino acid is optimized, and the antibacterial activity of the antibacterial peptide is remarkably improved. The antibacterial peptide cd77AHP-2 has a remarkable antibacterial effect on acinetobacter baumannii which are gram-negative bacteria and multi-drug resistant acinetobacter baumannii, and the antibacterial peptide cd77AHP-2 has a remarkable antibacterial effect on the acinetobacter baumannii which are gram-negative bacteria. The antibacterial peptide cd77AHP-2 provided by the invention has relatively low cytotoxicity to human bronchial epithelial cells, and has the potential of preparing a drug for resisting drug-resistant acinetobacter baumannii. The invention provides a novel functional polypeptide for the field of antibacterial peptides, and the novel functional polypeptide has important practical application value.

The invention relates to an antibacterial peptide generation method and device based on a generative model and computer equipment, and relates to the technical field of artificial intelligence and bioinformatics. Predicting the novel antibacterial peptide on the basis of the existing antibacterial peptide sequence by using a pre-trained generative model to obtain a predicted sequence; inputting the prediction sequence into a pre-trained antibacterial peptide classifier, and judging whether the prediction sequence has antibacterial activity or not; the antibacterial peptide classifier is obtained by training based on an antibacterial peptide tag set and a non-antibacterial peptide sequence tag set; and outputting the prediction sequence with the antibacterial activity as a final target antibacterial peptide sequence, so that the problem of low antibacterial peptide design generation efficiency is solved, de novo generation and judgment of the antibacterial peptide can be realized by virtue of a generative model and a classifier, and the generation efficiency and accuracy are improved.

The present disclosure relates to the technical field of antibacterial drugs, and specifically relates to a micromolecular antibacterial polypeptide, and a preparation method therefor and the use thereof. The antibacterial peptide provided in the present disclosure has a stronger antibacterial activity compared with most other derived polypeptides and the antibacterial polypeptides disclosed in the existing reports. Bactericidal activity evaluation is carried out by using a plurality of strains known to have drug resistance, and the results show that the antibacterial peptide provided in the present disclosure has broad-spectrum antibacterial activity against drug-resistant strains and more comprehensive antibacterial effects, and allows for wider indications.

The invention discloses a BamA-targeting antibacterial peptide as well as a preparation method and application thereof, and is characterized in that amino acids in a sequence are all D-type amino acids, and the amino acid sequence is as follows: w-r-r-w-r-r-p-w-k-r (dTrp-dArg-dArg-dTrp-dArg-dArg-dPro-dTrp-dLys-dArg). The antibacterial peptide provided by the invention has good antibacterial activity, can be synthesized by adopting an Fmoc solid-phase chemical method, is low in preparation difficulty, and has high affinity with target protein BamA.

The invention provides an antibacterial peptide cAMP048 sourced from microorganisms in a deep sea environment and application of the antibacterial peptide cAMP048, and belongs to the technical field of peptide inhibitors. The antibacterial peptide cAMP048 has an amino acid sequence as shown in SEQ ID NO: 1 (Sequence Identity Number 1). The antibacterial peptide can inhibit the growth of acinetobacter baumannii at 64 mu M, inhibit the growth of multi-drug-resistant acinetobacter baumannii and multi-drug-resistant enterococcus faecium at 128 mu M and inhibit the growth of escherichia coli, staphylococcus aureus and multi-drug-resistant klebsiella pneumoniae at 256 mu M. The antibacterial peptide can be used for preparing products with antibacterial and / or bactericidal performance, and can be applied to preparation of antibacterial and / or bactericidal products. Such as food, skin care products or medical supplies.

The invention relates to the field of gene engineering, and particularly discloses a barnacle chitin antibacterial peptide, an engineering algal strain of the barnacle chitin antibacterial peptide and a preparation method and application of the engineering algal strain. Wherein the amino acid sequence of the barnacle chitin antibacterial peptide is as shown in SEQ ID NO. 1; or an amino acid sequence which is obtained by substitution and / or deletion and / or addition of one or more amino acids of SEQ ID NO.1 and has the same function as SEQ ID NO.1; or an amino acid sequence which has 70%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% homology with the SEQ ID NO.1 and has the same function as the SEQ ID NO.1. The brand-new barnacle chitin antibacterial peptide obtained in the application has a good antibacterial effect, bacteria can be killed through a cell protection barrier, and the cell hemolysis rate at the minimum inhibition concentration is 7.2%.

The invention discloses an antibacterial peptide recognition method and system based on a sequence-structure dual-channel neural network, and the method comprises the steps: splicing amino acid features and amino acid-level manual features extracted by ProtT5 to obtain peptide embedding, and transmitting the peptide embedding to a sequence channel composed of a plurality of Transform blocks to extract the sequence features of the peptide; predicting a three-dimensional structure of the peptide by using ESM-Fold to construct an adjacency graph, taking amino acid features obtained by ESM-2 as node features of the adjacency graph, and performing layer-by-layer extraction and enhancement by fusing structural channels of multi-head graph attention, a residual network, layer normalization and a feedforward neural network; and carrying out maximum pooling and splicing on the sequence features and the structural features, and then, carrying out antibacterial peptide prediction. According to the method, a multi-feature fusion strategy is adopted, meanwhile, the three-dimensional structure information of the antibacterial peptide is introduced, and the sequence and the structural features are fused through a two-channel architecture, so that the recognition accuracy of the antibacterial peptide is effectively improved.

The invention discloses an antibacterial peptide SAMP4 or a derivative thereof, a pharmaceutical composition and application, and belongs to the technical field of biology, the amino acid sequence of the antibacterial peptide SAMP4 is as shown in SEQ ID NO: 1, and the antibacterial peptide SAMP4 has a broad-spectrum antibacterial effect and can be used for preparing antibacterial peptide SAMP4. The compound has a strong bacteriostatic effect on various gram-positive bacteria such as staphylococcus aureus, enterococcus and streptococcus and various gram-negative bacteria such as escherichia coli, acinetobacter baumannii and pseudomonas aeruginosa, and is strong in antibacterial activity, wide in antibacterial spectrum and low in toxicity. The invention also provides a derivative and a salt of the antibacterial peptide SAMP4 and application of the antibacterial peptide SAMP4 and the derivative and the salt of the antibacterial peptide SAMP4 to research, development and preparation of various antibacterial products or / and antibacterial drugs and treatment of bacterial infectious diseases, and the antibacterial peptide SAMP4 and the derivative and the salt of the antibacterial peptide SAMP4 are remarkable in advantages and wide in application prospect.

The invention relates to a polyurethane foam technology in the technical field of medical dressings, in particular to medical silver-containing porous polyurethane foam. The composite material comprises a foam matrix, the foam matrix adopts gradient layering design and comprises a matrix inner layer, a matrix middle layer and a matrix outer layer, the aperture of each layer is sequentially increased, the porosity is gradually increased layer by layer, the matrix inner layer is provided with randomly dispersed inner-layer hollow silver-loaded fibers capable of slowly releasing silver ions for bacteriostasis, the matrix middle layer is fixedly provided with pH response microcapsules, and the pH response microcapsules are fixed on the matrix outer layer. In an alkaline environment, antibacterial peptides are released for synergic antibiosis, and silver-loaded fibers in the outer layer of the matrix outer layer are arranged in the radial direction to form a flow guide channel and release silver ions. Through gradient layered design, different sterilization structures are added, the temperature-sensitive hydrogel layer covering the surface of the outer layer of the base body is matched, sterilization and seepage are managed through environmental changes, and the advantages of being excellent in antibacterial performance, high in seepage management capacity, intelligent in adjustment and the like are achieved.

The invention belongs to the field of antibacterial peptides, and particularly relates to an antibacterial peptide with a broad-spectrum antibacterial effect, an antibacterial product and application. The antibacterial peptide is named as CAMP1111NC, and is obtained by performing N-terminal acetyl end capping and C-terminal amino end capping on polypeptide shown in SEQ ID NO: 1. The antibacterial peptide has remarkable antibacterial activity on a staphylococcus aureus standard strain ATCC12600, pseudomonas aeruginosa PAO1, klebsiella pneumoniae, an acinetobacter baumannii standard strain ATCC19606, methicillin-resistant staphylococcus aureus ATCC33591, methicillin-resistant and gentamicin-resistant staphylococcus aureus ATCC33592 and acinetobacter baumannii bio-53272 resistant to various antibiotics, and the antibacterial peptide can be used for preparing the antibacterial peptide. The limitation of the traditional antibacterial peptide is effectively overcome.

The invention relates to the technical field of antibacterial peptide application, in particular to an antibacterial peptide for inhibiting drug-resistant staphylococcus aureus and application of the antibacterial peptide. The antibacterial peptide is obtained by performing N-terminal acetylation modification and C-terminal amidation modification on polypeptide as shown in SEQ ID NO.1. The invention further discloses a preparation method of the antibacterial peptide. The antibacterial peptide provided by the invention is a novel cationic antibacterial peptide, the minimum inhibitory concentrations of the antibacterial peptide to pathogenic bacteria staphylococcus aureus ATCC12600 and staphylococcus aureus ATCC33591 are respectively 4 [mu] g / mL and 32 [mu] g / mL, the biological safety is extremely high, and due to the characteristics, the antibacterial peptide shows extremely high medical drug antibacterial value, and can be used for preparing the antibacterial peptide. Alternative medicinal resources are provided for clinically resisting the two human pathogenic bacteria in the future.

The invention discloses bacillus subtilis Gxunw-30 and application thereof, and belongs to the technical field of agricultural microorganisms. The bacillus subtilis Gxunw-30 provided by the invention is preserved in Guangdong Microbial Culture Collection Center on October 12, 2024, and the preservation number of the bacillus subtilis Gxunw-30 is GDMCC No: 65245. The bacillus subtilis Gxunw-30 provided by the invention has the capability of inhibiting plant pathogens in a broad spectrum, and can be used for antagonizing a variety of plant pathogens such as helminthosporium triticum, trichosporon pseudoacaceae, hechiense fusarium, fusarium chlamydosporum, cryphonectria parasitica, fusarium pseudograminearum, botryosphaeria dothidea and the like. The strain has the properties of decomposing organophosphorus, producing protease, producing ammonia, producing indole and fixing nitrogen, and has the biological properties of plant growth promotion and the like. The recombinant bacterium also contains a gene for coding an antibacterial substance, and has the capability of synthesizing the antibacterial peptides of iturin, surfactin, fengmycin and bacilysin, and the recombinant bacterium also contains a gene for coding the antibacterial substance and has the capability of synthesizing the antibacterial peptides of iturin, surfactin, fengmycin and bacilysin. The strain has the effects of preventing diseases and promoting growth, provides a good biocontrol resource for prevention and treatment of plant diseases, and has a relatively good application value for research and development of plant growth-promoting preparations and biocontrol microbial agents.

The invention belongs to the technical field of genetic engineering, and particularly relates to an antibacterial peptide with antibacterial and antiviral effects and application and a product thereof. The amino acid sequence of the antibacterial peptide provided by the invention has the following general formula: X1GX2FX3FX4KKFX5LFX6X7SKVLK, x1 is M or has no amino acid; x2 is one of R, G and H; x3 is one of KS, KR, HR and HH; x4 is R or L; x5 is one of KK, HH and HK; x6 is RR or KK; and X7 is I or L. The antibacterial peptide disclosed by the invention has a relatively good antibacterial effect, and shows antiviral activity on HPV16 (Human Papilloma Virus 16) and HPV18 (Human Papilloma Virus 18). Good application prospects are shown in the preparation of antibacterial or antiviral products.

The invention discloses an antibacterial peptide and application thereof, and belongs to the technical field of biology. The antibacterial peptide with an inhibition effect on various clinically common pathogenic microorganisms is obtained, and the antibacterial peptide comprises gram-negative bacteria such as escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, acinetobacter baumannii, vibrio parahaemolyticus, salmonella gallinarum, salmonella typhimurium and enterobacter sakazakii, and gram-positive bacteria. The antibacterial peptide provided by the invention can be used as an antibacterial peptide, such as staphylococcus aureus, listeria monocytogenes and bacillus cereus, and the antibacterial peptide provided by the invention is novel in structure and easy to prepare.

The invention discloses an antibacterial peptide and application thereof. The amino acid sequence of the antibacterial peptide disclosed by the invention is KKKEHRLLHRVLFHRL. The minimum inhibitory concentration of the antibacterial peptide to staphylococcus aureus is 4.5 mu g / mL, and the minimum bactericidal concentration of the antibacterial peptide to staphylococcus aureus is 72.7 mu g / mL. The antibacterial peptide disclosed by the invention has remarkable antibacterial activity on staphylococcus aureus and is expected to be widely applied as a novel bacteriostatic agent for preventing and treating staphylococcus aureus.

According to the method, an antibacterial peptide sequence design framework is designed based on protein language model supervised fine tuning and human feedback reinforcement learning, a multiple screening framework is designed, and specifically, an antibacterial peptide design and screening model and a fine tuning mode of the model are developed through an innovative calculation method and a comprehensive analysis process; the method effectively solves the problems of low antibacterial peptide design and screening efficiency, insufficient accuracy, single optimization dimension and the like in the prior art, and an efficient, accurate and flexible new method is provided for research and development of the antibacterial peptide.

The invention discloses a milk-derived broad-spectrum antibacterial peptide and application thereof, and relates to the technical field of biology. The amino acid sequence of the antibacterial peptide is as shown in any one of SEQ ID NO.2-6. Five novel antibacterial peptides are obtained by carrying out symmetrical structure design and amino acid mutation on the basis of a template peptide, and tests find that the five novel antibacterial peptides have broad-spectrum antibacterial activity which is obviously higher than that of the template peptide, and basically have no cytotoxicity. Wherein the geometric mean (GM) of the minimum inhibitory concentration can reach 3.60, and the therapeutic index (TI) can reach 71.11. The antibacterial peptide prepared by the invention still keeps good antibacterial activity in physiological salt concentration and protease environment, has certain serum stability, and has higher application value; in addition, the antibacterial peptide has a good inhibition effect on the formation of a bacterial biofilm, and has a synergistic effect with traditional antibiotics.

The invention relates to a novel antibacterial peptide sequence intelligent generation method and system and computer equipment, and the method comprises the steps: inputting a first antibacterial peptide sequence data set containing multi-sequence alignment into a pre-trained generator, and outputting a novel first candidate antibacterial peptide sequence set according to a preset condition; inputting the first candidate antibacterial peptide sequence set into a pre-trained discriminator to discriminate a second candidate antibacterial peptide sequence set belonging to the antibacterial peptide sequence; inputting the second candidate antibacterial peptide sequence set into a pre-trained predictor to predict the antibacterial activity of each second candidate antibacterial peptide sequence in the second candidate antibacterial peptide sequence set; and based on the antibacterial activity of each second candidate antibacterial peptide sequence, selecting at least one optimal target antibacterial peptide sequence from each second candidate antibacterial peptide sequence set. According to the application, the generator can be used for capturing sequence diversity and generating a wider-spectrum antibacterial peptide sequence, and through cascade optimization of the discriminator and the predictor, the generated antibacterial peptide sequence has higher antibacterial activity.

The invention belongs to the technical field of antibacterial peptides, and particularly relates to an antibacterial peptide and application thereof. The amino acid sequence of the antibacterial peptide is shown as SEQ ID NO: 1, the number of amino acids is small, the synthesis cost is low, the antibacterial peptide has high antibacterial activity on gram-negative bacteria and gram-positive bacteria, the minimum inhibitory concentration of the antibacterial peptide on acinetobacter baumannii, escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is 4.68-37.5 mu g / mL, and the antibacterial peptide has the advantages of broad-spectrum antibacterial property, good stability and good application prospect. No obvious cytotoxicity and hemolysis effect exist; moreover, end-to-end amido bond cyclization is carried out, so that the antibacterial activity is further enhanced, the antibacterial effect on acinetobacter baumannii, escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is enhanced by 2-4 times, and the minimum inhibitory concentration is reduced to 2.34-9.38 mu g / mL; after the end-to-end amido bonds are cyclized, the plasma stability and safety of the antibacterial peptide are further improved, and the cytotoxicity and hemolysis are reduced.

The present invention discloses a recombinant sheep β-defensin 2 protein expressed by Pichia pastoris and its application. The recombinant sheep β-defensin 2 gene designed according to the CDS of the sheep β-defensin 2 gene is integrated into the genome of Pichia pastoris GS115, thereby realizing the secretory expression of the target gene on Pichia pastoris. The recombinant sheep β-defensin 2 protein expressed by Pichia pastoris eukaryotic cells has a strong antibacterial effect and has broad application prospects in the development of new antibiotic alternative products and antimicrobial peptides for sheep feed.

The invention discloses application of a low-toxicity broad-spectrum antibacterial peptide taking WW as a symmetric center, WK is repeated twice and symmetrically distributed on two sides, WW is taken as the symmetric center to obtain an antibacterial peptide WKWKWWKWKW-NH2 (N2W2), and tryptophan at the C terminal and the N terminal of the N2W2 is replaced with leucine and / or isoleucine to obtain the antibacterial peptide. The antibacterial peptide can basically maintain the excellent antibacterial activity of the parent peptide, and the hemolytic activity of the antibacterial peptide is greatly reduced, so that the safety is improved. Wherein the antibacterial activity of IL-N2W2 is the highest, but the stability of IL-N2W2 needs to be improved, so that D-IL-N2W2 is obtained by carrying out D-type amino acid substitution on IL-N2W2. The D-IL-N2W2 keeps the high antibacterial activity and low toxicity of IL-N2W2, can still completely inhibit the growth of bacteria after being incubated with high-concentration trypsin or chymotrypsin, has great potential in the aspect of relieving the drug resistance of antibiotics, and has good application prospects in preparation of clinical antibacterial drugs.

Provided is an antibacterial peptide having an amino acid sequence X1KRFKKFFX2KLKKWV-NH2, wherein X1 is selected from any one or of amino acids A, C, D, E, F, G, H, K, L, N, M, P, Q, R, S, I, V, W, Y, and T or is absent; and X2 is an amino acid having an aromatic side chain or an amino acid having an alkaline side chain. In view of defects such as poor gastrointestinal fluid stability of antibacterial peptides in the prior art, a brand-new sequence design scheme and preparation method for an antibacterial peptide are provided. By means of a complete or partial D-amino acid substitution or structural derivatization of a peptide sequence, a series of antimicrobial peptides having stronger antibacterial activity and gastrointestinal stability as compared with the prior art are obtained, such that the antibacterial peptides have a wider application range and higher development potential value.

The invention discloses a full D-type antibacterial peptide with high enzymolysis stability and broad-spectrum antibacterial activity and application thereof. The antibacterial peptide is obtained by sequentially and repeatedly arranging D-type tryptophan, D-type arginine and D-type lysine for four times and carrying out C-terminal amidation; the amino acid sequence of the gene is (D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-NH2, and is marked as DWRK-12. The antibacterial peptide shows broad-spectrum antibacterial activity and excellent stability, can effectively resist clinically separated multidrug resistant strains, and keeps high cell selectivity at the same time. Due to the characteristics, the antibacterial peptide has important application value in the aspect of developing novel antibacterial drugs, especially in the field of treatment of infection of multiple drug-resistant bacteria.

The invention provides copper-loaded duck-origin lactobacillus plantarum with high antibacterial peptide yield and application of the copper-loaded duck-origin lactobacillus plantarum. The preservation number of the provided copper-loaded duck-origin lactobacillus plantarum is CGMCC (China General Microbiological Culture Collection Center) NO.32835. The domesticated and bred duck-origin lactobacillus plantarum with high antibacterial peptide yield can tolerate high-concentration copper ions, the domesticated and bred lactobacillus plantarum can stably grow, and the contents of antibacterial peptide, extracellular protein, lipase, amylase, lactic acid, acetic acid and the like in the domesticated and bred lactobacillus plantarum strain are increased; and the amino acid composition is changed. The strain can convert inorganic copper into organic copper, the utilization rate of copper is increased, and growth and development of organisms are promoted. Moreover, small peptides and extracellular proteins in metabiotics generated after fermentation have the effect of effectively inhibiting harmful bacteria such as riemerella anatipestifer, escherichia coli, salmonella and staphylococcus of poultry, and are beneficial to eliminating intestinal inflammatory factors, maintaining intestinal health and improving the feed utilization rate.

The invention relates to a novel application of animal bifidobacterium subsp. Lactis BGI-N3, in particular to an application of the animal bifidobacterium subsp. Lactis BGI-N3 in preparation of a preparation for relieving skin allergy. The invention finds that the bifidobacterium animalis subsp. Lactis BGI-N3 has a very remarkable effect in the aspect of relieving skin allergy, and the effect is specifically shown as follows: in an atopic dermatitis animal model, the dermatitis score, scratching times and percutaneous water loss are remarkably reduced, and the atopic dermatitis skin tissue damage condition is relieved; the immune organ edema condition is improved, the levels of Th2 type cell factors and inflammatory factors IL-6, TNF-alpha and IFN-gamma related to dermatitis are reduced, and the immune balance of the body is recovered; expression of fibroin and endothelial protein in skin tissue is improved, and the skin barrier is repaired; the level of antibacterial peptide in skin tissues is recovered, and the antibacterial activity of the skin is enhanced. Meanwhile, compared with a traditional chemical medicine for treating atopic dermatitis, the animal bifidobacterium subsp. Lactis BGI-N3 has no side effects such as weight loss, immune organ atrophy, immune imbalance and the like.