40 results about "Vaginal tissue" patented technology

OF THE INVENTION Provided herein is a method of preparing an extracellular matrix (ECM) material, including incubating vaginal tissue in a protease, incubating the vaginal tissue in a solution including at least one detergent, incubating the vaginal tissue in a composition including at least one disinfecting agent, thereby producing a decellularized ECM material, lyophilizing the decellularized ECM material, thereby producing a lyophilized ECM material, comminuting the lyophilized ECM material, partially or completely solubilizing the comminuted, lyophilized ECM material with an acid protease to produce solubilized ECM, lyophilizing the solubilized ECM to produce lyophilized, solubilized ECM.

The invention discloses lactobacillus gasseri capable of improving expression of host antibacterial peptide Cathelicidin and secretory immunoglobulin sIgA and enhancing infection resistance by oral administration and external application and a metagen thereof, and belongs to the technical field of microorganisms. The lactobacillus gasseri disclosed by the invention can be used for promoting the generation of a vaginal epithelial cell antibacterial peptide Cathelicidin; the shedding of vaginal epithelial cells is reduced, the fungal load is reduced, and the generation of vaginal tissue antibacterial peptide CRAMP is improved; the pIgR and immune globulin content of the vaginal tissue is increased; the invention also finds that the lactobacillus gasseri for external use can regulate and control TLR2 (Toll-Like Receptor 2), and further has a good balancing effect on body immunity. Therefore, the lactobacillus gasseri has a huge application prospect in a product for improving the pathogenic bacterium infection resistance of a host, enhancing the self-defense capability and inhibiting the vagina inflammation.

The invention provides a degradable vaginal repair injection material and application thereof, and relates to the technical field of biomedical materials. The degradable vaginal repair injection material is formed by compounding a dispersing agent and ECM particles, the mass percent of the ECM particles is 20%-80%, and the particle size of the ECM particles is 100-1000 microns. According to the application, the ECM particles are used as a core repairing component, and the ECM particles are rich in bioactive substances such as growth factors and collagen, so that repairing and regeneration of vaginal tissues can be effectively promoted. After being injected into the vagina, the degradable vaginal repair injection material can fill relaxed sites to increase stress after injection, and stimulate tissue collagen regeneration along with the degradation of ECM particles to repair the mechanical properties of the vagina.

The invention belongs to the technical field of female private part nursing, and particularly relates to andrographolide gel as well as a preparation method and application thereof. The invention provides an andrographolide gel, which is prepared from the following components in parts by mass: 0.1 to 0.5 part of andrographolide, 2.0 parts of caprylic / capric polyethylene glycol glyceride, 5.0 parts of propylene glycol, 0.05 to 0.2 part of chitosan, 10.0 parts of 1 percent W / V lactic acid solution, 0.15 to 0.6 part of hydroxyethyl cellulose and 30.0 parts of water. The andrographolide, the caprylic / capric polyethylene glycol glyceride, the propylene glycol, the chitosan, the 1% W / V lactic acid solution, the hydroxyethyl cellulose and the water are combined for use, the proportion of the components is strictly limited, and the obtained andrographolide gel can effectively inhibit vaginal pathogenic bacteria (including candida chromosomes, escherichia coli, staphylococcus aureus and gardnerella); the traditional Chinese medicine is used for treating fungal vaginitis and has no irritation to vaginal tissues.

The application discloses an active oxygen response type bacteriostatic and repair promoting hydrogel and a preparation method and application thereof, the hydrogel is formed by disulfide bond cross-linked hydrogel in response to active oxygen free radicals in the vagina of vaginitis patients through thiol modified hyaluronic acid (HASH), and can enhance in-vivo retention by thiol and vaginal tissue interaction. Cationic surfactant such as didecyldimethylammonium chloride (DDAC) as the bacteriostatic component of the hydrogel, efficiently killing pathogenic bacteria while having good biocompatibility, and is not prone to cause bacterial drug resistance. As a natural immune regulator, beta-glucan regulates the vaginal microenvironment, promotes the polarization of macrophages into anti-inflammatory M2 type and promotes cell migration, etc., to promote the repair of the vaginal immune barrier, regulate the vaginal flora, and reduce the probability of vaginitis recurrence. The HASH hydrogel provides an efficient, convenient and highly transformative potential strategy to provide more choices for the treatment of vaginitis.

The invention discloses an efficient radiotherapy flusher for the gynecology department, and belongs to the field of medical instruments. The efficient radiotherapy flusher for the gynecology department comprises a bearing disc and an ozone generator, a flushing pipe is fixedly connected to the middle of the bearing disc, a diversion trench is formed in the bottom of an inner cavity of the flushing pipe, the efficient radiotherapy flusher further comprises a mixing ball, the mixing ball is fixedly connected to the bottom of the flushing pipe, and an ozone conveying pipe is fixedly connected to the side wall of the mixing ball. The input end of the ozone conveying pipe is communicated with the output end of the ozone generator; through expansion of the expansion air bag, the vagina wall is expanded to form the flushing cavity, so that liquid medicine flushing is facilitated, the flushing effect is improved, meanwhile, the situation that fibrosis of vagina tissue caused by radiotherapy causes vagina stenosis or adhesion between different parts is effectively reduced, and complications are prevented; and the flexibility of the expansion air bag is utilized, so that the damage to the vaginal wall can be reduced to the greatest extent, and the use safety is improved.

The utility model relates to the technical field of surgical instruments, in particular to an inflatable vagina plug ball which comprises a plug ball body and an air supply device, the plug ball body is made of silica gel materials, the air supply device is arranged on the surface of the plug ball body and comprises a main pipe, the main pipe is fixedly connected with the surface of the plug ball body, and a cavity is formed in the plug ball body. The air supply device is arranged, the inflating assembly can be matched with the three-way pipe, the first one-way valve, the second one-way valve and the main pipe to inflate the inner cavity of the plug ball body and enable the plug ball body to conduct expansion plugging, the plug ball body is made of silica gel materials, and the plug ball body is made of silica gel materials. The vagina plugging device is simple in structure, soft, good in biocompatibility and capable of better adapting to the vagina physiological structure, damage to vagina tissue is reduced, it is not needed to spend time in making a spherical plugging object through gloves and gauze, and the operation preparation efficiency and the plugging effect are greatly improved.

The present invention relates to a uterus manipulator in minimally invasive surgery that facilitates procedures of manipulation of the uterus, incising and suturing of all kinds of tissue connected to the uterus and particularly, incising the cervico-vaginal tissue in a circular line in laparoscopic hysterectomy, that prevents the incidence of various complications during said procedures, and that can be actuated (driven) manually without requiring any external energy source.

The invention discloses skin mucosa maintenance liquid capable of killing fungi and HPV (human papillomavirus) as well as a preparation method and application of the skin mucosa maintenance liquid, and belongs to the technical field of sterilization and virus removal. The skin mucosa maintenance liquid is prepared from octanol ether, benzalkonium bromide, phenoxyethanol, yermate, parachlorometaxylenol, taetinic acid, chitosan, keratinase, fluconazole, glycerol, borneol, menthol, absolute ethyl alcohol and tween-40. Wherein the skin mucosa maintenance liquid has an effect of regulating apoptosis induction on abnormal cells and an effect on vaginal flora, and has an obvious inhibition effect on cervicitis and colpitis mycotica, namely an anti-inflammatory effect; meanwhile, apoptosis of cells containing HPV16 and HPV18 genes can be induced, shedding of abnormal cells is promoted, diseased cells are killed, and vaginal tissues with pathological changes are removed.

The present invention discloses a high-efficiency gynecological radiotherapy irrigator, belonging to the field of medical devices. The high-efficiency gynecological radiotherapy irrigator comprises a tray and an ozone generator. A irrigating tube is fixedly connected to the middle of the tray, a guide groove is provided at the bottom of the inner cavity of the irrigating tube, and the tray further comprises a mixing ball fixedly connected to the bottom of the irrigating tube. An ozone delivery tube is fixedly connected to the side wall of the mixing ball, and the input end of the ozone delivery tube is connected to the output end of the ozone generator. The present invention expands the vaginal wall to form an irrigating cavity for irrigating with liquid medicine, thereby improving the irrigating effect and effectively reducing the risk of vaginal fibrosis caused by radiotherapy, which may lead to vaginal stenosis or adhesions between different parts, thereby preventing complications. Furthermore, the softness of the expansion balloon can minimize damage to the vaginal wall, improving safety in use.

The invention relates to the technical field of biology, and discloses a Lactobacillus paracasei KFY202407 and an application thereof in preparation of a preparation for preventing and treating vaginitis, the collection number of the Lactobacillus paracasei KFY202407 in China General Microbiological Culture Collection Center (CGMCC) is CGMCC NO: 30736, and the collection date is May 22, 2024. The lactobacillus paracasei KFY202407 disclosed by the invention can relieve inflammation of mice with vaginitis by regulating secretion of mouse serum inflammatory factors, activity of vaginal tissue MPO and expression conditions of vaginal tissue inflammatory genes. The microbial inoculum prepared from the lactobacillus paracasei KFY202407 has good stability and can be used as a medicine raw material.

Devices and methods that prepare the vaginal tissue of the mother's birth canal during labor so as to prevent pelvic floor damage, and vaginal and perineal lacerations. The devices may be modular and in one example include two modules, a dilator module that comprises a dilator capable of expanding the vaginal canal of a mother who is experiencing labor and a control module that is capable of connecting to the dilator module. The two modules can be separated so that the dilator module can be physically separated from the control module. In one embodiment the dilator module is comprised of disposable elements and maybe disposed of after use. The control module may be a reusable module that can be covered during use and sterilized after use for reuse in subsequent procedures.

Described is a vaginal speculum having a vaginal assembly of at least two longitudinal elements connected at a distal end for insertion into the vagina of a subject. The vaginal speculum is configured for holding the vaginal walls of the subject apart, thereby permitting examination and / or suturing of at least the posterior part of the vaginal tissue.

The invention provides a 3D vaginal stent capable of being transplanted in situ and a preparation method of the 3D vaginal stent, and relates to the technical field of regenerative medicine and tissue engineering. The preparation method of the 3D vaginal stent capable of being transplanted in situ comprises the following steps: mixing pig vagina acellular matrix native gel with a gelatin methacrylamide solution, performing pasteurization, adding silk fibroin, and uniformly mixing to obtain a 3D printing matrix mixture; filling the 3D printing matrix mixture into a 3D printer; and designing a model structure and parameters by applying CAD software according to a vagina structure to be printed, setting a printing system, and carrying out blue light irradiation on a printed object while printing, so as to obtain the 3D vagina stent capable of being transplanted in situ. The vagina-like stent capable of being transplanted in situ is good in biological safety and mechanical performance, especially capable of reconstructing vagina tissue, and has functional characteristics, so that in-situ transplantation of large and small animal vagina deletion models and repair of deleted vagina tissue can be achieved.

The invention discloses a vaginal dilatation device used after vaginoplasty, and relates to the technical field of medical instruments, the technical key point is that the vaginal dilatation device comprises a base cylinder and a plurality of pipeline limiting pieces fixedly mounted on the outer circular surface of the base cylinder, a dilatation mechanism is arranged on the outer side of the base cylinder, and the dilatation mechanism comprises an inflation assembly, an exhaust assembly and a pressure detection assembly; the inflation assembly comprises a plurality of inflation main pipes fixedly installed on the pipeline limiting piece, inflation branch pipes communicating with inner cavities of the inflation main pipes are fixedly installed on the outer circle faces of the inflation main pipes, the air outlet ends of the inflation branch pipes are fixedly connected with unit air bags, and one-way valves are fixedly installed at the air inlet ends of the inflation main pipes. Through the synergistic effect of the dilation mechanism, the antibacterial layer and the mounting and positioning mechanism, precise dilation of vaginal tissue is achieved, the wearing comfort of a patient is improved, infection is effectively prevented, it is ensured that the device is stably fixed in the vagina, and an efficient, safe and comfortable vaginal dilation treatment scheme is provided for the patient.

The application discloses a lactobacillus gasseri for repairing a vaginal barrier and relieving a vaginal infection, and a postbiotic thereof, and belongs to the technical field of microorganisms.The lactobacillus gasseri and the postbiotic thereof can repair a vaginal barrier and relieve a vaginal infection when being used externally.The lactobacillus gasseri is separated from vaginal secretion of a healthy female, has the functions of repairing a vaginal mucosa barrier and relieving a vaginal infection, and specifically has the following effects: improving a cell monolayer barrier transendothelial electrical resistance value, increasing integrity, reducing FITC-labeled dextran permeability of the cell monolayer barrier, and reducing permeability;adjusting a mouse vaginal mucin level;improving a mouse vaginal tissue protein expression level;reducing mouse vaginal tissue IL-1 beta secretion and myeloperoxidase content;and improving a mouse vaginal tissue pathological condition.Therefore, the lactobacillus gasseri has great application prospects in products for repairing a vaginal mucosa barrier and relieving a vaginal infection caused by pathogenic bacteria.

The application discloses a composition for relieving vaginitis by simultaneously activating immune regulation and antioxidant pathways, and belongs to the technical field of microorganisms. The application screens a composite strain containing a strain of Paracaseolovis casei CCFM1316 and a strain of Paracaseolovis casei CCFM1317, and the composition containing the composite strain has the effect of repairing immune disorders, oxidative damage and other related symptoms caused by vaginitis, which is specifically embodied in: regulating the immune response of the mouse vagina; activating the TLR-4 / MyD88 pathway, and reducing the IL-1beta concentration of the vaginal tissue to 29.79 ng / L; improving the oxidative stress of the mouse vagina; and increasing the Nrf2 of the vaginal tissue to 36.58 ng / L. Therefore, the composition of the Paracaseolovis casei CCFM1316 and the Paracaseolovis casei CCFM1317 has great application prospect in products for improving and repairing the inflammatory response and oxidative damage caused by vaginitis.

Nanoparticles and nanoparticle-releasing vaginal rings for intermediate- to long-term delivery of drugs to the female genital and reproductive tract have been developed. The nanoparticles are loaded with drugs and coated with a sheddable poly(ethylene glycol) (PEG) layer that promotes mucus penetration and then converts to an adhesive form after penetration. This platform technology readily distributes drug through the mucosa and throughout the vaginal tissue, enhances local retention of drugs within the vaginal tissue, thereby providing a sustained delivery of drugs beyond the natural shedding and turnover of vaginal mucous and epithelial cells.

A method of treating vaginal tissue atrophy in a female subject, the method including the steps of engaging an energy delivery element with tissue in or around the subject's vagina; applying energy to the tissue from the energy delivery element; and increasing blood flow to internal vaginal tissue to an increased level above a baseline level of blood flow to the internal vaginal tissue, the increased level of blood flow to the internal vaginal tissue persisting after the applying step ceases. The invention also provides devices for performing this therapy.

The present invention relates to a method of lubricating a biological tissue (such as a joint, bone, eye tissue, nasal tissue, tendon, tendon sheath, and vaginal tissue) by contacting the biological tissue with an effective amount of a block copolymer lubricating composition, the function of the block copolymer lubricating composition being at least equal to or superior to that of lubricin. In a particular embodiment, the method is used for treating osteoarthritis. In a specific embodiment, the block copolymer has a polymer block containing ammonium and a nonionic hydrophilic polymer block, or the copolymer has a polymer block containing carboxylic acid and a non-acidic nonionic hydrophilic polymer block.

The invention discloses a Lactobacillus jensenii strain for regulating and controlling expression of host defense peptide and interferon to reduce the risk of host infection and a metagen thereof, and belongs to the technical field of microorganisms. The lactobacillus jensenii disclosed by the invention is separated from the vagina of a healthy female, and has the effects of improving the immunocompetence of the vagina and enhancing the self-defense of a host, which are specifically embodied in that: the expression and secretion of host defense peptide of vaginal tissues of an organism are promoted; the generation of body interferon is reduced; the level of myeloperoxidase is reduced; characterizing the fungal infection resistance of the organism through periodic acid Schiff staining; the pathological characterization of the body vagina is improved. Therefore, the lactobacillus jensenii has a huge application prospect in products for improving vaginal immunity, enhancing host defense and preventing infection.

The application discloses a composition for preventing and / or treating candidal vaginitis, and belongs to the field of medicine. It is found for the first time that a composition containing volatile oil of pachystachys jutna and total alkaloids of Sophora flavescens can significantly inhibit the adhesion and invasion ability of Candida albicans to VK2 / E6E7 cells. Meanwhile, in a mouse candidal vaginitis model, the composition can effectively reduce the vaginal fungal load of the mouse candidal vaginitis model, improve the pH value of vaginal secretion, and improve the inflammatory cell infiltration of the vaginal tissue, and has clinical popularization and application value.

A handheld ultrasound device and corresponding methods, including devices and methods used for rejuvenating the vulvovaginal area of the user. In general, the handheld ultrasound devices include a device body coupled to an acoustic coupler and a handle. The device body further includes internal components including an ultrasound transducer, an energy delivery element, and circuitry for controlling the ultrasound output. In particular examples, the methods of using the handheld ultrasound device include engaging the tissue in and around the vulvovaginal area with the energy delivery element, applying ultrasound energy to the vulvovaginal tissue from the energy delivery element and through the acoustic coupler, and affecting a measurable parameter associated with vulvovaginal rejuvenation.

The application discloses lactobacillus johnsonii capable of orally assisting in relieving vaginitis and improving skin aging, and belongs to the technical field of microorganisms.The lactobacillus johnsonii is separated from vaginal secretions of healthy women, has the effects of repairing immune disorders caused by vaginitis and skin aging of mice with vaginitis, and is specifically reflected in the following aspects: reducing the content of IL-1beta in cell supernatant; improving inflammatory reactions of mouse vaginas; reducing the expression of TLR-4 mRNA and the level of TNF-alpha in vaginal tissues; enhancing the anti-aging ability of mouse skin; reducing the expression of MAPK / AP-1 / MMP-1 mRNA, increasing the content of Col I and Col III in skin; improving pathological characteristics of mouse vaginas and reducing the load of pathogenic bacteria.Therefore, the lactobacillus johnsonii has great application prospects in products for improving and repairing inflammatory damage caused by vaginitis and skin health problems of mice with vaginitis.

The application discloses a vaginal probiotic composition for relieving multiple vaginitis, and belongs to the technical field of microorganisms. The combination of Lactobacillus crispatus CCFM1298, Lactobacillus gasseri CCFM1201 and fructooligosaccharide is selected based on the growth characteristics of the strains, the synergistic symbiosis of the combined strains is realized, and the effect of multiple relief of vaginitis is realized. The probiotic composition can relieve vaginal tissue inflammation, regulate the local immune system of the vagina, and help relieve and improve bacterial vaginitis and candidal vaginitis of women. Moreover, since the probiotics are all derived from the vagina of healthy women, the probiotics are used in the preparation of products and sanitary products for female vaginitis, help relieve and improve female vaginitis, and have a good application prospect.

To obtain a bacterium inhibiting the proliferation of S. aureus and E. coli and participating in the increase of the expression of genes of six factors of CLD1, OCLN, elafin, MUC1, HAS1 and HAS3 relating to the barrier function of vaginal tissues and a preparation, etc., utilizing a culture supernatant or dead cells obtained from the bacterium.SOLUTION: A BG-strain of STBs325 belonging to the species Lactobacillusparagasseri deposited under accession number NITEP - 04114, wherein the culture supernatant inhibits the growth of S. aureus and E. coli and increases the expression of the genes for the six factors CLD1, OCLN, Elafin, MUC1, HAS1, HAS3, which are associated with the barrier function of vaginal tissue. A preparation using the culture supernatant or dead bacterial cells of the bacteria can be used as an agent for suppressing proliferation of Staphylococcus aureus or Escherichia coli and as an agent for improving the barrier function of vaginal tissue.SELECTED DRAWING: Figure 2

The invention discloses a double-balloon vaginal dilation device for cervical cancer focus MRI (Magnetic Resonance Imaging) development and an operation method, and relates to the field of II-type medical instruments. The main balloon is elliptical and is made of a polyurethane material, the long diameter of the main balloon after water injection is 3.5-4.5 cm, and the short diameter of the main balloon after water injection is 2.5-3.5 cm; according to the invention, through the design of cooperative dilation of the double balloons, the accuracy and efficiency of MRI development of cervical cancer lesions are significantly improved; the main balloon is made of an oval polyurethane material and is regularly expanded to be matched with the anatomical form of the vagina fornix, the oval corrugated design of the anti-skid balloon is combined, the vagina wall is effectively expanded, slippage is prevented, and attaching interference of the front wall and the rear wall of the vagina is eliminated. The dielectric constant epsilon r of the balloon material is 55 + / -5 and is highly matched with the dielectric constant epsilon r of a vaginal tissue of 50-60, normal saline containing 0.5% of Gd-DTPA is adopted as a developing solution, the focus display definition is improved to 92% + / -5% from 65% + / -12% of a traditional method, the misjudgment rate is remarkably reduced from 35%, and the examination efficiency and the patient safety are effectively improved.

The invention discloses an application of a composition containing lactobacillus extracellular vesicle CEV nanoparticles in preparation of drugs for promoting epithelial homeostasis, resisting infection and repairing injuries. Based on a special lactobacillus type of a female cervix and vagina tissue microenvironment, through screening, separation, purification and identification and in-vivo and in-vitro cell and animal experiments, it is confirmed that the extracellular vesicles CEV derived from lactobacillus crispatus and packaging micromolecules of the extracellular vesicles CEV can promote epithelial homeostasis, wound healing and virus infection resistance, and the extracellular vesicles CEV and the packaging micromolecules of the extracellular vesicles CEV have safety and effectiveness. The invention also comprises the method which is independently used or combined with clinical surgical treatment, and is used for clinical prevention and treatment of cervical, vaginal and skin injuries and infectious diseases such as HPV (human papillomavirus), so that a rapid, safe and efficient treatment scheme is provided for patients.

Devices and methods that prepare the vaginal tissue of the mother's birth canal during labor so as to prevent pelvic floor damage, and vaginal and perineal lacerations. The devices may be modular and in one example include two modules, a dilator module that comprises a dilator capable of expanding the vaginal canal of a mother who is experiencing labor and a control module that is capable of connecting to the dilator module. The two modules can be separated so that the dilator module can be physically separated from the control module. In one embodiment the dilator module is comprised of disposable elements and maybe disposed of after use. The control module may be a reusable module that can be covered during use and sterilized after use for reuse in subsequent procedures.

The application discloses a lactobacillus rhamnosus capable of improving oxidative damage to relieve vaginitis, and belongs to the technical field of microorganisms. The lactobacillus rhamnosus has the effect of repairing oxidative damage related symptoms caused by vaginitis, and further improves intestinal health problems caused by vaginitis, specifically embodied in: reducing cell Keap1 mRNA expression, increasing cell supernatant Nrf2 content; improving mouse vaginal oxidative stress: activating the Keap1 / Nrf2 pathway, increasing the Nrf2 level of vaginal tissue; enhancing the antioxidant capacity of the mouse intestinal tract: reducing the Keap1 mRNA level of colon tissue; improving the pathological characteristics of the mouse vagina and reducing the pathogenic bacterial load. Therefore, the lactobacillus rhamnosus CCFM1315 has great application prospect in products for improving and repairing the vaginal oxidative damage problems caused by vaginitis.