19 results about "Vaginal tissue" patented technology

The application discloses an active oxygen response type bacteriostatic and repair promoting hydrogel and a preparation method and application thereof, the hydrogel is formed by disulfide bond cross-linked hydrogel in response to active oxygen free radicals in the vagina of vaginitis patients through thiol modified hyaluronic acid (HASH), and can enhance in-vivo retention by thiol and vaginal tissue interaction. Cationic surfactant such as didecyldimethylammonium chloride (DDAC) as the bacteriostatic component of the hydrogel, efficiently killing pathogenic bacteria while having good biocompatibility, and is not prone to cause bacterial drug resistance. As a natural immune regulator, beta-glucan regulates the vaginal microenvironment, promotes the polarization of macrophages into anti-inflammatory M2 type and promotes cell migration, etc., to promote the repair of the vaginal immune barrier, regulate the vaginal flora, and reduce the probability of vaginitis recurrence. The HASH hydrogel provides an efficient, convenient and highly transformative potential strategy to provide more choices for the treatment of vaginitis.

The utility model relates to the technical field of surgical instruments, in particular to an inflatable vagina plug ball which comprises a plug ball body and an air supply device, the plug ball body is made of silica gel materials, the air supply device is arranged on the surface of the plug ball body and comprises a main pipe, the main pipe is fixedly connected with the surface of the plug ball body, and a cavity is formed in the plug ball body. The air supply device is arranged, the inflating assembly can be matched with the three-way pipe, the first one-way valve, the second one-way valve and the main pipe to inflate the inner cavity of the plug ball body and enable the plug ball body to conduct expansion plugging, the plug ball body is made of silica gel materials, and the plug ball body is made of silica gel materials. The vagina plugging device is simple in structure, soft, good in biocompatibility and capable of better adapting to the vagina physiological structure, damage to vagina tissue is reduced, it is not needed to spend time in making a spherical plugging object through gloves and gauze, and the operation preparation efficiency and the plugging effect are greatly improved.

The invention discloses skin mucosa maintenance liquid capable of killing fungi and HPV (human papillomavirus) as well as a preparation method and application of the skin mucosa maintenance liquid, and belongs to the technical field of sterilization and virus removal. The skin mucosa maintenance liquid is prepared from octanol ether, benzalkonium bromide, phenoxyethanol, yermate, parachlorometaxylenol, taetinic acid, chitosan, keratinase, fluconazole, glycerol, borneol, menthol, absolute ethyl alcohol and tween-40. Wherein the skin mucosa maintenance liquid has an effect of regulating apoptosis induction on abnormal cells and an effect on vaginal flora, and has an obvious inhibition effect on cervicitis and colpitis mycotica, namely an anti-inflammatory effect; meanwhile, apoptosis of cells containing HPV16 and HPV18 genes can be induced, shedding of abnormal cells is promoted, diseased cells are killed, and vaginal tissues with pathological changes are removed.

The invention relates to the technical field of biology, and discloses a Lactobacillus paracasei KFY202407 and an application thereof in preparation of a preparation for preventing and treating vaginitis, the collection number of the Lactobacillus paracasei KFY202407 in China General Microbiological Culture Collection Center (CGMCC) is CGMCC NO: 30736, and the collection date is May 22, 2024. The lactobacillus paracasei KFY202407 disclosed by the invention can relieve inflammation of mice with vaginitis by regulating secretion of mouse serum inflammatory factors, activity of vaginal tissue MPO and expression conditions of vaginal tissue inflammatory genes. The microbial inoculum prepared from the lactobacillus paracasei KFY202407 has good stability and can be used as a medicine raw material.

Devices and methods that prepare the vaginal tissue of the mother's birth canal during labor so as to prevent pelvic floor damage, and vaginal and perineal lacerations. The devices may be modular and in one example include two modules, a dilator module that comprises a dilator capable of expanding the vaginal canal of a mother who is experiencing labor and a control module that is capable of connecting to the dilator module. The two modules can be separated so that the dilator module can be physically separated from the control module. In one embodiment the dilator module is comprised of disposable elements and maybe disposed of after use. The control module may be a reusable module that can be covered during use and sterilized after use for reuse in subsequent procedures.

The invention discloses a vaginal dilatation device used after vaginoplasty, and relates to the technical field of medical instruments, the technical key point is that the vaginal dilatation device comprises a base cylinder and a plurality of pipeline limiting pieces fixedly mounted on the outer circular surface of the base cylinder, a dilatation mechanism is arranged on the outer side of the base cylinder, and the dilatation mechanism comprises an inflation assembly, an exhaust assembly and a pressure detection assembly; the inflation assembly comprises a plurality of inflation main pipes fixedly installed on the pipeline limiting piece, inflation branch pipes communicating with inner cavities of the inflation main pipes are fixedly installed on the outer circle faces of the inflation main pipes, the air outlet ends of the inflation branch pipes are fixedly connected with unit air bags, and one-way valves are fixedly installed at the air inlet ends of the inflation main pipes. Through the synergistic effect of the dilation mechanism, the antibacterial layer and the mounting and positioning mechanism, precise dilation of vaginal tissue is achieved, the wearing comfort of a patient is improved, infection is effectively prevented, it is ensured that the device is stably fixed in the vagina, and an efficient, safe and comfortable vaginal dilation treatment scheme is provided for the patient.

The application discloses a composition for relieving vaginitis by simultaneously activating immune regulation and antioxidant pathways, and belongs to the technical field of microorganisms. The application screens a composite strain containing a strain of Paracaseolovis casei CCFM1316 and a strain of Paracaseolovis casei CCFM1317, and the composition containing the composite strain has the effect of repairing immune disorders, oxidative damage and other related symptoms caused by vaginitis, which is specifically embodied in: regulating the immune response of the mouse vagina; activating the TLR-4 / MyD88 pathway, and reducing the IL-1beta concentration of the vaginal tissue to 29.79 ng / L; improving the oxidative stress of the mouse vagina; and increasing the Nrf2 of the vaginal tissue to 36.58 ng / L. Therefore, the composition of the Paracaseolovis casei CCFM1316 and the Paracaseolovis casei CCFM1317 has great application prospect in products for improving and repairing the inflammatory response and oxidative damage caused by vaginitis.

The application discloses a composition for preventing and / or treating candidal vaginitis, and belongs to the field of medicine. It is found for the first time that a composition containing volatile oil of pachystachys jutna and total alkaloids of Sophora flavescens can significantly inhibit the adhesion and invasion ability of Candida albicans to VK2 / E6E7 cells. Meanwhile, in a mouse candidal vaginitis model, the composition can effectively reduce the vaginal fungal load of the mouse candidal vaginitis model, improve the pH value of vaginal secretion, and improve the inflammatory cell infiltration of the vaginal tissue, and has clinical popularization and application value.

A handheld ultrasound device and corresponding methods, including devices and methods used for rejuvenating the vulvovaginal area of the user. In general, the handheld ultrasound devices include a device body coupled to an acoustic coupler and a handle. The device body further includes internal components including an ultrasound transducer, an energy delivery element, and circuitry for controlling the ultrasound output. In particular examples, the methods of using the handheld ultrasound device include engaging the tissue in and around the vulvovaginal area with the energy delivery element, applying ultrasound energy to the vulvovaginal tissue from the energy delivery element and through the acoustic coupler, and affecting a measurable parameter associated with vulvovaginal rejuvenation.

The application discloses lactobacillus johnsonii capable of orally assisting in relieving vaginitis and improving skin aging, and belongs to the technical field of microorganisms.The lactobacillus johnsonii is separated from vaginal secretions of healthy women, has the effects of repairing immune disorders caused by vaginitis and skin aging of mice with vaginitis, and is specifically reflected in the following aspects: reducing the content of IL-1beta in cell supernatant; improving inflammatory reactions of mouse vaginas; reducing the expression of TLR-4 mRNA and the level of TNF-alpha in vaginal tissues; enhancing the anti-aging ability of mouse skin; reducing the expression of MAPK / AP-1 / MMP-1 mRNA, increasing the content of Col I and Col III in skin; improving pathological characteristics of mouse vaginas and reducing the load of pathogenic bacteria.Therefore, the lactobacillus johnsonii has great application prospects in products for improving and repairing inflammatory damage caused by vaginitis and skin health problems of mice with vaginitis.

The application discloses a vaginal probiotic composition for relieving multiple vaginitis, and belongs to the technical field of microorganisms. The combination of Lactobacillus crispatus CCFM1298, Lactobacillus gasseri CCFM1201 and fructooligosaccharide is selected based on the growth characteristics of the strains, the synergistic symbiosis of the combined strains is realized, and the effect of multiple relief of vaginitis is realized. The probiotic composition can relieve vaginal tissue inflammation, regulate the local immune system of the vagina, and help relieve and improve bacterial vaginitis and candidal vaginitis of women. Moreover, since the probiotics are all derived from the vagina of healthy women, the probiotics are used in the preparation of products and sanitary products for female vaginitis, help relieve and improve female vaginitis, and have a good application prospect.

To obtain a bacterium inhibiting the proliferation of S. aureus and E. coli and participating in the increase of the expression of genes of six factors of CLD1, OCLN, elafin, MUC1, HAS1 and HAS3 relating to the barrier function of vaginal tissues and a preparation, etc., utilizing a culture supernatant or dead cells obtained from the bacterium.SOLUTION: A BG-strain of STBs325 belonging to the species Lactobacillusparagasseri deposited under accession number NITEP - 04114, wherein the culture supernatant inhibits the growth of S. aureus and E. coli and increases the expression of the genes for the six factors CLD1, OCLN, Elafin, MUC1, HAS1, HAS3, which are associated with the barrier function of vaginal tissue. A preparation using the culture supernatant or dead bacterial cells of the bacteria can be used as an agent for suppressing proliferation of Staphylococcus aureus or Escherichia coli and as an agent for improving the barrier function of vaginal tissue.SELECTED DRAWING: Figure 2

Devices and methods that prepare the vaginal tissue of the mother's birth canal during labor so as to prevent pelvic floor damage, and vaginal and perineal lacerations. The devices may be modular and in one example include two modules, a dilator module that comprises a dilator capable of expanding the vaginal canal of a mother who is experiencing labor and a control module that is capable of connecting to the dilator module. The two modules can be separated so that the dilator module can be physically separated from the control module. In one embodiment the dilator module is comprised of disposable elements and maybe disposed of after use. The control module may be a reusable module that can be covered during use and sterilized after use for reuse in subsequent procedures.

The application discloses a lactobacillus rhamnosus capable of improving oxidative damage to relieve vaginitis, and belongs to the technical field of microorganisms. The lactobacillus rhamnosus has the effect of repairing oxidative damage related symptoms caused by vaginitis, and further improves intestinal health problems caused by vaginitis, specifically embodied in: reducing cell Keap1 mRNA expression, increasing cell supernatant Nrf2 content; improving mouse vaginal oxidative stress: activating the Keap1 / Nrf2 pathway, increasing the Nrf2 level of vaginal tissue; enhancing the antioxidant capacity of the mouse intestinal tract: reducing the Keap1 mRNA level of colon tissue; improving the pathological characteristics of the mouse vagina and reducing the pathogenic bacterial load. Therefore, the lactobacillus rhamnosus CCFM1315 has great application prospect in products for improving and repairing the vaginal oxidative damage problems caused by vaginitis.

The present invention relates to a device for capturing, fragmenting, and safely removing tissue from a mammalian body. The device comprises a double-layered bag (80) for receiving a tissue sample (110), a tissue capturer (70) configured to facilitate placement of the tissue sample (110) into the bag (80) and to temporarily hold the bag (80), a cutting tool (20) configured to cut at least a portion of the tissue sample (110) within the bag (80), and a vaginal plug (100) configured to prevent gas leakage during laparoscopic procedures. The tissue capturer (70) is removably attached to the bag (80), and the cutting tool (20) is configured to cut the tissue sample (110) into spiral pieces (112). The device is particularly useful in the context of gynecological procedures, allowing for the safe and efficient removal of tissue samples (110) through a natural vaginal opening.

A method of treating vaginal tissue atrophy in a female subject, the method including the steps of engaging an energy delivery element with tissue in or around the subject's vagina; applying energy to the tissue from the energy delivery element; and increasing blood flow to internal vaginal tissue to an increased level above a baseline level of blood flow to the internal vaginal tissue, the increased level of blood flow to the internal vaginal tissue persisting after the applying step ceases. The invention also provides devices for performing this therapy.

To obtain a bacterium inhibiting the proliferation of S. aureus and E. coli and participating in the increase of the expression of genes of six factors of CLD1, OCLN, elafin, MUC1, HAS1 and HAS3 relating to the barrier function of vaginal tissues and a preparation, etc., utilizing a culture supernatant or dead cells obtained from the bacterium.SOLUTION: A BG-strain of DL427 belonging to the species Lactobacillusparagasseri deposited under accession number NITEP - 04115, wherein the culture supernatant inhibits the growth of S. aureus and E. coli and increases the expression of the genes for the six factors CLD1, OCLN, Elafin, MUC1, HAS1, HAS3, which are associated with the barrier function of vaginal tissue. A preparation using the culture supernatant or dead bacterial cells of the bacteria can be used as an agent for suppressing proliferation of Staphylococcus aureus or Escherichia coli and as an agent for improving the barrier function of vaginal tissue.SELECTED DRAWING: Figure 2

The invention relates to methods of lubricating biological tissue, such as joints, bone, ocular tissue, nasal tissue, tendons, tendon capsule, and vaginal tissue, by contacting the biological tissue with an effective amount of a block copolymer lubricating composition which functions at least or better than lubricin. In particular embodiments, the method is used to treat osteoarthritis. In specific embodiments, the block copolymer has an ammonium-containing polymer block and a non-ionic hydrophilic polymer block, or the copolymer has a carboxylic acid-containing polymer block and a non-acid non-ionic hydrophilic polymer block.

Vaginal dilation devices are provided that may include a number of configurations. One feature of the vaginal dilation devices is that they are configured to dilate vaginal tissue during labor to prevent tissue damage. Another feature of the vaginal dilation devices is that they allow for both manual and automatic control of vaginal tissue dilation. In some embodiments, the vaginal dilation devices are configured to measure the force applied to the tissue by the device. Methods related to the use of the vaginal dilation devices are also provided.