91 results about "Vaginal secretions" patented technology

The present invention discloses one plant lactobacillus strain and its application. The plant lactobacillus, Lactobacillus plantarum L323 CGMCC No. 1329, is separated from Chinese pregnant woman's vaginal secretion, and has relatively high bacteriotasis on common vaginal pathogens, such as staphylococcus aureus, candida albicans, colibacillus and vaginal Gardnar bacillus, and acid producing and H2O2 producing capacity higher than other lactobacillus. The plant lactobacillus, Lactobacillus plantarum L323 CGMCC No. 1329, may be used in preparing vaginal microbial preparation for preventing and / or treating vaginal infectious diseases.

This disclosure provides a method for detecting and / or identifying uncultured bacteria. The sample is an aerosol sample selected from a group consisting of cough, sneeze, saliva, mucus, bile, urine, vaginal secretions, middle ear aspirate, pus, pleural effusions, synovial fluid, abscesses, cavity swabs, serum, blood and spinal fluid. The method comprises obtaining absorption spectra (AS) of the sample, extracting and processing the acquired data, thereby detecting and / or identifying the bacteria.

The present invention relates to the use of benzoic acid and / or its sodium salt in combination with saccharide(s) as active components in the manufacture of a vaginal composition for modulating vaginal flora and vaginal acidity, thereby maintaining the pH value of vaginal secretion within a range from 3.5 to 4.5; and the present invention further relates to a vaginal composition and a method for modulating and maintaining normal vaginal flora and vaginal acidity.

The present invention discloses a female reproductive tract microecology evaluation and detection system. The system includes a full-automatic intelligent stainer, a vaginitis automatic detection workstation, a morphology full-automatic microscopic detection platform, a computer, an input device and an output device. The full-automatic intelligent stainer is used for automatic staining on a sample of vaginal secretions; the vaginitis automatic detection workstation is used for biochemical detection on preformed enzymes and metabolites in the vaginal secretions to obtain the functional assessment result data; the morphology full-automatic microscopic detection platform is connected to the computer and used for the detection of a smear formed after staining by the full- automatic intelligent stainer, and the morphology full-automatic microscopic detection platform detects and analyzes the visible components in the vaginal secretions to obtain morphological pattern data; the computer is used for controlling the full-automatic intelligent stainer, the vaginitis automatic detection workstation, the morphology full-automatic microscopic detection platform, the input device and the output device; the computer is equipped with application software and pathological knowledge base; and the input device is connected to the computer.

The invention discloses a vaginal secretion staining fluid, and a preparation method and a staining method thereof. According to the preparation method, a blue basic dyestuff and a red basic dyestuff are mixed so as to obtain the vaginal secretion staining fluid, so that the vaginal secretion staining fluid possesses staining effects of universal staining fluid, staining time can be shortened greatly, staining time is shortened from general 5-30min to 20s, staining efficiency is increased greatly, and screening speed of clinical samples is accelerated. And in addition, imagines obtained via staining with the vaginal secretion staining fluid are clear, and are convenient for identification; surface layer squamous epithelial cells, middle layer epithelial cells, bottom layer epithelial cells, clue cells, leukocytes, erythrocytes, monilia albicans, and trichomonad can be identified clearly; and the vaginal secretion staining fluid is suitable for large-scale sample clinical screening.

The invention aims to provide a joint vaginitis detection kit which is convenient, quick and sensitive to operate, does not need any high-end instrument and equipment, and has low price. The technical scheme of the invention is to provide the joint vaginitis detection kit comprising a clamp-shaped reaction device with four dry chemical reaction blind holes, diluent and chromogenic reagent; and the four blind holes are respectively provided with a hydrogen peroxide concentration determination test reagent pad, a sialic acid glucoside enzyme activity test reagent pad, a leukocyte esterase activity determination test reagent pad and a vaginal fluid pH test reagent pad. The joint vaginitis detection kit can simultaneously test four indexes, i.e. the pH value of vaginal secretion, hydrogen peroxide, sialic acid glucoside enzyme and leukocyte esterase. Through the four indexes, the micro-ecological environment of vagina is determined, and the joint vaginitis detection kit is for identifying bacterial vaginosis of normal vaginal flora and bacteria groups.

The invention discloses a vaginal secretion sampling device used for gynecological clinic. The vaginal secretion sampling device comprises a sampling sleeve, wherein arc-shaped expansion pieces whichare symmetrically arranged are rotationally hinged to the left end of the sampling sleeve, silica gel is arranged on the outer walls of the arc-shaped expansion pieces, the two arc-shaped expansion pieces are matched to form a cone shape, a movable suction pipe is movably arranged in the sampling sleeve, and the left end of the movable suction pipe is fixedly connected with a sampling collection head of a hollow structure. The vagina is expanded through the arc-shaped expansion pieces, secretions at the deep position in the vagina can be sampled easily, the trouble that the secretions at the deep position in the vagina cannot be directly sampled in the past is solved, a secretion sample is sucked through negative pressure, the operation is easy, convenient and rapid, the sampling difficulty is reduced, meanwhile, after sampling is completed, the sample is relatively sealed, so that the sample is prevented from being polluted by the outside to influence the accuracy of a detection result.

The invention discloses a bionic gynecologic care solution and its preparation method. The gynecologic care solution comprises antibacterial peptides and an artificial vaginal secretion solution having a pH value of 3.3-4.4, and the content of the antibacterial peptides in the artificial vaginal secretion solution is 0.1-10.0g / L; and the artificial vaginal secretion solution comprises an artificial body fluid and a thickening agent, and the content of the thickening agent in the artificial body fluid is 0.5-5.0g / L. The bionic gynecologic care solution adopts a bionic design, the artificial body fluid is treated as a solvent, is added with the thickening agent to adjust the viscosity, and is added with an acid or an alkali to adjust the pH value in order to obtain the artificial vaginal secretion solution similar to a human vaginal secretion solution in component, viscosity and pH, and the antibacterial peptides are selected as a as bactericide. The bionic gynecologic care solution does not have an abuse that a chemical bactericide chronically erodes the vaginal viscosity, does not excessively change the vaginal microenvironment or destroy the vaginal physiological balance, and can be used for intractable vaginitis treatment and daily vagina healthcare and disease prevention.

The present invention provides a preventive or a remedy for penile erectile dysfunction, which promotes blood-flow in a penile sponge body over long time and thus induces erection while showing high safety without any adverse effect on a body as a whole, when externally administered to a penis. Use of a drug of the present invention enables to prevent or treat male penile erectile dysfunction and, at the same time, overcome a problem of female insertion impediment caused by increased resistance due to vaginal secretion disorder. Namely, a sexual life of patients (including aged persons) having coital dysfunction can be normalized and thus QOL can be improved.

The invention discloses a human body pathological change sensing device belonging to the technical field of clinical diagnosis instruments. Actual operation of diagnosing flora imbalance bacterial vaginosis with Amsel and Nugent standards is difficult; although certain new technology applications exist, the bacterial vaginosis is actually caused by a plurality of intricately interweaved factors; the methods are rough; and the operation is complicated and overloaded. The invention provides a complete, precise and convenient diagnosis method. The device comprises a vaginal chemoreception chip and a handle, wherein the chip consists of a substrate and a tunica; one surface of the substrate is combined with specific detection reagents to form detection units; the detection units are arrayed; the substrate is covered with a thin film; the handle consists of a handle head and a handle tail; the handle head is provided with a groove for placing the chemoreception chip; pits are formed in the middle parts of the two side wings of the substrate; and bulges are arranged at the middle parts of the inner faces on the two sides of the groove. The device and the method have the beneficial effects that more pathogenic factor changes in a vagina can be detected directly; the device is small in size; vaginal secretions are collected without swabs; elution and dilution are avoided; and the device is suitable for bedside operation by an outpatient doctor of a hospital or household use by a patient.

The invention discloses a detection reagent card and a kit and relates to the technical field of disease detection reagents. The detection reagent card disclosed by the invention is provided with a detection groove capable of detecting neuraminidase, catalase, leucocyte esterase or a pH (Potential of Hydrogen) value index. The invention further provides a bacterial vaginal disease multi-index self-detection kit comprising the detection card and a self-heating pad. The detection of each index of the reagent card disclosed by the invention is mutually independent and is one-step reaction; an additional developing solution or stopping solution is not needed; a subject only needs to add collected vaginal secretion into the reagent card and can detect the vaginal discharge; the self-heating padis introduced into the kit and heating equipment does not need to be additionally arranged, so that detection conditions are greatly widened and the reagent card is convenient for the subjects to useat home; domestic popularization of bacterial vaginosis detection is facilitated.

The invention discloses a vaginal secretion extraction device for gynecological clinical examination, and belongs to the technical field of equipment for gynecological clinical examination. The vaginal secretion extraction device for gynecological clinical detection comprises a shell; a motor box is arranged on the right side of the middle of the front end face of the shell; a motor is arranged in the motor box; the end of an output shaft of the motor is connected with a main shaft; a two-way lead screw is arranged at the rear end of the main shaft; driving blocks are arranged on both the left side and the right side of the peripheral outer wall of the two-way lead screw; a semi-cylindrical distraction sleeve is arranged on the front end faces of the driving blocks; a fine adjustment assembly is arranged on the right side of a pushing handle; and an extension assembly is arranged on the left side of an inner cavity of the shell. Through cooperation of the motor arranged in the motor box, the two-way lead screw at the rear end of the main shaft and the extension assembly on the left side of the inner cavity of the shell, after sampling is completed, when the semi-cylindrical distraction sleeve is reset, a sterile swab automatically returns to the interior of the semi-cylindrical distraction sleeve under the action of the extension assembly, and pollution of a sample caused by secretions at other parts in a vagina and the external environment is avoided.

The invention discloses a clinical vaginal secretion sampling device for obstetrics and gynecology, comprising a fixed block with activity slots positioned on one side of the fixed block; the link blocks are installed at the sliding activity slot, and the attachment blocks are connected with the link block on one side near the opening of the activity slot; a sampling tank is arranged at the activity slot, a liquid absorption head is fixed at the side of the sampling tank away from the link block, the open holes are fixed at the side of the sampling tank near the liquid absorption head; the open holes are communicated to the liquid absorption head, a piston is installed at the sliding sampling tank, a push rod motor is fixed at the side of the sampling tank away from the liquid absorption head, and the output shaft of the push rod motor extends to the sampling tank and connected to the piston. The clinical vaginal secretion sampling device holds a simple structure and is convenient to use to quickly take vaginal secretion, reducing the possibility of vaginal secretion contacting with air, preventing the inaccuracy of test caused by contaminated secretion, improving the accuracy of test and easy operation.

The invention discloses a vaginal secretion sampling device convenient for gynecological clinic, and relates to the field of medical instruments. The vaginal secretion sampling device comprises an insertion rod, wherein the right end of the insertion rod is detachably connected with a connecting pipe; the right end of the connecting pipe is connected with a holding mechanism; a storage cavity anda ventilation cavity are formed in the left end of the insertion rod; the ventilation cavity is positioned on the left side of the storage cavity; a feeding hole communicating with the storage cavityisformed in the outer side of the insertion rod; an air guide pipe is fixed in the insertion rod; the left end of the air guide pipe communicates with the ventilation cavity; the right end of the airguide pipe communicates with the connecting pipe; and an air bag is fixedly arranged at the left end of the insertion rod in a sleeving manner. According to the vaginal secretion sampling device disclosed by the invention, the secretion in the vagina can be conveniently sampled, the vagina is not injured, and the sampling effect is good. Meanwhile, the insertion rod and the connecting pipe are detachable and can be assembled and used according to needs. In addition, a movable pipe can be pulled after a locking cap is manually unscrewed, so that the holding pipe is exposed for a longer distance, and the device is conveniently used by medical staff with different hand sizes.

A method is taught for the accurate determination of the premature rupture of membranes (PROM), defined as spontaneous rupture of membranes before the onset of uterine contractions. More specifically, a lateral flow assay strip tests for at least two antigens to greatly limit or eliminate the possibility of false negatives. A built in timer in the cassette holding the lateral flow assay further increases the accuracy of the test. A collection buffer vial with self-contained shipping and dropper caps and built in stand is also taught.

Methods for diagnosis to allow prediction of the likelihood of preterm birth based upon the concentration of lipocalin-type prostaglandin D2 synthase (L-PGDS) in cervical vaginal secretions. In addition, specific prostaglandin D2 receptor antagonists may represent novel tocolytic therapeutics.

The invention discloses a vaginal secretion sampling device for clinical application of gynaecology. The vaginal secretion sampling device comprises a cylinder, wherein a rectangular plate is welded to the center position of the bottom end of the cylinder; an accumulator is mounted on the left side of the rectangular plate; a first control switch is mounted at the top end of the right side of therectangular plate; a second control switch is mounted at the bottom end of the first control switch; a horizontal plate is welded to the bottom end of the rectangular plate; a handle is welded to thebottom end of the horizontal plate; electric telescopic rods are welded to the left side and the right side of the bottom end of the inner part of the cylinder; a rubber head is connected to the top end of the rotating rod in a sleeving manner; connecting rods are welded to the left side and the right side of the cylinder; a blocking block is welded to the top end of each connecting rod; and the collecting devices are welded to the left side and the right side of the top end of the cylinder. According to the vaginal secretion sampling device disclosed by the invention, through the collecting devices, the collected secretions can be quickly taken and are easy to take, so that operations of medical personnel are convenient, and the working efficiency of the medical personnel is improved.

The clinical vaginal secretion sampling device comprises a mounting shell and a feeding shell, a fixing shell is arranged in the feeding shell, a sampling capsule connected through a fastening assembly is arranged in the fixing shell, the sampling capsule is made of a polycarbonate plastic material, a sampling opening is formed in one end of the sampling capsule, and a sampling hole is formed in the other end of the sampling capsule. The sampling port is arranged in the sampling pipe at one end of the fixed shell in a penetrating manner, the mounting shell is connected with the feeding shell through an adjusting mechanism, two groups of positioning frames are arranged in the mounting shell, pull rods are arranged in the two groups of positioning frames in a penetrating manner, two groups of through holes are formed in one end of the feeding shell, and the two groups of pull rods are respectively arranged in the two groups of through holes in a penetrating manner; one end of the pull rod is connected with the mounting shell through a clamping mechanism, a control hook is arranged at the bottom of the clamping mechanism, and the other end of the pull rod is connected with the fixing shell through an extrusion assembly. The sampling device can be used for rapidly sampling secretions, and the sampling depth can be accurately adjusted, so that vaginal secretion sampling is more convenient and efficient. And cross infection in the sampling process can be effectively prevented.

The invention discloses a vaginal secretion sampling device for obstetrics and gynecology department. The device comprises a sampling tube and a protective tube, a sampling head is in communication with the interior of the sampling tube, a plurality of sampling holes are formed in the sampling head, the protective tube comprises an outer protective tube body, an inner protective tube body, a protective head and connecting pieces, the outer protective tube body sleeves the outer side of the inner protective tube body, the inner protective tube body sleeves the outer side of the sampling tube, a gap is formed between the inner wall of the inner protective tube body and the outer side of the sampling tube, the protective head is arranged at the front end of the outer protective tube body, one end of the connecting pieces is hinged to the outer wall of the front end of the inner protective tube body, the other end thereof is hinged to the inner wall of the protective head, the inner protective tube body is pushed towards a front end, and therefore, the protective head is opened through the connecting pieces, and the sampling pipe can penetrate through the protective head. According to the vaginal secretion sampling device, through dual protection of the outer protective tube body and the inner protective tube body on the sampling tube, in the process that the sampling tube extends into the vagina, the sampling head is isolated from vaginal tissues, so that the sampled vaginal secretion is prevented from being polluted.

The invention relates to the field of medical tools, and particularly discloses a vaginal secretion sampling device for obstetrics clinical application, which comprises a support rod, a sampling headand a grip, the sampling head is connected to one end of the support rod, the other end is connected with the grip, the sampling head is an egg-shaped hollow structure, the side wall of the sampling head is spaced apart from at least one notch, the outer wall of the sampling head is provided with an arc-shaped protrusion on a side of the notch, the inner wall of the sampling head is fixedly disposed with a limit position on one side of the notch, the support rod and the handle are provided with an active passage along the axial direction, and the movable passage is provided with a connecting rod. The device is used for sampling by the sampling head. After the sampling head extends into the vagina, the vaginal secretions flow into the sampling head through the notch, and the sampling head is rotated to scrape the secretion at the inner wall of the vagina into the sampling head through the arc-shaped protrusion, the efficiency of sampling is improved, and the usage is more convenient.

This invention provides methods and compositions for testing for pregnancy and non-pregnancy in ungulates and non-hoofed ruminates. The tests provided by this invention are useful during a time that coincides with the estrus cycle during which breeding occurs or the first estrus cycle after breeding of a non-pregnant animal. The tests provided by this invention are useful in estrus and ovulation synchronization programs, with pregnancy testing useful at a time allowing for resynchronization of non-pregnant animals within the first estrus cycle. The tests provided by this invention assay for the presence, absence, or level of a selected IFN-τ-induced protein in a sample from a female animal. The tests of this invention are useful for testing cells, blood, plasma, serum, cells, milk, nasal secretions, ocular secretions, vaginal secretions, urine, and saliva samples. The tests provided by this invention are immunoassays. Polyclonal and monoclonal antibodies useful in such tests, as well as methods of making such antibodies and hybridoma cell lines, are provided. Devices for performing such tests, methods of using such devices, and methods of making such devices are provided. Kits containing such devices are also provided. This invention provides a method for determining readiness for breeding. This invention provides a method for resynchronizing breeding with breeding cycle times of one estrus cycle or shorter. This invention also provides a method for breeding by forcing estrus and artificial insemination by appointment.

The invention relates to a vaginal secretion sampling device. The vaginal secretion sampling device is characterized in that a tube body is a cylindrical hollow tube, a hollow collecting tube is arranged at the axis in the tube body, the collecting tube and the tube body are connected through an annular support wall, a funnel-shaped cavity is formed between the annular support wall and the wall of the tube body; a collection hole B is formed in the wall of the collecting tube at the connecting part of the bottom of the funnel-shaped cavity between the annular support wall and the wall of the tube body and the collecting tube; collection holes A are also formed in the tube body; a silica gel layer is arranged on the surface of the outer wall, without the collection holes A, of the tube body; bristles are arranged on the silica gel layer; the contact end of the collecting tube is connected with a concave wall, and a collection hole C is formed in port of the contact end; and a suction tube is arranged at the port of the other end of the collecting tube and communicated with the inner chamber of the collecting tube. The vaginal secretion sampling device has the benefits of being reasonable in structure, convenient and quick in use, comprehensive in sampling and high in efficiency.

The present invention provides a method of stimulating cervical and vaginal secretions in a mammal by treatment with P2Y2, and / or P2Y4 purinergic receptor agonists. Treatment of vaginal dryness associated with menopause, chemotherapy, and various disease states as well as the treatment of vulvar pain is discussed. Suitable purinergic receptor agonists include nucleotide triphosphates such as uridine 5-triphosphate, cytidine 5'-triphosphate and adenosine 5'-triphosphate; dinucleotide polyphosphates such as P<1>, P<4>-di(uridine-5') tetraphosphate; and their analogs. These purinergic receptor agonists are useful in stimulating cervical and vaginal secretions and treating vaginal dryness in mammals.

The present invention discloses a primer set for detecting candida albicans in female vaginal secretions. The primer set comprises an external primer pair F3 / B3 and an internal primer pair FIP / BIP. The present invention also relates to a method for detecting the candida albicans in the female vaginal secretions by using the primer set and also relates to a rapid quantitative detection kit for detecting the e candida albicans in the female vaginal secretions by using the primer set. The primer set has an advantage of providing results in a short period of time, much faster than time required for detecting and identifying fungi based on a culture method.

The invention discloses a vaginal secretion detector. The detector comprises a base, a sample detection device, and a sample storage device, a sample transportation device, a color detection device, asample adding device and a control device are arranged on the base. The invention also discloses a vaginal secretion detection method, and the method comprises the following steps: (1) putting a sample on a test tube disc, and driving the test tube disc to a working position; (2) enabling the sample transportation device to extract a sample and convey the sample to the color detection device to collect the current color of the sample as a ground color; (3) adding a BV color developing agent, collecting a color as a contrast color after the color developing reaction is finished, and performingcleaning; (4) calculating the difference between the ground color and the control color and judging the difference as positive or negative; (5) adding a coloring agent A and a coloring agent B into the sample by the sample adding device, and conveying the sample to the sample detection device after the dyeing reaction is finished; (6) detecting the sample by the sample detection device, outputting a detection result and storing original picture data.

The invention discloses a manufacturing method of a multiplex PCR kit for quickly detecting vaginal pathogenic microorganisms. The manufacturing method comprises the following steps of: firstly, respectively determining specific primer sequences of candida, Gardnerella vaginalis and trichomonad; preparing a nucleic acid extraction kit suitable for the three pathogens of the candida, the Gardnerella vaginalis and the trichomonad, wherein the nucleic acid extraction kit is suitable for vaginal secretion specimens; finding out fluorescent PCR reaction conditions suitable for the three pathogens of the candida, the Gardnerella vaginalis and the trichomonad, and preparing a fluorescent quantitative PCR detection reagent; and finally, assembling into a complete kit. According to the manufacturing method disclosed by the invention, by preparing the multiplex PCR kit suitable for the three pathogens of the candida, the Gardnerella vaginalis and the trichomonad, which one or mixed infection of the three commonly infected pathogenic microorganisms in a vagina can be quickly detected in one PCR reaction system, so that guidance is provided for clinically selecting targeted treatment medicines as early as possible.

The invention provides gynecological antibacterial gel and a preparation method thereof. The gynecological gel is prepared from the following components in parts by weight: 0.5 to 2.5 parts of carbomer, 0.23 to 1.5 parts of cyclodextrin, 2 to 8 parts of nano-silver, 1 to 10 parts of chitosan, 1 to 8 parts of radix sophorae flavescentis, 0.1 to 0.6 part of radix stemonae, 0.2 to 0.8 part of fructus cnidii, 0.1 to 0.4 part of cortex phellodendri, 0.2 to 0.7 part of herba leonuri, 2 to 30 parts of Tween-80, 0.5 to 1 part of citric acid, 0.7 to 1 part of lactic acid, 0.5 to 1.5 parts of menthol, 0.2 to 0.5 part of borneol and 60 to 80 parts of ultrapure water. The gel provided by the invention has more stable texture and is not easily diluted by vaginal secretions to reduce the medicine effect; and the gel is combined with traditional Chinese medicine components, in a process of treating vaginal diseases, the gel also has the effects of removing wound surfaces, repairing wounds and promoting healing, and can keep a vaginal micro-ecological environment stable, so that dual effects of repairing and treating are achieved.

The invention provides a vaginitis joint detection kit. The vaginitis joint detection kit comprises a vaginal secretion sterile swab (1), a reaction detection plate (2), a dilution solution dropping bottle (3), a developing solution dropping bottle (4) and a reaction developing colorimetric card which are independently arranged, wherein a sampling hole (21) and a group of reaction holes (22) are formed in the reaction detection plate (2), and the sampling holes (21) are respectively connected with the reaction holes (22) through a drainage trough (23). The detection plate can detect various types of vaginitis, is low in cost, high in detection accuracy, convenient and fast to use and free from professional training for operating staff, and can be used by patients, thus being easy to popularize.

The invention relates to the technical field of medical equipment, especially to a vaginal secretion automatic analyzer. The invention provides the vaginal secretion automatic analyzer which includes a control device, a liquid feeding device, a constant-temperature heating device and a sample feeding mechanism, a conveying mechanism and a detection device which are connected in order. The control device is connected to the liquid feeding device, the constant-temperature heating device, the sampling feeding mechanism, the conveying mechanism and the detection device. Automatic sample feeding, conveying, liquid feeding and detection operation are realized by the control device, and so the degree pf automation is high and the coordination is good. Moreover, in a process of detecting vaginal secretions, automatic sampling feeding can effectively avoid uncertain factors caused by manual sample feeding and improve the detection accuracy. In addition, the analyzer provided by the invention is also provided with the constant-temperature heating device which can maintain temperature required by an effective biochemical reaction. Furthermore, the vaginal secretion automatic analyzer has the advantages of simple structure, reasonable design and simple operation and helps to save human resources and the improvement of detection time and detection efficiency.

A method is taught for the accurate determination of the premature rupture of membranes (PROM), defined as spontaneous rupture of membranes before the onset of uterine contractions. More specifically, a lateral flow assay strip tests for at least two antigens to greatly limit or eliminate the possibility of false negatives. A built-in timer in the cassette holding the lateral flow assay further increases the accuracy of the test. A collection buffer vial with self-contained shipping and dropper caps and built-in stand is also taught.