162 results about "Monilinia" patented technology

The subject matter of the present invention is a bacteria or mix of bacteria having an antagonistic activity with respect to stains of S. aureus, P. aeruginosa, Streptococcus pyogenes, Enterococcus faecium, Enterobacter cloacae, Proteus mirabilis, Bacteroides fragilis Staphylococcus epidermidis, Propionibacterium acnes, Candida albicans and / or Malassezia furfur as well as the use thereof in the treatment and / or prevention of infections or colonisations related to those pathogens. The invention pertains to care products containing one or more non-pathogenic antagonistic strains intended to prevent and / or treat infections or colonisations on skin, wounds, mucous membranes and appendages.

The present invention discloses one plant lactobacillus strain and its application. The plant lactobacillus, Lactobacillus plantarum L323 CGMCC No. 1329, is separated from Chinese pregnant woman's vaginal secretion, and has relatively high bacteriotasis on common vaginal pathogens, such as staphylococcus aureus, candida albicans, colibacillus and vaginal Gardnar bacillus, and acid producing and H2O2 producing capacity higher than other lactobacillus. The plant lactobacillus, Lactobacillus plantarum L323 CGMCC No. 1329, may be used in preparing vaginal microbial preparation for preventing and / or treating vaginal infectious diseases.

The invention provides a weissella cibaria XHR1 and applications thereof and a weissella cibaria XHR1 containing pickled vegetable. The preparation of the pickled vegetable is implemented through the steps of adding a culture solution of weissella cibaria XHR1 and bacterial powder of lactobacillus plantarum CICC 20764 into a pickled vegetable fermentation starting solution for pickling vegetables, so that the final concentration of weissella cibaria XHR1 is 10<6>-10<7> cfu / mL eventually, and then the final concentration of lactobacillus plantarum CICC 2076 is 10<5>-10<6> CFU / mL; and then, adding vegetables into the pickled vegetable fermentation starting solution, and carrying out vegetable pickling according to a traditional vegetable fermentation process, so that the pickled vegetable disclosed by the invention is obtained finally. According to the invention, prebiotic lactobacillus for inhibiting the growth of Candida albicans is applied to the fermentation of Sichuan pickled vegetables, so that the consumer group is wider, and the micro ecological level of alimentary canals of wide consumers can be improved, thereby inhibiting Candida albicans diseases from the perspective of public health.

The invention discloses a Bacillus subtilis strain and application thereof. The strain is named as Bacillus subtilis ZJU007 and preserved in the China general microbiological culture collection center (CGMCC) of Chinese Academy of Sciences on yard No.1 on Beichen West Road, in Chaoyang district in Beijing on September 3rd, 2010, and has the preservation number of CGMCC No.4140. A bactericidal substance generated by the strain of the invention has very strong inhibition effect on Candida albicans and has better bacteriostasis effect compared with common fungicidin. The bactericidal substance not only has very strong bacteriostasis effect on the Candida albicans and other yeast like fungi, and the like, but also has excellent effect on Aspergillus niger and other filamentous fungi, and meanwhile, has better bacteriostasis effect on escherichia coli and other bacteria.

The present invention relates to a composition comprising IgY antibodies against at least two different fungi, the use of the composition for the preparation of a pharmaceutical especially for prophylaxis and / or therapy of all kinds of fungal infections, such as conditions caused by organisms belonging to the Candida genus or Aspergillus genus, especially of fungi that are less sensitive to antimycotica and a diagnotstic method using the IgY antibodies. Further it relates to immunisation of birds with a combination of at least two different species of fungi to the Candida genus or Aspergillus genus and a diagnostic method for fungi. It also relates to relates to a novel method for treatment and / or prophylaxis of fungal infections, especially infections by fungi which have lowered sensitivity or resistance to antimycotics. The method is both safe and effective. This is achieved by using IgY directed against fungi, in particular against Candida species, which have a lowered sensitivity or resistance against antimycotics. The specific IgY has been obtained by hyper immunising birds with one or several fungi as antigen in order to stimulate the production of immune globulins (IgY) against such fungi. The present invention also relates to a pharmaceutical product from eggs of birds containing immune globulin or a fragment thereof, which can be combined with other preparations, nutritients or pharmaceuticals for simultaneous, separate or sequential use in the prophylaxis or therapy of gastrointestinal infections in newborn infants.

The invention relates to preparation for a pinus koraiensis phytoncide finishing agent, a fabric finished by same and a finishing method thereof. The formula of the finishing agent contains 10-40g / L of pinus koraiensis phytoncide microcapsule, 10-35g / L of chitosan cross-linking agent, 2-5g / L of organic silicon soft finishing agent and 1-3g / L of penetrant. The pinus koraiensis phytoncide finishing agent is prepared according to the steps of extracting pinus koraiensis phytoncide, preparing the pinus koraiensis phytoncide microcapsule, preparing the pinus koraiensis phytoncide finishing agent, bottling and packaging. The finishing agent is applied to the finishing of the cotton fabric. The cotton fabric has the antibacterial rate for staphylococcus aureus of above 98.2%, antibacterial rate for escherichia coli of above 92.3%, antibacterial rate for candida albicans of above 90.5%, deodorization rate of above 97.2%, mite-proof rate of above 90.6% and the reducing rate of sterilizing, deodorizing and mite-proof effects of below 10% after being cleaned for more than 20 times.

The invention discloses bacillus amyloliquefaciens and application thereof in preparation of antibacterial agents for plant pathogenic fungi. The bacillus amyloliquefaciens LM-Y is separated from rhizosphere soil of diseased peach plants. Compared with the common biocontrol fungi, the bacillus amyloliquefaciens does not produce sensitization spores and is safe to humans, livestock, fruits and vegetables and environmental-friendly. The bacillus amyloliquefaciens LM-Y disclosed by the invention has obvious antagonistic effects on multiple pathogenic fungi such as monilinia fruticola, gibberella zeae, grey mould germs of strawberry and the like, has an inhibition rate of 80% or higher on the monilinia fruticola, has the antibacterial rate higher than that of the conventional biocontrol fungi by about 10% and has great research and development potential. The bacillus amyloliquefaciens LM-Y disclosed by the invention has an obvious effect for controlling the monilinia fruticola, has the field trial control effect of 78.5%, is simple in production process and has very wide application prospects in biocontrol of plant diseases.

The present invention discloses a lysostaphin compounded preparation. Said preparation comprises bacteria-killing effective quantity of lysostaphin and lysozyme. Said lysostaphin compounded preparation has higher bacteria-killing effect as compared with single lysostaphin, not only has the strong bacteria-killing action for Gram-positive bacterium and Gram-negative bacterium, but also has the good effect for killing the fungi of Candida albicans and red trichophyton, etc. It has high bacteria-killing activity and stability, does not produce drug resistance, and has no toxic side effect.

Methods and devices for the detection of proteins secreted by the hyphal growth form of Candida species are disclosed. The disclosed devices may constitute a method for the diagnosis of acute or chronic infections, including candidiasis, caused by microorganisms of the species Candida, such as C. albicans, for example. The devices of the present invention incorporate antibodies specific to secreted aspartyl protease proteins whose expression is upregulated upon the conversion of the Candida species from the commensal to the pathogenic form. The antibodies may be used in assays to allow the diagnosis of candidal infections and disease conditions. Either monoclonal antibodies or polyclonal antibodies may be used, and in the case of the monoclonals, the specific epitopes of the SAP protein may be detected as well as the SAP protein itself.

The invention relates to a dairy cow breast disinfectant, and belongs to the fields of biomedicine and medicaments for agriculture and livestock. The organic dairy cow breast disinfectant is characterized by comprising the following raw materials in percentage by mass according to the formula: 0.25 to 1 percent of 99 percent glycerol, 0.25 to 1 percent of synthetic Chinese medicinal herb concentrate, and the balance of deionized water. The Chinese medicinal herb concentrate is prepared from extracts of honeysuckle, indigowoad leaf, Chinese violet, muskroot-like semiaquilegia root, atractylodes rhizome, folium artemisiae argyi, phyllanthus ruinaria, dandelion, sophora flavescens, glabrous greenbrier rhizome, fructus cnidii, patrinia and groundsel by cleaning, extraction, re-extraction of primary residue, synthesis, decolorization and concentration, and the density of the concentrate is more than or equal to 1.04g / mm<3>. The disinfectant is used for diminishing dairy cow breast inflammation caused by invasion of multiple microbes such as candida albicans, escherichia coli, streptococcus, microsporum, salmonella and shigella and controlling invasion of pathogenic microbes on breasts and mammary glands of dairy cows.

The invention relates to mouthwash prepared in a Chinese medical formula, and has the functions of replenishing qi, strengthening the spleen, tonifying the kidney, soothing the nerves, clearing the heat, detoxicating, clearing the damp, reducing the cellular immune response, the capillary permeability and the inflammatory exudates, and improving the immunity of the organism. The invention has the advantages of good treatment effect, high cure rate and no recurrence fundamentally; and the oral drug not only has good preventive effect, but also has good therapeutic effect.

The invention provides an external used medicine for dermatologic diseases, which is characterized in that phellodendron, lightyellow sophora root, common cnidium fruit, broom cypress fruit, pericarpium zanthoxyli and chloroxylenol are used as active medicine ingredients, and the invention is prepared by mixing the active medicine ingredients with assistant ingredients that are acceptable in preparing external used medicines, wherein, the weight proportions of the active medicine ingredients are as follow: 2-8 parts of phellodendron, 1-5 parts of lightyellow sophora root, 1-5 parts of common cnidium fruit, 1-5 parts of broom cypress fruit, 4-15 parts of pericarpium zanthoxyli and 0.1-5 parts of chloroxylenol. The medicine is a combination of traditional Chinese medicine and western medicine, with the sterilizing rate of over 99.9%, and can effectively sterilize diverse bacteria and fungi such as golden brown staphylococcus, colon bacillus, candida albicans, etc. The external used medicine has quick effect on dermatologic diseases, has high cure rate, few side effects and no drug resistance, and can cure both symptom and root diseases.

The invention provides an external medicament which cures dermatosis. The invention is produced by raw material drugs according to weight share as follows: 100 to 150 shares of wild chrysanthemum flower, 50 to 100 shares of Chinese lobelia, 35 to 75 shares of purple flower violet and 10 to 15 shares of China rose. The invention proceeds reasonable combination of natural plants with the function of bacterium restraining and sterilization and proceeds the craft operations such as extraction and refining according to modern Chinese traditional medicine production craftwork so as to produce antipoisoning products widely used. The invention has restraining effect on golden brown staphylococcus, colon bacillus and candida albicans. The invention is mainly used for restraining bacterium of furunculosis, carbuncle, malignant sore and varied nameless pyogenic infections caused by the golden brown staphylococcus and also can be used for curing the bite of poisonous insects.

The invention discloses a Chinese herbal medicine formaldehyde scavenger and a preparation method thereof. The Chinese herbal medicine formaldehyde scavenger contains the following raw materials in parts by mass: 5-10 parts of fructus forsythiae, 5-10 parts of folium artemisiae argyi, 6-15 parts of cassia seeds, 10-15 parts of lonicera japonica, 5-15 parts of radix isatidis, 10-20 parts of herba artemisiae, 5-10 parts of herba houttuyniae, 3-6 parts of cassia barks, 3-10 parts of dried tangerine peels, 1-5 parts of radix sophorae subporstratae, 5-10 parts of aloe vera, 5-10 parts of taraxacum mongolicum, 5-10 parts of folium isatidis and 5-10 parts of mint leaves. According to the Chinese herbal medicine formaldehyde scavenger and the preparation method thereof, the production process is simple, the preparation cost is low, the produced Chinese herbal medicine formaldehyde scavenger can be used for remarkably lowering the concentration of formaldehyde in indoor air, and the removal efficiency reaches 90% or more; the durability is good, meanwhile, a good bactericidal effect can be achieved, and the rate of killing of staphylococcus aureus, Escherichia coli, black Bacillus subtilis variants and Candida albicans is 80% or more. Furthermore, the Chinese herbal medicine formaldehyde scavenger is non-toxic, nonirritant and readily-degradable.

The present invention relates to the use of compositions that, when applied to citrus, are capable of controlling the psyllids Trioza erytreae and Diaphorina citri, vectors of bacteria of the genus Candidatus liberibacter, which cause the disease known as Huanglongbing (HLB), deemed to be the most destructive disease currently to affect citrus crops worldwide. These compositions may contain, without distinction, or jointly, as active components, vitamin K3, soluble derivatives thereof (preferably menadione sodium bisulphite [MSB]) or sparingly soluble derivatives thereof (preferably menadione nicotinamide bisulphite [MNB]), with respective concentrations of between 0.0001 and 200 ppm, 0.001 and 10 000 ppm, preferably vitamin K3 between 0.001 and 100 ppm, MSB between 0.01 and 5000 ppm, and MNB between 0.01 and 5000 ppm. Said compositions are applied preferably by spraying to the aerial part of the plant or via the irrigation system, and may be mixed with a variety of additives, such as organic and inorganic fertilizers, insecticides, nematocides, fungicides, bactericides, acaricides or herbicides.

The invention relates to a novel wide-spectrum bacterial strain Bacillus sp. AH-E-1 inhibiting clinical and plant pathogenic fungi, and an application thereof. The main content comprises: (1) Bacillus sp. AH-E-1 is a newly-discovered bacillus strain or subspecies; (2) Bacillus sp. AH-E-1 can produce anti-fungus substances after fermentation under appropriate conditions; (3) Bacillus sp. AH-E-1 can significantly inhibit 20 clinical pathogenic fungi such as aspergillus flavus, aspergillus fumigates, trichophyton rubrum, trichophyton mentagrophyte, candida glabrata, cryptococcus neoformans, and the like; (4) Bacillus sp. AH-E-1 can significantly inhibit 13 plant pathogenic fungi such as staphylococcus, magnaporthe oryzae, rhizopusstolonife, and the like. The invention provides an excellent novel anti-fungus substance producing bacterial strain which has the advantages of wide fungus-inhibiting spectrum, obvious effect, and the like.

The invention relates to the aplication of amigo-smile polyoses used for resisting bacteria or viruses, in particular to the application of the amigo-smile polyoses for preparing a medicament with the effects of resisting the bacteria or the viruses. The amigo-smile polyoses of the invention has inhibition effects to a plurality of bacteria or viruses, such as Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, Escherichia coli, salmonella, Proteus vuigaris, Shigella dysenteriae, Candida albicans or parainfluenza virus, and the like. The known method of the prior art can be adopted to prepare the amigo-smile polyoses of the invention into a medicament compound and the medicament compounds of any preparation formulation acceptable on pharmacy, such as granular formulation, oral liquid, capsule, troche, injection, pulvis, and the like.

The invention discloses application of amomum tsao-ko oil on preparing medicaments with functions of restraining or killing candida albicans. The invention further discloses a medicine composite with the functions of restraining or killing the candida albicans. The medicine composite enables the amomum tsao-ko oil to serve as an active ingredient, and auxiliary materials or auxiliary ingredients which are acceptable on the pharmacy are added to prepare. The amomum tsao-ko oil has the functions of restraining or killing the candida albicans, can treat candida albicans diseases, and has strong practical application value.

The invention discloses a novel actinomycin strain which generates actinomycin D: Streptomycesmutabilis TRM45540, preserved in U. S. Department of Agriculture Agricultural Research Service (ABS) Culture Collection on 14th, April, 2014 with the preservation number of NRRL B-59117. Meanwhile, the invention further discloses a seed medium which efficiently produces actinomycin D by using the strain, a fermentation medium and a preparation process of extracting and separating actinomycin D from fermentation liquor. An antibacterial activity test shows that the strain and the actinomycin D generated by fermentation of the strain have broad-spectrum and efficient antagonistic activity on pathogenic bacteria such as cotton verticillium and fusarium wilts, walnut pythium ultimum, staphylococcus aureus, staphylococcus epidermidis, candida albicans and the like and have an important application value and a very good application and development prospect on safe production of crops such as cotton, walnuts and the like and in preventing and controlling diseases such as bovine mastitis, women's vaginitis and the like.

The present invention discloses a novel anti-crop-epiphyte polypeptide and a preparation method thereof. A recombined anti-crop-epiphyte polypeptide is formed by linking gene which codes white candida pheromone and the gene which codes colicin. Compared with the prior anti-crop-epiphyte medicine, the novel anti-crop-epiphyte polypeptide of the present invention has the advantages that the novel anti-crop-epiphyte polypeptide directly forms ionic passage at epiphytic cell membrane to kill the epiphyte, so the killing efficiency is thousands times stronger than the prior anti-crop-epiphyte medicine; the epiphyte can hardly amend the geometrical damage at the cell membrane caused by the polypeptide by the mutation-expression form, so the polypeptide can not induce the epiphyte producing the traditional drug resistance; the polypeptide is a biological preparation and has target killing towards the epiphyte, so the novel anti-crop-epiphyte polypeptide does not have the toxic and side effects of the prior anti-crop-epiphyte medicine.

The invention belongs to the field of natural preservatives and discloses a natural botanical preservative and a preparation method and application thereof. The natural botanical preservative is prepared from, by mass, 10-25% of a stemona tuberosa extract, 10-25% of an eleutherine plicata extract, 10-25% of a litsea cubeba extract, 10-25% of a murraya paniculata extract and 30%-60% of a solvent. The natural botanical preservative is composed of botanical complex extract obtained by supercritical CO2 extraction in four plants including murraya paniculata, stemona tuberosa, eleutherine plicata and litsea cubeba, a synergistic effect is achieved, an antibacterial spectrum of each single plant is expanded to achieve a wide antibacterial spectrum, and effectiveness in inhibition of microbes including escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, bacillus subtilis, candida albicans, aspergillus niger and the like is achieved, so that the natural botanical preservative canbe applied to the field of cosmetics.

The invention discloses a gene chip for detecting 15 clinical common pathogenic microorganisms. The gene chip comprises specific detection probes fixed on a solid phase vector, wherein the probes are designed for 16SrRNA gene and ITS gene sequences of staphylococcus aureus, klebsiella pneumoniae, pseudomonas aeruginosa, proteus mirabilis, Escherichia coli, shigella, enterobacter aerogenes, pseudomonas fluorescens, candida albicans, candida glabrata, candida tropicalis, candida parapsilosis, aspergillus terreus, aspergillus flavus and rhizopus oryzae, and screened and verified by repeated tests, and have high hybridization specificity and accuracy. The chip provided by the invention ensures simple detection operations and relatively lower cost, saves time, is applied to the screening of the clinical common pathogenic microorganisms, the early rapid diagnosis of critical patients and the diagnosis of suddenly occurring infection event pathogens and favorable for clinically rapidly diagnosing infection sources and functions in the early detection and early diagnosis of clinical diseases.

The present invention discloses an application of the extract of Lo Han Kuo (LHK) fruit (Siraitia grosvenorii Swingle) for its dual related functions. Specifically, this is related to the use of LHK extract for its antimicrobial activities against pathogens Streptococcus mutans, Porphyromonas gingivalis, A. actinomycecomitan, F. nucleatum, and Candida albicans, and its low glycemic index for use by general population as well as the diabetics to improve oral health.

Proguanil has been found to have rapid and effective killing activity against a variety of disease-causing micro organisms. For example, when applied topically, proguanil is particularly effective against Propionibacterium acnes, a bacteria that causes acne; Corynebacterium minutissimum, a bacteria that causes erythrasma, Gardnerella vaginalis, a bacteria that causes vaginosis; Trichomonas vaginalis, a protozoan that causes trichomoniasis and C. albicans, a fungus (a form of yeast).

The present invention relates to a novel Lactobacillus sp. isolation strain having an activity to inhibit the growth of vaginitis pathogens, and a pharmaceutical composition, a health functional food, and a cleansing product, comprising the strain as an active ingredient. Therefore, the present invention exhibits an effect of inhibiting the growth of Sneathia spp. pathogens associated with the infection with human papillomavirus (HPV) and the incidence of bacterial vaginitis, Gardnerella vaginalis as a vaginitis pathogen, and Candida albicans as a causative bacteria of Candidal vaginitis, and an effect of recovering and maintaining the vaginal microflora, and thus can be used for the prevention and treatment of female vaginitis.

The invention discloses three specific genes capable of generating fumonisins fusarium microspecies and application thereof and belongs to the field of molecular biology. On the one hand, three specific gene sequences for generation of the fumonisins fusarium microspecies are disclosed; on the other hand, the application of the three specific genes capable of generating the fumonisins fusarium microspecies in detection of rice spike monilinia fiucticola is also disclosed. The three specific genes have the advantages that specific genes of the microspecies are obtained from genomic sequence information of three kinds of fusarium capable of generating fumonisins, detection of pathogenic bacteria is achieved according to specific nucleotide sequences of the microspecies, detection primers have high specificity, and therefore bands with specificity can be amplified from a target strain. The specific genes, the primers and the detection method can be adopted for fast, conveniently and accurately distinguishing three kinds of bacterial strains which can generate fumonisins and trigger rice spike rot.

The purpose of this study was to test the efficacy of an oregano extract containing carvacrol and capyrlic acid blend by screening for inhibition and by conducting a preservative efficacy test, USP 51, in skin creams. Minimum inhibitory concentrations were found for Escherichia coli, Staphylococcus aureus, Pseudomonsas aeruginosa, Streptococcus sanguinis, Salmonella enterica, Candida albicans, and Aspergillus brasiliensis.

24H+ Antibacterial liquid is made from, by weight, 5 parts of lightyellow sophora root liquid, 3 parts of sessile stemona root liquid, 8 parts of amur corktree bark liquid, 8.5 parts of aloe liquid, 8.5 parts of common cnidium fruit liquid, 0.5 part of chlorhexidine acetate, and 70 parts of purified water. A preparation method of the 24H+ antibacterial liquid comprises: first, taking lightyellow sophora root extract, sessile stemona root extract, amur corktree bark extract, aloe extract, common cnidium fruit extract, and chlorhexidine acetate extract; second, adding the extracts into purifiedwater, mixing well, using a stirring rod to continuously mix, allowing standing, and filling. The preparation method herein is simple; the 24H+ antibacterial liquid has good antibacterial effect uponthe fungi, such as Staphylococcus aureus, Escherichia coli and Candida albicans, and has the advantages of pudendum cleaning and moistening, freshness, mildness and coolness, and good safety and convenience.

The present invention relates to a method and a means of diagnosing Candida infection. In particular, the present invention relates to a method of diagnosing Candida infection comprising the steps of obtaining a biological sample from a subject at risk of, or suspected to be suffering from, Candida infection, contacting the sample with a mannose depleted antigen composition comprising a soluble cytoplasmic antigen preparation comprising antigens of molecular weight 55 kDa, 30 kDa and 20 kDa and detecting the antigen / antibody reaction.

The invention discloses gynaecological antibacterial gel, which is prepared from radix notoginseng extracts, aloe extracts, safflower extracts, herba houttuyniae extracts, radix isatidis extracts, nano-silver, antibacterial peptide, polyethylene glycol, gel substrates and deionized water. The gynaecological antibacterial gel provided by the invention uses the plant extracts as major antibacterial agents; meanwhile, the nanometer silver and the antibacterial peptide are added; various antibacterial ingredients have the cooperated effects, so that the product has the broad-spectrum antibacterial effects; the effect taking speed is high; safety is realized; no side effect exists; in addition, the antibacterial peptide kills the bacteria and can also improve the body immunity and help human body to resist the invasion from pathogens. Through being proved by experiments, the gynaecological antibacterial gel has the obvious inhibition effects on escherichia coli, candida albicans, staphylococcus aureus and pseudomonas aeruginosa; the cure rate on vaginitis is as high as 98.2 percent.